Corneal collagen cross-linking (CXL)
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Transcript of Corneal collagen cross-linking (CXL)
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Corneal collagen cross-linking
(CXL)
ALIREZA PEYMAN, MD
ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
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CXL with riboflavin and ultraviolet-A irradiation introduced in 1998
Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998;66:97–103.
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IndicationsCornea ectasias
KCPMD
Iatrogenic ectasiasPost-LASIK keratectasia
Infectious ulcersCorneal edema
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Importance of age of the patient
<10 years old 10-20 years 20-30 30-40 >40
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Technique
Using a wavelength of 370 nm with an accumulated irradiance of 5.4 J/cm2 ensures that the exposure of all structures is below harmful levels
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Epi-Off
Epi-On
Penetration of riboflavin
Role of oxygen
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Combinations
CXL + ICRSCXL + Microwave keratoplasty
(Keraflex)
CXL + PRKCXL + LASIK