COURSE PROGRAM

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Table of Contents Information and Overview………………………………..…...………2

Faculty Listing……………………………………………..………….3

Agenda ………………………………..………………..…..................4

Course Materials Registered participants can access recorded lectures for on demand viewing

beginning September 28, 2020 via the link below:

https://www.movementdisorders.org/MDS/Education/Workshops-

Conferences/Virtual-Education-Courses/MDS-ES/BASIC20VIRT/Main.htm

Lectures are available on-demand through October 31, 2020 to registered participants.

International Parkinson and Movement

Disorder Society - European Section

International Secretariat 555 East Wells Street, Suite 1100 • Milwaukee, WI 53202 USA

Email: education@movementdisorders.org

Tel: +1 (414) 276-2145 • Fax: +1 (414) 276-3349

The International Parkinson and Movement Disorder Society (MDS) is an international

professional society of clinicians, scientists, and other healthcare professionals who are interested

in Parkinson’s disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic

Movement Disorders, and abnormalities in muscle tone and motor control.

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COURSE DESCRIPTION

The overall aim of the course is to teach the fundamental mechanisms underlying aggregation

and propagation of -synuclein and tau protein in neurodegenerative movement disorders.

Ongoing efforts for the development of therapeutic strategies targeting these two proteins will

also be discussed. The course consists of seven virtual lectures given by international experts in

the field, followed by an interactive Q&A session to answer the questions of the participants.

The course will close with an interactive panel discussion including all experts to address the

critical next steps to move the field forward.

The course is part of a broader effort of the International Parkinson and Movement Disorder

Society to engage young neurologists and neuroscientists into research on movement disorders

and promote translational research involving multidisciplinary approaches.

LEARNING OBJECTIVES

At the conclusion of this activity, you should be able to:

Describe the prototypical neuropathological lesions observed in synucleinopathies and

tauopathies

Recognize the complex mechanisms underlying pathological aggregation of -synuclein

and tau protein

Debate the putative role of distinct -synuclein and tau species/strains for disease

phenotypes and progression

Discuss ongoing efforts towards the development of therapies targeting -synuclein or

tau protein

EDUCATION DISCLAIMER

The primary purpose of MDS programming is to provide educational opportunities that enhance patient

care. Information presented, as well as publications, technologies, products and/or services discussed are

intended to inform attendees about the knowledge, techniques and experiences of physicians who are

willing to share such information with colleagues. A diversity of opinions exists in the medical field, and

the views of the workshop’s faculty are offered solely for educational purposes. Faculty members’ views

do not represent those of the MDS and do not constitute endorsement by MDS.

RECORDINGS PROHIBITED

Audio and videotaping are not allowed during the course. Photography of the presentations and slides is

not allowed during the activity.

COURSE EVALUATIONS

Course evaluations are available online. Please take time to complete the online evaluation form provided

following this course. Your input and comments are essential in planning future educational programs.

INFORMATION AND OVERVIEW

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COURSE DIRECTORS

Erwan Bezard, PhD

Institute of Neurodegenerative Diseases

(IMN), University Bordeaux

Bordeaux, France

Wassilios Meissner, MD, PhD

Institute of Neurodegenerative Diseases

(IMN), University Bordeaux

Bordeaux, France

COURSE FACULTY

Morvane Colin, PhD

University of Lille

Lille, France

Maria Grazia Spillantini, FRS FMedSci

University of Cambridge

Cambridge, United Kingdom

Gunter Höglinger, MD, PhD Medical School Hannover

Hannover, Germany

Tiago Outeiro, PhD University Medical Center Goettingen

Goettingen, Germany

Laura Parkkinen, PhD

University of Oxford

Oxford, United Kingdom

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Streaming Schedule

14:00

CEST

Welcome and Course Introduction

Erwan Bezard and Wassilios Meissner

14:05

CEST

Neuropathology in Synucleinopathies and Tauopathies

Laura Parkkinen

14:33

CEST

Mechanisms Underlying Protein Aggregation in Synucleinopathies

Tiago Outeiro

15:05

CEST

Mechanisms Underlying Protein Aggregation in Tauopathies

Maria Grazia Spillantini

15:35

CEST

Propagation of α-synucleinopathy

Erwan Bezard

16:05

CEST

Spreading of Tauopathies

Morvane Colin

16:35

CEST

Therapeutic Strategies Targeting α-synuclein: From Bench to Bed

Wassilios Meissner

17:08

CEST

Therapeutic Strategies Targeting Tau Protein: From Bench to Bed

Günther Höglinger

Live Interaction Schedule

17:40

CEST

Interactive Question and Answer Session

All Faculty – Moderated by

18:05

CEST

Critical Next Steps to Move the Field Forward

Discussion between faculty and participants

18:30

CEST

Concluding Remarks

Erwan Bezard and Wassilios Meissner

ONLINE COURSE AGENDA