Credo Xtreme® Shipper vs. Active Container

By: Manuel G. Sardinas, ME, CSCP Clinical Supply Operations Logistics Manager Americas

Bristol-Myers Squibb

• Opportunities:o Reduction of carbon footprint in Clinical Supply chaino Reduce operational costs

• Challenges:o Maintain product integrity (Conditions 2˚- 8˚C)o Evolving and dynamic Clinical Supply chaino Active container lane limitationo Customs delayso Logistics delays

Active container securing Time (7 business days) Active container availability (peak season challenges)

Bristol-Myers Squibb Cold Chain Opportunities

Credo Xtreme® Model

Credo Xtreme® shipment starts

Shipment to destination Country

Integrated Business Partner receives drug

material for clinical site distribution

Credo Xtreme® is processed to be

transported back to origin

Credo Xtreme® is transported back to HUB

Warehouse

Credo Xtreme® is received in HUB

Warehouse and it is maintained to be reused

Advantages:

• Reusable technology

• Lower projected cost of ownership

• Efficient use of the payload (up to 98%)

• Active container securing time delay avoided

• Flexible to any lane

Disadvantages:

• Reverse logistics

• Manual operation

Credo Xtreme® Model

Full Pallet Xtreme® Active Container Capacity 890 L 2300 LPayload Dimensions

41.21” x 33.21” x 39.70” 52.7" x 51.9" x 51.7"

ExteriorDimensions

48.0” x 40.0” x 52.0” 78.7" x 60.2" x 63.8"

Thermal Performance

120 hours 100 hours without being connected

Tare Weight 548 lb 1400 lbUse of Payload 95 - 98% 56 - 75%

Factors:

• Total Cost of Ownership of current Technology

• Investment and Depreciation of Credo Xtreme® Units

• Include Forwards and Reverse Logisticso Importation Feeso Customs Charges

Results:

• Savings in year 0

• Savings in 5-Year Term

Financial Model Projection

• Credo Xtreme® qualification

• Vendor collaboration (DHL, MTS, Logistics Partners in each country, Customs Agents)

• Guide Development and Training

• Reverse Logistics Process Implementation: Latin America, EU

• Credo Xtreme ® Testing

• Communication to Network Country Warehouses

• Obtain Inventory

• Launch

• Post-launch Monitoring and Tracking

Project Deployment

Vendor Collaboration – Reverse Logistics

Process Development

U.S. Customs Subject-Matter

Experts

Local Import/Export

Agents (Destination

Country)

Local Integrated Partner (Country

Warehouse)

Transportation Integrated Partners

HUB Process Monitor

HUB Warehouse

Service Integrated Partner

• Shipper performanceo No temperature excursion using Credo

Xtreme®

• Carbon emissions reduction o Average reduction per shipment: 41%

• Realized savings o Average cost reduction per shipment: 65%

• Lead Time eliminated

Results

• Commitment to “green” technology

• Commitment to reducing operational cost

• Costumer-focus service of integrated partners

• Detailed and accurate financial models

• Available options while implementing project

• Frequent communication

• Process development

Success Factors

•Q&A

Manuel G. Sardinas, ME, CSCPManuel.sardinas@bms.com