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CTSA Education Resources

“Educating a new generation of clinical investigators to bring discovery into practice”

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CTSA Master’s Degree New Scholar/Mentor Orientation

AgendaDecember 6, 2012

Introductions Scholar/Mentor Relationships CTSA Program Overview MS Requirements Program Evaluation & Outcomes Questions

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CTSA Executive Committee

Robert A. Rizza, MDMayo Clinic Director for Research

CTSA Director and Principal Investigator

David O. Warner, MDMayo Clinic Associate Director for Clinical/Translational Research

CTSA Associate Director and Co-PI

Scott Kaese / Cheryl A. NelsonAdministrators, Mayo Clinic Research Administrative Services

CTSA Director / Associate Director of Administration

ResearchResourcesS. Khosla, MD

Co-PI and Director

Education Resources

D. O. Warner, MDCo-PI and Director

External AdvisoryCommittee

Internal AdvisoryCommittee

CTSA Academic AffairsCommittee

CommunityEngagement

D. O. Warner, MDCo-PI and Director

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Pilot andFeasibility

Research ResourcesReview Panel (RRRP)

ScientificReview Panels

NovelMethodology

Community-Based Research Networks

Translating Comparative Effectiveness Research into Practice (TRACER)

Office for Community EngagedResearch(OCER)

ResearchVolunteerResource (RVR)

PredoctoralPrograms

PostdoctoralPrograms

Research ManagementPrograms

ClinicalResearchUnit (CRU)

Saint MarysCharltonMobile

MedicalStudentPrograms

CTS Masters and CertificatePrograms

TranslationalTechnologyCores (TTC)PhD & MD/PhD

Program in CTSKL2 Mentored Career DevelProgram

Scholarly OpportunityAward

RegulatorySupport

Research EthicsResource

Consultative, Regulatory, and

Informatics Services

R. D. Simari, MDCo-PI and Director

Communications

Continuous Professional Development Program

Study Coordinator Degreeand DiplomaPrograms

SpecializedPhenotypingFacilities

Study Design and Biostatistics

BiomedicalInformatics

Res. SubjectAdvocacyServices

Research Information Center

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CTSA Reseach Resources

CTSA Community Engagement

CTSA Service Center

CTSA Education Resources –

David O. Warner, Director

Glenn E. Smith, PhD, LP, Associate Director

Mayo Clinic Center for Translational Science Activities (CTSA)

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Mayo Clinic Center for Translational Science Activities (CTSA)

•CTSA Education Resources

•Predoctoral Programs

•Postdoctoral Programs

•Certificate Program (CTSA)

•Master’s Degree (CTSA)

•KL2 Career Development Program

•Research Management Programs

•Continuing Professional Development Courses

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W. Ray Kim, M.D.• Associate Director, Postdoctoral Programs

Katrin Frimannsdottir, Ph.D.• Director of Program Evaluation

Karen Weavers – Operations Manager Tauna Juengers – Operations Coordinator Anne Bofferding – Curriculum Manager Linda Wenner/Nicole Ramaker –Program Coordinators Ashley Noelke– Administrative Assistant

Postdoctoral Administrative Staff

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Postdoctoral Program

Goals

• To train independent investigators to perform outstanding extramurally-funded patient-based research

• To enhance clinical research skills for Mayo faculty as a whole

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Competencies

• Critically evaluate clinical/translational research in the medical literature

• Articulate the ethical & legal responsibilities of an investigator

• Develop feasible and testable hypotheses

• Design and conduct a clinical/translational research project

• Write competitive grant proposals

• Effectively communicate research results through publication

• Effectively communicate research results through presentation

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Competencies (cont.)

• Articulate and apply appropriate study designs

• Use appropriate biostatistical methods

• Understand the peer-review process

• Ability to navigate the peer-review process for grants and papers

See complete list of competencies on the CTSA web site.

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What does it take to gain these competencies? TIME

Coursework (Each 1 hr of lecture requires 2-4 hours outside class)

Write proposal

Gather/analyze data

Write thesis

TIMELINE ON YOUR CALENDAR

WRITING SKILLS (reviews/critiques, proposals, hypotheses, manuscripts

PROJECT MANAGEMENT

EFFORT

MENTORING (Asking questions, incorporating feedback)

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Mentoring

Scholar and Mentor ExpectationsThese expectations are meant as a guide to help facilitate optimal

scholar/mentor relationships.

http://www.mayo.edu/ctsa/education/postdoctoral-masters-degree-program/for-current-scholars/mentoring-expectations

1) Initial Agreement – at time of application2) Detailed Agreement – to be discussed and completed with mentor

and submitted with proposal by Jan. 2, 2013.3) Mentoring Effectiveness Assessment (Scholar & Mentor) – will

be requested annually, spring quarter.

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Scholar Expectations• Clarify expectations of mentor's role and communicate mutually agreed

expectations.

• Take the initiative and bring ideas to the table.

• Follow up with these ideas or suggestions of the mentor.

• Progress with their research and course work in a timely manner.

• Accept critical appraisals of their work.

• Communicate effectively and timely regarding progress and questions.

• Take responsibility and initiative for their career development.

• Meet with their mentor on a weekly basis to ensure progress.

• Provide useful and important content to the research program of the mentor.

• Perform at an acceptable level.

• Be first author on research publications.

• Exhibit mutual respect.

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Mentor Expectations

• Clarify expectations of scholar's role and communicate mutually agreed expectations.

• Meet with the scholar on a weekly basis to ensure progress.

• Provide opportunities for scholar's ideas and input.

• Provide critical appraisal of writing and presentation skills.

• Communicate effectively and timely regarding progress of research and papers.

• Provide guidance on career development.

• The scholar's research should provide useful and important content to your research.

• Provide for research costs and expenses related to successful completion of the thesis/certificate project.

• Exhibit mutual respect.

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Program Overview

Postdoctoral Master’s Degree - MGS

1) Coursework/Degree Program Form: 24 credits - 3.0 GPA

2) Comprehensive Written Examination (full-day)

3) Research project resulting in a thesis (2-3 papers)

4) Thesis Advisory Committee/ Progress Reports

5) Final Oral Examination (thesis defense)

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1) Coursework - Required Courses (16 credits)

5010-Clinical Research Protocol Development (2)

5020-Regulatory Issues in Clinical Research (1)

6000-Responsible Conduct of Research (1)

Grant Writing Wksp – Nov. 9, 2012

Publication Wksp - Mar. 1, 2013

5300 & 5310-Clinical Epidemiology I & II (1 ea) 5390- Advanced Applied

Epidemiological Methods (2) 5600-Statistics in Clinical Research (2) 5601-Utilizing Statistics in Clinical

Research (1) 5610-Introductory Stats Methods II (3) 5720-Clinical Trials: Design and

Conduct (1) 5690-Critical Appraisal of Statistical Methods in the Medical Literature (1)

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• Electives can be CTSC or any other MGS courses

• 25% of the credits can be transfer credits

CTSA Required & Elective Credits

Mayo Graduate School Catalog

2) Coursework – Elective Courses (8 credits)

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1) Coursework/Degree Program Form (DPF) – due Jan. 2, 2013

Submit with thesis proposal and Thesis Advisory Committee forms

Include courses completed and those you propose to take to fulfill degree requirements (24 credits total; 16 required)

Can transfer in up to 6 credits (25%) Form on Mayo Graduate School Web site:

http://mayoweb.mayo.edu/sp-forms/mc5900-mc5999/mc5999-20.pdf

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2) Comprehensive Written Exam

Taken after completion of (14 cr):• CTSC 5010 - Protocol Development• CTSC 5300 & 5310 - Epi I & II• CTSC 5390 - Advanced Applied Epi (III)• CTSC 5600 & 5610 - Stats I & II• CTSC 5690 - Critical App of Stat Methods (III)• CTSC 5720 - Clinical Trials Design

Full day exam 2013 - January 15, April 16 or August 20 (

http://ctsa.mayo.edu/education/cs-masters-comprehensive-written-exam.html)

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3) Research Project Proposal – due Jan. 2, 2013

1. Proposal - submitted for CTSA approval by January 2, 2013

a. Proposal Format (http://www.mayo.edu/ctsa/education/postdoctoral-masters-degree-program/for-current-scholars/research-requirements)

b.Feasible to complete within timeline indicatedc. Can be submitted earlier for approvald.Utilize Protocol Development course for another projecte. Include a definition of scholar’s role of in the projectf. Note standards for thesis (2-3 original papers)

2. Notice of IRB Approval

3. Notice of divisional research committee approval

4. Detailed Mentoring Agreement

Reviewed by CTSA Postdoc Committee using proposal review criteria (http://ctsa.mayo.edu/education/protocol-review-criteria.html)

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4) Thesis Advisory Committee (TAC) – due Jan. 2, 2013

Minimum of 4 members – RATP forms* • Chair - usually primary mentor – only member who can also be co-investigator

(exception for statistician)• Members - need MGS Faculty Privileges (check MGS website)• *Thesis Advisory Committee (TAC) Form:

http://mayoweb.mayo.edu/sp-forms/mc5900-mc5999/mc5999-21.pdf

• *Recommended Action on Thesis Protocol form:http://mayoweb.mayo.edu/sp-forms/mc5900-mc5999/mc5999-36.pdf

TAC and scholar have defined roles and expectations

Oversees progress and quality of research project

Meet every 6 months to review progress of scholar• Submit summary of Progress Meeting to CTSA

http://ctsa.mayo.edu/education/upload/thesis-advisory-committee-progress-meeting-report.pdf

Becomes Final Oral Examining Committee at Thesis Defense

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Other Components

Required Workshops:• Write Winning Grants

• Friday, November 9, 2012• Available at all three sites (MCR, MCA and MCF) • Registration Fee - $275.00 (fee waived)• Registration deadline October 26, 2012• http://ctsa.mayo.edu/education/writing-

workshops.html#grants

• Writing for Biomedical Publications• Friday, March 1, 2013 • Available at all three sites (MCR, MCA and MCF) • Registration Fee - $275.00 (fee waived)• Registration deadline February 22, 2013• http://ctsa.mayo.edu/education/writing-

workshops.html#biomedical

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Final Oral Examination –Thesis Defense

After completion of all course work, Comprehensive Written Exam and approval of DPF, research proposal and TAC

Follow CTSA and MGS Thesis Guidelines

Requires a minimum of THREE MONTHS for scheduling. Contact Linda Wenner/Nicole Ramaker to set preliminary thesis defense date

Six weeks prior to your anticipated defense date – • Submit thesis draft for CTSA review (allow 1 week)• Find a date/time all TAC members will be present• Allow 3 weeks for TAC to review final draft and prepare

examination questions

After successful defense, submit Verification of Thesis Corrections and Final thesis to Mayo Graduate School

Complete Evaluations

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Degree Clearance - Completion

Review DPF with transcript Grade point average of 3.0 Two Workshops - required

• Grant Writing – November 9, 2012• Publication – March 1, 2013

Comprehensive Written Examination Research Proposal & TAC & Progress Reports Final Oral Examination (thesis defense) Current CV

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Graduation

Degrees conferred quarterly (requirements completed by first day of preceding month)

• August (July 1)• November (Oct. 1)• February (Jan. 1) • May (Apr. 8)

Formal Graduation Ceremony – May ONLY• For a May graduation –

• Thesis to CTSA by February 8• All requirements completed by April 8

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Evaluation

Program Evaluation Activities• CTRAI (Pre/Post self-assessment – in CTSC 5000

and at awarding of Degree)• Mentor Assessments (annual)• Course evaluations (each course)• Graduate tracking (annual CVs)

• Publications, grants, promotions, awards, patents, leadership and professional activities, etc.

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Outcomes

• Career Development Awards (K Awards)

• Intra- or Extramural Funding

• Publications, Presentations

• Academic Rank and career promotion

• Research leadership & mentoring

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What’s NEW?

New Winter Qtr 2013• CTSC 5082 American Indian Health Disparities

(online from Kansas University Medical Center)• CTSC 5920 Introduction to Health Care Systems Engineering• CTSC 6140 Epigenetics and Epigenomics

New Spring Qtr 2013• CTSC 5081 Advanced Topics in Health Disparities• CTSC 5510 Genetic Epidemiology (new revision)• CTSC 5960 Medical Informatics for the Clinical Researcher• CTSC 5761 Evidence-Based Medicine for Clinical Researchers• CTSC 5870 Social and Behavioral Foundations of Health

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Web sites to know:

CTSA Education Resourceshttp://ctsa.mayo.edu/education/index.html

• Quarterly Course Schedule• New course listings• This presentation

Mayo Graduate School http://mayoweb.mayo.edu/mgs/

• Quarterly course listing• Registration forms• Other required forms

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2013 Dates to Remember:

January 2, 2013:• Degree Program Form (DPF)

• Thesis Advisory Committee Form (TAC)• With a Recommended Action Form for each Member

• Research Proposal• Cover letter signed by you & your mentor• IRB Approval (or evidence of submission)• Divisional Research Committee Approval

• Detailed Mentoring Agreement

March 1, 2013 – Publishing Workshop

August 1, 2013 – First Progress Report

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“The research we do today will determine

the type of medical and surgical practice

we carry on at the Clinic tomorrow.”

-William J. Mayo, M.D.

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Questions???