Council of Councils NIH Updated September 24,...
Transcript of Council of Councils NIH Updated September 24,...
Council of Councils
NIH Update September 24, 2013
Lawrence A. Tabak, DDS, PhD
Principal Deputy Director, NIH
Department of Health and Human Services
1
NIH Update
Budget Update
Biomedical Research Workforce
BRAIN
Big Data
2
NIH Update
Budget Update
Biomedical Research Workforce
BRAIN
Big Data
3
NIH Extramural & Intramural Funding FY 2013 Full-Year CR Level: $29.1 Billion
Spending
at NIH
Spending Outside NIH
4
$35
$30
$25
$20
$15
$10
$5
$0
(In
Billio
ns)
Appropriation Appropriation in 1998 Dollars
NIH Program Level in Appropriated Dollars and Constant 1998 Dollars
5
S
ucce
ss R
ate
5%
10%
15%
20%
25%
30%
35%
40%
45%
?
19
78
19
79
19
80
19
81
19
82
19
83
19
84
19
85
19
86
19
87
19
88
19
89
19
90
19
91
19
92
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
20
03
20
04
20
05
20
06
20
07
20
08
20
09
20
10
20
11
20
12
20
13
Fiscal Year 6
Grant Success Rates FY 1978-2013
Source: Biology Boom Goes Bust.
Ch
an
ge f
ro
m 2
01
2-2
01
3
20%
15%
10%
5%
0%
-5%
-10%
China
Germany Japan S. Korea
Canada
U.S.
Cell 154, July 3, 2013
Scientific Research & Development Spending Change from 2012 to 2013
7
NIH Update
Budget Update
Biomedical Research Workforce
BRAIN
Big Data
8
Biomedical Research Workforce
Unprecedented scientific opportunities; profound implications For expanding our understanding of biology Improving health
Need to attract, retain, best & brightest researchers Numbers sufficient to carry out exciting work Broadly representative of our societies Gender Race Specialty training
Well-mentored and encouraged to collaborate – and innovate
9
Strengthening the Workforce at NI H: Continuing Challenges
Increasingly difficult to launch traditional, independent academic research careers Rising numbers of PhDs Number of established researchers staying in field longer
Lengthier training periods, relatively low early career salariemake profession less attractive
Training programs offer little preparation for careers outsidacademia
Efforts to increase diversity less successful than we had hoped<;
s,
e
NIH Advisory Council to the Director (ACD): Working Groups assigned; recommendations coming 10in
Biomedical Research Workforce Working Group: Recommendations
Graduate Students: enhanced training for multiple
career outcomes
Postdoctoral Researchers: shorten pathway to
independent career; increase support for training;
improve pay, benefits
Information Analysis: improve tracking of career
outcomes, workforce analysis
Staff Scientists: promote their value, stature
Diversity of the Workforce: needs urgent attention
Physician Scientists: conduct further study
11
BEST Program:
Broadening Experiences in Scientific Training
Seeks innovative approaches to complement traditional research training at NIH-funded institutions
Encourages institutions to leverage funds with
Existing institutional offices, programs
Local resources outside the institution, or that partner with industry/other entities
Must include rigorous analysis to demonstrate impact Proven approaches will be widely disseminated
throughout biomedical research community Awardees will meet to exchange ideas
Applications currently being reviewed http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-12-022.html
12
Biomedical Research Workforce Working Group: Recommendations
Graduate Students: enhanced training for multiple
career outcomes
Postdoctoral Researchers: shorten pathway to
independent career; increase support for training;
improve pay, benefits
Information Analysis: improve tracking of career
outcomes, workforce analysis
Staff Scientists: promote their value, stature
Diversity of the Workforce: needs urgent attention
Physician Scientists: conduct further study
13
Diversity Initiative: Overarching Strategy
Four interrelated approaches will be implemented:
NIH Building Infrastructure Leading to Diversity (BUILD) Program
National Research Mentoring Network (NRMN)
Ensuring Fairness in Peer Review
Increased Engagement by all NIH Leadership
14
Biomedical Research Workforce Working Group: Recommendations
Graduate Students: enhanced training for multiple
career outcomes
Postdoctoral Researchers: shorten pathway to
independent career; increase support for training;
improve pay, benefits
Information Analysis: improve tracking of career
outcomes, workforce analysis
Staff Scientists: promote their value, stature
Diversity of the Workforce: needs urgent attention
Physician Scientists: conduct further study
15
Working Group on the Physician* Scientist Workforce
Charge
Analyze current composition of workforce to understan d consequences of current funding policies
Assess needs, career opportunities available to support physician-scientist trainees in diverse biomedical resear ch sectors
Identify incentives, barriers to MDs, DDSs, and
DVMs entering and sustaining scientific activities
Recommend ways to support sustainable, diverse clinical research infrastructure
Final Report to ACD: June 2014
*Includes physicians, dentists, veterinarians 16
NIH Update
Budget Update
Biomedical Research Workforce
BRAIN
Big Data NIH BRAIN
17
WHO, 2008
Brain Disorders: The Need Is Great
Brain disorders: #1 source of disability in U.S.
> 100 million Americans affected
Rates are increasing: autism, !lzheimer’s disease, and in our soldiers PTSD and TBI
Costs are increasing: annual cost of dementia ~$200B
Already equals cost of cancer and heart disease
18
Mechanisms of brain disease
Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative
Goal: Accelerate new technologies to
Produce real-time pictures of complex neural circuit
Visualize rapid-fire interactions of cells at the speed thought
Promise: Open new doors to understanding
How brain function is linked to human behavior and learning
s
of
19
NIH BRAIN Initiative: Process
Plan to be developed by a working group of the Advisory Committee to the Director, NIH
Selected for visionary leadership, expertise
Charged with articulating scientific goals, developing plan
Including timetables, milestones, costs
Informed by experts across sectors and disciplines – assisted by NIH Blueprint for Neuroscience Research
NIH BRAIN Working Group
Has sought broad input; hold open meetings, workshops
Delivered interim report on high‐priority areas for FY14 funding in summer 2013;will issue final report, June 2014
Public can receive updates, contribute to discussion, at http://www.nih.gov/science/brain/
20
NIH Update
Budget Update
Biomedical Research Workforce
BRAIN
Big Data
21
22
Myriad Data Types
‘Omic Imaging
Phenotypic Clinical 23
Six Big Problems to Solve
1. Locating the data
2. Getting access to the data
3. Extending policies and practices for data sharing
4. Organizing, managing, and processing biomedical Big Data
5. Developing new methods for analyzing biomedical Big Data
6. Training researchers who can use biomedical Big Data effectively
24
NIH is Tackling the Big Data Problem
New NIH Leadership Position Reporting to NIH Director
Associate Director for Data Science (ADDS)
New Internal NIH Governing/Oversight Bodies
Scientific Data Council (ADDS)
Administrative Data Council (CIO)
New Trans-NIH Initiative
Big Data to Knowledge (BD2K)
25
Big Data: Challenges for Biomedicine
NIH’s Big Data to Knowledge (BD2K) program, starting in FY 2014, will: Facilitate the broad use and sharing of large, complex
biomedical data sets through the development of policiesresources and standards Develop and disseminate new analytical methods and
software Enhance training of data scientists, computer engineers,
and bioinformaticians; and Establish Centers of Excellence to address biomedical
analytics, computational biology, and medical informatics
,
.
26