Cost Utility Analysis of Postoperative Discharge Pathways...
Transcript of Cost Utility Analysis of Postoperative Discharge Pathways...
Cost Utility Analysis of Postoperative Discharge Pathways Following Posterior Spinal Fusion for Scoliosis in Non-Ambulatory Cerebral Palsy Patients
K. Aaron Shaw DOVahe Heboyan PhDNicholas Fletcher MDJoshua S. Murphy MD
Dwight D. Eisenhower Army Medical CenterChildren’s Healthcare of Atlanta
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Introduction
• Scoliosis is common in children with non-ambulatory cerebral palsy (CP)– Affects upwards of 100% of patients(Saito
et al. Lancet. 1998)
• Traditionally, there has been controversary as to the preferred treatment approach to in non-ambulatory CP
• A recent critical review analysis identified improved patient outcomes and caregiver satisfaction with operative intervention – Shaw et al. JBJS Reviews. 2019
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Accelerated Discharge Pathway
• Accelerated discharge (AD) pathways are multidisciplinary approaches targeted to improve perioperative care and safely expedite patient discharge to home
• AD have been shown to decrease hospital length of stay in adolescent idiopathic scoliosis without increasing postoperative complications compared with more traditional (TD) approaches (Fletcher et al. J Pediatri Orthop 2015)
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Accelerated Discharge Pathway
• Bellaire et al. demonstrated significantly shorter hospital length of stay, with a trend toward lower complication rates with AD for non-ambulatory CP patients undergoing PSF– Spine Deform. 2019;7(5):804-11.
• Although this evidence supports the utility of AD pathways over a TD pathways for some patients, the impact of these pathways on the cost-utility of treatment has not been investigated.
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Methods
• Decision-analysis model was constructed using TreeAge Pro
• Hypothetical Patient: 15-year-old male with non-ambulatory CP and 65-degree thoracolumbar scoliosis with associated pelvic obliquity
• Treatment: Posterior spinal fusion from T2-pelvis with pedicle screw fixation.
1 Serhan et al. J Spinal Disord Tech. 2013.
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Data Variable
• Literature review was performed to identify associated complication profiles for TD and AD pathways in the setting of non-ambulatory CP scoliosis and to estimate probability, health utility, and quality-adjusted life years (QALYs)
• Complication Profiles Idenitified:– Death– Neurologic injury– Pulmonary complication– Infection– Revision Surgery
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Data Variables
Event Net Probability (%) Net Cost ($) Net QALY
Traditional PathwayUncomplicated 41 50,952 16 .5
Death 5 50,952 0Pulmonary
Complication20 28,915 15.9
Revision Surgery 19 130,000 16.3Neurologic Injury 5 45,000 12.9
Infection 10 104,000 16.3Accelerated Pathway
Uncomplicated 51 42,992 16.5Death 5 42,992 0
Pulmonary Complication
15 28,915 15.9
Revision Surgery 14 130,000 16.3Neurologic Injury 5 45,000 12.9
Infection 10 104,000 16.3 7
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Final Decision Analysis Model
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Analysis
• Health utility and QALYs were constructed using age-matched values for US population average, applying a corrective value for diagnosis of CP. Craig et al. Matern Child Life. 2016;20(4)
• A sensitivity analysis was performed using Mixed first-order and second-order Monte Carlo simulations. Incremental cost utility ratio (ICUR) and incremental net monetary benefit (NMB) were calculated.
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Results
• Operative treatment, combining AD and TD, resulted in a NMB of $629,783 with cost utility ratio of $4426.70/life years.
• AD pathway resulted in a net cost of $57,353 compared to a net cost of $65,001 for the TD pathway.
• AD resulted in a 29% greater NMB with a cost utility ratio of $3,734.58/life year compared with the TD cost utility ratio of $5,292.81/life year. Both figures falling below the societal willingness-to-pay threshold of $50,000/life year.
Protocol Cost ($)Effectiveness (Life Years)
Net Monetary Benefit ($)
C/E ratio ($/Life Year)
Operative Treatment
61,177 13.82 629,783 4,426.70
Accelerated (AD) 57,353 15.36 710,516 3,734.58Traditional (TD) 65,001 12.28 549,052 5,292.81
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Conclusion
• An AD pathway following PSF for non-ambulatory cerebral palsy may provide a 29% greater NMB with a favored cost utility ratio when compared with a TD pathway
• Future studies should aim to identify pre-operative and post-operative variables that increase safety and decrease cost of treating these patients.
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Thank You