CORTICOSTERIODS3

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CORTICOSTEROIDS

BY: JAVAID MUSTUFFA ILYAS5TH SEMESTER


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INTRODUCTION

Corticosteroids are Steriod Hormones.

Secreated by Adrenal Cortex.

Involved in normal metabolism of body,

resistance to stress, salt and water

metabolism


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INTRODUCTION

Two types : (Glucocorticoids and Mineralocorticoids)

In humans, the major glucocorticoid is cortisol

and the most important mineralocorticoid is

aldosterone.

Glucocorticoids: Primarily Effect

carbohydrate,protein and fat Metabolism


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GLUCOCORTICOID ACTION

Carbohydrate Metabolism Enhance Gluconeogenesis Promote glycogen deposition in liver Enhance proteolysis from tissues Inhibit glucose utilization by peripheral Tissues

Fat Metabolism Promotes Lypolysis

Calcium Metabolism Inhibit Intestinal Absorption of Calcium


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CVS Facilitate actions of Adrenaline and Angiotensin Restrict cappilary permeability and cardiac

contractility. CNS

Maintain normal level of sensory preception andnormal level of excitability of neurons

GIT Increased secretion of gastric acid and pepsin


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Inflamatory Response Reduce capillary permeability, Local Exudation,

cellular infiltration and phagocytosis

Immunity

Lymphocyte activity is supressed Inhibits release of Histamine, cytokines,interleukin, TNF etc


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MINERALOCORTICOID ACTION

Enhance reabsorption of Sodium in kidney Increase Excretion of potassium and H ions from

kidney Similer effects on other tissues (colon, swet

glands,slivary glands)


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CORTICOSTEROIDS

Mechanism Of Action They penetrate cells and bind to high affinity

cytoplasmic receptor proteins. The ligand-bound receptor complex transported into

the nucleus, where it interacts with DNA and nuclearproteins

Binds to glucocorticoid receptor elements (GRE) Produce mRNAs Which then encode specific proteins


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SYNTHETIC CORTICOSTEROID PREPARATIONS


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CORTICOSTEROIDS

THERAPEUTIC USES Replacement Therapy

Adrenal insufficiencyAddison`s diseaseCongenital Adrenal hyperplasia

Organ transplant( immunosupressive effect)

Combined with other immunosuppressants


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THERAPEUTIC USES

Non-Endocrine use Rheumatic disorders

Gout Heamolytic anemia etc

Renal Diseases Nephrotic syndrome in childeren Renal sarcoidosis Glomerunephritis

Anti-inflamatorry effect Asthama,arthritis,inflammatory bowel disease(LETS SEE)


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THERAPEUTIC USES

Allergic Disorders Seasonal Allergies, Bee sting, drug allergies Allergic rhinitis

Infectious Diseases Only in sever infections to prevent complications AIDS

Tubercular Meningitis Speticaemia etc


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THERAPEUTIC USES

Occular Diseases For supperessing inflammation in eye and preserving

sight. Contraindicated in glaucoma, injuries, viral and fungal

infections. Skin Diseases

Major application of corticosteroid therapy inAllergic conditions, Eczema

Psoriasis, pemphigus

Creams/ointments are used(betamethasone,aclomethasone e.t.c)


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THERAPEUTIC USES

GIT Ulcerative cholitis Crohn`s disease

Hepatic Diseases Autoimmune chronic hepatitis Alcoholic liver disease

Other uses In cerebral edema, COPD Spinal cord injury, antiemetic hyperthyroidism


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ADVERSE EFFECTS

Mostly seen with prolong therapy Edema Hypertension Muscular weakness Suseptibility to infections Hyperglycemia and diabetic effects Fragile skin,hirsuitism,easy bruising,cutaneous

atrophy with topical use Delayed wound healing Risk of peptic ulcer


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Glaucoma Teratogenic Osteoprosis

CONTRAINDICATIONSTB, peptic ulcer, epilepsy,viral & fungal infections,

osteoprosis, renal failure


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THANKYOU

ANY QUESTIONS?

Presentedby : Me

CORTICOSTERIODS3

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