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CURRICULUM VITAE BIODATA Name : Jacob Ogweno MIDIWO Address : Department of Chemistry University of Nairobi P.O. Box 30197 Nairobi KENYA Date of Birth : March 31, 1953 Marital Status : Married with two children Nationality : Kenyan SCHOLASTIC CAREER E.A.C.E. : Sawagongo Secondary School, 1970 E.A.A.C.E. : Alliance High School, 1972 BSC. (Hons) : Chemistry, University of Nairobi, 1976 Ph.D : Organic Chemistry, University of Maryland, 1981 PROFESSIONAL ORGANIZATION

1. The Kenya Chemical Society. 2. Natural Product Research Network for East and Central Africa (NAPRECA)- Executive

Secretary since November 2004. 3. American Chemical Society

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AWARDS FOR RESEARCH. 1. Deans' Committee, University of Nairobi, KShs 14,000/=, 1984. 2. Dean's Committee , University of Nairobi, KShs. 98,255/=, 1988. 3. University of Maryland Research Fellow, January 1986 - June, 1987. 4. The Matsumae International Foundation Scholarship Award, Meiji College of Pharmacy, Tokyo,

Japan, June-October, 1990. 5. (1990-1995) International Foundation for Science (Sweden). US$ 12,000- Development of

mosquito larvicidal agents from Polygonum senegalense 6. The DAAD Research Fellowship, September, 1991 - Hohenheim University, Stuttgart,

Germany. 7. (1995-1997) International Foundation for Science (Sweden) US$ 12,000 – Development of

mosquito larvicidal agents from Polygonum senegalense Part II. 8. (1994-1996) The Agricultural Research Foundation (Kenya) US$ 25,000 – Discovery of

Botanical Crop Protection Agents. 9. (1993-2004) Strathclyde Institute of Drug Research, University of Strathclyde, Glasgow,

Scotland, US$ 200,000, Bioprospecting for Active Bioactive Principles from Tropical Plants. 10. (2001- 2005) Analyticon Discovery, Potsdam, Germany, approx. US$ 30,000.

Bioprospecting for Active Bioactive Principles from Tropical Plants. 11. (2002 -2006) L’Oreal Cosmetic Company, Paris, France approx. US$ 40,000. Search for

Cosmetic principles from plants. 12. (2005-2009) WHO, Geneva Malaria program,US$ 80,000. Bioprospecting for anti-

malarial principles from tropical flora.

13. (2009- 2010) Organization for Prohibition of Chemical Weapons, US$ 30,000. Structure Activity Relationship Study of Natural Flavonoids as brain radical scavengers.

14. (2010-2012) Deans Committee, University of Nairobi, US$ 10,000. Search for Anti- plasmodial principles from Kenyan flora. NATIONAL ACHIEVEMENTS

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1. With others, successfully (as Secretary) started and launched The Kenya Chemical Society in

1990. 2. With others and as secretary of the society, successfully organised the Inaugral International

Chemistry Conferences of the Kenya Chemical Society; June, 1993 at University of Nairobi, Nairobi.

3. With others and secretary of the society, succesfully organized the Second International

Chemistry Conference of the Kenya Chemical Society, September, 1996 at Moi University, Eldoret.

4. Patron of a Committee formed to develop Ndori Mixed Secondary School (My village school). 1990- 2005 5. With others and secretary of the society organized the Kenya Chemical Society seminar on Chemistry for Health and Environmental Protection, Department of Chemistry , University of Nairobi, July 1998. 6. With others, as Chairman of Organizing Committee successfully organized the 3rd.

International Kenya Chemical Society Conference at JKUAT. August 1999. 7. As Chairman and with others Organized the Ninth NAPRECA International Symposium

and Workshop on Natural Products August 22-31, 2001 at the Kenyatta International Conference Centre after successfully reviving NAPRECA-K.

8. In April 2005, as Executive Secretary , organized the NAPRECA Summer School in

Nairobi for local and African regional participants. 9. In August 2005 as the Executive Secretary organized the 11th NAPRECA Symposium on

Natural Products in Antananarivo, Madagascar. 10. In July 2007 as Executive secretary organized the 12th. NAPRECA Symposium on Natural

Products at the Hotel Africana, Kampala, Uganda. EMPLOYMENT RECORD 1976-1977 : Laboratory Manager, Sterling International Ltd., Nairobi. 1977-1979 : Teaching Assistant, University of Maryland - Organized

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and conducted citation sessions in basic organic chemistry; supervised chemistry laboratories.

1979-1981 : Research Assistant working in areas of thesis concentration,

University of Maryland. 1981-1985 : Lecturer, University of Nairobi. 1985-1987 : Research Fellow, University of Maryland, U. S. A. 1987-1993 : Senior Lecturer, Department of Chemistry, University of

Nairobi. 1993 -2002 : Associate Professor, Department of Chemistry, University

of Nairobi. 2002 to present : Professor, Department of Chemistry, University of Nairobi. UNIVERSITY TEACHING EXPERIENCE Chemistry Department Most organic Chemistry courses at Undergraduate and Post-graduate level. General Chemistry (Inorganic and Physical ) courses for 1st year college students. SKILLS Spectroscopy : Experience in the operation and interpretation of FT and

continuous Wave NMR; Infrared, UV -visible; mass spectrometry and polarimetry.

Separation techniques : Extensive experience in the use of HPLC (analytical and

preparative), gas liquid chromatography. Column chromatography (gravity, flash and medium pressure). Thin layer chromatography (analytical, preparative).

Analysis : Extensive experience in analysis of environmental pollutants by wet and dry methods.

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POST-GRADUATE STUDENTS SUPERVISION Name Title 1. Geoffrey M. Rukunga : Phytochemical Screening of Kenyan Rumex Species (MSc. 1984) as a possible source of Purgatives. 2. Julius J. Matasi : Chemical Screening of some Kenyan Polygonum (MSc. 1987) Species. 3. Lawrence A. Manguro : Phytochemical Analysis of the Kenyan Medicinal (MSc. 1988) Myrsinaceae plants. 4. Onesmus M. Wanjau : Further Chemical Analysis of Kenyan Polygonum (MSc. 1990) species. 5. Catherine Githinji : Ethnobotanical and Chemotaxonomic study of some (MSc. 1990) Kenyan Medicinal Labiate species. 6. Elizabeth Achola : A Study of the Apocynaceae species used in (MSc. 1990) traditional medicine in Kenya. 7. Nicholas K. Gikonyo : Hydrophilic Flavonoid components of Leaves and (MSc. 1991) Flower Heads of Polygonum senegalense and the

Larvicidal and anti-feedant activities of its hydrophobic principles.

8. Yacob Ghebremeskel : Chemical Analysis of Rapanea melanphloes (MSc. 1991) (Myrsinaceae) alkylbenzoquinones and some of their

biological activities. 9. Lawrence A. Manguro : Isolation Characterization and Synthesis of (Ph.D 1995) Benzoquinones from Kenyan Myrsinaceae Plants for male

antifertility regulation. 10. Nobert O. Owino : Structure Elucidation of Hydrophilic Flavonoids (MSc. 1993) of Polygonum senegalanse and their comparative anti-

feedant activity with Hydrophobic components. 11. Catherine W. Githinji : An Ethnobotanical and Phytochemical study of the (Ph.D. current) genera Ocimum and Plectranthus in Kenya.

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12. Nelson Omagor : An Ethnobotanical study of Poisonous plants of (MSc. 1994) Busoga District, Uganda. 13. Charles A. Angedu : Determination of the relationship between the (MSc 1994) pyrethrins and yellow pigmentation in Pyrethrum flowers. 14. Rusula A. Owino : A Study of selected indigenous vegetables of (MSc.1995) Kisumu District. 15. Regina A. Ochieng : An Ethno-botanical and Chemical study of medicinal (MSc. 1995) plants used in the treatment of gastro-intestinal disorders

in Siaya District, Kenya. 16. Paul C. Kiprono : Chemistry and biological activity of benzoquinones

(Msc 1997) from Embelia schimperi. 17. Solomon Derese : Chemistry and Biological Activity of Hypericum (MSc.1998) species. 18. Abiy Yenesew : Chemistry of Biological Activities of Kenyan (Ph.D.1997) Papilionoidae. 19. J. M. Wanjohi : Chemical and Biological characterestics of a (Ph.D.2005) Anthraquinone Pigments of Kenyan Aloes. 20. Austin O. Aluoch : Characterestics and Biological activity of Erythrina

excelsa and Zanthoxylum chalybeum. (MSc. 2000) 21. B. F. Juma : Studies on the surface exudate chemicals of Psiadia (MSc 2001) punctulata. 23. J.A. Ayoo : Chemistry and biological activity of Zanthoxylum (MSc 2001) usambarense 25. Salome Guchu : Chemical and anti-malarial characteristics of (MSc 2002) Rawsonia lucida. 26. Leonida Kerubo Omosa : Chemical Investigation and Industrial Application of (PhD. Current) Matricaria chamomilla grown in Kenya.

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27. Humphrey Simukoko : The effects of Embelin (a benzoquinone compound of (MSc 2001) plant origin) on some reproductive parameter of female Sprague-Dawley rats. 28. John T. Kiplagat : Anti-plasmodial flavonoids from Derris trifoliate. (MSc 2005) 29. Martha Induli : Anti-plasmodial flavonoids from Erythrina abysinica bark. (MSc 2006) 30. Charles O Ochieng : Surface and internal tissue flavonoids from Gardenia (MSc 2008) ternifolia. 31. Solomon Derese : Anti-plasmodial flavonoids from some Kenyan Papilionoideae. (PhD 2004) 32. Leonida Kerubo Omosa : 33. Francis Machumi 34. Everlyn Kasima 35. Aggrey Akimanya 36. Beth Ndunda EXTERNAL EXAMINATION 1. Bakari S. Kaoneka : Chemical Studies of some plants with Anti-feedant (University of Dar-es-Salaam Activity against Emperor Moth, Nadaurella belina 1990) (Saturnidae). 2. Nigist Asfaw : Chemical Investigation on the Essential Oils of (Addis Ababa University, 1992 ) Endemic wild and cultivated Lippia adoensis Hochst. Ex.

Walp. 3. Muniru K. Tsanuo : Bioassay Guided Chromatographic and structural (Kenyatta University, 1994) elucidation of anti-feedant compounds against Chilo

partellus (shinhoe) found in Fruits of Elaeodendron buchananii.

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4. Phoebe Gubya : An Investigation into the Fate of some of the (Makerere University, 1995) mineral ions in a Papyrus Ecosystem. 5. Ms. S. Kariuki : Chemistry of Pyrethrum (Egerton University, 1995) 6. Department of Chemistry : Assessment of Examination Standards and marking (Egerton University 1996-9) Consistency. 7. Department of Chemistry : Assessment of Examination Standards and marking (University of Dar-es-Salaam, Consistency. (1997-1999) 8. G. Duker-Eshun, MPhil : Chemical analysis of Parkia clappertononia, Keay ( University of Ghana 1997) 9. Mr. A. Silayo, MSc

(University of Botswana 1998): Homoisoflavonoids from Scilla nervosa (Burch.) Jessop, found in Botswana

10. Mr. Osei Akoto, MPhil ( University of Ghana, 1998) : Phytochemical and Pharmacological Investigation of Capparis tomentosa.

11. Mr. F. Moyo (University of Botswana, MSC 1998) : Phytochemical and Anti-microbiol Studies on Elephantorhiza goetzei. 12. G. Bojase, MSc : Isoflavonoids and Pterocarpans from Bolusanthus (University of Botswana speciosus and their anti-microbial activities 2001) 13. Ms Tracey Lee Pohl : Extractives of Amaryllidaceous and the Hyacanthaceae (PhD. University of Natal Durban 2002) 14. Ms Imelda Mbena : Phytochemical studies on leaves and twigs of Spristachys ( MSc , University of africana. Botswana, 2006) 15. Mr. Joseph J. Magadula : Extractives of the Gentianaceae and Euphorbiaceae.

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( PhD. University of Kwazulu Natal, 2006). 16. Department of Chemistry (Maseno University 2007- 2009). : Assessment of examination standards and marking consistency. 17. Department of Chemistry

Chancellor College, University of Malawi. : Assessment of examination standards and marking consistency.

RESPONSIBILITIES 1. Faculty of Science Senate Representative 1987-1996 2. Secretary, The Kenya Chemical Society 1993-1998. 3. Warden, Dag Hammarskjold Hall (10) 1990-1997. 4. Member, University of Nairobi, Office of International Programmes. 5. Co-ordinator, departmental Committee on Curricullum Development. 6. Chairman, Natural Products Research Network for Eastern and Central Africa, Kenya

(NAPRECA-K) branch, 2000-2005. 7. Executive secretary, Natural Products Network for east and Central Africa (NAPRECA), 2004-

2008. 8. Vice-President, Working Group of Plant Chemistry of the International Organisation of

Chemical Sciences in Development (IOCD). RESEARCH PUBLICATIONS 1. Jarvis, B.B., Midiwo, J.O.,,, Stahly, G.P., Pavanasasivam, G., Mazzola, E.P.,

Trichodermadiene. A New Trichothecene, Tetrahedron Lett. 1980, 787.

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2. Jarvis, B.B., Midiwo, J.O., Desilva, T., Modification of Flash Chromatography, Aldrichimica

Acta, 1981, 1, 2. 3. Jarvis, B.B., Midiwo, J.O.,,, Desilva, T., Mazzola, E.P., Verrucarin, L. A new Macrocyclic

Trichothecene, J. Antibiotics, 1981, 120. 4. Jarvis, B.B., Nicholas, P.E. Midiwo, J.O.,, Thermolysis of a-Azido Sulfides, Sulfoxides and

Sufones: Dependence of Mechanism on Oxidation State of Sulfur, J. Am. Chem Soc. 1981, 3878.

5. Jarvis, B.B., Midiwo, J.O., Tutthill, D., Bean, G.A. Interaction Between the Antibiotic

Trichothecenes and the Higher Plant, Baccaharis megapotomica, Science 1981, 460. 6. Jarvis, B.B., Midiwo, J.O., Flippen-Andersen, T.L., Mazzola, P.E. Stereochemistry of the

Roridins, J. Nat. Prod. 45, 1982, 440. 7. Jarvis, B.B., Stahly, G.P., Midiwo, J.O.,,, Pavanasasivam, G., Desilva, T., Holmlund, C.E.

Mazzola, E.P., Geoghegan, R.F Isolation and Characterization of the Trichoverroids and New Roridins and Verrucarins, J. Org. Chem 1982, 47 1117.

8. Jarvis, B.B. Vrudhula, V.M., Midiwo, J.O., Mazzola, E.P. New Trichoverrins from

Myrothecium verrucaria: verrol and 12, 13-Deoxytrichodermadiene, J. Org Chem 1983, 48 276.

9. Jarvis, B.B., Midiwo, J.O., Mazzola, E.P. Anti-leukemic compounds Derived by chemical

Modification of Macrocyclic Trichothecenes. Derivatives of Roridins A and H and Verrucarins A and J., J. Med. Chem (1984) 27 239.

10. Midiwo, J.O., Rukunga, G.M. Distribution of Anthraquinone of Pigments in Rumex species of

Kenya, Phytochemistry 24, (1985), 1390. 11. Midiwo, J.O., Arot, H.M., Mbakaya, C.L., Distribution of Benzoquinone Pigments in Kenya

Myrsinaceae Bull. Chem. Soc Ethiop. (1988), 2(2) 83. 12. Jarvis, B.B., Midiwo, J.O.,,, Bean, G.A., Aboul-Nasr, M.B., Barros, C.S. The Mystery of

Trichothecene Antibiotics in Baccharis species J. Nat. Prod. (1988) 51, 736. 13. Jarvis, B.B., Midiwo, J.O., Maodi, G., 12, 13-Deoxytrichoverrins A and B: Novel

Trichoverroids. J. Nat. Prod., (1989) 52 (3), 663. 14. Midiwo, J.O., Odingo, J.O., and Arot, L.M. Benzoquinone Pigments in Kenyan Myrsinaceae:

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New 2, 5-dihydroxyakyl derivatives from Maesa lanceolata. Bull. Chem. Soc. Ethiop. (1990), 4 (1) 71.

15. Midiwo, J.O., Matasi, J.J., Wanjau, O.M., R.W. Mwangi, Waterman, P.G. and Wollenweber,

E. Anti-feedant effects of surface accumulated flavonoids of Polygonum senegalense. Bull. Chem. Soc. Ethiop. (1990), 4(2), 123.

16. Sreekantha B., Jonnalagadda, Wafulla, F.W., Midiwo, J.O., Periodic reaction between m-

nitrophenol and potassium bromide in acidic solution, Kenya Journal of Science Series A (1988) 9 (1 & 2): 91.

17. Githui, E.K., Makawiti, D.W., Midiwo, J.O.,, Changes in the Concentrations of Testosterone,

Luteinising hormone and Progesterone associated with administration of embelin. Contraception (1991), 44(3), 311.

18. Makawiti, D.W., Midiwo, J.O., The Effect of Maesequinone on Plasma testosterone levels in

the rabbit. Adv. Contr. Deliv. Syst. (1991) VII, 253. 19. Midiwo, J.O.,,, Ghebremeskel, Y., Arot, L.M., Koyama, K., Natori, S. Benzoquinones in

Kenyan Myrsinaceae Part III: A new 2,3-Dihydroxyalkyl-1, 4-benzoquinone (myrsinone) and 5-0-methylembelin from Myrsine africana. Bull. Chem. Soc. Ethiop. (1992) 6(1), 15-19.

20. Midiwo, J.O.,,, Arot, L.M. Polynuclear Acetogenic Pigments in the Fruits of the Myrsinaceae.

Biochemiphysics (1993) (1,2), 115. 21. Midiwo, J.O., Chromatographic separation and spectroscopic analysis of Kenyan

Myrsinaceae benzoquinones. The Matsumae International Foundation Fellowship Report, (1992), Vol. 2. 143.

22. Midiwo, J.O.,,, Gikonyo, N.K., Wanjau, D.O., Matasi, J.J. and Waterman, P.G. Flavonoids of

Polygonum senegalense (Meisn) Part II: More surface and Internal Tissue Flavonoid Aglycones. Bull. Chem. Soc. Ethip. (1992, 6(2) 119-122.

23. Midiwo, J.O.,,, Ghebremeskel, Y. (1993). Benzoquinones in Kenyan Myrsinaceae: 6,6¢

Biembelin, A new symmetrical long alkyl side chain bisbenzoquinone from Rapanea melanphloes (L), Mez, Bull. Chem. Soc. Ethiop. 7(1) 67-69.

24. Midiwo, J.O.,,, Gikonyo, H.K., Mwangi, R.W. (1994). Toxic and Growth Inhibition Activity of

Polygonum senegalense (Meisn) surface Exudate on larvae of Aedes aegypti. Insect Science and its Applications. (1994).

25. Midiwo, J.O., Owino N.O., Dagne E. (1994). Flavonoids of Polygonum senegalense Part III :

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Isolation of Dihydrochalcone Glucoside and Quercetin glycosides. Bull. Chem. Soc. Ethiop. 8(2), 79-84. 26. Midiwo, J.O.,,, Mwangi, R.W., Ghebremeskel, Y. (1995). Insect Anti-feedant, Growth

Inhibiting and Larvicidal Compounds from Rapanea melanphloes (Myrsinaceae). Insect Science Application, 16 (2) pp. 163-166.

27. Manguro, L.O., Midiwo, J.O.,, and Kraus, W. (1996). A flavonoid glycoside from Myrsine

africana leaves. Phytochemistry 43, (5) 1107-1109 28. Abiy Yenesew, Midiwo, J.O.,, and Waterman, P.G. (1996). Four flavones from seed pods of

Milletia dura, Phytochemistry 41(3) pp 951-955. 29. Midiwo, J.O.,,, Arot, L.M., (1996). A new Dialkyl benzoquinones from fruits of Myrsine

africana and Maesa lanceolata, Forsk. Natural Products Letters 8, pp 11-14. 30. Abiy Yenesew, Midiwo, J.O.,,, Waterman, P.G., (1997) 6-methoxycalopogonium Isoflavone.

A new isoflavone from the seed pods of Milletia dura. J. Natural Prod. 806-807. 31. Midiwo, J.O., Juma, B.F., Owour, F.A.O, Waterman, P.G. (1997). Diterpenoids from the leaf

exudate of Psiada punctulata. Phytochemistry Vol. 45, (1) 117-120 32. Abiy Yenesew, Midiwo, J.O., Waterman, P.G. (1998). Rotenoids, Isoflavones and Chalcones

from the stem bark of Millettia usaramensis subspecies usaramensis. Phytochemistry Vol.47 (2) 295-300.

33. Magiri, E.N., Konji, V.N., Makawiti, D.W. and Midiwo, J.O., (1996). The effect of plant

quinones on Insect Flight muscle mitochondria. Insect Science its Applications, 16, 2 183-189. 34. Abiy Yenesew, Midiwo, J.O., Merle Meissner and Peter, M.G. (1998). Two prenylated

flavonones from stem bark of Erythrina burtii. Phytochemistry, 48, 8, 1439-14443. 35. Manguro, L.O., Midiwo, J.O and Kraus W. (1997). A new flavonol tetraglycoside from

Myrsine africana leaves. Natural Products letters, 9, 121-126. 36. Arot, L. O. M., Midiwo, J. O. and Kraus, W. (1997). Further flavonol glycosides from Myrsine africana. Natural Product Sciences 3(1) 8-10. 37. Abiy Yenessew, Midiwo, J.O., Heydenreich, M.ed Peter, M. G. (1998). Four Isoflavones from the Stem Bark of Erythrina sacleuxii. Phytochemistry, 49,1, 247-249.

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38. Abiy Yenesew, Midiwo J. O., Heydenreich, M. Schanzenbach, Peter G. M. (2000). Two

isoflavanones form the stem bark of Erythrina sacleuxii. Phytochemistry 55, 457-459. 39. Bernard F. Juma, Yenesew A., Midiwo J. O. and Waterman P.G. (2001) Flavones and

Phenylpropanoids in the exudate of Psiadia punctulata. Phytochemistry. Vol. 57 (4), 571-574. 40. Abiy Yenesew, Midiwo J.O., (2001) Effect of crude extracts and rotenoids from Millettia dura on larvae of Aedes aegypti, Insect Science Its Applications. Paper returned for minor revision. 41. Abiy Yenesew, Jacob O. Midiwo, S. M. Guchu, M. Heydenreich M. G. Peter (2002) Three isoflav-3-enes and 2-arylbenzofuran from the root bark of Erythrina burttii. Phytochemistry 59, 337-341. 42. Abiy Yenesew, Midiwo J. O. , Heydenreich, M. Schanzenbach, Peter G. M. (2000). Two

isoflavanones from the stem bark of Erythrina sacleuxii. Phytochemistry 55, 457-459. 43. Bernard F. Juma, Yenesew A., Midiwo J. O. and Waterman P.G. (2001) Flavones and Phenylpropanoids in the exudate of Psiadia punctulata. Phytochemistry. Vol. 57 (4) , 571- 574. 44. J. Ogweno Midiwo, A. Yenesew, B.F. Juma, S. Derese, J. A. Ayoo, A. O. Aluoch and S. Guchu (2002), Bioactive Compounds from some Kenyan Medicinal Plants: Myrsinaceae, Polygonaceae and Psiadia punctulata. Phytochemistry Reviews 1: 311-323. 45. A. Yenesew, S. Derese, B. Irungu, Jacob O Midiwo, N. C. Waters, P. Liyala, H. Akala, M. Heydenreich, M. G. Peter (2003), Flavonoids and Isoflavonoids with Anti-plasmodial activities from Root Bark of Erythrina abyssinica. Planta Med. 69,658-661. 46. A. Yenesew, S. Derese, Jacob O Midiwo, H. A. Oketch, J. Lisgarten, Rex Palmer, M. Heydenreich, M. G. Peter, H. Akala, J. Wangui, P. Liyala, N. C. Waters (2003). Anti- plasmodial activities and X-ray Crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis. Phytochemistry 64, 773-779. 47. A. Yenesew, B. Irungu, S. Derese, Jacob O Midiwo, M. Heydenreich, Martin G. Peter (2003). Two prenylated flavonoids from from stem back of Erythrina burttii. Phytochemistry 445-448. 48. A. Yenesew S. Derese, Jacob O Midiwo, M. Heydenreich and M. G. Peter (2003). Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti. Pest Management Science 59, 1159-1161.

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49. L. O Arot Manguro, Jacob O Midiwo, W. Kraus, I Ugi (2003). Benzoquinone derivatives of Myrsine africana and Maesa lanceolata. Phytochemistry 64, 855-862. 50. A. Yenesew, M. Induli, S. Derese, Jacob O Midiwo, M. Heydenreich, M. G. Peter, H. Akala, Julia Wangui, P. Liyala and N. Waters (2004). Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry 65, 3005-3032. 51. A. Yenesew, E. Mushibe, M. Induli, S. Derese, J. O. Midiwo, J. Kabaru, M. Heydenreich, A. Koch, M. G. Peter (2005) . 7a-O-methyldeguelol, a modified rotenoid with an open ring-C from the roots of Derris trifoliata. Phytochemistry 653-657. 52. A. Yenesew, S. Derese, Jacob O Midiwo, C.C. Bii, M. Heydenreich, M. G. Peter (2005). Antimicrobial flavonoids from the stem bark of Erythrina burttii. Fitoterapia 469-472. 53. J. M. Wanjohi, A. Yenesew, Jacob O Midiwo, M. Heydenreich, M. G. Peter, M. Dreyer, M. Reichert and G. Bringmann (2005). Three dimeric anthracene derivatives from the fruits of

Bulbine abyssinica. Tetrahedron 61, 2667-2674.

54. B.F. Juma, Jacob O. Midiwo, A. Yenesew, P.G. Waterman, M. Heydenreich, M. G. Peter (2006). Three ent-trachylobane diterpenes from the leaf exudates of Psiadia punctulata. Phytochemistry 67, 1322-1325.

55. Jacob O Midiwo, F. M. Omoto, A. Yenesew, H.M. Akala, J. Wangui, P. Liyala, C. Wasuna, N.C. Waters (2007). The first 9-hydroxy isoflavanone and anti-plasmodial chalcones from the aerial exudates of Polygonum senegalense. Arkivoc (ix) 21-27. 56. Volodymyr Samoylenko, Melissa R. Jacob, Shabana I. Khan, Jianping Zhao, Babu L. Tekwani, Jacob O Midiwo, Larry A. Walker and Ilias Muhammad( 2009) Anti- microbial, Antiparasitic, and Cytotoxic Spermine Alkaloids from Albizia schimperiana. Natural Products Communications. 4 (6) 791-796. 57. Carolina Echeverry, Florencia Arredondo, Juan Andres Abin-Carriquiry, Jacob Ogweno Midiwo, Charles Ochieng, Leonidah Kerubo and Federico Dajas. Pretreatment with Natural Flavones and Neuronal Cell Survival after Oxidative Stress: A Structure−Activity Relationship Study. J. Agric. Food Chem., 2010, 58 (4), pp 2111–2115

CONFERENCE PRESENTATIONS

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58. Midiwo, J.O.,, Jarvis, B.B., Pavanasasivam, G.J., Desilva, T. Isolation, Characterization and

chemical Modification of Trichothecenes, 179th ACS National Meeting, Houston, Texas, March, 1980.

59. Midiwo, J.O.,, Jarvis, B.B. Thermolysis of a-Azido Sulfides, Sulfoxides and Sulfones:

Dependence of Mechanism on Oxidation State of sulfur, 15th ACS Middle Atlantic Regional Meeting, Washington, D.C. January, 1981.

60. Midiwo, J.O.,, Jarvis, B.B. Anti-leukemic compounds from the Chemical Modification of

Macrocylclic Trichothecenes . Derivatives of Roridins and Verrucarins, the 2nd International Chemistry Conference in Africa, Nairobi, June 1983.

62. Midiwo, J.O., The Potential Utility of Kenyan Rumex Species for Development of Purgative

Drugs: UNESCO, Chemistry and Health-Educational Aspects V Conference, Yugoslavia, August, 1984.

63. Midiwo, J.O., Anthraquinones of the Polygonaceae, "International Symposium on Alkaloids

and Anthraquinones of African Medicinal Plants", Addis Ababa, Ethiopia, August, 1985. 64. Akunda, E.M.W., Midiwo, J.O., and Coulson, C.C. Intercropping, Plant Density and Yield

components on Protein and Oil Yield of Soybean. Colloques et Seminaries pg. 384. Dakar, Senegal, 1986.

63. Midiwo, J.O.,, Jarvis, B.B. Chemical Modification of Macrocyclic Trichothecenes, 20th ACS

MARM, Baltimore, Maryland, 1986. 64. Midiwo, J.O., Matasi, J.J. A-ring only Tetra and trioxygeneated chalcones in Kenyan

Medicinal Polygonum senegalense var senegalense. The First princess Chulabhorn Science Congress, December, 1987. Bangkok, Thailand.

65. Jarvis, B.B., Bean, G.A., Midiwo, J.O.,, Aboul-Nasr, M.B. Kuti, J. The Mystery of

Trichothecene in higher plants, "Mycotoxins and Phycotoxins `88' pg. 197. IUPAC symposium, Tokyo, Japan, August 1988. Elsevier.

66. Midiwo, J.O., Chemical Studies on Kenyan Polygonaceae and Myrsinaceae Second

NAPRECA symposium on Natural Products and Workshop on Development of Data bases, Nairobi, Kenya, September, 1988.

67. Midiwo, J.O., and Arot, L.M. Benzoquinone Pigments of Myrsinaceae ibid., 1988 69. Midiwo, J.O., and Wanjau, O.M. Insect Anti-feedant principles from leaves of Polygonum

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senegalense. Third NAPRECA Symposium on Natural Products. Arusha, Tanzania, May, 1989. 70. Makawiti, D.W., Githui, K.E. and Midiwo, J.O., Male Antifertility Effects of Embelin and

Maesaquinone of the Kenyan Myrsinaceae, ibid. 1989. 71. Midiwo, J.O.,, Ghebremeskel Yacob, Makawiti, D.W. and Arot, L.M. Benzoquinone Pigments

in Kenyan Myrsinacea Plants: New structures and Biological activity. 10th Anniversary of CURPHAMETRA Conference, Kigali, Rwanda, February, 1990.

72. Midiwo, J.O.,, Wanjau, O.M., Mwangi, R.W. Surface and Tissue Flavonoid of Polygonum

senegalense: Identity and Biological Activity, Fourth NAPRECA Symposium on Natural Products, Addis Ababa, Ethiopia, December, 1991.

73. Midiwo, J.O.,, Gikonyo, N.K. Epicuticular and Tissue Flavonoid Profile of Polygonum

senegalense. "The Fifth International Chemistry Conference in Africa", July 1992, Gaborone, Botswana.

74. Midiwo, J.O.,, Owour, F.A.O. Epicuticular Flavonoids of Psiadia punctualata and

Polygonum senegalense. Fifth NAPRECA sysmposium an Natural Products, Antananavivo, Madagascar, September, 1993 Extended Abstracts pg. 81.

75. Idowu, A., Midiwo, J.O., Bioactive Compounds from Embelia schimperi Kenya Chemical

Society, The Inaugural Conference, June 1993, University of Nairobi, Nairobi. 76. Owuor, F.A.O., Midiwo, J.O., Chemical Composition and Biological Activity of the leaf

surface Exudate of Psiadia punctulata, (D.C.) vatke, The Inaugural Conference, June 1993, University of Nairobi, Nairobi.

77. Owino, N.O., Midiwo, J.O., Internal tissue vs. surface Exudate Flavonoids of Polygonum

senegalense (Meisn), The Inaugural Conference, June 1993, University of Nairobi, Nairobi 78. Angedu, C.A., Midiwo, J.O.,, Odinga, W.A. The Relationship between Pyrethrins and Yellow

Pigments in Pyrethrum flowers The Inaugural Conference, June 1993, University of Nairobi, Nairobi.

79. Midiwo, J.O., Benzoquinone Pigments in Kenyan Myrsinaceae Plant: New structures and

Biological Activity The Inaugural Conference, June 1993, University of Nairobi, Nairobi. 80. Midiwo, J.O.,, Owour, F.A.O. Epicuticular flavonoids of Psiadia punctulata and Polygonum

senaglense, Fifth NAPRECA Symposium on Natural Products, Antananarivo Madagascar, September, 1993.

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81. Midiwo, J.O.,, Owuor, F.A.O., Juma, B.F. and Waterman, P.G. Composition of Aerial Exudates of Psiadia punctulata (D.C.) Vatke, and Polygonum senegalense (Meisn), 6th International Chemistry Conference in Africa, Accra, Ghana, August, 1995.

82. Midiwo, J.O.,, Arot, L.M. and Krauss, W. New Benzoquinones from Myrsine africana and

Maesa lanceolata. Forsk fruits 6th NAPRECA Symposium on Natural Products, Kampala, Uganda, September, 1995.

83. Midiwo, J.O.,, Aluoch, A.O., Owour, F.A.O., Juma, B.F., Waterman, P.G. Composition and

Biological Potential of Aerial Exudates of Plants. The Kenya Chemical Society, 2nd Conference, Eldoret, Kenya, September, 1996.

84. Derese, S. and Midiwo, J.O., Chemistry and Biological Activity of Hypericum lanceolatum

ibid. 85. Abiy, Y., Midiwo, J.O., and Waterman, P.G. Novel Isoflavones and Rotenoids from two

Milletia species ibid. 86. Midiwo, J.O, Kiprono, C.P. New Natural Benzoquinones from Embelia schimperi ibid. 87. Midiwo J. O., L. A. Manguro, W, Wanzala C. Kiprono and W. Kraus Anti-feedant Principles from the Myrsinaceae and Polygonum senegalense. Kenya Agricultural Research Institute, Workshop on Funding of Agricultural Research. March 1997. 88. Midiwo, J. O., Yenesew, A. Peter M.G. Flavonoids from the bark of Erythrina burtii and E. sacleuxii. Seventh NAPRECA SYMPOSIUM Dar es Salaam 1997. 89. Midiwo, J. O. , Kiprono, C. P. , Novel, Bioactive Benzoquinones for Kenyan Myrsinaceae 7th. International Chemistry Conference in Africa and 34th. South African Chemical Convention, Durban, South Africa, 1998. 90. Midiwo, J.O., Juma B.F. and Aduda, V.O., Secondary Metabolites in the Aerial Exudates of Certain Kenyan Plants. The 8th. NAPRECA Symposium in Natural Products, University of Botswana, Gaborone, Botswana, August,1999. 91. Ayoo, J. A., Aluoch, A. O., Yenesew, A. and Midiwo, J.O., Alkaloids and Lignans from Zanthoxyllum usambarense and Zanthoxyllum chalybeum. The 8th. NAPRECA Symposium in Natural Products, University of Botswana, August 1999. 92. Yenesew, A., Derese, S., and Midiwo, J.O., Flavonoids of the Root and Stem bark of Erythrina burttii and Erythrina abyssinica. The 8th. NAPRECA Symposium in Natural Products. University of Botswana. Gaborone, Botswana.

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93. Kiprono Chepkwony, P. and Midiwo J.O. Larvicidal benzoquinone from Embelia schimperi. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT, August 1999. 94. Juma, B.F. Midiwo, J.O. Abiy Y. Surface Compounds of Psiadia punctulata. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT, August 1999. 95. Ayoo, J. A., Abiy Y. Midiwo, J. O., Chemistry and Biological Activity of Zanthoxyllum usambarense. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT, August 1999. 96. Midiwo J.O. , Yenesew A., Juma B. F. Derese, S. Arot, L.M. Bioactive Compounds from Kenyan Ethno-medicinal Plants. The 3rd. International Chemistry Conference of the Kenya Chemical Society, JKUAT August 1999. 97. Kerubo I . Midiwo J. O. and Kariuki, D.N., The Potential of Matricaria chamomilla as a commercial plant in semi-arid areas of Kenya. The 3rd. International Chemistry Conference of the Kenya Chemical Society, JKUAT, August 1999. 98. Aduda V. O., Midiwo, J. O., Chemical Investigation of Dodonaea angustifolia and Dodonaea viscosa species in Kenya. The 3rd. International Chemistry Conference of the Kenya Chemical Society, JKUAT August 1999. 99. Abiy, Y. Midiwo, J.O. Heydenreich M.and Peter, M. New isoflavonoids from the stem bark of Erythrina sacleuxii. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT August 1999. 100. Midiwo J.O., Development of Chamomilla as a commercial crop in Kenya,. UNESCO Workshop on University Industry Co-operation at the University of Ljubljana, Ljubljana, Slovenia. June 1999 101. Midiwo, J. O., Secondary Metabolites from some Kenyan Medicinal Plants, University of Ljubljana UNESCO affiliated International Centre for Chemical Studies, Slovenia , December, 1999. 102. Midiwo, J. O. Secondary Metabolites from some Kenyan Medicinal Plants, University of Lausanne, Department of Pharmacy, Lausanne, Switzerland, December, 1999. 103. Midiwo, J. O. , Yenesew, Abiy, Juma, B. F., Derese, S., Ayoo, J. A., Aluoch, A.O., Guchu,S. Bioactive Compounds from Kenyan ethno-medicinal Plants. International Symposium of the Phytochemical Society of Europe. Lausanne, Switzerland. September, 2001.

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104. Midiwo, J. O., A. Yenesew, Juma B. F., Derese, S. Ayoo, J. A. Kerubo, L. Guchu, S. Phytochemical studies on popular Kenyan Medicinal Plants. IOCD International symposium, Bamako Mali, March 2002. 105. Midiwo J. O. Secondary Metabolites from popular Kenyan Medicinal Plants. National Natural Products Symposium, Butare, Rwanda June 2002. Bamako Mali, March 2002. 106. Midiwo, J.O., Juma B.F. and Aduda, V.O., Secondary Metabolites in the Aerial Exudates of Certain Kenyan Plants. The 8th. NAPRECA Symposium in Natural Products. University of Botswana, Gaborone, Botswana , August,1999. 107. Ayoo, J. A., Aluoch, A. O., Yenesew, A. and Midiwo, J.O., Alkaloids and Lignans from Zanthoxyllum usambarense and Zanthoxyllum chalybeum. The 8th. NAPRECA Symposium in Natural Products, University of Botswana, August 1999. 108. Yenesew, A., Derese, S., and Midiwo, J.O., Flavonoids of the Root and Stem bark of Erythrina burttii and Erythrina abyssinica. The 8th. NAPRECA Symposium in Natural Products. University of Botswana. Gaborone, Botswana. 109. Kiprono Chepkwony, P. and Midiwo J.O. Larvicidal benzoquinone from Embelia schimperi. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT, August, 1999. 110. Juma, B.F. Midiwo, J.O. Abiy Y. Surface Compounds of Psiadia punctulata. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT, August 1999. 111. Ayoo, J. A., Abiy Y. Midiwo, J. O., Chemistry and Biological Activity of Zanthoxyllum usambarense. The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT, August 1999. 112. Midiwo J.O. , Yenesew A., Juma B. F. Derese, S. Arot, L.M. Bioactive Compounds from Kenyan Ethno-medicinal Plants. The 3rd. International Chemistry Conference of the Kenya Chemical Society, JKUAT August 1999. 113. Kerubo I. Midiwo J. O. and Kariuki, D.N., The Potential of Matricaria chamomilla as a commercial plant in semi-arid areas of Kenya. The 3rd. International Chemistry Conference of the Kenya Chemical Society, JKUAT, August 1999. 114. Aduda V. O., Midiwo, J. O., Chemical Investigation of Dodonaea angustifolia and Dodonaea viscosa species in Kenya. The 3rd. International Chemistry Conference of the Kenya Chemical Society, JKUAT August 1999.

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115. Abiy, Y. Midiwo, J.O. Heydenreich M.and Peter, M. New isoflavonoids from the stem bark

of Erythrina sacleuxii . The 3rd. International Chemistry Conference of the Kenya Chemical Society. JKUAT August 1999.

116. Midiwo J.O., Development of Chamomilla as a commercial crop in Kenya,. UNESCO Workshop on University Industry Co-operation at the University of Ljubljana, Ljubljana, Slovenia. June 1999. 117. Midiwo, J. O. , Secondary Metabolites from some Kenyan Medicinal Plants, University of Ljubljana UNESCO affiliated International Centre for Chemical Studies, Slovenia , December, 1999. 118. Midiwo , J. O. Secondary Metabolites from some Kenyan Medicinal Plants, University of Lausanne, Department of Pharmacy, Lausanne, Switzerland, December, 1999. 118. Midiwo, J. O. , Yenesew, Abiy, Juma, B. F., Derese, S., Ayoo, J. A., Aluoch, A.O., Guchu,S. Bioactive Compounds from Kenyan ethno-medicinal Plants. International Symposium of the Phytochemical Society of Europe. Lausanne, Switzerland. September, 2001. 120. Midiwo, J. O., A. Yenesew, Juma B. F., Derese, S. Ayoo, J. A. Kerubo, L. Guchu, S. Phytochemical studies on popular Kenyan Medicinal Plants. IOCD International symposium, Bamako Mali , March 2002. 121. Midiwo J. O. Secondary Metabolites from popular Kenyan Medicinal Plants. National Natural Products Symposium, Butare, Rwanda June 2002. 122. Midiwo J.O., A. Yenesew, Juma B.F., Derese S., Ayoo J.A., Aluoch A.O., and Guchu S., Bioactive compounds from some Kenyan ethno-medicinal Plants. The 9th NAPRECA Symposium, Nairobi, Kenya August 2001.

123. Midiwo J.O., Phytochemical evaluation of Kenyan medicinal plants. The 11th. NAPRECA Symposium. Antananarivo, Madagascar, August 2005. 124. Midiwo J. O. A. Yenesew. Biologically active compounds from Kenyan plants. University of Wurzburg/ NAPRECa Symposium. Kinshasa June 27-30, 2005.

125. Midiwo J.O., A. Yenesew and S. Derese. The search for anti-malarial principles from Kenyan plants. AFASSA Symposium. Montevideo, Uruguay, March 2006.

126. Midiwo J. O., A. Yenesew. Potential of Kenyan Medicinal Plants in Malaria

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Control.APCCEM Inaugral Conference, Blantyre, Malawi. June 2006.

127. Midiwo J. O. A. Yenesew . Anti-malarial compounds from Kenyan plants. 4th. IDNP conference on Natural Products. Leysin, Switzerland, June 2006. 128. Midiwo J. O. A. Yenesew, B.F. Juma, S, Derese, J. L. Kerubo. Bioactive compounds from popular Kenyan medicinal plants. 5th. ANRAP International Seminar- 22nd MNPS Annual Seminar November 2006, Kuala Lumpur, Malaysia. 129. Midiwo J.O. and A. Yenesew. Potential of Kenyan Medicinal Plants in Malaria Control. IOCD International Symposium (Biology, Chemistry,, Pharmacology and Clinical Studies of Asian Medicinal plants). Hyatt Regency Hotel, Surabaya, Indonesia, April 2007. 130. Midiwo J.O. et al. Potential of Kenyan Plants in Malaria Control. The 12th. NAPRECA Symposium in Natural Products. Hotel Africana, Kampala. July 2007.

131. Midiwo J.O., Abiy Y., Solomon D. The search for anti-malarial principles from Kenyan plants. The first joint IOCD-ISDNP International Symposium on Natural Products. Mowana Safari Lodge, Kasane, Botswana, Feb 25-29 2008. 132. Midiwo J.O., Natural Products and neglected Diseases. NAPRECA One day Workshop at the

University of Science and Technology, Omdurman, Khartoum, Sudan. 2008. 133. Midiwo J.O., Pan African Chemistry Network. SAICM meeting, Kunduchi Beach Resort, Dar

es Salaam, Tanzania, June 2008. 134. Midiwo J.O., Bioactive Principles from Kenyan Medicinal Plants. Gibex Workshop on Screens

to Nature. Kunduchi Beach, Dar es Salaam, August 2008. 135. Midiwo J.O., NAPRECA , Science with Africa, Addis Ababa, Ethiopia, March 2008. 136. Midiwo J.O., PACN Annual Meeting, Burlington House, London, UK, December 2008 137. Midiwo J.O., Natural Products and Neglected Diseases, ANDI Conference, Cape Town South

Africa, August 2009. 138. Midiwo, J.O., Natural Products and Neglected Diseases, the 2ndBCNP, Sao Pedro, Sao Paulo,

November 2009. 139. Midiwo, J.O., NAPRECA ISP Workshop on Scientific Networking, Addis Ababab, Ethiopia.

September 2009.

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140. Midiwo, J. O. Chogii, I, and Mwaniki J Natural Products and Green Chemistry, Workshop at the 13th NAPRECA Symposium on Natural Products. August 2008.

141. Midiwo, J. O. PACN Annual meeting, Burlington House, London , England. December 2009. BOOKS AND BOOKLETS 142. Midiwo, J.O., PhD. Thesis Part I. Mechanism of the Thermal Decomposition of a-Azido

Sulfoxides. Part II Isolation, Elucidation and Chemical Modification of Trichothecenes from Myrothecium verrucaria. University of Maryland, 1981.

143. Midiwo, J.O., Introduction to Organic Chemistry (course ECH 103)- University of Nairobi 1998. 144. Midiwo, J.O., John Clough (Eds). Aspects of African Biodiversity. “Proceedings of the Pan African Chemistry Network Conference, September 2008”. Publication of the Royal Society of Chemistry 2009.