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Curriculum Vitae

WEN-XING DING, PhD Business Address Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA Phone: 913-588-9813 Email: wxding@kumc.edu Fax: 913- 588-7501 Education Nov. 2001-2003: Post-doctoral research fellow Department of Pathology University of Pittsburgh (Mentor: Dr. Xiao-Ming Yin) Pittsburgh, PA 15261, USA Aug. 1998 - June. 2002 Ph.D. (Molecular Toxicology) Department of Community, Occupational and Family Medicine (Mentor: Professor Choon-Nam Ong)

National University of Singapore, Singapore Nov 1996- May 1997 China Medical Board, New York (CMB) Fellow, Department of Community,

Occupational and Family Medicine National University of Singapore, Singapore

Sep. 1992 - July 1995: M. Med (Master of Medicine on Environmental Toxicology) Shanghai Medical University, China (Mentor: Professor Huigang Zhu) Sep. 1986 - July 1992: B. Med. (Bachelor of Medicine on Preventive Medicine) Shanghai Medical University, China Professional Position and Working Experience July 2017- Professor (with tenure),

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

July 2013-2017 Associate Professor (with tenure),

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

July 2012- Director of Histology Core,

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

July 2009-2013 Assistant Professor,

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas

July 2005-2009: Research Assistant Professor

Department of Pathology University of Pittsburgh Pittsburgh, PA 15261, USA

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(Projects: (1) Studies on the role of autophagy in alcohol-induced liver injury; (2) Studies on mitochondrial autophagy

Nov. 2003-2005: Research Associate Department of Pathology University of Pittsburgh Pittsburgh, PA 15261, USA (Project: Studies on proteasome inhibitor-induced apoptosis and autophagy in

cancer therapy) Nov. 2001-2003: Post-doctoral research fellow Department of Pathology University of Pittsburgh Pittsburgh 15261, USA

(Project: Studies on death-receptor activation-induced apoptosis in hepatocytes and liver)

Aug. 1998 to Nov 2001: Ph.D. student

Dept. of Community, Occupational and Family Medicine Faculty of Medicine, National University of Singapore (Project: Studies on the hepatotoxicity of cyanobacterial toxin-microcystin)

Jul. 1995 to Jul. 1998: Research and Teaching Assistant Dept. of Environmental Health,

School of Public Health, Shanghai Medical University, P.R. China (Project: Studies on the genotoxicity and mutagenicity of water pollutants from Changjiang River in China)

Honors and Awards: • 1995 Science Technology Progress Awards by Shanghai Municipality, Shanghai, P.R. China • 1996 Science Technology Progress Awards by Shanghai Municipality, Shanghai, P.R. China • 1997 Research Scholarship, National University of Singapore, Singapore • 2000 DSO Top-up Scholarship, National University of Singapore, Singapore • 2003 The Pathology Post-doctoral Research Training Program (PPRTP), Department of

Pathology, University of Pittsburgh • 2003 American Liver Foundation Postdoctoral Fellowship • 2004 Third Place Award for the oral presentation at Department of Pathology Annual

Research Retreat, University of Pittsburgh • 2005 Liver Scholar, American Liver Foundation • 2010 KUMC Faculty Travel Award • 2011 KUMC Liver Center Symposium Best Poster Award • 2012 7th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis in

Beijing Travel Award • 2012 Best Poster Award at 6th International Symposium on Autophagy 2012 Okinawa Japan • 2013 AASLD President Best Poster Award (2 awards for 2 posters). • 2014 KUMC Faculty Travel Award • 2014 AASLD (American Association for the Study of Liver Disease) President Best Poster Award • 2014 AASLD Basic Science Plenary Presentation • 2014 TOP#1 Manuscript Reviewer for American Journal of Pathology • 2015 TOP#1 Manuscript Reviewer for American Journal of Pathology

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• 2015 Poster presentation Award 10th International Symposium on ALPD and Cirrhosis; • 2016 AASLD President Best Poster Award; • 2016 University Scholarly Achievement Award (KU) • 2017 AASLD President Best Poster Award; • 2017 Faculty Research Investigator Award (KUMC) • 2018 Fellow of AASLD

Press Release

1. Ni, H.M., Duo, K., You, M., and Ding, W.X. (2013). Critical Roles of FoxO3 in Alcohol-Induced Autophagy and Hepatotoxicity. American J of Pathology. 84(10):103511. This paper was selected as AJP Press Release.

2. Ni, H.M., McGill M., Jaeschke, H and Ding, W.X. Sequestosome 1/p62-mediated selective removal of acetaminophen protein adducts and damaged mitochondria protects against acetaminophen-induced liver injury. AASLD Annul Meeting Press Release 2014 November.

3. Ni, H.M., McGill, M.R, Chao, X., Woolbright, B., Jaeschke, H., and Ding W.X. (2016). Caspase inhibition prevents TNF-α-induced apoptosis and promotes necrotic cell death in mouse hepatocytes in vivo and in vitro. Am J. Pathol. PMID: 27616656. This paper was selected as AJP Press Release.

Service Activities • Member, Cell Death Society (2002) • Member, American Association for the Studies of Liver Disease (AASLD) (2004-) • Member, Liver Center of KUMC (2009-) • Member, Research Society of Alcoholism (2010-) • Member, International Society of Biomedical Research on Alcoholism (2012-) • Member, Cancer Center of KUMC (2013-) • Member, American Society of Investigative Pathology (ASIP) (2013-) • Member, Society of Toxicology (SOT) (2015-) • Member, Society of Chinese Bioscientist in America (SCBA) (2018-) • Program Committee Member of ASIP (2013-) • American Society of Investigative Pathology (ASIP) program Committee: 2013-2019

• AASLD Basic Research Committee: 2017-2020. • AASLD Research Award Committee: 2018-2021. • AASLD Taxonomy Task Force committee: 2018 • 2016-2020 XNDA Study Section Standing Member • • • Book Editor: Cell Death In Liver Disease (2017, Springer) • Book Editor: Molecules, Systems and Signaling in Hepatic Cell Death (2017, Springer)

• Associate Editor: Autophagy (2017-) • Editorial Board: Hepatology (2017-) • Editorial Board: Hepatology Communications (2018-)

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• Editorial Board: Liver Research (2017-) • Editorial Board: Scientific Reports (2016-) • Editorial Board: Cells (2018-) • Editorial Board: Biological Chemistry (2015-) • Editorial Board: American Journal of Pathology (2014-) • Editorial Board: Experimental Biology and Medicine (2014-2016) • Editorial Board: Autophagy (2012-2016) • Editorial Board: Translational Surgery (2015-) • Editor: Journal of Biological Medicine (2010-) • Academic Editor: British Journal of Pharmaceutical Research (2013-) • Editorial Board: Drug Metabolism & Toxicology (2011-)

Bioenergetics (2011-) • Associate Editor: World Journal of Biological Chemistry (2009-2013) • Foreign Members of Editorial: J Medical Postgraduates (China) (2010-2013) • Meeting Organizer and Moderator • Early Morning Workshop Moderator: Autophagy session. AASLD 2013 Annual Meeting. Nov 1-5th,

Washington DC, USA. • Conference Chair. Minisymposium: Cancer Biology and Cancer Therapeutics. Experimental Biology 2009.

April 18-22, 2009. New Orleans. Louisiana, USA. • Conference Chair. Minisymposium: Cell Death: Pathways and Mechanisms” Experimental Biology

Meeting, March 18-22, Boston, 2015. • Abstract Reviewer. AASLD Annual Meeting 2014, 2015, 2016, 2017. • Conference Chair. Symposium: Programmed non-apoptotic cell death in tissue injury. Experimental

Biology 2015. March 18-22, 2015. Boston, USA. • Conference co-organizer: AASLD Basic Science Symposium: Autophagy in the Livers. AASLD Annual

Meeting Nov 14th, 2015. San Francisco, USA. • Conference Chair. Symposium: Autophagy: Basic Mechanisms and Pathophysiological Roles in Diseases.

Experimental Biology 2016. April 6th, 2016. San Diego, USA. • Abstract Reviewer. DDW (Digestive Disease Week) Annual Meeting 2015, 2016, 2017. • Early Morning Workshop Moderator: Autophagy session. AASLD 2016 Annual Meeting. Nov 11-15th,

Boston, USA. • Early Morning Workshop Moderator: Autophagy session. AASLD 2017 Annual Meeting. 2017 October

21, Washington DC, USA. • AASLD 2017 Annual Meeting Moderator for “Meet the Professor Luncheon” session title “Proteostasis”.

AASLD 2017 Annual Meeting. 2017 October 21, Washington DC, USA. • AASLD 2017 Annual Meeting Parallel Session moderator for Inflammation and Innate Immunity. 2017

October 22, Washington DC, USA. • Conference Chair. Symposium: Cellular Adaptive Response and its Role in Tissue Injury, Tumorigenesis

and Cancer Progression. Experimental Biology 2018. April 22, 2018. San Diego, USA. • Conference Chair. 2018 AASLD Annual Meeting Basic Research Workshop. Emerging Role of Novel

Cell Death Pathways and Mediators In Liver Disease. AAASLD Annual Meeting 2018. November 11, 2018. San Francisco, USA

• Conference Chair. Gordon Research Conference 2019: Alcohol-induced Endo Organ Disease. 2019 March, Ventura, USA

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Book Editor: 1. Ding, W.X. and Yin, X.M. Ed. Cell Death In Liver Diseases. Springer (planned to be published in January

2017). 2. Ding, W.X. and Yin, X.M. Ed. Molecules, Systems and Signaling in Hepatic Cell Death. Springer (planned

to be published in January 2017).

Special Issue Editor: Special Issue entitled “Autophagy in Pathobiology” for Current Pathobiology Reports 2017. Volume 5, issue 2.

• Grant Reviewer: • Ad hoc reviewer: NIH HBPP Study Section, NIH Special Emphasis Panel ZRG1 EMNR-R(02);

NIH/NIAAA Special Emphasis Panel/Scientific Review Group 2014/10 ZAA1 DD; NIH XNDA Study Section; NIH Special Emphasis Panel ZRG1 DKUS-C(04); NIH Special Emphasis Panel ZDK1 GRB-7 (O2) 1; NIH Special Emphasis Panel ZRG1 DKUS-C 82 A; AA1, ZAG1 ZIJ-P (A1) NIA review; ZCA1 PPRB-L (O1) P (NCI Program Project Review)

• 2018: NIH XNDA, University of New Mexica COBRE pilot grants; AASLD Foundation Award; Research

Grant Council (Hong Kong), ZAG1 ZIJ-P (A1) NIA review; ZCA1 PPRB-L (O1) P (NCI Program Project Review); Research Grant Council (UK); Hongkong Baptist University Research Grant; Health and Medical Research Fund from The Government of the Hong Kong Special Administrative Region (HKSAR)

• 2017: NIH XNDA, Research Grant Council (Hong Kong), Université Bourgogne Franche-Comté (UBFC);

VA Gulf War Illness, MRC UK, KUMC Lied Grant; Health and Medical Research Fund (Hong Kong); Fonds de recherche du Québec - Nature et technologies.

• 2016: NIH/NIAAA AA1 Study Section; Israel Science Foundation; Hongkong Baptist University

Interdisciplinary Research Matching Scheme; Research Grant Council (Hong Kong), The Welcome Trust (UK); Université Bourgogne Franche-Comté (UBFC); City University of Hong Kong; NIH XNDA.

• 2015: FWF Austrian Science Fund, Israel Science Foundation; Research Grant Council (Hong Kong), The

French National Research Agency, Action Medical Research UK, NIH HBPP study section; NIH Special Emphasis Panel ZDK1 GRB-7 (O2) 1; NIH Special Emphasis Panel ZRG1 DKUS-C 82 A; NIH XNDA study section

• 2014: NIH Special Emphasis Panel ZRG1 DKUS-C(04); XNDA Study Section Ad Hoc Reviewer

(October); HBPP Study Section Ad Hoc Reviewer (February); NIH Special Emphasis Panel ZRG1 EMNR-R(02) April; NIH/NIAAA Special Emphasis Panel/Scientific Review Group 2014/10 ZAA1 DD (01); Israel Science Foundation; Research Grant Council (Hong Kong); COBRE Project University of Nebraska; Frontiers Clinical Pilot project; Applied Research Grant City University of Hong Kong; Lied Basic Science Grant KUMC

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• 2013: HBPP Study Section Ad Hoc Reviewer; FCT Investigator 2013-Call Portugal; Oklahoma Center for the Advancement of Sciences & Technology (OCAST) grant review; Israel Science Foundation; Lied Basic Science Grant KUMC

• 2012: Grants Proposal for Research Grants Council, Hong Kong; Bankhead-Coley Cancer Research Program; HKBU IRMS (Hong Kong Baptist University Interdisciplinary Matching Scheme); Medical Research Council Career Development Award Proposal (UK); COBRE Pilot Project North Dakota State University; KUADC (University of Kansas Alzheimer’s Disease Center) Pilot Project

• 2011: Grants Proposal for Research Grants Council, Hong Kong; Cancer Research UK; Biomedical

Research Training Program Grants KUMC; South African Medical Research Council

• 2010: Grants Proposal for Research Grants Council, Hong Kong ; Biomedical Research Training Program Grants KUMC;

• 2007: The International Foundation for Science (IFS)

• Journal Ad hoc Reviewer : • Before 2010: Hepatology, American Journal of Pathology, Molecular pharmacology, Journal of Cell

Science, Biochemical Pharmacology, Free Radical Research, Toxicology, Environmental Toxicology, Journal of Biological Chemistry, Liver International, World Journal of Gastroenterology, World Journal of Biological Chemistry, Apoptosis.

• 2010: American Journal of Pathology, Journal of Cell Science, Biochemical Pharmacology, Liver International, Toxicology Letter, Pediatric Research, Shock

• 2011: Autophagy, American Journal of Pathology, Biochemical Pharmacology, Current Pharmaceutics Design; Clinical Nutrition; Experimental Biology and Medicine, Hepatology, Liver International, Journal of Biological Chemistry, Journal of Hepatology, Molecular Pharmaceutics; PLOS ONE, Carcinogenesis, Toxicology, Toxicology & Applied Pharmacology.

• 2012: Autophagy, American Journal of Pathology, Cell Metabolism, Digestive Disease and Sciences;

Experimental Biology and Medicine, FEBS Letters; Hepatology, Liver International, Toxicology, Toxicology and Applied Pharmacology, Journal of Biological Chemistry, Journal of Hepatology, Journal of Molecular Cell Biology, Journal of Nutritional Biochemistry, Journal of Pharmacology and Experimental Therapeutics, World Journal of Microbiology and Biotechnology; World Journal of Gastroenterology, BMC Gastroenterology

• 2013 (2-3 manuscripts per week): Autophagy, Cell Metabolism, PNAS, Nature review Gastroenterology

and Hepatology, Nature review Endocrinology, Cell Death & Differentiation, Cell Communication and Signaling, Cellular Physiology and Biochemistry, Hepatology, Journal of Hepatology; Journal of Biological Chemistry, Biochemical J; International Journal of Molecular Sciences, Journal of Biochemical and Molecular Toxicology, Journal of Nutritional Biochemistry; PLOS ONE, Biochemical Pharmacology, American Journal of Pathology, American Journal of Physiology - Gastrointestinal and Liver Physiology, Journal of Pharmacology and Experimental Therapeutics, Experimental Biology and Medicine, Biomed Research International, World Journal of Biological Chemistry, World Journal of Gastroenterology, World Journal of Hepatology,

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• 2014 (3 manuscripts per week): Autophagy, Cell Metabolism, Cell Report, Hepatology, Journal of Hepatology, Journal of Clinical Investigation, American Journal of Pathology, American Journal of Physiology-Gastroenterology, American Journal of Physiology-Cell Physiology, Alcoholism Clinical & Experimental Research, BMC Cancer, Clinics and Research in Hepatology and Gastroenterology, Human Molecular Genetics, Journal of Biological Chemistry, Journal of Biochemical and Molecular Toxicology, Journal of Pharmacology and Experimental Therapeutics, Experimental Biology and Medicine, Biochemical Pharmacology, Biomed Research International, Digestive Diseases and Sciences, Digestive and Liver Diseases, Expert Opinion on Investigational Drugs, BBA, Lipids, Molecular Cellular Endocrinology, PLOS ONE, Oncotarget, Toxicology & Applied Pharmacology, Toxicology Reports, Toxicological Sciences, World Journal of Gastroenterology, World Journal of Hepatology

• 2015: Nature, Autophagy, Gastroenterology, Hepatology, Journal of Hepatology, Cell Report, American

Journal of Pathology, Alcoholism Clinical & Experimental Research, Journal of Pharmacology and Therapeutics, Journal of Endocrinology, BBA, Cell Death and Diseases, Cancer Biology and Therapy, Digestive and Liver Diseases, Scientific Report, Cell Signaling, Experimental Biology and Medicine, Histology and Histopathology, Oncotarget, Plos One, Plos Genetics, Plos Biology, Toxicological Sciences, International Scholar Research, BMC Cancer, Toxicology & Applied Pharmacology ,World Journal of Clinical Oncology,

• 2016: Nature communication, Gut, Gastroenterology, Hepatology, Hepatology Communications,

Autophagy, American Journal of Pathology, BBA, Cell Death and Diseases, Digestive and Liver Diseases, Experimental Biology and Medicine, European Journal of Pharmacology, Journal of Hepatology, Journal of Lipid Research, Molecular and Cellular Biochemistry, Stem Cells International, Journal of Pharmacology and Therapeutics, Cell Death and Diseases; Alcoholism Clinical & Experimental Research, Biomed Research International, Oncotarget, Scientific Reports, Science Advances, World Journal of Gastroenterology, Toxicological Sciences; Toxicology & Applied Pharmacology;Toxicology Research, Acta Pharmaceutica Sinica B,

• 2017: Autophagy, Hepatology, Gastroenterology, Gut, Molecular Cell; Cells; Journal of Clinical

Investigation Insights, Journal of Hepatology, Hepatology Communications, American Journal of Pathology, American Journal of Physiology-Gastroenterology, Liver Research, Current Pathobiology Reports, Toxicology & Applied Pharmacology, Journal of Cellular and Molecular Medicine; Journal of Pharmacology and Experimental Therapeutics; Toxicological Sciences, Translational Research; Oncotarget, Scientific Reports; Biology Open, Biological Chemistry; Cell Death and Differentiation; Digestive and Liver Diseases, Journal of Lipid Research, Chemical Research Toxicology, GE The Liver, Alcohol; Toxicology Letters; Toxicology & Applied Pharmacology; Plos One, Journal of Molecular Medicine; Science Signaling, Science Translational Medicine.

• 2018: Autophagy, Hepatology, Gastroenterology; Cell Reports; Nature Communication; Journal of

Hepatology, Hepatology Communications, FASEB J, Journal of Lipid Research; Journal of Cell Science, Journal of Cellular Physiology, American Journal of Pathology; Toxicology & Applied Pharmacology; FSAEB J; Liver Research, JOVE, Scientific Reports, Plos One, International Journal of Biological Sciences; Seminars in Liver Disease

• Other Service Activities: • May, 2008 Judge for the 8th Department Retreat 2008. Department of Pathology,

University of Pittsburgh. • April, 2010 Judge for the 32nd Annual Student Research Forum, KUMC. • May, 2010 Judge for the 1ST Annual Resident, Postdoc and Fellow Research Day, KUMC. • June 2010, Reviewer for Biomedical Research Training Program Grants KUMC.

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• May, 2011 Judge for the 2ST Annual Resident, Postdoc and Fellow Research Day, KUMC. • May 2011, Reviewer for Biomedical Research Training Program Grants KUMC • March, 2012, Judge for the 34th Annual Student Research Forum, KUMC. • April, 2012; Judge for the 3rd Annual Resident, Postdoc and Fellow Research Day, KUMC • April, 2013, Judge for the 35th Annual Student Research Forum, KUMC. • April, 2014, Judge for the 35th Annual Student Research Forum, KUMC. • 2013-2015, Faculty Council KUMC • June 2014, Reviewer for Biomedical Research Training Program Grants KUMC. • 2015-2017 KUMC IACUC Committee • 2015- KUMC Communication, Technology, & Library (CTL) Committee • 2015- The Heartland Center for Mitochondrial Medicine Regional Symposium program

Committee • 2016, Reviewer for COBRE Grant Application Writing Workshop • 2017- KUMC Faculty Council Admission Subcommittee • •

Teaching Experience and Interest Jul. 1995 to Jul. 1998 Undergraduate student class: Environmental Toxicology 2010 IGPBS graduate student: Toxicology Pathology; 2011 Medical Student: Pharmacology group discussion; 2011 IGPBS graduate student: Immunotoxicology 2012 Medical Student: Pharmacology group discussion 2012 IGPBS graduate student: Autophagy and Immunology 2012 IGPBS graduate student: Cell proliferation and cell death 2013 IGPBS graduate student: Cell proliferation and cell death 2012 IGPBS graduate student: Toxicology Pathology 2013 IGPBS graduate student: Pharmacology 2013 Medical Student: Pharmacology group discussion 2013 IGPBS graduate student: Immunotoxicology 2013 MS online course: Mitochondrial Toxicity in Drug Development. School of

Pharmacy, University of Maryland. 2014 IGPBS graduate student: Cell proliferation and cell death; 2015 IGPBS graduate student: Cell proliferation and cell death; 2015 IGPBS graduate student: Immunotoxicology Currently Teaching Interest: Autophagy and cell death; autophagy in alcoholic and drug-induced liver

injury; Mitochondrial apoptotic pathway and cell death, Cell Cycle and cell proliferation; mOTR and nutrient signaling

• Direct Mentor for graduate students and postdocs: Shaogui Wang, Postdoc (2017-) Shaung Mei, Postdoc (2010-2011) Hua Yang, Postdoc (2011-2013) Sharon Manley, PhD candidate (2010-2014) Jessica Williams, PhD candidate (2011-2015)

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Steven McGreal, Master graduate student (2014) Namila, Master graduate student (2014) Yuan Li, PhD candidate (2013-) Xiaojuan Chao, PhD candidate (2016-) Xiaowen Ma, PhD candidate (2017-) Hui Qian, PhD candidate (2018-) Kuo Du, rotation student (2012) Zhenrui Li, rotation student (2012) James Wheemholf, rotation student (2013) Kristen Mickey, rotation student (2013) Jennifer McCracken, rotation student (2013) Ian Weidling, rotation student (2014) Jephte Akakpo, rotation student (2015) Sachith Polpitiyaarachchige (2015) Yssa Ann Rodriguez, rotation student (2017) Ashley Reed, rotation student (2017) Hui Qian, rotation student (2017) Nikki Boggess, summer undergraduate student ASPET (2011)

Anna Haynes, summer undergraduate student ASPET (American Society of Pharmacology and Experimental Therapeutics) (2012) (University of Minnesota)

Brandon Drenner, summer undergraduate student ASPET (2013) Amar Bhakta, summer medical student (2013) Kevin Li, high school summer student (2014) Na Mila, Master graduate student (2014)

Brittany Jack summer undergraduate student ASPET (2015) Joshua Kaseff summer undergraduate student ASPET (2017)

• Direct Mentor for visiting graduate students and postdocs: Yan Zhou (Shanghai Jiaotong University, 2015-2016) Xiao Yang (Shanghai Chinese Medical University, 2015-2016) Qingyun Bai (Shanghai Chinese Medical University, 2016-2017) Hua Wang (Anhui Medical University, 2016-2017)

• Committee Member:

• 2011- KUMC Biomedical Research Training Program Fellowship Selection Committee; • 2011- Seminar Committee Department of Pharmacology • 2012 COBRE Faculty search committee • 2013 KUMC Faculty Council • 2013- American Society of Investigative Pathology Program Committee

• PhD student Thesis committee:

Jessica Williams (direct mentor, Graduated in 2015); Sharon Manley (direct mentor, Graduated in 2014); Yuan Li (direct mentor, 2013-, plan to graduate in August 2018);

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Xiaojuan Chao (direct mentor, 2016-); Xiaowen Ma (direct mentor, 2017-);

Hui Qian (direct mentor 2018-)

Zidong Fu (committee member, Graduated in 2013); Mitch McGill (Graduated in 2012); Lei Zhang (Graduated in 2015); Ben Woolbright (Graduated in 2015); Yuchao Xie (Graduated in 2016); Bharat Bhushan (Graduated in 2016); Kuo Du (Graduated in 2016) Kishore Polireddy (Graduated in 2015) Jennifer McCracken (Graduated in 2017) James Wheemholf (Graduated in 2017) Prachi Borude (Graduated in 2017) Pingping Fang (Graduated in 2018) Ruochen Dong Yifeng Wang Prabhakar Bastola (Graduated in 2018) Nancy Magee Alex Von Schulz Ziyan Zhang (external committee member, KU Lawrence, Pharmacology and Toxicology, Graduated in 2014); Kellyann Jones (external committee member, Microbiology, Graduated in 2016); Weiran Shen (external committee member, Microbiology, Graduated in 2016); Emily Carson (external committee member, KU Lawrence, Pharmacology and Toxicology Graduated in 2016); Long Wu (external committee member, KU Lawrence, Pharmacology and Toxicology Graduated in 2017); Erdong Chen (external committee member, Microbiology, Graduated in 2014) Jacob New (external committee member, Anatomy and Cell Biology) Ian Weidling (external committee member, Neuroscience) Zhengrui Li (external committee member, Stowers Institute); Yssa Ann Rodriguez, rotation student (external committee member, KU Lawrence, Pharmacology and Toxicology);

• Other Experience and Professional Memberships • 2002 Cell Death Society • 2004 American Association for the Studies of Liver Disease (AASLD) • 2009 United Mitochondria Disease Foundation • 2009 Liver Center, KUMC (member) • 2010 Research Society of Alcoholism • 2012 International Society of Biomedical Research on Alcoholism • 2013 Cancer Center, KUMC (member) • 2013 American Society of Investigative Pathology • 2013 Experimental Biology and Medicine • 2014 Society of Toxicology

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• 2018 Society of Chinese Bioscientist in America

Publications (since 1998); total citations 15220 by May 2018, H-Index: 50;

1. Ding, W.X., Shen, H.M., Shen, Y., Zhu, H.G. and Ong, C.N. (1998) Microcystic cyanobacteria caused mitochondrial membrane potential alteration and reactive oxygen species formation in primary cultured rat hepatocytes. Envrion. Health Perspect. 106:409-413. PMID:9630440.

2. Ding, W.X., Shen, H.M., Zhu, H.G. and Ong, C.N. (1998) Studies on oxidative damage induced by cyanobacteria-Extract in primary cultured rat hepatocytes. Environ. Res. 78:12-18. PMID:9637798.

3. Ding W.X., Shen H.M., Zhu H.G. and Ong C.N. (1999) Evaluation of the genotoxicity and mutagenicity of microcystic cyanobacteria from China. Mutat. Res. 442:69-77. PMID: 10393275.

4. Xu, J.K., Liu, Y.F., Zhu, H.G. and Ding, W.X. (2000) The identification and toxicity of the microcystin in the waterbloom obtained from an eutrophied lake. Biomed Environ Sci.13:97-104. PMID: 11055011.

5. Ding, W.X., Shen, H.M. and Ong, C.N. (2000) Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Perspect. 108:605-609. PIMID:10903612.

6. Ding, W.X., Shen, H.M. and Ong, C.N. (2000) The critical role of ROS and mitochondrial membrane permeability in microcystin-LR induced rapid apoptosis in primary rat hepatocytes. Hepatology 32:547-555. PIMID: 10960448.

7. Shen, H.M., Yang, C.F., Ding, W.X., Liu, J., and Ong, C.N. (2001) Oxidative stress mediated apoptotic signaling pathway in sodium selenite-treated HepG2 cells: mitochondria serve as the main target. Free Radic. Biol. Med 30:9-21. PIMID:11134891.

8. Ding, W.X., Shen, H.M. and Ong, C.N. (2001) Pivotal role of mitochondrial Ca(2+) in microcystin-induced mitochondrial permeability transition in rat hepatocytes. Biochem Biophys Res Commun. 285:1155-1161. PIMID: 11478775.

9. Ding, W.X., Shen, H.M. and Ong, C.N. (2001) Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes. J Toxicol Environ Health A. 64:507-519. PIMID: 11732701.

10. Ding, W.X., Shen, H.M. and Ong, C.N. (2002) Calpain Activation after Mitochondrial Permeability Transition in Microcystin-Induced Cell Death in Rat Hepatocytes. Biochem Biophys Res Commun. 291:321-331. PIMID: 11846407.

11. Shen, H.M., Ding, W.X. and Ong, C.N. (2002) Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HepG2 cells. Free Radic. Biol. Med. 33:552-61. PIMID: 12160937.

12. Ding, W.X*. and Ong, C.N. (2003) Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol Lett. 220:1-7. Invited review. * correspondence author. PIMID: 12644220.

13. Zhao, Y, Ding, W.X*, Qian T, Watkin S, Lemasters J.J. and Yin, X.M. (2003) Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology 125:854-67. *Co-first author. PIMID: 12949730.

14. Yin X.M. and Ding W.X. (2003) Death Receptor Activation-Induced Hepatocytes Apoptosis and Liver Injury. Current Molecular Medicine. 3: 85-94. PMID: 14527081.

15. Kim, T.H.*, Zhao, Y*, Ding, W.X*., Shin, J.N., He, X., Seo Y.W., Chen, J., Rabinowich H., Amoscato, A. and Yin, X.M. (2004) Bid-cardiolipin interaction at the mitochondria contact site contributes to mitochondria cristae reorganization. Mol Biol Cell. 15:3061-72. *Co-first author. PMID: 15107464.

16. Ding, W.X, Ni, H.M., Defrancesca, D., Stolz, D.B., and Yin, X.M (2004) Bid-Induced Oxygen Radicals Promote Mitochondrial Dysfunction, Caspase Activation and Hepatocyte Apoptosis. Hepatology 40:403-413. * Highlighted article in Hepatology. PMID: 15368445.

17. Ding, W.X., and Yin X.M. (2004) Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med. 8(4):445-54. PMID: 15601573.

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18. Chen X, Ding, W.X. Ni, H.M., Gao, W., Shi, Y.H., Gambotto, A.A., Fan, J., Beg, A.A. and Yin, X.M. (2007) Bid-independent Mitochondria Activation in TNF{alpha}-induced Apoptosis and Liver Injury. Mol Cell Biol. 27(2):541-53. PMID: 17101783. PMCID: PMC1800794.

19. Ding, W.X. Ni, H.M., Gao, W., Hou, Y.F., Melan, M.A., Chen X, Stolz, D.B., Shao, Z.M., and Yin, X.M. (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem. 282(7):4702-10. Faculty of 1000 Biology (http://f1000biology.com/article/id/1070875). PMID: 17135238.

20. Ding, W.X., Ni, H.M, Chen, X., Yu, J., Zhang, L., and Yin, X.M. (2007) A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. Mol Cancer Ther. 6(3):1062-9. * Cover story. PMID: 17363499.

21. Ding, W.X. Ni, H.M., Gao, W., Yoshimori, T., Stolz, D.B., Ron, D., and Yin, X.M. (2007) Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability. Am J Pathol. 171(2):513-24. * Top 10 cited AJP paper. PMID: 17620365. PMCID: PMC1934546.

22. Ding, W.X*. Ni, H.M.,and Yin, X.M. (2007) Absence of bax switched MG132-induced apoptosis to non-apoptotic cell death that is suppressed by transcriptional and translational inhibitors. Apoptosis. 12(12):2233-44. * correspondence author. PMID: 17912641.

23. Ding, W.X., and Yin, X.M. (2008) Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy. 4(2):141-50. PMID: 17986870.

24. Yin, X.M., Ding, W.X., and Gao, W. (2008) Autophagy in the liver. Hepatology. 47(5):1773-85. Review. PMID: 18393362.

25. Gao, W., Ding, W.X., Stolz, D., and Yin, X.M. (2008) Induction of macroautophagy by exogenously introduced calcium. Autophagy. 30;4(6). PMID: 18560273. PMCID: PMC2696695.

26. Shi, Y.H., Ding, W.X., Zhou, J., He, J.Y., Xu, Y., Gambotto, A.A., Rabinowich, H., Fan, J. and Yin, X.M. (2008) Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology. 48(2):497-507. PMID: 18666224. PMCID: PMC2768766.

27. Ni, H.M., Chen, X, Ding, W.X., Schuchmann, M., and Yin, X.M. (2008) Differential Roles of JNK in ConA/GalN and ConA-Induced Liver Injury in Mice. Am J Pathol. 173(4):962-72. PMID: 18772342. PMCID: PMC2543065.

28. Ding, W.X., and Yin, X.M. (2009) Analyzing macroautophagy in hepatocytes and the liver. Methods Enzymol. 453: 397-416. PMID: 19216918.

29. Ding, W.X. Combined inhibition of proteasome and autophagy: a novel cancer therapeutic approach. (2009) J of Medical Postgraduates (China). 22(5) 449-451 (English). Leading Article.

30. Ding, W.X. Ni, H.M., Gao, W., Chen, X., Kang, J.H., Stolz, D.B., Liu, J., and Yin, X.M. (2009) Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Mol Cancer Ther. 8(7):2036-45. PMID: 19584239. PMCID:PMC2711219.

31. Chu, R, Upreti,M, Ding, W.X., Yin, X.M., and Chambers, C.T. (2009). Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochemical Pharmacology. 78(3):241-8. PMID: 19427996. PMCID: 19427996. PMCID: PMC2692743.

32. Gao, W., Kang, J.H., Liao, Y., Ding, W.X., Gambotto, A., Watkins, S., Liu,Y.J., Stolz, D.B. and Yin, X.M. (2010) Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. J Biol Chem 8;285(2):1371-83. PMID: 19910472.

33. Ding, W.X. (2010). The role of autophagy in liver physiology and pathophysiology. World J Biol Chem. 1 (1): 3-12. PMID: 21540988. PMCID:PMC3083930.

34. Ni, H.M., Ni HM, Baty CJ, Li N, Ding WX, Gao W, Li M, Chen X, Ma J, Michalopoulos GK, and Yin XM X.M. (2010) Bid Regulates Murine Hepatocyte Proliferation by Controlling ER Calcium Homeostasis. Hepatology 52(1):338-48. PMID: 20578150. PMCID: PMC2943424.

35. Ding, W.X., Ni, H.M., Liao, Y., Li, M., Gao, W., Stolz, D.B., Gerald, W.D.II. and Yin, X.M. (2010) Nix is critical to two distinct phases of mitophagy: reactive oxygen species (ROS)-mediated autophagy induction and Parkin-ubiqutin- p62-mediated mitochondria priming. J Biol Chem. 3;285(36):27879-90. PMID: 20573959. PMCID:PMC2934655.

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36. Ding, W.X. Li, M., Chen, X., Ni, H.M., Lu, B., Stolz, D.B., Clemens, D.L. and Yin, X.M. (2010) Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology. 139(5):1740-52. PMID: 20659474.

37. Ni, H.M., Bockus, B., Wozniak, A.L., Jones, K., Weinman, S., Yin, X.M., and Ding, W.X*. (2011) Dissecting the Dynamic Turn Over of GFP-LC3 in the Autolysosome. Autophagy. 7(2):54-7. * correspondence author. PMID: 21107021. PMCID:PMC3039769

38. Ding, W.X., Li, M., and Yin, X.M. (2011) Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets. Autophagy. 7(2):248-249. PMID: 21150309. PMCID:PMC3039771.

39. Ding, W.X*., Manley, S., and Ni, H.M. (2011) The emerging role of autophagy in alcoholic liver disease. Exp. Biol. Med. 1;236(5):546-56. PMID: 21478210. PMCID: PMC4096159.* correspondence author.

40. Li., H., Wang, P., Sun, Q., Ding, W.X., Yin, X.M., Sobol., R.W., Stolz, D.B., Yu, J., and Zhang, L. (2011). Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase-8-mediated cleavage of Beclin-1. Cancer Res. 71(10): 3625-34. PMID: 21444671. PMCID: PMC3096685.

41. Mei., S., Ni, H.M., Manley, S., Bockus, A., Kassel, K., Luyendyke, J., Copple, B., and Ding, W.X*. (2011) Differential role of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J Pharmacol Exp Ther. 339(2):487-98. PMID: 21856859 * correspondence author. Highlighted article in JPET. PMCID:PMC3199993

42. Ni, H.M., Bockus, A., Boggess, N.,Jaeschke, H. and Ding, W.X*. (2012) Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology. 55(1):222-32. PMID:21932416. * correspondence author. Faculty of 1000 Biology: (http://f1000.com/13759957). PMCID:PMC3245329

43. Dolganiuc A, Thomes P, Ding W.X., Lemasters J.J. and Donohue, Jr, T. (2012) Autophagy in alcohol-induced liver diseases. Alcohol Clin & Exp Res. 36(8):1301-8. PMID: 22551004. PMCID: PMC3653416.

44. Ni, H.M., Jaeschke, H. and Ding, W.X*. Targeting autophagy for drug-induced liver injury. (2012) Autophagy. 1;8(4). PMID: 22441014. * correspondence author. PMCID:PMC3679091.

45. Ni, H.M., Boggess, N, Magill, M., Lebofsky,M., Borude,P., Apte,U., Jaeschke, H and Ding. W.X.* (2012)

Liver specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxi. Sci. (Cover Story). *. 127 (2): 438-450. correspondence author. PMID: 22491424. PMCID:PMC3355320.

46. Jaeschke, H and Ding, W.X. (2012) Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice? Journal of Gastroenterology. 47(7):845-6. PMID: 22565638.

47. Ding, W.X*. and Yin, X.M. (2012) Mitophagy: Mechanisms, Pathophysiological Role and Analysis. Biological Chemistry. 393(7):547-64. PMID: 22944659. Invited review. * correspondence author. PMCID: PMC3630798.

48. Ni, H.M, Williams, J., Yang, H, Shi, Y.H., Fan, J and W.X. Ding *. (2012). Targeting autophagy for liver diseases. Pharm. Res. Invited review. 66(6):463-74. PMID: 22871337.* correspondence author. PMCID: PMC3502728.

49. Klionsky, D., …, Ding, W.X., ..et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. (2012) Autophagy. 8(4):445-544. PMID: 22966490.PMCID:PMC3404883.

50. Williams J.A., Thomas, A., Li G., Kong B., Inaba, Y., Xie W., Ding W.X. and Guo G.L. (2012) Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor in Mouse. PLOS ONE 7(8):e43961. PMID: 22952826. PMCID: PMC3428273.

51. Ding, W.X, Chen, X and Yin, X.M. (2012) Tumor cells can evade survival dependence on autophagy through adaptation. Biochem Biophys Res Commun. 425(3):684-8. PMID: 22842577. PMCID: PMC3653416.

52. Ding, W.X. (2012) Autophagy in Toxicology: Defence against Xenobiotics. Journal of Drug Metabolism and Toxicology. 3(4).

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53. Ding WX*, Li M, Biazik JM, Morgan DG, Guo F, Ni HM, Goheen M, Eskelinen EL, Yin XM. (2012) Electron Microscopic analysis of a spherical mitochondrial structure. J. Biol. Chem. 287(50):42373-8. * correspondence author. PMID: 23093403. PMCID:PMC3516780.

54. Ding, W.X.*, Guo, F., Ni, H.M., Bockus, A., Manley, S., Stolz, D.B., Eskelinen, E.L., Jaeschke, H. and Yin, X.M. (2012) Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation. J Biol. Chem. 287(50):42379-88.. * correspondence author. PMID: 23095748. PMCID:PMC3516781.

55. Chen D, Chen X., Li, M., Zhang, H., Ding, W.X. and Yin, X.M. (2013) CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable. Biochem Biophys Res Commun. 432(2):226-30. PMID: 22842577. PMCID: PMC3595373.

56. Czaja M, Ding, W.X., Donohue,T.M., Friedman, S.L., Kim, J.S., Komatsu, M., Lemasters,J.J., Lemoine, A., Lin, J.D., Ou, J.H., Perlmutter,D.H., Randall, G., Ray, R.B., Tsung, A., and Yin, X.M. (2013) Functions of autophagy in normal and diseased liver. Autophagy. 9(8):1131-58. PMID: 23774882. PMCID: PMC3748187.

57. Ramachandran, A., McGill , M.R., Xie, Y., Ni, H.M., Ding, W.X. and Jaeschke, H. (2013) Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology. 58(6):2099-108. PMID: 23744808. PMCID:PMC3791212.

58. Manley, S., Williams, J.A., and Ding, W.X. (2013) The pathophysiological role of p62 in the liver. Experimental Biology and Medicine. Experimental Biology and Medicine. 238(5):525-38. PMID: 23856904. PMCID: PMC4096157.

59. Ni, H.M., Duo, K., You, M., and Ding, W.X. (2013). Critical Roles of FoxO3 in Alcohol-Induced Autophagy and Hepatotoxicity. American J of Pathology. 84(10):103511. PMID: 24095927. PMCID: PMC4851739. Selected as AJP Press Release.

60. Williams JA, Hou, Y., Ni, H.M, and Ding, W.X. (2013) Role of intracellular calcium in proteasome inhibitor MG132-induced ER stress, autophagy and cell death. Pharm Res. 30(9):2279-89. PMID: 23893020. PMCID: PMC3788613.

61. Bi L, Chiang JY, Ding WX, Dunn W, Roberts B, Li T. (2013) Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J. Lipid Res. 54(10):2754-62. PMID: 23904453. PMICD: PMC3770088.

62. Yin, X.M and Ding, W.X. (2013) The reciprocal roles of PARK2 and mitofusins in mitophagy and mitochondrial spheroid formation. Autophagy. 9(11):1687-1692. PMID: 24162069.

63. Ni, H.M, Williams, J.A., Jaeschke. H and Ding, W.X. (2013) Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver. Redox Biology. 1(1): 427-432. PMID: 24191236. PMCID: PMC3814950.

64. Ding, W.X. (2013) Induction of autophagy, a promising approach for treating liver injury. Hepatology. 59(1):340-3. PMID: 23775596. PMCID: PMC4096158.

65. Ding, W.X. (2014) Drinking Coffee Burns Hepatic Fat by Inducing Lipophagy Coupled with Mitochondrial ß-Oxidation. Hepatology. 59(4):1235-8. PMID: 24114874. PMCID: PMC3966934.

66. Manley, S., Ni, H.M., Kong, B., Apte, U., Guo, G and Ding, W.X. (2014) Suppression of Autophagic Flux by Bile Acids in Hepatocytes. Toxi Sci .137(2):478-90. PMID: 24189133. PMCID: PMC3908720

67. Ni, H.M., Woolbright, B., Copple, B, Luyendyke, J., Cui, W., Jaeschke, H and Ding, W.X. (2014) Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy. J of Hepatology 61(3):617-25. PMID: 24815875. PMCID: PMC4143992. *Commentary: Scott L Friedman. Tracking HCC pathogenesis but not the tumor cells after biopsy. J of Hepatology 61(3):589-93.

68. Williams, J, Manley, S and Ding, W.X. (2014) New advances and therapeutic targets for alcoholic liver diseases. World J of Gastroenterology 20(36):12908-12933. PMID: 25278688. PMCID: PMC4177473.

69. Li Y., Wang S., Ni, H.M., Huang H. and Ding, W.X. (2014) Autophagy in alcohol-induced multi-organ injury: mechanisms and potential therapeutic targets. BioMed Research International. 2014:498491. PMID: 25140315. PMCID: PMC4124834.

70. McGill MR, Du K, Xie Y, Bajt ML, Ding WX, Jaeschke H. (2014) The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury. Xenobiotica. Nov 25: 1-8. PMID: 25423287. PMCID: PMC4442771.

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71. Manley S., Ni, H.M, Williams, J.A., Guo, G, and Ding, W.X. (2014) Farnesoid X receptor regulates Fork head Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biology 28;2C:991-1002. PMID: 25460735. PMCID: PMC4215528.

72. Ni, H.M., Bhakta, A., Wang, S.G., Li, Z., Manley, S., Huang H., Copple, B., and Ding, W.X. (2014) Role of hypoxia inducing factor-1β in Alcohol-induced autophagy, steatosis and liver injury in mice. PLoS ONE. 23;9(12):e115849. PMID: 25536043. PMCID: PMC4275262.

73. Ding, W.X and Eskelinen, E.L. (2014) Do mitochondria donate membrane to form autophagosomes or undergo remodeling to form mitochondrial spheroids? Cell & Bioscience 14;4(1):65. PMID: 25436108. PMCID: PMC4247758.

74. Ni, H.M., Williams, J.A., and Ding, W.X. (2015) Mitochondrial dynamics and mitochondrial quality control. Redox Biology 20;4C:6-13. PMID: 25479550. PMCID: PMC4309858.

75. Ding, W.X. (2015) Uncoupling AMPK from autophagy: a foe that hinders the beneficial effects of metformin treatment on metabolic syndrome-associated atherosclerosis? American J Physiol-Cell Physiol. 308(3):C246-8. PMID:25500743. PMCID: PMC4312841.

76. Williams, J, Ni, H.M., Hayness, A, Manley, S., Li, Y., Jaeschke, H. and Ding, W.X. (2015) Chronic deletion and acute knockdown of Parkin have differential responses in acetaminophen-induced mitophagy and liver injury in mice. J. Biol. Chem. 290(17):10934-46. PMID: 25752611. PMCID: PMC4409255.

77. Yang, H., Peng, Y.F., Ni, H.M., Li, Y., Shi, Y.H, Ding, W.X*. and Fan,J. (2015) Basal autophagy and feed back activation of Akt are associated with resistance to metformin-induced inhibition of hepatic tumor cell growth. PloS One. 2015 Jun 25;10(6):e0130953. eCollection 2015. PMID 26111001. PMCID: PMC4482411.

78. Williams, J, Ni, H.M., and Ding, W.X. (2015) Parkin Regulates Mitophagy and Mitochondrial Function to Protect Against Alcohol induced Liver Injury and Steatosis in Mice. American J Physiol-Gastrointestinal and Liver Physiology. 309(5):G324-40. PMID: 26159696. PMCID:PMC4556950.

79. Manley, S., and Ding, W.X. (2015) Role of farnesoid X receptor and bile acids in alcoholic liver disease. Acta Pharmaceutica Sinica B 5 (2), 158-167. PMID: 26579442. PMCID: PMC4629219.

80. Williams, J. and Ding, W.X. (2015). Mitophagy, mitochondrial spheroids and mitochondrial derived vesicles in alcohol-induced liver injury. American J Physiol-Gastrointestinal and Liver Physiology. 15;309(6):G515. PMID: 26374876.

81. Yang, X., Chao, X., Wang, Z.T and Ding, W.X. (2015) The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity? Hepatology. PMID: 26418225.

82. Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H (2015). Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol. 289(2):213-22. PMID: 26431796. PMCID PMC4651811.

83. Williams, J. and Ding, W.X. (2015). A mechanistic review of mitophagy and its role in protection against alcoholic liver disease. Biomolecules. 16; 5(4):2619-42. PMID: 26501336. PMCID: PMC4693250.

84. Williams, J. and Ding, W.X. (2015). Targeting Pink1-Parkin-mediated mitophagy for treating liver injury. Pharm Res. 102:264-9. PMID: 26655101. PMCID: PMC4684418.

85. Ding, W.X. and Jaeschke, H. (2016) Autophagy in Macrophages Regulates the Inflammasome and Protects Against Liver Injury. J Hepatology. 64(1): 16-8. PMID: 26456339. PMC4888871.

86. Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC (2015). Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Diabetologia. PMID 26471901.

87. Li, Y and Ding, W.X. (2016) A Gene Transcription Program Decides the Differential Regulation of Autophagy by acute vs Chronic Ethanol? Alcohol Clin Exp Res. 40(1):47-9. PMID: 26727521.

88. Wang S., Ni, H.M., Dorko, K., Kumer, S.C., Schmitt, T.M., Nawabi, A., Huang H and Ding, W.X. (2016) Increased hepatic expression of receptor interacting protein 3 due to impaired proteasomal functions contributes to Alcohol-induced steatosis and liver injury. Oncotarget 7(14):17681-98. PMID. 26769816. PMCID: PMC4951242.

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89. Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. (2016) The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell. 18(2):214-228. PMID: 26627594.

90. Klionsky, D., …, Ding, W.X., ..et al. (2016) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition). Autophagy. 12(1):1-222. PMID: 26799652. PMCID: PMC in progress.

91. Ni, H.M., McGill., M.R, Chao, X., Du, K., Williams, J.A., Xie, Y., Jaeschke, H., and Ding W.X. (2016) Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice. J of Hepatology. 65(2):354-62. PMID: 27151180. PMCID: PMC4955750.

92. Nagy, L.E., Ding, W.X., Cresci, G., Saikia, P and Shah, V. (2016) Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes. Gastroenterology. 150(8):1756-68. PMID: 26919968. PMCID: PMC4887335.

93. Pan, J.A., Sun, Y., Jaber, N., Dou, Z., Yang, B., Chen, J.S., Catanzaro, J.M., Du, C., Ding, W.X., Moscat, J., Ozato, K., and Zong, W.X. (2016) TRIM21 suppresses protein sequestration and anti-oxidant response by ubiquitylating SQSTM1/p62. Mol Cell. 3;61(5):720-33. PMID: 26942676. PMCID; PMC4779181.

94. Li Y., McGreal S., Zhao, J., Huang, R., Zhou, Y., Zhong, H., Xia M and Ding, W.X. A cell-based quantitative high-throughput imaging screening identified novel autophagy modulators. (2016) Pharm. Res. 110:35-49. PMID: 27168224. PMCID PMC4995889.

95. Wang S.G., Pacher, P., De Lisle, R.C., Huang, H., and Ding, W.X. (2016) A mechanistic review of cell death in alcohol-induced liver injury. Alcohol Clin Exp Res. 2016 Apr 30. PMID: 27130888.

96. Ni, H.M., McGill, M.R, Chao, X., Woolbright, B., Jaeschke, H., and Ding W.X. (2016). Caspase inhibition prevents TNF-α-induced apoptosis and promotes necrotic cell death in mouse hepatocytes in vivo and in vitro. Am J. Pathol. 186(10):2623-36. PMID: 27616656. PMCID: PMC5222974. Selected as AJP Press Release.

97. Yang, H, Ni, HM, Guo, F, Ding, Y, Shi, YH, Lahiri, P, Fröhlich, LF, Rülicke, T, Smole, C, Schmidt, VC, Zatloukal, K, Cui, Y, Komatsu, M, Fan, J, Ding, WX. (2016) Sequestosome-1/p62 is associated with autophagic removal of excess endoplasmic reticulum in mice. J Biol Chem. 291(36):18663-74. PMID: 27325701. PMCID: PMC5009243.

98. Zhou, Y., Li, Y., Ni, H.M., Ding, W.X. and Zhong, H. (2016) Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small lung cancer cells. Toxicol Appl Pharmacol. 310:140-149. PMID: 27639429. PMCID: PMC5470646.

99. Wang, S. and Ding, W.X. (2016) A small RNA in neutrophils protects against acute-on-chronic liver injury. Gut 66(4):565-566. PMID: 27802158.

100. Li, Y. and Ding, W.X. (2017) Does genetic loss of immunoglobulin A have no impact on alcoholic liver disease? Alcohol Clin Exp Res. 41(1):20-22. PMID: 28042659. PMCID: PMC5215837.

101. Wang, Y., Ding, Y., Li, J., Chavan, H, Matye, D., Ni, H.M., Yoshimori, T., Chiang, Y.L., Krishnamurthy, P., Ding, W.X. and Li, T. (2016) Targeting the enterohepatic bile acid signaling induces hepatic autophagy via a CYP7A1-AKT-mTOR axis in mice. Cellular and Molecular Gastroenterology and Hepatology. 22;3(2):245-260. PMID: 28275691.PMCID:PMC5331786.

102. Morris, EM., McCoin, C., Allen, J., Gastecki, M., Koch, LG., Britton, SL., Fletcher, JA., Fu, X., , Burgess, SC., Ding, WX., Rector, RS., Thyfault, JP. (2017) Low Aerobic Capacity Increases Susceptibility to High-Fat, High-Cholesterol Diet-Induced Steatohepatitis. J of Physiology. PMID: 28504310. PMCID: PMC

103. Williams, J., Zhao, K., Jin, S.K. and Ding, W.X. (2017) New Methods for Monitoring Mitochondrial Biogenesis and Mitophagy in vitro and in vivo. Experimental Biology and Medicine. 242(8):781-787. PMID:28093935. PMCID: PMC5407538.

104. Yang, X., Wang, H., Ni, H.M., Wang, Z.T., Sesaki, H., Ding, W.X. and Yang, L. (2017) Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biology 2;12:264-273. PMID:28282614. PMCID: PMC5344326.

105. Woolbright, B., Ding, W.X., and Jaeschke, H. (2017) Caspase inhibitors for the treatment of liver disease: friend or foe? Expert Review for Gastroenterology & Hepatology 4:1-3. PMID:28276808.

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106. Li, Y and Ding, W.X. (2017) Adipose Tissue Autophagy and Homeostasis in Alcohol-Induced Liver Injury. Liver Research 1; 54-62. PMID:29109891. PMCID: PMC5669268

107. Li, Y and Ding, W.X. (2017) Impaired Rab7 and Dynamin2 Block Fat Turnover by Autophagy in Alcoholic Fatty Livers. Hepatology Communications 1(6); 473-475. PIMID:29124250. PMCID: PMC5673279.

108. Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H. (2017). Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol. PMID:28827156. PMICD:

109. Li J, Chen C, Li Y, Matye DJ, Wang Y, Ding WX, Li T. (2017) Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochim Biophys Acta. 2017 Aug 24. PMID: 28844948.

110. Li Y, Zong WX and Ding WX. (2017) Recycling the Danger via Lipid Droplet Biogenesis After Autophagy. Autophagy. 13(11):1995-1997. PMID: 28873005. PMCID: PMC5788485.

111. Rogers RS, Tungtur S, Tanaka T, Nadeau LL, Badawi Y, Wang H, Ni HM, Ding WX and Nishimune H. (2017) Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice. Front Neurosci. 2017 Aug 25;11:473. doi: 10.3389/fnins.2017.00473. eCollection 2017. PMID:28890682. PMCID: PMC5575151.

112. New J, Arnold L, Ananth M, Alvi S, Thornton M, Werner L, Tawfik O, Dai H, Shnayder Y, Kakarala K, Tsue TT, Girod D, Ding WX, Anant S, Thomas SM. (2017) Secretory autophagy in cancer-associated fibroblasts promotes head and neck cancer progression and offers a novel therapeutic target. Cancer Research. 1;77(23):6679-6691. PMID:28972076. PMCID: PMC5712244.

113. Williams, J.A. and Ding, W.X. (2018) Mechanisms, Pathophysiological Roles, and Methods for Analyzing Mitophagy – Recent Insights. Biol Chem. 399(2):147-178. PMID:28976892.

114. Qian, Q, Zhang, Z, Orwig, A, Chen, S, Ding, WX, Xu, Y, Kunz, RC, Lind, NRL, Stamler, JS, Yang, L. S-nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy. Diabetes. 2017 Oct 26. PMID: 29074597.

115. Qiang, H, Chao, X. and Ding, W.X. (2018) A PINK1-Mediated Mitophagy Pathway Decides the Fate a Tumor to be Benign or Malignant? Autophagy.9: 1-13. PMID 29313453.PMCID: 5959334.

116. Wang, S., Wang, H, and Ding, W.X. (2018) Pyroptosis, a novel target for alcoholic hepatitis? Hepatology. ;67(5):1660-1662. PMID: 29222919. PMCID: PMC5906175.

117. Lang, A.L., Chen, L., Poff, G.D., Ding, W.X. Barnett, R.A., Arteel, G.E. and Beier, J.I. (2018) Vinyl chloride dysregulates metabolic homeostasis and enhances diet-induced liver injury in mice. Hepatology Communications. 9;2(3):270-284. PMID: 29507902. PMCID: PMC5831023.

118. Wang, Y., Ding, W.X. and Li, T. (2018) Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis. Biochim Biophys Acta. 2018 Apr 10. PMID: 29653253.

119. Chao, X., Jaeschke and Ding, W.X. (2018) Role and mechanisms of autophagy in acetaminophen-induced liver injury. Liver International. PMID: 29682868.

120. Li, Y., Chao, X., Yang, L., Li, T., Ding, W.X. and Ni, H.M. (2018) Impaired Fasting-induced Adaptive Lipid Droplet Biogenesis in Liver-specific Atg5 Deficient Mouse Liver Is Mediated by Persistent Nrf2 Activation. Am. J. Pathol. PMID: 29823835.

121. Wang Y, Li J, Matye D, Zhang Y, Dennis K, Ding WX and Li T. (2018) Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury. JCI Insight. 2018 Apr 19;3(8). PMID: 29669937.

122. Wang Y, Ding WX and Li T. (20108) Cholestrol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis. Biochim Biophys Acta. 2018 Apr 10;1863(7):726-733. PMID: 29653253.

123. Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX. (2018) Impaired TFEB-mediated lysosomal biogenesis in acute-on-chronic alcohol induced-liver injury in mice. Gastroenterology. PMID: 29782848.

124. Wang, S., Ni, H.M., Chao, X., Wang, H., Bridge, B., Kumer, S., Schmitt, T., De Lisle, R.C., Ballabio, A., Pacher, P and Ding, W.X. (2018) Impaired TFEB-Mediated Lysosomal Biogenesis Promotes the Development of Pancreatitis in Mice and is Associated with Human Pancreatitis. Autophagy (under revision).

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125. Chao, X., Ni, H.M. and Ding, W.X. (2018) Insufficient Autophagy: A Novel Autophagic Flux Scenario Uncovered by Impaired Liver TFEB-Mediated Lysosomal Biogenesis From Chronic Alcohol-Drinking Mice. Autophagy 2018. PMID: 29969942.

126. Wang, S and Ding, W.X (2018) Does Autophagy Promote or Protect Against the Pathogenesis of Pancreatitis? Gastroenterology (accepted).

127. Wang, H., Ni, H.M., Chao, X., Rodriguez, Y.A., Chavan, H., Wang, S.G., Krishnamurthy, P., Dobrowsky, R., Xu, D.X., Jaeschke, H and Ding, W.X. (2018) Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice. Autophagy (under review).

128. Ma, X., Parson, C and Ding, W.X. (2018) Regulation of the Homeostasis of Hepatic Endoplasmic Reticulum and Cytochrome P450 Enzymes by Autophagy. Liver Research (In press).

129. Li, Y., Ni, H.M., Jaeschke, H and Ding, W.X. (2018) Chlorpromazine Protects Against Acetaminophen-Induced Liver Injury in Mice by Modulating Autophagy and JNK Activation. Liver Research (in revision).

130.

Publications (in Chinese, before 1998) 1. Ding, W.X., Jiang, S, Yao, J and Zhu, H.G . Studies on Mutagenicity of Water in Changjiang. Shanghai

Environmental Sciences. 1994. 13(9). 2. Ding, W.X., Nie, N and Zhu, H.G. Transformation of Water Samples in Changjiang River With Syrian

Hamester Embryo Cells. China Public Health. 1994. 13(6). 3. Ding, W.X., Nie, N and Zhu, H.G. Detection of genotoxicity of water in Changjang River by using UDS

test. China Environmental Science. 1995. 15 (4). 4. Ding, W.X. and Zhu, H.G. The effects of Changjiang water on the micronuclei formation in SHE cells.

Shanghai Journal of Preventive Medicine. 1995. 7(12). 5. Zhang J., Wu Z., Zhang, Y., Ding, W.X. and Zhu, H.G. Evaluation of Genotoxicity of Source Water and

Tap Water Samples by Using Mouse Micronucleus Test. Shanghai Environmental Sciences. 1997. 16(2). 6. Zhang J., Wu Z., Zhang, Y., Ding, W.X. and Zhu, H.G. Studies on the mutagenicity of tap water and

source water in G city. JOURNAL OF ENVIRONMENT AND HEALTH. 1997. 7. Ren, T., Ding W.X and Song, H. Analysis of the contamination and toxicity of algae from Dalan lake in

Dongguan city. GUANGDONG JOURNAL OF HEALTH AND EPIDEMIC PREVENT. 1998 .24 (3). 8. Ding, W.X., Shen, H.M., Zhu, H.G and Ong C.N. Hepatotoxicity and Formation of Reactive Oxygen

Species Induced by Microcystis Aeruginosa Toxin. Chinese Journal of Preventive Medicine. 1998. 32(5). C. Book Chapters

1. Yin, X.M., Ding, W.X. and Zhao, Y.G. Bcl-2 family proteins, the master regulators of apoptosis. Humana Press Inc., Totowa, NJ. 2003: The essential of apoptosis: A guide for Basic and Clinical Research. Edited by Yin, X.M and Dong Z. 2. Ding, W.X. and Yin, X.M. Bcl-2 family proteins. Humana Press Inc., Totowa, NJ. 2009: The essential of apoptosis: A guide for Basic and Clinical Research (Edition 2). Edited by Yin, X.M and Dong Z. 3. Shi Y., Fan, .J., Ling, C.W., Ding., W.X. and Yin, X.M.. Macroautophagy and liver pathobiology. 2010. In Satdarshan P.S. Monga, Ed. MOLECULAR PATHOLOGY OF LIVER DISEASES. 4. Yang, H., Williams, J.A, Hou, Y., Xia, M., Shi, Y., Fan, .J. and Ding, W.X. Autophagy and Drug Discovery. 2013 In Honggang Wang, Ed. Autophagy and Cancer (Springer Science).

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5. Williams, J.A, Ni, H.M. and Ding, W.X. Mitochondrial dynamics, mitophagy and mitochondrial spheroids in drug-induced liver injury. 2015. In Neil Kaplowitz & Derick Han, Ed. Mitochondria in Liver Diseases. CRC press. 6. Chao, X., Wang, S and Ding, W.X. Cell death in alcohol-induced liver injury. 2017. In Wen-Xing Ding & Xiao-Ming Yin, Ed. Cellular Injury in Liver Diseases. Springer.

D. Oral Presentations at Scientific Conferences 1. Ni, H.M., Chen, X.Y, Ding, W.X.* Yin, X.M. Bid-independent Mitochondria Activation in

TNF{alpha}-induced Apoptosis and Liver Injury. Experimental Biology 2007. April 28-May 3. Washington DC, USA. Oral presentation*.

2. Ding, W.X., Ni, H.M., Chen X., Stolz, D., and Yin, X.M. Caspase-inhibition switched TNF-alpha-induced apoptosis to autophagic cell death in hepatocytes. Oral presentation at AASLD Annual Meeting 2007, Nov 2-5. Boston, MS, USA. Oral presentation*.

3. Ding, W.X., Ni, H.M., Chen X., Stolz, D., and Yin, X.M. Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Experimental Biology 2009. April 18-22, 2009. New Orleans. Louisiana, USA. Oral presentation*.

4. Ding, W.X., Ni, H.M., Bockus, A. and Jaeschke, H. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. AASLD Annual Meeting 2011, Nov 5-8. San Francisco, CA, USA. Oral presentation*.

5. Ding, W.X., Yang, H, and Ni, H.M. Excess endoplasmic reticulum is degraded by p62-mediated selective autophagy in mammals. Experimental Biology 2014. April 27, 2014. San Diego, CA, USA. Oral presentation*.

6. Ding, W.X. Yang, H, and Ni, H.M. Excess endoplasmic reticulum is degraded by SQSTM1/p62-mediated selective autophagy in mammals. Keystone Symposium: Autophagy: Fundamentals to Disease. May23-28, 2014. Austin, TX, USA. Oral presentation*.

7. Ding, W.X. Squestosome 1/p62-mediated selective removal of acetaminophen protein adducts and damaged mitochondria protects against acetaminophen-induced liver injury. AASLD November 10th, 2014 Boston. Plenary Talk at Basic Science.

E. Invited Speaker at Scientific Conferences or Institutes

2010-2011

1. Ding, W.X. Role of autophagy in acute ethanol-induced liver injury. Third Annual Liver Symposium. May

27, 2010. KUMC, Kansas City, Kansas. Invited Speaker. 2. Ding, W.X. Role of autophagy in alcoholic liver injury. RSA 33rd Annual Scientific Meeting at June 26-30,

2010, San Antonio, Texas. Invited Speaker. 3. Ding, W.X. Activation of autophagy protects against acetaminophen-induced liver injurynol-induced liver

injury. Forth Annual Liver Symposium. June 16, 2011. KUMC, Kansas City, Kansas. Invited Speaker. 4. Ding, W.X. Regulating of autophagy in alcohol-induced liver injury. Department of Pharmacology and

Toxicology. UMKC. Kansas City, Missouri. Sept 8, 2011. Invited Speaker. (Dr. Santosh Kumar).

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2012 5. Ding, W.X. Role of autophagy in alcohol and drug-induced liver injury. University of Louisville.

Department of Pharmacology and Toxicology. Louisville, Kentucky. January 5, 2012. Invited Speaker. 6. Ding, W.X. Targeting autophagy for drug-induced liver injury. University of Connecticut. Department of

Pharmaceutical Sciences. Storrs, Connecticut. January 19, 2012. Invited Speaker. 7. Ding, W.X. Regulating of autophagy in ethanol-induced hepatotoxicity and steatosis. The Henry M. and

Lillian Stratton; Basic Research Single Topic Conference; Mitochondria and Hepatotoxicity; Emory Conference Center Hotel; Atlanta, GA; June 8 – 9, 2012. Invited Speaker.

8. Ding, W.X. Autophagy in drug-induced liver injury. Research Institute of Nephrology, Nanjing University School of Medicine, Nanjing, P.R. China, June 18, 2012. Invited Speaker (Drs. Dai Chunsun and Yang Junwei).

9. Ding, W.X. Critical role of Foxo3 in alcohol-induced autophagy and liver injury. 2012 ISBRA (The International Society for Biomedical Research on Alcohol) Congress. Sapporo, September 9-12, 2012. Invited Speaker.

10. Ding, W.X. Mitophagy in drug-induced hepatotoxicity. Center for Free Radical Biology. University of Alabama. Birmingham, Alabama. August 30, 2012. Invited Speaker. (Dr. Victor Darley-Usmar).

2013 11. Ding, W.X. Autophagy in drug-induced liver injury. Department of Pharmaceutical Sciences. UMKC.

Kansas City, Missouri. March 5, 2013. Invited Speaker. (Dr. Kun Cheng). 12. Ding, W.X. Autophagy in Alcohol-induced liver injury, role of Foxo3. Department of

Gastroenterology/Hepatology. University of Indiana. Indianapolis, Indiana. April 8, 2013. Invited Speaker. (Dr. Charlie Dong).

13. Ding, W.X. Mitophagy and mitochondrial spheroids in drug-induced liver injury Department of Pharmacology and Toxicology. University of Kansas. Lawrence, Kansas. April 24, 2013. Invited Speaker. (Dr. Honglian Shi).

14. Ding, W.X. Mechanistic Insight of Mitophagy Learned From Research On Alcohol-Induced Liver Injury. Department of Internal Medicine. University of Nebraska Medical Center. Omaha, Nebraska. May 24, 2013. Invited Speaker. (Dr. Carol Casey).

15. Ding, W.X. Foxo3 regulates alcohol-induced autophagy and steatosis in mice. 36th RSA Annual Scientific Meeting. June 22-26, Orlando, Florida 2013. Invited Speaker.

16. Ding, W.X. Role of Parkin in alcohol-induced liver injury. Alcoholic Liver Disease Mini Symposium, October 10, 2013. Kansas City, KS. Invited Speaker.

17. Ding, W.X. Autophagy and alcohol-induced liver injury. December 11, 2013. NIAAA, Washington DC. Invited Speaker. (Dr. Bin Gao).

2014 18. Ding, W.X. Regulating the homeostasis of hepatic ER and P450 enzymes and hepatotoxicity by autophagy.

March 18, 2014. University of Pittsburgh, School of Pharmacy. Pittsburgh, PA. Invited Speaker. (Dr. Xiaochao Ma).

19. Ding, W.X. Regulation of mitophagy and mitochondrial spheroid formation by Parkin. April 25, 2014. Division of Biology, Kansas State University. Manhattan, KS. Invited Speaker. (Dr. Stella Lee).

20. Ding, W.X. Excess endoplasmic reticulum is degraded by p62-mediated selective autophagy in mammals. Experimental Biology 2014, San Diego, CA. April 27, 2014. Invited Speaker.

21. Ding, W.X. Excess endoplasmic reticulum is degraded by p62-mediated selective autophagy in mammals. Keystone Symposium: Autophagy: Fundamentals to Disease, Austin, TX. May 23-28, 2014. Selected as a

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short talk. 22. Ding.W.X. Role of mitophagy in regulating lipid metabolism. 74th American Diabetes Association's

Scientific Sessions. June 13-17, 2014, San Francisco, CA. Invited Speaker. 23. Ding,W.X. Autophagy in tissue injury, tumorigenesis and cancer therapy. July 25th, 2014. Shanghai

University of Traditional Chinese Medicine, Shanghai, P.R. China. Invited Speaker (Dr. Laurence Lao). 24. Ding,W.X. The double-edged Sword of Autophagy and Nrf2 in Cancer. July 28th, 2014. Hong Kong

Baptist University, Hong Kong, P.R. China. Invited Speaker (Dr. Min Li). 25. Ding,W.X. Autophagy in drug-induced liver injury, tumorigenesis and cancer therapy. July 29th, 2014.

University of Hong Kong, Hong Kong, P.R. China. Invited Speaker (Dr. Jianbo Yue). 26. Ding,W.X. The role of autophagy in drug-induced liver injury. August 13th, 2014. Children's Mercy

Hospital, UMKC. Kansas City, Missouri. Invited Speaker (Dr. Shui Qing Ye). 27. Ding,W.X. Mechanisms of autophagy in protecting against drug-induced liver injury. September 18th,

2014. Liver Center, University of Southern California, Los Angeles, USA. Invited Speaker (Dr. Neil Kaplowitz).

28. Ding,W.X. Linking of Nrf2 to Autophagy-Deficiency in Drug-Induced Liver Injury and Tumorigenesis. October 1st, 2014. Department of Pharmacology and Toxicology, Michigan State University, USA. Invited Speaker (Dr. Bryan Copple).

29. Ding, W.X. Squestosome 1/p62-mediated selective removal of acetaminophen protein adducts and damaged mitochondria protects against acetaminophen-induced liver injury. AASLD November 10th, 2014 Boston, USA. Plenary Talk at Basic Science.

30. Ding,W.X. Autophagy regulates liver homeostasis and metabolic enzymes to protect against tumorigenesis and drug-induced liver injury. December 8th, 2014. School of Pharmacy, University of Maryland, USA. Invited Speaker (Dr. Hongbing Wang).

2015 31. Ding, W.X. Role of Autophagy in alcoholic pancreatitis. January 20th, 2015. Department of Pharmacology,

Toxicology and Therapeutics. University of Kansas Medical Center. 32. Ding, W.X. Autophagy and Nrf2: two double-edged swords in cancer. March 2, 2015. Graduate Center for

Toxicology, University of Kentucky. Invited Speaker (Dr. Xianglin Shi) 33. Ding, W.X. Blocking caspases switched TNFα-induced apoptosis to necrosis in hepatocytes and mouse

livers. Experimental Biology 2015, Boston, MA, March 30, 2015. Invited Speaker. 34. Ding, W.X. Autophagy in alcohol and drug-induced liver injury. April 7, 2015. Department of Integrative

Sciences. Northeastern Ohio Medical University. Invited Speaker (Drs. Yoon-Kwang Lee & John Chiang). 35. Ding, W.X. Autophagy and Nrf2, two double-edged swords in Cancer. April 14th, 2015. KU Cancer Center.

Kansas City, KS. Invited Speaker. 36. Ding, W.X. Autophagy in Alcoholic Pancreatitis. April 20th, 2015. KU Liver Center. Kansas City, KS.

Invited Speaker. 37. Ding, W.X. Autophagy in alcohol and drug-induced liver injury. June 2nd, 2015. 2015 Central Region

IDeA Conference. Alerus Center, Grand Forks, ND. Invited Speaker. 38. Ding, W.X. Selective Autophagy in alcohol and drug-induced liver injury. June 19th, 2015. Department of

Pharmaceutical Sciences, University of Colorado. Denver, Colorado. Invited Speaker. 39. Ding, W.X. Selective Autophagy for Mitochondria. October 13th, 2015. Department of Microbiology,

Molecular Genetics and Immunology, KUMC, Kansas City, Kansas. Invited Speaker. 40. Ding, W.X Mitophagy in Liver Disease. 2nd Research symposium Advances in pancreatitis mechanisms:

focus on organelle disordering in pancreatitis. November 2nd 2015, ULCA, Los Angeles, USA. Invited Speaker.

41. Ding, W.X. Autophagy in acetaminophen poisoning. November 14th, 2015. Basic Science Symposium, AASLD Liver Meeting. November 13-17, San Francisco. Invited Speaker.

42. Ding, W.X. Targeting autophagy for treating liver diseases. The 3rd International Symposium on Liver Fibrosis, Liver Autophagy and New Drug Target Development. December 1st, 2015. Anhui Medical

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University, Hefei, Anhui, China. Invited Speaker. 43. Ding, W.X. Complex roles of Nrf2 and autophagy in liver toxicity and cancer. December 1st, 2015. School

of Public Health, Anhui Medical University, Hefei, Anhui, China. Invited Speaker.

2016 44. Ding, W.X. Autophagy and drug-induced liver injury. Experimental Biology Meeting 2016, April 5, 2016.

San Diego, USA. Invited Speaker. 45. Ding, W.X. Autophagy in alcoholic pancreatitis. The 4th International Symposium on Liver Fibrosis, Liver

Autophagy and New Drug Target Development. April 22, 2016. Anhui Medical University, Hefei, Anhui, China. Invited Speaker.

46. Ding, W.X. Autophagy in fatty liver. Shanghai International Conferences on Digestive Disease. April 22-24, 2016. Shanghai, China. Invited Speaker.

47. Ding, W.X . Proper interpretation of data obtained from transgenic mice in studying autophagy in liver disease. April 26, 2016. Shanghai University of Traditional Chinese Medicine Institute, Shanghai, P.R. China. Invited Speaker (Dr. Zhengtao Wang and Li Yang).

48. Ding, W.X. Autophagy in liver diseases. The 22nd Annual Meeting of the Korea Association of the Study of the Liver and Postgraduate Course. June 16-18, 2016. Seoul, Korea. Invited Speaker.

49. Ding, W.X. Autophagy and Liver Injury. School of Pharmacy, Fudan University. June 22, 2016. Shanghai, China. Invited Speaker (Professor Xiaoyan Shen).

50. Ding, W.X. Role of Autophagy in liver Disease. Department of Physiology, National University of Singapore. June 28, 2016. Singapore. Invited Speaker.

51. Ding, W.X. Liver Diseases and Autophagy. Department of Hepatology. The First Bethune Hospital of JiLin University. July 5, 2016. Changchun, China. Invited Speaker

52. Ding, W.X. Regulation of hepatic endoplasmic reticulum and P450 Enzymes Homeostasis by Autophagy. 21st International Symposium on Microsomes and Drug Oxidations (MDO2016). October 2-6, 2016. Davis, California, USA. Invited Speaker.

53. Ding, W.X. Autophagy in alcohol-induced liver and pancreatic injury. Cleveland Clinic. October 21, 2016. Cleveland, Ohio, USA. Invited Speaker (Dr. Laura Nagy).

54. Ding, W.X. Autophagy and liver disease. Department of Anatomy and Cell Biology. November 2, 2016. Iowa City, USA. Invited Speaker (Dr. Ling Yang).

55. Ding, W.X. Autophagy in alcohol and drug-induced liver injury, lessons from genetic knockout animal models. Seminars in Physiology, KUMC. November 28, 2016. Kansas City, KS, USA. Invited Speaker.

2017 56. Ding, W.X. Mechanisms regulating mitochondrial homeostasis. Department of Biochemistry and

Molecular Biology. Wright State University. March 16th. 2017. Dayton, OH, USA. Invited Speaker (Dr. HongMei Ren).

57. Ding, W.X. Autophagy: a common mechanism in alcohol-induced liver and pancreatic injury. Gordon Research Conferences. Alcohol-induced end organ diseases. March 26-31. 2017. Ventura, CA, USA. Invited Speaker.

58. Ding, W.X. Autophagy in alcohol and non-alcoholic fatty liver disease. 4thAnnual Conference of the Prevention and Control of Cardiovascular Metabolic Disease. April 15-16. 2017. Wuhan, China. Invited Speaker.

59. Ding, W.X. Autophagy in alcohol and non-alcoholic fatty liver disease. April 17, 2017. The first affiliated hospital of Xian Jiaotong University, Xian, China. Invited Speaker.

60. Ding, W.X. Assays to monitor mitochondrial biogenesis and mitophagy in vivo. Collaborate2cure Mitochondrial Dysfunction Seminar Series. May 15, 2017. Kansas City Area Life Sciences Institute. Kansas City. USA Invited Speaker

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61. Ding, W.X. Impaired TFEB-mediated lysosomal biogenesis in alcoholic pancreatitis. 40th Annual RSA Scientific Meeting. June 24-28. 2017. Denver, CO, USA. Invited Speaker.

62. Ding, W.X. Autophagy and Nrf2 in Drug-Induced Liver Injury and Tumorigenesis. August 30th, 2017. University of Arizona. Tucson, Arizona, USA. Invited Speaker (Dr. Aikseng Ooi).

63. Ding, W.X. Autophagy in Drug and alcohol-Induced Liver Injury. September 7, 2017. Virginia Commonwealth University. Richmond, VA, USA. Invited Speaker (Dr. Huiping Zhou).

64. Ding, W.X. Autophagy in tumorigenesis and cancer therapy. September 27, 2017. University of Texas at San Antonio. San Antonio,TX, USA. Invited Speaker (Dr. Mengwei Zang).

65. Ding, W.X. TFEB-mediated lysosomal biogenesis in alcoholic liver disease. November 6-7, 2017. First International Conference on Autophagy and Liver Diseases. Beijing, China. Invited Speaker.

66. Ding, W.X. How to properly prepare and write a scientific manuscript. November 14, 2017. Shanghai Traditional Chinese Medicine University. Shanghai, China. Invited Speaker.

67. Ding, W.X. Paradoxical role of Autophagy in drug-induced liver injury and tumorigenesis. December 1, 2017. University of Macau. Macau, China. Invited Speaker (Dr. Jiahong Lu).

68. Ding, W.X. Regulating hepatic homeostasis and endoplasmic reticulum and P450 enzymes by autophagy.. The 2nd Ling-Nan International Conference on Pharmaceutical Sciences-Pharmacology. December 2nd, 2017, Guangzhou, China. Invited Speaker.

69. Ding, W.X. Autophagy in drug-induced liver injury and tumorigenesis. December 3, 2017. Guangdong University of Technology. Guangzhou, China. Invited Speaker (Dr. Allan Zhao).

70. Ding, W.X. Autophagy in drug-induced liver injury and tumorigenesis. December 4, 2017. Sun Yat-Sen University. Guangzhou, China. Invited Speaker (Dr. Gengshu Wang).

71. Ding, W.X. Paradoxical role of Autophagy in drug-induced liver injury and tumorigenesis. December 15, 2017. Emory University. Atlanta, USA. Invited Speaker (Dr. Mark Czaja).

2018 72. Ding, W.X. Autophagy in drug-induced liver injury and tumorigenesis. January 12, 2018. Cedars-Sinai

Medical Center, Los Angeles, USA. Invited Speaker (Dr. Shelly Lu). 73. Ding, W.X. Autophagy, a double edged sword in drug-induced liver injury and tumorigenesis. February 22,

2018. Texas A&M University, Temple, Texas, USA. Invited Speaker (Dr. Gianfranco Alpini). 74. Ding, W.X. Autophagy in alcohol and drug-induced liver injury and tumorigenesis. February 27, 2018.

University of Pittsburgh, Pittsburgh, USA. Invited Speaker (Dr. Paul Monga). 75. Ding, W.X. Autophagy in alcohol and drug-induced liver injury and tumorigenesis. March 7, 2018. Mayo

Clinic, Rochester, USA. Invited Speaker (Dr. Mark McNivien). 76. Ding, W.X. Lysosomal biogenesis and autophagy in alcohol-induced tissue injury. April 7, 2018.

University of North Carolina. Charlotte, USA. Invited Speaker (Dr. Zhangxiang Zhou). 77. Ding, W.X. Lysosomal biogenesis and autophagy in pancreatitis. April 19, 2018. University of Kansas

Medical Center, Department of Anatomy and Cell Biology. Kansas City, USA. Invited Speaker (Dr. Saadi).

78. Ding, W.X. Autophagy and MTOR in liver tumorigenesis. April 22, 2018. Experimental Biology Meeting. San Diego, USA. Invited Speaker and Organizer of Molecular and Cellular Basis of Cancer Symposium: Cellular adaptive response in tissue injury, tumorigenesis and cancer progression.

79. Ding, W.X. Autophagy in drug-induced liver injury and tumorigenesis. June 19, 2018. Sun Yat-Sen University. Guangzhou, China. Invited Speaker (Dr. Huichang Bi).

80. Ding, W.X. Autophagy in drug-induced liver injury and tumorigenesis. June 22, 2018. Institute of Botany, Chinese Academy of Sciences. Kunming, China. Invited Speaker (Dr. Fei Li).

81. Ding, W.X. Autophagy and Nrf2 in drug-induced liver injury and tumorigenesis. June 22, 2018. Institute of Zoology, Chinese Academy of Sciences. Kunming. Invited Speaker (Dr. Bin Liang).

82. Ding, W.X. Autophagy in alcohol-induced liver injury and tumorigenesis. June 26, 2018. Zunyi Medical University. Zunyi, China. Invited Speaker (Dr. Yiqu He).

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83. Ding, W.X. Lysosomal biogenesis and autophagy in Alcohol-induced pancreatitis. June 28, 2018. Guilin Medical University. Guilin, China. International symposium on Environment, nutrition and health. Invited Speaker.

84. Ding, W.X. Autophagy in Drug-induced liver injury and tumorigenesis: Friend or Foe? July 2, 2018. Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. Shanghai, China. Invited Speaker (Dr. Yu Li).

85. Ding, W.X. Lysosomal Biogenesis and Alcoholic Pancreatitis. September 11, 2018. ISBRA 2018. Invited Speaker. 2018. Kyoto, Japan 2018.

86. Ding, W.X. Role of autophagy in alcohol-induced adipose atrophy and liver injury. 13th International Symposium on ALPD and Cirrhosis. Kyoto, Japan. September 9-13, 2018. Invited Speaker.

87. Ding, W.X. Regulation of Hepatic Homeostasis by Autophagy in Drug-Induced Liver Injury and Tumorigenesis. Wayne State University. Detroit, USA. October 2, 2018. Invited Speaker (Dr. Wanqing Liu).

F. Presentations at International Scientific Conferences

1. Ding, W.X., Shen, H.M. and Ong, C.N. Critical role of mitochondrial Ca2+ and reactive oxygen species in microcystin-induced mitochondrial permeability transition in rat hepatocytes. 51st Annual Meeting of American Association for the Study of Liver Diseases (AASLD), October, 27-31, 2000. Dallas, Texas.

2. Ding, W.X., Shen, H.M. and Ong, C.N. Regulation of reactive oxygen species production in microcystin treated rat hepatocytes. 7th Annual Meeting of the Oxygen Society, November 16-20, 2000, San Diego, California.

3. Ding, W.X. and Yin, X.M. Critical role of reactive oxygen species in death-receptor induced apoptosis in primary cultured mouse hepatocytes. Keystone Symposia-Molecular mechanisms of apoptosis (B6). Feb 8-13, 2003. Banff, Alberta, Canada.

4. Zhao, Y, Ding WX, Kuharsky D.K., and Yin, X.M. Dissection of Bid-mediated mitochondrial events in primary hepatocytes following death receptor activation. FASEB Office of Scientific Meetings and Conferences. Experimental Biology April 11-15, 2003. San Diego, California.

5. Yin X.M, Ding WX. An orchestrated activation of multiple mitochondria apoptotic events by Bid. Oral presentation at Keystone Symposia-Apoptosis in Biochemistry and Structure Biology (J6). Feb 3-8, 2004. Keystone, CO, USA.

6. Ding, W.X., Ni, H.M., Defrancesca, D., Stolz, D.B., and Yin, X.M.TNF-α and anti-Fas induced reactive oxygen species requires bid for generation and compromise mitochondria structures and functions. Abstract presented at Keystone Symposia-Apoptosis in Biochemistry and Structure Biology (J6). Feb 3-8, 2004. Keystone, CO, USA.

7. Ding, W.X. and Yin, X.M. Critical role of Reactive Oxygen Species in the Regulation of Bax Translocation Following Death Receptor Activation. 2004 June 8-10, Department of Pathology Annual Research Retreat, Seven Spring, Pittsburgh, PA. (Selected as oral presentation and Third Place Award).

8. Ni, H.M., Ding, W.X., Defrancesca, D and Yin, X.M. Bid Dependent Reactive Oxygen Species Production Promotes TNF-α and Anti-Fas-Induced Apoptosis by Multiple Mechanisms. Cell Death. Gordon Research Conference. Aug 29-Sept. 3 2004 Big Sky, MT, USA.

9. Ding, W.X., Ni, H.M., Chen X., and Yin, X.M. Critical role of Reactive Oxygen Species in the Regulation of Bax Translocation Following Death Receptor Activation. Abstract presented at AASLD Annual Meeting 2005 Nov 11-15, San Francisco, CA, USA.

10. Yin, X.M., Ding, W.X., Gao, W., Ni, H,M., Chen, X.Y., Stolz, D.B. Control of ER stress by autophagy. Abstract presented at Keystone Symposia. 2007 April 15-20, Monterey, CA, USA.

11. Ni, H.M., Chen, X.Y, Ding, W.X.* Yin, X.M. Bid-independent Mitochondria Activation in TNF{alpha}-induced Apoptosis and Liver Injury. Experimental Biology 2007. April 28-May 3. Washington DC, USA. Oral presentation*.

12. Ding, W.X., Ni, H.M., Chen X., Stolz, D., and Yin, X.M. Caspase-inhibition switched TNF-alpha-induced apoptosis to autophagic cell death in hepatocytes. Oral presentation at AASLD Annual Meeting

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2007, Nov 2-5. Boston, MS, USA. Oral presentation*. 13. Ding, W.X., Ni, H.M., Chen X., Gao, W., and Yin, X.M. Simultaneously inhibition of autophagy and

proteasome preferentially kills tumor cells. Gordon Research Conference. Autophagy in Stress, Development & Disease. January 6-11, 2008 Ventura Beach Marriott Ventura, CA.

14. Ding, W.X., Ni, H.M., Chen X., Gao, W., and Yin, X.M. Suppression of autophagy enhanced proteasome inhibitor-induced cell death selectively in cancer cells. Abstract submitted to Experimental Biology 2009. April 18-22 New Orleans.

15. Kang, Z.H., Ding, W.X., Liao, Y. and Yin, X.M. Abstract submitted to Experimental Biology 2009. April 18-22 New Orleans.

16. Ding, W.X. Chen, X., Ni, H.M., Gao, W., Stolz, D.B., Lu, B., Clemens, D.L. and Yin, X.M. Autophagy is activated as a pro-survival mechanism to protect against ethanol-induced hepatotoxicity. AASLD Oct 30-Nov 3, 2009 Boston.

17. Ding, W.X. Ni, H.M., Liao, Y., Li, M., Gao, W., Stolz, D.B., and Yin, X.M. (2010) Nix is critical to two distinct phases of mitophagy: reactive oxygen species (ROS)-mediated autophagy induction and Parkin-ubiqutin-p62-mediated. Keystone Symposia on Cell death pathways: Apoptosis, Necrosis and Autophagy. March 12-17, 2010 Vancouver, Canada.

18. Ding, W.X., Chen., X., Ni, H.M., and Yin, X.M. (2010) Macroautophagy protects against acute ethanol-induced hepatotoxicity and steatosis. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 34 (8): 146A-146A.

19. Yin, X,M., Ding, W.X., Li, M., Chen, X., and Ni, H.M. An important role of autophgy in controlling acute ethanol-induced mitochondria damage, steatosis and hepatotoxicity. FASEB Summer Research Conference. August, 17, 2010, Snowmass Village, Colorado. Oral presentation*.

20. Ni, H.M., Bockus, B., Wozniak, A.L., Jones, K., Weinman, S., Yin, X.M., and Ding, W.X*. Dissecting the Dynamic Turn Over of GFP-LC3 in Autophagolysosomes. Keystone Symposium on AUTOPHAGY. March 27-April 1, 2011. Whistler, British Columbia, Canada.

21. Ding, W.X., Ni, H.M and Jaeschke, H. Autophagy protects against acetaminophen-induced hepatotoxicity. AASLD Annual Meeting 2011, Nov 5-8. San Francisco, CA, USA. Oral presentation*.

22. Jessica A. Williams; Ann M. Thomas; Guodong Li; Bo Kong; Yuka Inaba; Wen Xie; Wen-Xing Ding and Grace L. Guo. (2011) Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor in Mouse. AASLD Annual Meeting 2011, Nov 5-8. San Francisco, CA, USA.

23. Ni, H.M., Apte, U, Jaeschke, H and Ding, W.X. Loss of Atg5 in the mouse liver causes persistent activation of NRF2 and resistant to acetaminophen-induced liver injury. Gordon Conference (Autophagy, stress and diseases). March 11-16, 2012. Ventura, CA, USA.

24. Manley, S, Guo, G, Apte, U and Ding, W.X. Modulation of autophagy by bile acids in hepatocytes. Experimental Biology Meeting. 2012 April, San Diego, USA. Oral presentation.

25. Ni, H.M, Yin, X.M, Jaeschke, H and Ding, W.X. Induction of mitophagy protects against acetaminophen-induced liver injury. FASEB Summer Research Conference. 2012 July, Snowmass, Colorado, USA.

26. Ding, W.X, Ni, H.M, Du, K and You, M. Foxo3a regulates ethanol-induced autophagy and hepatotoxicity. 7th International Symposium on ALPD and Cirrhosis. Sept. 7-8, 2012. Beijing, China.

27. Williams, J.A., Ni, H.M., Haynes, A., and Ding, W.X. The role of parkin in acetaminophen-induced mitophagy and liver injury. The 6th International Symposium on Autophagy 2012. Oct 28-Nov 1, 2012. Okinawa, Japan.

28. Ni, H.M., Jaeschke, H., Eskelinen, E-L., Yin, X.M. and Ding, W.X. Formation of a novel mitochondrial phagosome structure during mitochondrial oxidative stress. The 6th International Symposium on Autophagy 2012. Oct 28-Nov 1, 2012. Okinawa, Japan.

29. Manley S, Ni, H.M. Yang, H., Guo, G, Apte, U and Ding W.X. (2013) Role of bile acids in autophagy and alcohol-induced liver injury. EB Meeting. 2013 April 20-23, Boston, USA.

30. Ni, H.M., Copple, B, Luyendyke, J and Ding, W.X. Loss of Atg5 in the mouse liver leads to inflammation, fibrosis and liver tumorigenesis. EMBO Autophagy: Molecular Mechanisms, Physiology and Pathology. 2013 May 5-9 Norway.

31. Ni, H.M, Copple, B., Luyendyke, J and Ding, W.X. (2013) Loss of Atg5 in the mouse liver leads to inflammation, fibrosis and liver tumorigenesis. AASLD. 2013 November 1-5. Washington DC, USA.

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32. Williams, J., Ni, H.M, and Ding, W.X. (2013) Role of Parkin in acetaminophen-induced mitophagy and liver injury. AASLD. 2013 November 1-5. Washington DC, USA.

33. Ding, W.X., Yang, H and Ni, H.M. (2014) Excess endoplasmic reticulum is degraded via SSQSTM1/p62-mediated selective autophagy. Experimental Biology Meeting. 2014 April 26-30. San Diego, USA.

34. Williams, J.A., Ni, H.M., Li, Y., Jaeschke, H., and Ding, W.X. (2015) Chronic Deletion and Acute Knockdown of Parkin Have Differential Effects on Acetaminophen-Induced Mitophagy and Liver Injury in Mice. Keystone Autophagy Symposium. 2015, June 19-24. Keystone, Colorado, USA.

35. Ni, H.M., Wang, S., and Ding, W.X. (2015) Role of autophagy in alcoholic pancreatitis. 10th International Symposium on ALPD and Cirrhosis. September 30-October 2, 2015. Sao Paulo, Brazil.

G. Published Abstracts: 1. Ding, W.X., Shen, H.M, and Ong C.N. (2000) Regulation of reactive oxygen species production in microcystin treated rat hepatocytes. Free Radical Biology and Medicine. 2000. 29:S23. 2. Zhao, Y.G., Ding, W.X. Kuhasrsky, D and Yin, X.M. (2003) Dissection of Bid-mediated mitochondrial events in primary hepatocytes following death receptor activation. FASEB Journal 2003. 17:412. 3. Ding, W.X., Ni, H.M., Chen X., and Yin, X.M. (2005) Critical role of reactive oxygen species in the regulation of Bax translocation following death receptor activation. HEPATOLOGY 42 (4): 498A-498A Supplement: Suppl. S. 4. Ding, W.X., Ni, H.M., Chen X., and Yin, X.M. Caspase inhibition switched TNF-alpha-induced apoptosis to autophagic cell death in hepatocytes. (2007). HEPATOLOGY 46 (4): 280A-280A Supplement: Suppl. S. 5. Ni, H.M., Chen, X.Y, Ding, W.X. Yin, X.M. Bid-independent Mitochondria Activation in TNF{alpha}-induced Apoptosis and Liver Injury. (2007) FASEB JOURNAL 21(5): A188-A188. 6. Ding, W.X., Ni, H.M., Chen X., and Yin, X.M. Autophagy is activated as a pro-survival mechanism to protect against ethanol-induced hepatotoxicity. (2009) HEPATOLOGY 50 (4): 1153A-1153A Supplement: Suppl. S. 7. Ding, W.X., Ni, H.M., Gao, W., Chen X., Kang, J.H. and Yin, X.M. (2009) Suppression of autophagy enhanced proteasome inhibitor-induced cell death selectively in cancer cells. FASEB Journal 2009 April 23:438. 9. Gao, W., Ding, W.X. and Stolz, D. (2009) Induction of macroautophagy by exogenously introduced calcium.

FASEB Journal 2009 April 23:739. 10.Kang, J.H., Ding, W.X., Liao, Y and Yin, X.M (2009) Proteomics analysis of autophagic cells under starvation. FASEB Journal 2009 April 23:858. 11. Ni, H.M., Chen, X.Y., Ding, W.X. and Yin, X.M. (2009) Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. FASEB Journal 2009 April 23:741. 12. Ding, W.X., Ni, H.M., Chen X. and Yin, X.M. Macroautophagy protects against acute ethanol-induced hepatotoxicity and steatossi. (2010). ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 34 (8): 146A-146A Supplement: Suppl. S. 13. Liao Y., Ding, W.X., Chen, X., Ni, H.M., Stolz, D.,and Yin, X.M. (2010) Autophagy is Important for the Mitigation of Ethanol-Induced Hepatotoxicity and Steatosis. FASEB Journal 2010 April 24. 14. LI, M., Ni, H.M, Baty, C.J., Ding, W.X., Chen, X.Y., and Yin, X.M. (2010) Bid Regulates Murine Hepatocyte Proliferation by Controlling ER Calcium Homeostasis. FASEB Journal 2010 April 24. 15. Manley S, Guo, G, Apte, U and Ding W.X. (2012) Modulation of autophagy by bile acids in hepatocytes and liver. FASEB Journal 2012 April 24. 16. Ding, W.X., Ni, H.M., Apte, U. and Jaeschke, H. (2012) Liver Specific Knockout Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury. FASEB Journal 2012 April. 24. 17. Ding, W.X., Ni, H.M., Bockus, A. and Jaeschke, H. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. (2011) HEPATOLOGY 54 (4): 382A Supplement: Suppl. S. 18. Jessica A. Williams; Ann M. Thomas; Guodong Li; Bo Kong; Yuka Inaba; Wen Xie; Wen-Xing Ding and Grace L. Guo. (2011) Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor in Mouse. (2011)

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Hepatology 54 (1): 718A. 19. Manley S, Ni, H.M. Yang, H., Guo, G, Apte, U and Ding W.X. (2013) Role of bile acids in autophagy and alcohol-induced liver injury. FASEB Journal 2013 April. 27:1086. 20. Yin, X.M. and Ding, W.X. (2013) Control of Mitochondria Destiny by Autophagy and a Novel Mitochondrial Dynamics. FASEB Journal 2013 April. 27:832. 21. Ni, H.M, Copple, B., Luyendyke, J and Ding, W.X. (2013) Loss of Atg5 in the mouse liver leads to inflammation, fibrosis and liver tumorigenesis. (2013) HEPATOLOGY 58 (4): 945A. 22. Williams, J., Ni, H.M, and Ding, W.X. (2013) Role of Parkin in acetaminophen-induced mitophagy and liver injury. (2013) HEPATOLOGY 58 (4): 377A. 23. Ding, W.X., Yang, H and Ni, H.M. (2014) Excess endoplasmic reticulum is degraded via SSQSTM1/p62-mediated selective autophagy. The FASEB Journal. April 28:151.6. 24. Kong B., Zhan, L., Shen, J., Forostyan, T., Wang, L., Ding, W.X. and Guo, G.L. Hepatoprotective effects of Farnesoid X receptor in a mouse chronic alcohol feeding model. (2014) HEPATOLOGY 60, 767A. 25. Ni, H.M., McGill, M.R., Jaeschke, H., and Ding, W.X. SQSTM1/p62-mediated autophagic removal of acetaminophen-protein adducts and damaged mitochondrial protects against acetaminophen-induced liver injury. (2014) HEPATOLOGY 60, 251A. 26. Manley, S., Ni, H.M., Williams, J.A., and Ding, W.X. Farnesoid X receptor (FXR) regulaes FoxO3 activation in ethanol-induced autophagy and liver injury. (2014) HEPATOLOGY 60, 775A. 27. Ni, H.M., Chao, X., McGill, M.R., Jaeschke, H and Ding, W.X. Caspase inhibition switched TNF-a-induced apoptosis to necroptosis but not autophagic cell death in hepatocytes and mouse livers. (2015) HEPATOLOGY 62, 505A. 28. Ding, W.X., Wang, S. and Ni, H.M. Impaired proteasome function is associated with alcohol-induced hepatic receptor interacting protein 3-mediated necroptosis, steatosis and liver injury. (2015) HEPATOLOGY, 62, 861A. 29. Wang, Y., Ding, Y., Ni, H.M., Ding, W.X. and Li, T. Targeting enterohepatic bile acid signaling as a novel approach to modulate hepatic autophagic activity in maintaining cholesterol homeostasis. (2015) HEPATOLOGY, 62, 280A. 30. Woolbright, B., Williams, C., Bajt, M.L., Ding, W.X. and Jaeschke, H. Receptor interacting protein kinase 3 deficiency exacerbates cholestatic liver injury in mice. (2016) The FASEB Journal 29 (1 Supplement), 63.8. 31. Li, Y., McGreal, S., Zhao, J., Huang, R., Xia, M and Ding, W.X. A high throughput image-based screening reveals novel autophagy inducers for treating drug-induced liver injury. (2016) The FASEB Journal 40 (1 Supplement), 444.4 32. Ramirez, T., Li, Y., Feng, D., Ding, W.X. and Gao, B. Aging downregulates hepatic sirtuin 1 and exacerbates chronic-plus-binge ethanol-induced liver injury. (2016) Alcoholism Clinical and Experimental Research. (2016) 39: 290A-290A. 33. Y Wang, Y Ding, J Li, H Chavan, D Matye, H Ni, P Krishnamurthy, W Ding, T Li. Targeting the Enterohepatic Bile Acid Signaling to Modulate Hepatic Autophagic Activity in Non-alcoholic steatohepatitis. (2016) The FASEB Journal 30 (1 Supplement), 444.3. 34. Ni, H.M, and Ding, W.X. The Dual Role of mTOR in Regulating Liver Inflammation, Fibrosis and Tumorigenesis in Autophagy Defective Mouse Liver . (2016) HEPATOLOGY, 63, 344A. 35. X Yang, HM Ni, L Yang, WX Ding, Z Wang. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. (2016) HEPATOLOGY, 63, 316A. 36. Y Li, HM Ni, X Chao, WX Ding. Impaired Adipocyte Autophagy Promotes White Adipocyte Browning And Protects Against Alcohol-Induced Liver Injury. (2016) HEPATOLOGY, 63, 614A. 37. Y Wang, J Li, D Matye, L Zhang, K Dennis, WX Ding, T Li. Bile acids and FXR modulate hepatic antioxidant defense by regulating hepatic cysteine and glutathione metabolism in mice. (2017) HEPATOLOGY 66, 227A-228A 38. Y Li, X Chao, S Wang, HM Ni, WX Ding. Acute-On-Chronic Alcohol Induces Adipose Tissue Atrophy, Hepatic Steatosis and Liver Injury via Inhibition of mTOC1 in Adipose Tissue in Mice. (2017) HEPATOLOGY 66, 697A-697A. 39. H Wang, HM Ni, H Jaeschke, WX Ding. Double Deletion of Pink1 and Parkin Eliminates Compensatory Effects of a Single deletion of Pink1 or Parkin on Acetaminophen-Induced Mitophagy and Liver Injury. (2017) HEPATOLOGY 66, 417A-417A.

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40. X Chao, S Wang, Y Li, T Li, HM Ni, WX Ding. Impaired TFEB-Mediated Lysosomal Biogenesis Contributes to Acute-on-Chronic Alcohol-Induced Liver Injury in Mice. (2017) HEPATOLOGY 66, 692A-692A 41. S Wang, HM Ni, RC De Lisle, B Gao, P Pacher, WX Ding. Role and mechanisms of autophagy in alcohol-

induced pancreatitis. (2017) ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 41, 328A-328A

H. Research Support Active R21 AA027250 Ding (Co-PI) 08/10/2018-07/31/2020

Prevention and treatment of ALD by inducing hepatic mitochondrial uncoupling The major goal of this project is to investigate novel mitochondrial uncouplers in protecting against alcohol-induced liver injury Role: Co-PI (Multi-PI, 5% effort) Direct cost: $240,557

R01 DK102142 Ding (Co-PI) 09/23/2014-NCE

Autophagy and Drug-Induced Liver Injury The major goal of this project is to study the mechanisms of autophagy in protecting against acetaminophen-induced liver injury Role: Contact PI Direct cost: $1,125,000

R01 AA020518 Ding (PI) 05/01/2011-07/31/2022

Mechanisms regulating autophagy in alcohol-induced liver injury The major goal of this project is to study the transcription factor FoxO3 in alcohol-induced autophagy and liver injury. Role: PI (20% effort) Direct cost: $1,125,000.

U01 AA024733 Ding (PI) 05/15/2017- 04/31/2022 Autophagy in alcohol-induced pancreatitis Goals: The major goal of this project is to understand how alcohol activates autophagy in pancreas and how activation of cannabinoid receptors modulate autophagy and protects against alcoholic pancreatitis. Role: PI. (20% effort) Direct cost: $1,125,000.

5 P20 RR021940-07 Jaeschke, Hartmut (PI) 06/01/2011 - 09/01/2021 0.6 calendar $1,339,602 Nuclear Receptors in Liver Health and Disease Role: Core Director (Histopathology)

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Major Goals: The major goal of this project is to provide infrastructure and mentor young investigators to compete for NIH program grants.

Pending

R01 ES029355-01A1 Ding (Multi-PI with Zong) 10/01/2018-07/31/2023

Redox regulation in arsenic-induced metabolic disease The major goal of this project is to study the Trim21-p62-keap1-Nrf2 axis in arsenic-induced diabetes and NAFLD Role: Co-PI (15% effort) Direct cost: $1,125,000 Scored 19 percentile

Completed

No Number Available Ding (PI) Lied Basic Science Award 03/01/2016-03/01/2017

Autophagy in alcohol-induced liver injury The major goal of this project is to study the role of autophagy in alcohol-induced liver injury. Role: PI Direct cost: $20,000

No Number Available Ding (PI) Lied Basic Science Award 03/01/2015 – 03/31/2016 Autophagy in alcohol-induced pancreatitis The major goal of this project is to study the role of autophagy in alcohol-induced pancreatitis. Role: PI Direct cost: $20,000

2 T32 ES007079-31 Hagenbuch, Bruno Angelo (PI) 07/01/2011 - 06/30/2016 0.6 calendar $296,072

Training Program in Environmental Toxicology. Role: mentor Major Goals: This is a grant for the training of graduate and postdoctoral students in Toxicology.

No Number Available Ding (PI) KUMC Bridging Grant 04/01/2014 – 03/31/2015 Mechanisms of Mitophagy in Protecting Against Alcohol-Induced Liver Injury The major goal of this project is to study the role of Parkin in alcohol-mediated mitophagy and liver injury. Role: PI.

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Direct cost: $35,000

R21 AA017421 Ding (PI) 08/20/2009 – 07/31/2012 The role of autophagy in alcohol-induced liver injury. The major goal of this project is to investigate whether autophagy plays a protective role against ethanol-induced liver injury. Role: PI. Direct cost: $275,000 P20 RR021940 (1-5) Klaassen (PI) 7/1/2006 – 7/30/2011

Nuclear Receptors in Liver Health and Disease. The major goal of this project is to provide infrastructure and mentor young investigators to compete for NIH grants. Role: Project Leader. P20 RR016475 7/1/2006 – 7/30/2011 From the IDeA Networks of Biomedical Research Excellence (INBR) Role: Project Leader American Liver Foundation. Liver Scholar Award. Title “Bcl-2 family proteins regulate autophagy, a

poptosis and necrosis in hepatocytes ” Role: Principal Investigator. Effort: 60%. $225,000. 2005-2008

American Liver Foundation. Post-doctoral Fellowship. Title “Critical Role of Reactive Oxygen Species in Bid-mediated Mitochondrial Alteration Following death receptor engagement in hepatocytes.” Role: Principal Investigator. Effort: 70%. $10,000. 2004-2005.

Department of Pathology, University of Pittsburgh. Pathology Post-doctoral Research Training Grant (PRTP). Title: “Critical Role of Reactive Oxygen Species and Mitochondria in Death Receptor Activation induced apoptosis in hepatocytes”. Role: Principal Investigator. Effort: 70%. $10,000. 2003-2004.