Corrective Cancer Care® and Cancer Stem Cell Therapy

8/4/2019 Corrective Cancer Care and Cancer Stem Cell Therapy

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The Weeks Clinic for Corrective Medicine and Psychiatry 2011

Corrective Cancer Care

and

Cancer Stem Cell Therapy

Japanese College of

Intravenous TherapyOsaka, Japan September 25th 2011

Bradford S. Weeks, M.D.

www.weeksmd.com

[email protected]
http://www.weeksmd.com/mailto:[email protected]:[email protected]://www.weeksmd.com/


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and

Cancer Stem Cell Therapy

Japanese College of

Intravenous TherapyOsaka, Japan September 25th 2010

Bradford S. Weeks, M.D.

www.weeksmd.com

[email protected]
http://www.weeksmd.com/mailto:[email protected]:[email protected]://www.weeksmd.com/


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DNA Damage

Toxic exposure

Radiation

Heavy metals

Pesticides

Synthetic hormones

Cancer Defined


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Goal: Protect DNA from radiation

CAT scan 1980 = 3 million people CAT scan 2007 = 70 million people

Ionizing radiation meets living tissues => reactive oxygen and nitrogen

species

Remedy: Antioxidant & Anti-inflammation (water soluble and fat soluble)



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Poison is a matter of Dosage

Toxic Dosage =

Amount of Exposure - Degree of Resistance


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Professor Peter Duesberg, Ph.D.The Aneuploidy Theory of Cancer

Anuploidy
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7/163The Weeks Clinic for Corrective Medicine and Psychiatry 2011

Aneuploidy is probably the only mutation that can explain all

aspects of carcinogenesis . On this basis we can now offer a coherent

two-stage mechanism of carcinogenesis. In stage one, carcinogens

cause aneuploidy which destabilizes the karyotype, and in stage two,aneuploidy evolves autocatalytically generating ever new and

eventually tumorigenic karyotypes, ie. "genetic instability" . Thus

cancer cells derive their unique and complex phenotypes from

random chromosome number mutation, a process that is similar to

regrouping assembly lines of a car factory and also to speciation.

References:

http://mcb.berkeley.edu/labs/duesberg/research.htmlhttp://barnesworld.blogs.com/barnes_world/2007/04/p

ewter_duesberg.html
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A disturbing study estimates over 220,000 cases of cancer willresult from the Japan nuclear radiation fallout. Those numbers

are based on officially released radiation data which we learnmore every day are understated lies put out by governments toavert panic. Furthermore the longer the disaster carries on thehigher the number of deaths from cancer will be.

JCIVT Policy statement: Use high dose IV vitamin C.

Also Saturated Solution of Potassium Iodide and other correctiveand protective nutrients.


220,000 cases of Cancer fromFukushima Nuclear Fallout
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A nuclear power plant accident occurred in 1999 inJapan. Patients who were exposed to high doses ofradiation developed severe bone marrow failure, andthereafter underwent stem cell transplantation.

However, they developed severe GI damage withdiarrhea and bleeding, and eventually died frommultiple organ failure.

Pretreatment with Ascorbic Acid Prevents

Lethal Gastrointestinal Syndrome in MiceReceiving a Massive Amount of Radiation.From

National Defense Medical College &

Ground Self- Defense Force in Japan

Yamamoto et al. J Radiat Res 2010;51:145-15.

#1: Vitamin C is a protector against externalradiation

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Courage and Wisdom of

Professor Atsuo Yanagisawa

At a time of crisis, he raised his voice and offered the only

realistic and beneficial solution to the radiation poisoning

of the people of Japan: high dose vitamin C for treatmentand prevention of radiation toxicity.

Consider: the Position Paper of the Japanese College of

Intravenous Therapies

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Working Group of The StatementAtsuo Yanagisawa M.D. Masashi Uwabu, M.D.Burton E. Burkson, M.D. Bradford S.Weeks, M.D.Ronald Hunninghake, M.D. Steven

Hickey, Ph.D.Thomas Levy, M.D.It is our strongest recommendation that those living in the

effected areas regularly take antioxidant supplements such as

vitamin C to counteract the negative consequences of long-term

low dose radiation exposure as well as to protect the health of

coming generations. It is further recommended that thoseworking in environments that require exposure to high-

concentrations of radiation should immediately undergo ultra

high dose vitamin C therapy along with a vigorous antioxidant

supplementation program.

Official Statement of JCIT about

environmental radioactivity andhealth

issued in March 29, 2011.
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If environmental radioactivity became two-foldhigher than usual, women with child bearing ageshould take the following basic anti-oxidativesupplements to keep optimal anti-oxidative

reserve.Vitamin C 1-2 g 3-4 times a day

Liposomal Vitamin C 1 g twice a day

Alpha-lipoic acid 100-200 mg twice a day

Selenium 50-100 g twice a day

Vitamin E 100-200 mg twice a day

with other essential vitamins and minerals.

Orthomolecular approach #1
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If environmental radioactivity became two-foldhigher than usual, women with child bearing ageshould take the following basic anti-oxidativesupplements to keep optimal anti-oxidative

reserve.Vitamin C 2-4 g 3-4 times a day (increase to boweltolerance)

OR Liposomal Vitamin C 3 g twice a day

Alpha-lipoic acid 300 mg twice a day

Selenium 200 g twice a day

Vitamin E 200 mg twice a day

with other essential vitamins and minerals.

Orthomolecular approach #2


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(1) I.V. Vitamin C 25g before and after work at

radiation-contaminated area.Sterile water 250mL with 50% vitamin C 50mL

with 20% Mg chloride 5ml with 1% B12 1ml with B-complex 100 1ml

with 10% B6 1mL with 25%Dexpanthenol 1mL - delivered 1 gm/min

(2) Daily supplements at work

Liposomal Vitamin C 2 g three times a day

Alpha-lipoic acid 300 mg twice a day

Orthomolecular approaches for people who

works at radiation-contaminated area in theFukishima Plant.

We must save FukushimaHeroes
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Orthomolecular approaches only can save the life of

Fukushima Heroes

The JCIT working group led by Professor Atsuo Yanigasawa, M.D.

NamelessFaceless

Heroes
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Spices against Radiation

Curcumin MOA = 1) radioprotective, 2) anti-oxidant, 3) gene expression modification, 4)

reduce tumor formation, 5) upregulation of genes

for apoptosis,

Ginseng MOA= 1) radio-protective of fast

growing tissues (esp. hair follicles); 2) immune-

enhancement 3)

Garlic, Ginger MOA = 1) decrease NF kappabeta mutation pathway; 2) increase WBC

production esp. after exposure;

The Weeks Clinic for Corrective Medicine a nd Psychiatry 2011


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Foods Against Radiation

1) Soy (Genistein, Haelan 951)

MOA = #1) radio-protective enzyme:

Bowman-Birk Inhibitor (BBI) for late or

post radiation exposure; also #2) anti-

lipid peroxidation, stimulates production

of WBC and RBC after radiation;

2) Brown seaweed with Fucanoid

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Brown seaweed (Laminaria Japonica)

extract contains the followinfg anti-cancer

agents:life Organic Iodine, Alginates,

Fucoidan and Laminarin.

Worldwide scientific studies and clinical

research of these elements showed:



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Brown seaweed Laminaria Japonica.

Organic Iodine feeds the Thyroid Gland and

occupies sites which otherwise would be

vulnerable to radioactive iodine.

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Foods Against Radiation (cont.)


Fucoidan promotes apoptosis (self-

destruction of cancer cells) in certain types

of rapidly growing cancer cells. Fucoidan

helps to naturally eliminate harmful cells

from organism.

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Alginate is a natural absorbent of radioactive

elements, heavy metals and free radicals. It hasthe unique ability of binding heavy metals and

radioactive elements to its own molecules. As the

Alginate cannot be broken down by the bile or

saliva and cannot be absorbed by the body, it issecreted from the body together with the heavy

metals and radioactive substances.

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Laminarin is a polysaccharide helpful in the

prevention and treatment of cardiovascular

diseases. It exhibits 30% of the

anticoagulant activity of heparin.



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Corrective Supplements NAC MOA = produces glutathione; Rx 1800mg

Glutathione MOA = 1) radio protection, 2)

produces cytokines which protect bone marrow

from radiation; 200-600mg IM, IVP, IV, Neb

S-Adenosylmethionine (SAMe) MOA= methyl

group donor to enhance levels of glutathione;DNA protection from ionizing radiation; Rx

1,200mg a day



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ACE (vitamins A, C and E)

Vit A MOA= 1) reversal of radiation induced

oxidized lipids; and 2) enhances apoptosis;

Vit C MOA= 1) anti-oxidant and 2) counteracts

radiation induced long lived radicals (LLRs)that destabilize chromosomes and induce

cancerous mutations

Vit E MOA = 1) lipid anti-oxidant and 2)

enhances growth inhibition of cancer cells



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Also worrisome

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To WIFI or Not to WIFI

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To WIFI or Not to WIFI

One more school removes WIFIhttp://weeksmd.com/2011/09/one-school-removes-wifi/

Vatican loses lawsuit over childrencancer

caused by radio transmitterhttp://weeksmd.com/2011/03/vatican-loses-lawsuit-over-cancer-caused-by/

WIFI is killing us slowly and our birds too http://weeksmd.com/2011/01/wifi-is-killing-us-slowly-and-our-birds-too/

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Compact Fluorescent Light Bulbs



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Compact Fluorescent Light Bulbs

Electrical Pollution The White Paperhttp://weeksmd.com/2011/05/electrical-pollution--the-white-paper/

Compact fluorescent lights and Diabeteshttp://weeksmd.com/2010/04/compact-fluorescent-lights-and-diabetes/

See this VIDEO:http://www.youtube.com/user/magdahavas#p/u/10/gJcM6RZwyfA

http://weeksmd.com/2011/05/electrical-pollution-%25E2%2580%2593-the-white-paper/http://weeksmd.com/2010/04/compact-fluorescent-lights-and-diabetes/http://weeksmd.com/2010/04/compact-fluorescent-lights-and-diabetes/http://weeksmd.com/2010/04/compact-fluorescent-lights-and-diabetes/http://weeksmd.com/2010/04/compact-fluorescent-lights-and-diabetes/http://weeksmd.com/2011/05/electrical-pollution-%25E2%2580%2593-the-white-paper/http://weeksmd.com/2011/05/electrical-pollution-%25E2%2580%2593-the-white-paper/


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Modern Romance

He grasped me firmly, but gently, just above my elbow and

guided me into a room, his room. Then he quietly shut the

door and we were alone. He approached me soundlessly,

from behind, and spoke in a low, reassuring voice close to

my ear: "Just relax. Without warning, he reached down andI felt his strong, calloused hands start at my ankles, gently

probing, and moving upward along my calves, slowly but

steadily. My breath caught in my throat. I knew I should be

afraid, but somehow I didn't care. His touch was soexperienced, so sure. When his hands moved up onto my

thighs, I gave a slight shudder and partly closed my eyes.

My pulse was pounding.



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Modern Romance (cont.)

I felt his knowing fingers caress my abdomen, my ribcage.

And then, as he cupped my firm, full breasts in his hands, I

inhaled sharply. Probing, searching, knowing what he

wanted, he brought his hands to my shoulders, slid them

down my tingling spine and into my panties.

Although I knew nothing about this man, I felt oddly trusting

and expectant. This is a man, I thought. A man used to

taking charge. A man not used to taking 'No' for an answer.

A man who would tell me what he wanted.A man who would look into my soul and say:

"Okay ma'am, you can board your flight now."



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Modern Romance (cont.)

I felt his knowing fingers caress my abdomen, my ribcage.

And then, as he cupped my firm, full breasts in his hands, I

inhaled sharply. Probing, searching, knowing what he

wanted, he brought his hands to my shoulders, slid them

down my tingling spine and into my panties.

Although I knew nothing about this man, I felt oddly trusting

and expectant. This is a man, I thought. A man used to

taking charge. A man not used to taking 'No' for an answer.

A man who would tell me what he wanted.A man who would look into my soul and say:

"Okay ma'am, you can board your flight now."



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BSW (c) 2011


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Airport scanners

Invasion of the Body Scanners: AirportSecurity May Not Work, But It DoesCause Cancerhttp://weeksmd.com/2010/11/travel-safe-and-avoid-the-scanners/

Scientists Question Safety Of NewAirport Scannershttp://weeksmd.com/2010/11/airport-x-ray-scanners-i-recommend-avoiding-t

http

://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective

/

http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/http://weeksmd.com/2010/11/tsa-and-radiation-aasp-has-a-wise-perspective/


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BSW (c) 2011


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Why women live longer than men



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Day 2 Day 4


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Day 6 Day 7


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Day 9 Day 14


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Day 17 The Tumor

Th D i f Si


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The Doctrine of Signatures(bloodroot)


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Cancerlytic Herbs-a history of suppression

http://www.altcancer.com/lysis.htm

http://www.meditopia.org/index_ing.htm

Escharotic agents, Fred Mohs, and

Harry Hoxsey JD. Elston J. AmericanAcademy of Dermatology, Vol 53, I 3, P

522-524
http://www.altcancer.com/lysis.htmhttp://www.meditopia.org/index_ing.htmhttp://www.meditopia.org/index_ing.htmhttp://www.altcancer.com/lysis.htm


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Electrical Pollution Where does it come from?

What are the effects on electrical equipment?

What are the effects on humans and animals?

What has to be done to control it?

What can we do?


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BioElectric Smog

The Plagueof

The 21st Century


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The new

environmentalhazard

Electrical Smog

Measurable

Preventable

andTreatable!


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My Medical Office(before electriclearing)


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8

TOXIC ! Computer On

BioElectric Smog Count = 1513(30X above upper limit if safety!)


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SOLUTION:Add two filters!

Computer on,2 filters

Bioelectric Smog

Count = 10
http://www.emrpolicy.org/


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Resources:www.safalab.com (search filter)

www.weeksmd.com (search electric)www.emrpolicy.orgwww.electricalpollution.com

Further Reading:Becker, Robert The Body Electric

Becker Robert Cross CurrentsBrodeur, Paul Currents of Death and

articles in The New Yorker Magazine

Wh D El i l P ll i
http://www.emrpolicy.org/http://www.emrpolicy.org/http://www.emrpolicy.org/http://www.emrpolicy.org/http://www.weeksmd.com/http://www.weeksmd.com/http://www.emrpolicy.org/http://www.emrpolicy.org/http://www.emrpolicy.org/http://www.emrpolicy.org/http://www.weeksmd.com/http://www.weeksmd.com/http://www.weeksmd.com/http://www.safalab.com/


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Where Does Electrical Pollution

Come From?

21st Century Technology

19th Century Distribution Lines


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A Brief History

1972 oil embargo forcedU.S. to become more

energy efficient

Equipment was designed to

operate using short pulsesof current instead of

continuous current

Variable speed frequencydrives, HID lighting, dimmerswitches, computers, TVs,

and most other modern

electronic devices are

energy efficient


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Linear Loads

Prior to 1972, most electrical

loads were linear; that is,

they operated on normal

utility supplied 60-Hertz sine

waves

Linear loads include devices

such as motors and

incandescent light bulbs

With linear loads, higher

voltage potential means

higher current draw, and

vice versa


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Non-linear Loads

Non-linear loads use

short pulses of

current

Therefore, load

current is NOT

proportional to the

voltage applied

When load current &

voltage are NOT

proportional entities,

harmonics are

generated and flow

on the power


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Electrical Pollution

Power Quality

Definition:

Anything that deviates from anormal sinusoid

Contributors to Electrical Pollution:

1. Harmonics

2. Transients

3. Sags

4. Swells

C C & C


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The Possible Role of Contact Current in CancerRisk Associated With Residential Magnetic Fields

R. Kavet,1* L. E. Zaffanella,2 J. P. Daigle,2 and K. L. Ebi1

1EPRI, PaloAlto, California

2Enertech Consultants, Lee,Massachusetts

Residential electrical wiring safety practices in the US result in the possibility of a small voltage (up

to a few tenths of a volt) on appliance surfaces with respect to water pipes or other grounded

surfaces. This ``open circuit voltage'' (VOC) will cause ``contact current'' to flow in a person who

touches the appliance and completes an electrical circuit to ground. This paper presents data

suggesting that contact current due to VOC is an exposure that may explain the reported associations

of residential magnetic fields with childhood leukemia. Our analysis is based on a computer model

of a 40 house (single-unit, detached dwelling) neighborhood with electrical service that is

representative of US grounding practices. The analysis was motivated by recent research suggesting

that the physical location of power lines in the backyard, in contrast to the street, may be relevant to

a relationship of power lines with childhood leukemia. In the model, the highest magnetic field

levels and VOCs were both associated with backyard lines, and the highest VOCs were also

associated with long ground paths in the residence. Across the entire neighborhood, magnetic field

exposure was highly correlated with VOC (r0.93). Dosimetric modeling indicates that, compared

to a very high residential level of a uniform horizontal magnetic field (10 mT) or a vertical electric

field (100 V/m), a modest level of contact current (18 mA) leads to considerably greater induced

. . . the absolute (as well as modest) level of contact current

modeled (18 uA) produces average electric fields in tissue

along its path that exceed 1 mV/m. At and above this level,

the NIEHS Working Group [1998] accepts that biological

effects relevant to cancer have been reported in

numerous well-programmed studies.

Contact Current & Cancer


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Ground Current

100 amps current

on phase conductors100% returned via

ground

100 amps via ground

1960s: Linear Loads

1000 amps current

on phase conductors

70% returned via ground

700 amps via ground

1990s: Non-Linear Loads


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EPRI Handbook (1995)

In the Handbook for the

Assessment and Management of

Magnetic Fields Caused by

Distribution Lines EPRI (Electrical

Power Research Institute) states,

Furthermore, proximity to

distribution lines has been

associated with the risk of

childhood cancer in three

epidemiological studies.

Copies of the paper bound book can

be purchased from EPRI for


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Cherry Report

This review cites a great deal of internationally published peer-reviewed scientific evidence from laboratories and universities around

the world, sourced from reports from reputable institutions and in

internationally published papers from peer-reviewed journals. This

shows compelling evidence of athermal biological changes incells and in animals, which relate to brain functionchange, sleep disruption, chronic fatigue, reproductiveproblems and adverse health problems such asimmune system impairment and cancers of manyorgans. Epidemiological studies have identified statisticallysignificant increases of the incidence of most of these symptoms and

diseases associated with above average exposure to radio-frequency

and microwave (RF/MW) exposure.


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Cherry Report

very low, non-thermal levels of RF/MW radiation alters the basic

biochemistry of cells which have a potential to cause altered brain

function, carcinogenesis and impaired immune system functioning.

Animal experiments show that these effects occur in living animals,

including DNA breakage, cancer at many body sites, behaviouralalteration, EEG change and ocular damage. Many epidemiological

studies show increased risks of cancer and many other health effects

with increase RF/MW exposure.


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Cherry Report

Epidemiologists should look for other possible

changes, including psychological depression,

fatigue, sleep inefficiency, chronic feelings of jet lag,

endocrine disturbances and other symptoms; all

these may result from a chronically low melatonin

rhythm.


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EPA Reports

Subjective Complaints of Persons


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Working in Rf Field:

HeadachesEyestrainFlow of Tears

FatigueWeaknessDisturbed SleepMoodyFrequently IrritatedUnsociable

Mental DepressionDeterioration of Intellectual FunctionsNotable Memory ImpairmentSluggishnessInability to make decisionsLoss of HairMuscle Pain

Pounding of HeartBreathing DifficultiesDifficulty in sex lifeIncreased perspiration of extremitiesBrittle fingernailsDecreased lactation in nursing mothers


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Effect of Rf Fields on OtherOrgans:

Acceleration or retardation of breathingrateHemorrhaging and bleeding in internalorgansDecreased filtration in renal tubulesIncreased activity of adrenal cortexHemorrhaging in the liverDegeneration of hepatic cellsEnlargement of thyroidHyperthyroidismIncrease of radioactive iodine


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California Health Department

EMFs can cause

some degree of

increased risk of

childhood leukemia,

adult brain cancer,

Lou Gehrigs

Disease,

and miscarriage.

S B


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Sacramento Bee (2002) Sacramento Bee

http://www.sacbee.com/content/news/story/4631375p-5649679c.html

Female teachers show higher cancerratesBy Edie Lau -- Bee Science WriterPublished 2:15 a.m. PDT Wednesday, October 2, 2002

California's female teachers have sharply higher rates of a host ofcancers, including breast, endometrial and ovarian cancer, than womenof the same age and race statewide, scientists will announce today.

Study findings: A study of cancer in California's female teachers found:

* 72 percent higher rate ofendometrial cancer than women of comparable age and race.* 59 percent higher rate ofmelanoma.* 51 percent higher rate ofbreast cancer.* 47 percent higher rate oflymphoma.* 47 percent lower rate ofcervical cancer.* 34 percent lower rate oflung cancer.* 28 percent higher rate ofovarian cancer.* 28 percent higher rate ofleukemia.

Source: California teachers' cancer study
http://www.sacbee.com/content/news/story/4631375p-5649679c.htmlhttp://www.sacbee.com/content/news/story/4631375p-5649679c.html


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Human cancer cells grow ata rate of 1600% and becomemore malignant.


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Symptoms of Radio Wave Sickness

Neurological: headaches, dizziness, nausea, difficulty concentrating, memory loss,

irritability, depression, anxiety, insomnia, fatigue, weakness, tremors, muscle spasms,numbness, tingling, altered reflexes, muscle and joint pain, leg/foot pain, Flu-like symptoms,

fever. More severe reactions can include seizures, paralysis, psychosis, and stroke.

Cardiac: palpitations, arrhythmias, pain or pressure in the chest, low or high blood pressure,

slow or fast heart rate, shortness of breath.

Respiratory: sinusitis, bronchitis, pneumonia, asthma.

Dermatological: skin rash, itching, burning, facial flushing.

Ophthalmologic: pain or burning in the eyes, pressure in/behind the eyes, deteriorating

vision, floaters, cataracts.

Others: digestive problems; abdominal pain; enlarged thyroid; testicular/ovarian pain;

dryness of lips, tongue, mouth, eyes; great thirst; dehydration; nosebleeds; internal bleeding;altered sugar metabolism; immune abnormalities; redistribution of metals within the body; hair

loss; pain in the teeth; deteriorating fillings; impaired sense of smell; ringing in the ears.

(Firstenberg, 7)

Energy Efficient Light Bulbs


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clean dirty

incandescent lights compact fluorescent lights

(~80%)

Energy Efficient Light Bulbs

MODELING OF INDUCED CURRENT INTO THE HUMAN BODY


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MODELING OF INDUCED CURRENT INTO THE HUMAN BODYBY L.F. MAGNETIC FIELD FROM EXPERIMENTAL DATA

R. ScorrettiEcole Centrale de Lyon, 36 av. Guy de Collongues, 69134 Ecully, France

URL : http://cegely.ce-lyon.fr

Fig 1 : Induced current density J ( A/M2)


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Research


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Research Dave Stetzer, Power Quality Expert, Stetzer Electric, Wisconsin

Dr. Martin Graham, Professor Emeritus, U.C. Berkeley, California

Dr. Donald Hillman, Professor Emeritus, Michigan State University

Dr. Magda Havas, ProfessorTrent University, Peterborough,Canada

Dr. Art Hughes, Ph.D., Electrical Engineering,Texas

Dr. Yuri Gregoriev, Ph.D., M.D., Moscow, Russia

Dr. NikitinaValentina, Doctor of Medicine, Saint Petersburg,Russia

Dr. Vitaly Resnik, Ph.D., Republic of Kazakhstan

have spearheaded worldwide research with numerous

researchers on the effects of electrical pollution on humans


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Chicken Embryo Experiment

(Graham & Stetzer)

The baby chickens shown here

were hatched in an incubator.

The chick on the right is a

sample of what the chicks

looked like that were notexposed to dirty power

The chick on the left is a

sample of what the chicks

looked like that were exposedto dirty power for30 minuteson the 10th day of being in theincubator. Noticeable

deformities and burn marks are

visible.


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An extremely low frequency magnetic field attenuatesinsulin secretion from the insulinoma cell line, RIN-m

Tomonori Sakurai 1, Akira Satake 1, Shoichiro Sumi 1, Kazutomo Inoue 1, Junji

Miyakoshi 2 *

1Department of Organ Reconstruction, Institute for Frontier Medical Sciences,

Kyoto University, Kyoto, Japan2Department of Radiological Technology, School of Health Sciences, Faculty of

Medicine, Hirosaki University, Hirosaki, Japan

Bioelectromagnetics 25:160-166, 2004. 2004

http://www3.interscience.wiley.com/cgi-bin/abstract/107638676/ABSTRACT

Insulin Secretion & ELF Magnetic Fields
http://www3.interscience.wiley.com/cgi-bin/abstract/107638676/ABSTRACThttp://www3.interscience.wiley.com/cgi-bin/abstract/107638676/ABSTRACT


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Solutions

Five Wire Solution


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Five-Wire Solution

40% lower

50% lower

T t l i


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Two neutral wires5-wire distribution system

hot wires

neutral

Thi k t l i


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Thicker neutral wireOversized Neutral

hot wires

neutral


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The Graham-Stetzer Filter

Side View Front View

This filteris a simple,

effective andCost-effectivesolution toelectricalpollution.www.safalab.com
http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/


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Stetzerizer Microsurge Meter

Front ViewThe Health Department of the Republic of

Kazakhstan has stated that any reading on

this meter exceeding 50 is unacceptable and

steps must be taken to lower such readings.

fil d i
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Unfiltered Environment

Here a woman is standing near a wall.The electric component measures 3

V/m. No Graham-Stetzer Filter is

plugged in.

A Filtered Environment
http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/


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A Filtered Environment

A Graham-Stetzer Filter is

plugged into the wall

The electric componentimmediately dropped to 2 V/m

Shortly, the electric

component read 0 V/m

Filtered HomesUnfiltered Homes
http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/http://www.safalab.com/


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143 mV

16.6 kHz

393 mV

12.5 kHz

56 mV

1.7 kHz

39 mV

0.8 kHz
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Filtered Schools

without

Graham-Stetzer filters

Etobicoke School of the Arts in Toronto

36 mV

12.5 kHz

Several Graham-Stetzer filters were

plugged-in nearby PCs in the library at

the time. The reading on the Microsurge

meter was 28 GS Units.

with

Graham-Stetzer filters

9 mV

1 kHz
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Cooperative Effort

1. The solution to this problem requires a cooperative

effort.

2. Utilities need to update their outdated distribution

systems to meet todays technological loads.

3. Consumers need to reduce the amount of RF they are

putting on electrical wires.
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YES Can we enjoy the benefits of electricity?

Can we use it safely?

Is the technology available to accomplish

this?

Can we achieve it with minimum expense?

Questions

Whats in our homes?
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What s in our homes?

Healthy Stem Cells are not Cancer Stem Cells
http://www.safalab.com/http://www.safalab.com/


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Successful Cancer Treatment requires anunderstanding of Stem Cells

Max Wicha M D
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Max Wicha, M.D.Distinguished Professor of Oncology

Director, University of Michigan

Comprehensive Cancer Center

The problem is, when we treat cancer cellswith chemotherapy, the cancer stem cells

are being stimulated to grow too.

When we take mesenchymal stem cells andmix them with tumor cells, the tumors grow

much more quickly in animals.


Cancer expert tells howt t t b bl
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treatment can be problem

Wednesday, February 24, 2010 By Mark Roth, Pittsburgh Post-Gazette

Max Wicha hopes cancer treatments can avoid generalchemo altogether and just use targeted therapies againstthe stem cells.

Max Wicha is coming to Pittsburgh today to deliver astartling message. Standard cancer treatmentsnot only often fail to eradicate cancer, butcan make it worse.

That argument isn't coming from a fringe proponent of

alternative medicine, but from the founder of theUniversity of Michigan's Comprehensive Cancer Centerand a pioneer in research on why cancers recur andspread to other parts of the body.


..conventional treatment is a problem
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..conventional treatment is a problem(cont.)

The reason breast cancer and other malignancies oftenreturn aggressively after treatment is that whentumor cells die under assault fromchemotherapy and radiation, they give off

substances that can reactivate a special setof master cells known as cancer stem cells,Dr. Wicha said in an interview Tuesday.

Dr. Wicha's lab has found that inflammatory moleculessecreted by dying tumor cells can hook up withthe stem cells and cause them in effect to come outof hibernation.


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Adult stem cells exist in most tissues, and go intoaction to repair damage from wounds or infections.

In cancer, they can mutate and no longer obeynormal bodily signals to stop growing, Dr. Wichasaid.

He and other researchers say that evenwhen chemotherapy and radiation cause

tumors to shrink dramatically, thesestem cells can stay alive, living underthe radar until they are once againspurred into action.


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They also believe stem cells are probably theones that break away from an original tumorand cause cancer to spread elsewhere in the body.

Chemo and radiation kill off the fastest-growing cells

in the body, which applies to most cancer cells, but thecancer stem cells that create those rapidly dividingtumor cells actually grow much more slowlythemselves, and are less susceptible to those

therapies, he said. One tactic to address this problem is to kill off both

types of cancer cells at once, Dr. Wicha said.


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A recent experimental trial with advanced breastcancer patients at the University of Michigan, BaylorUniversity in Texas and the Dana-Farber CancerInstitute at Harvard University used standard

chemotherapy along with a substancedesigned to block one of the biochemicalpathways of stem cells.

The approach killed off more than 90 percent

of the cancer stem cells, Dr. Wicha said, andresearchers now hope to expand the treatment to amuch larger group of patients.


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co e o a ea e s a p ob e(cont.)

Ultimately, he hopes cancer treatments can avoidgeneral chemo altogether, with its debilitatingside effects,and just use targeted therapiesagainst the stem cells.

There is still a long road ahead, he said, and "my feelingis, to really knock these stem cells out, we're probablygoing to have to use multiple inhibitors.

You Tube http://weeksmd.com/?p=5014 andhttp://wn.com/professor_max_wicha__breast_cancer_ste


The Public retraction
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The Public retraction

Cancer patients, follow recommendedcare!

An article published by the Post-Gazette claimed

that our research suggests cancer treatments "notonly often fail to eradicate cancer, butcan make it worse" This statement has beenmisinterpreted by patients currently receivingradiation or chemotherapy treatments. I have beencontacted by both my own patients and Pittsburgh-area patients who have questioned whether theyshould continue with their chemotherapy. In fact,these treatments are lifesaving for many patients.


Retraction ( )


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Retraction (cont.)

Our work does suggest that the resistance of a small population of tumorcells to these treatments may account for some of their limitations. Basedon this, we are working to develop new approaches to target this specificcell population -- treatments that could augment chemotherapy andradiation therapy. New treatments based on this theory are in their earlytesting stages. Only through the conduct of rigorous clinical trials will we

be able to determine whether addition of these new therapies improves theoutcome for patients with cancer.

In the meantime, patients diagnosed with cancer need to follow theirdoctors' recommendations for treatment according to thecurrent standards of care and inquire whether they are eligible for aclinical trial.

MAX WICHA, M.D.Distinguished Professor of OncologyDirector, University of Michigan Comprehensive Cancer CenterAnn Arbor, Mich.


Strategy for Corrective Care


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Strategy for Corrective Care

Know your enemy intimately,

See your target clearly,

Set your strategy carefully,

Before you attack wisely.


Chemotherapy increases numbers of dangerous


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Chemotherapy increases numbers of dangerouscancer STEM cells by increasing cytokines like IL-8 so thatcancer stem cell cannot differentiate *, which cause treatment

resistance.

The Goal is to combine chemotherapy with adjunctive therapieswhich prevent increase of cytokines (like IL-8) when tumors are

attacked with chemotherapy or radiation (and IPT).

BUT: If they would differentiate, they would becomesusceptible to chemotherapy again.

THEREFORE: The highest goal of Corrective Cancer Careis to re-educate the cancer STEM cells so theyredifferentiate and stop creating cancer TUMOR cells.

h i C ?


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What is Cancer?

Cancer is understood to be unregulated cells

proliferating autonomously within the human

being either in humoral or tumorous form.

(Query: Are these aggressive or

confused cells?)

Wh i T ?


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What is a Tumor?

A tumor, benign or malignant, is a

proliferation of cells of which, in the case of a

malignant cancer, less than 1% ofwhich are dangerous.

Is attacking cancer the best


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strategy?

The ideal strategy whereby one

could win without fighting,

accomplish the most by doing the

least, bears the characteristic stamp of

Taoism.- note by Thomas Cleary, translator, of Sun Tzus The Art of War


The problem is 0.1% of the


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The problem is 0.1% of theTumor!

99.1% - 99.6% of the tumor cells are NOTdangerous (aside from steric, obstructive factors).

Similarly, usually less than 1% ofprimary tumor cells cultured in vitro can

give rise to colonies.Diehn, M Therapeutic Implications of the Cancer Stem Cell Hypothesis

Semin Radiat Oncol. 2009 April; 19(2): 7886.

What metastasizes?


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What metastasizes?

Stem cells!

tumor cells are heterogeneous in their capacity to give rise

to tumors upon transplantation or to form colonies in cultureassays. Forin vivo tumor transplantation, this is reflected in thelarge numbers of tumor cells that must usually be transplanted toform a tumor. For primary human and mouse tumors,

this number often resides in the thousands or

millions.(ibid Diehn et al)

Only cancer STEM cells


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Only cancer STEM cellsmetastasize!

Considerable evidence suggests that tumorscontain only a minority of cells which arecapable of regrowing the tumor (ie. tumor

stem cells). Since all tumor stem cells must be killedif treatment is to be successful, the number of stem cells

in a tumor can be expected to be an important

determinant of curability. Hill RP The proportion of stemcells in murine tumors. Int J Radiat Oncol Biol Phys. 1989 Feb;16(2):513-8.

Normal Tissue STEM Cells


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Normal Tissue STEM Cellsresist Chemotherapy

A large number of the most frequently used therapiesfor cancer induce cell death by inducing DNA damage.

These agents are also toxic to normal stem cells and their

progeny. Fortunately, normal stem cells haveevolved multiple mechanisms to protectthemselves from toxins and genotoxic

stress, which make them relatively resistant

to cell killing with cytotoxic agents. (ibid Diehnet al)

All STEM Cells


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All STEM Cells

resist chemotherapy

The apparent similarities between normal tissue stemcells (NTSC) and cancer stem cells (CSC) led to thehypothesis that CSC may be relatively resistant to

common chemotherapeutic agents compared to theirmore differentiated non-tumorigenic counterparts and

that improvements in patient outcomes might beachieved by directly targeting CSC . Mounting evidence

suggests that this is the case. (ibid Diehn et al)


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Cancer Stem Cells resistChemotherapy

Baker, M Stem cells: Fast and furious.

Nature. 2009 Apr 23;458(7241):962-5.

Cancer STEM cells are resistant to


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chemotherapy

The apparent similarities between normal stem cells and CSCled to the hypothesis that CSC may be relatively resistant tocommon chemotherapeutic agents compared to their more

differentiated non-tumorigenic counterparts and thatimprovements in patient outcomes might be achieved by directlytargeting CSC. Mounting evidence suggests that this is the case.Recent studies have shown that cancer stem cell-like cells present in some established cell lines and

in long-term xenografts appear to be relativelyresistant to cytotoxic chemotherapeutics. (ibidDiehn et al)

CANCER is spread andkept alive by

Chemotherapy andRadiation is only effectivein non aggressive cancer


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InvasiveCarcinoma

Chemo-TherapyRadiationCancer Stem Cell

Normal Cells

Tumor cells

kept alive byCancer Stem Cells

Linheng Li and William B. NeavesCancer Res 2006; 66: (9). May 1, 2006

Aggressive

cancer stem cellssurvive chemo

in non-aggressive cancercells (tumor cells, not

cancer stem cells).

and Cancer Stem Cells are

i t t t R di ti Th


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resistant to Radiation Therapy

alsoThus, CSC in some tumors appear to be resistant to

cytotoxic chemotherapies. As is discussed elsewhere in

this issue, CSC in some tumors also appear tobe resistant to radiotherapy. These findings

suggest the overcoming CSC resistance mechanisms to

cytotoxic therapies may result in higher cure rates. (ibidDiehn et al)

Chemotherapy increasesCancer Stem Cell


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Cancer Stem Cell

proliferationSince it remains to be determined how representative

such cancer stem cell-like cells are of CSC in primarytumors, another group analyzed human CD44+ESA+

colon cancer stem cells were enriched inxenografts that had been treated with

cyclophosphamide compared to untreatedcontrol tumors.(ibid Diehn et al)

The worst case scenario(aka the Standard of Care)


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InvasiveCarcinoma

Chemotherapyor Radiation

Cancer Stem Cellssurvive

Cancer Stem Cell Normal cellTumor cell (non stemcell)

(aka the Standard of Care)

Resistence!

Chemotherapy increasescancer stem cell number


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cancer stem cell number

and virulenceEnrichment was documented both as an

increased percentage of cancer stem cellsas measured by flow cytometry and as

highertumor forming capacity in limiting dilutionassays.

Li X, Lewis MT, Huang J, et al. Intrinsic resistance of tumorigenic breastcancer cells to chemotherapy.J Natl Cancer Inst. 2008;100:6729.

Chemotherapy and Radiation


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Chemotherapy and Radiation

make Cancer worse.

Distinguished Prof.

Max Wicha, M.D.

Director, University of

Michigan

Comprehensive

Cancer Center

Primum Non Nocere

(First Do No Harm)

Example of Chemotherapy Worsening Cancer:Cytokines which inhibit Stem Cell Differentiation are


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Cytokines which inhibit Stem Cell Differentiation areincreased by doxorubicin inH460 tumor cells, In vitro

Int J Cancer, 2009, NIH-PA

CHEMOTHERAPY INCREASE CYTOKINES IN TUMORS


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Levina et al.Chemothera

peutic drugsand humantumor cellscytokinenetwork. IntJ Cancer.

2008

CYTOKINES LIKE IL-8, TNF-i hibit St C ll Diff ti ti


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inhibit Stem Cell Differentiation

D34+ cells towards CD14+

O Berthier-Vergnes etal.. Human melanomacells inhibit the earliestdifferentiation steps ofhuman Langerhans cellprecursors but failed toaffect the functionalmaturation ofepidermal LangerhanscellsHuman melanomacells inhibit the earliestdifferentiation steps ofhuman Langerhans cellprecursors but failed to

affect the functionalmaturation ofepidermal Langerhanscells . British Journal ofCancer (2001)


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BSW (c) 2011

New Directions in CancerTreatment: Fix Cancer STEM


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Treatment: Fix Cancer STEM

cellsRecent insights into tumor biology.indicate that in manycancers only a subset of malignant cells has the

potential to proliferate indefinitely and therefore to giverise to macroscopic metastases or to cause tumor recurrence after

treatment

It is this subset of cells, often called cancer stem cells(CSC), that needs to be targeted and eliminated inorder to achieve cures, since the remaining cancer cells

(called non-tumorigenic cells) are destined to stop dividing or todie. (ibid Diehl et al)

New Directions in Cancer Care


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Fix Cancer STEM cells (cont.)

The Cancer Stem Cell (CSC) hypothesis

suggests that agents targeting these cells should

ultimately lead to improved outcomes forcancer patients.

http://cirmresearch.blogspot.com/2011/04/shifting-balance-of-stem-cell-renewal.html

Going Forward
http://cirmresearch.blogspot.com/2011/04/shifting-balance-of-stem-cell-renewal.htmlhttp://cirmresearch.blogspot.com/2011/04/shifting-balance-of-stem-cell-renewal.htmlhttp://cirmresearch.blogspot.com/2011/04/shifting-balance-of-stem-cell-renewal.html


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Going Forward

Assessing the efficacy of such treatments will require the adventof new approaches to assessing CSC frequency and viabilitywithin tumors. Furthermore, classic mechanisms of

treatment resistance, such as clonal selection andthe tumor microenvironment, will continue to

present obstacles for achieving cure. It is therefore likelythat combinations of cytotoxic, biologic, and CSC-directed

therapies will ultimately allow the largest possible improvements

in patient outcomes.

We need a targeted


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therapy

One vexing dilemma in the nascent field ofCSC-based therapeutics is the high similaritybetween CSC and normal tissue stem

cells, which complicates the secondaforementioned goal of CSC-directed therapy avoiding normal stem cell toxicity. (ibid Diehn et

al)

Certainty in Clinical


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Practice

I stand firmly upon

the shifting sands ofclinical science.Dr. Weeks disclaimer to patients, the state medical board and

esteemed colleagues (and his mother).

IPT is better thanconventional Rx


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conventional Rx

Those wicked creatures yet do lookwell-favored, when others are more

wicked; not being the worst stands insome rank of praise

Ill go with thee: thy fifty yet dothdouble five and twenty, and thou art

twice her love

Lear, speaking to daughter Goneril when insulted by daughter Regan - Act 2 scene 1

But


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But.

IPT, being chemotherapy (albeit low dose and targetedkinder and gentler) nevertheless still worseningcancer prognosis since it still kills ONLY

cancer tumor cells (not the cancer stem cells):the resulting IL-8 SOS signal still goes out to musterreinforcements from the mesenchymal stem cells whichincrease the number and virulence of cancer stem cells.

SOLUTION: Use IPT with


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Adjuvant Therapies

Goal: Stem cell re education

Adjunctive therapies along with IPT to enticecancer stem cells to differentiate and become

normal tissue stem cells or normal tissue cells.

The Cordelia Effect


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The Cordelia Effect

Current Approach:

Killing the Messenger (Cut, Burn, Poison)

Better Approach:

Bring the cancer stem cells back in line because

re-differentiation is better than death.

King Lear


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and his

loving loyal3rd daughter

Cordelia

The Cordelia Effect (cont )


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The Cordelia Effect (cont.)

The goal of the Cordelia Effect (CorrectiveCancer Care) is to control the variables

including the local tumor environment so as toshift the cancer stem cells metabolism away

from proliferation and towards differentiation, in

order to decrease tumor size, growth and

virulence.

The Cordelia Effect


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The Cordelia Effect

(examples of Corrective Cancer Care)

1) Proteolytic Enzyme Therapy (pancreatic

enzymes)2) MEBO (moist exposed burn ointment)

3) Anti-inflammatory agents (tumeric, etc.)

4) Fermented Soy products (Haelan 951)

5) Ukrain

Proteolytics Enzymes


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Proteolytics Enzymes

Tumors are wounds, that do

not heal. Every cancer
http://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPG


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y

medication should improve

wound healing.- Rudolph Virchow, 1865

Today we know thatcytokines(inflammation)inhibit celldifferentiation andwound healing.

Anti-Inflammatory Agents
http://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPG


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Anti-Inflammatory Agents

Goal: To interrupt the IL-8 cytokine SOS and allowdifferentiation of cancer stem cells

Reprotaxin -CXCR1 receptor blocker- (Wicha)

Oxygen (hypoxemia stimulates CSCs)

Tumeric, Resveratrol, Brown Seaweed,

MEBO Gastro Intestinal Complex (GIC)

Fermented Soy (Haelan 951)

Anti-Inflammatory Agents in
http://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPG


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CANCER STEM CELLS AND FERMENTED SOY
http://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPGhttp://upload.wikimedia.org/wikipedia/commons/c/ce/Rudolf_Virchow_by_Hugo_Vogel,_1861.JPG


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1) Soy decreases cytokines (including IL-8)Handayani, R Soy Isoflavones Alter Expression of Genes Associated withCancer Progression, Including Interleukin-8, in Androgen-Independent PC-3

Human Prostate Cancer Cells1 J. Nutr. 136:75-82, January 2006

2) Fermented soy prom

Corrective Cancer Care® and Cancer Stem Cell Therapy

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