Copyright (c) by W. H. Freeman and Company Chapter 22 Integrating Cells into Tissues.

Copyright (c) by W. H. Freeman and Company

Chapter 22

Integrating Cells into Tissues


22.0 Schematic overview of the types of molecules that bind cells to each other and to the extracellular matrix

Figure 22-1


22.1 There are five principal classes of cell-adhesion molecules (CAMs)

Figure 22-2


22.1 Cadherins mediate Ca2+-dependent homophilic cell-cell adhesion


22.1 N-CAMs mediate Ca2+-independent homophilic cell-cell adhesion

Figure 22-3


Regulação da ligação de N-CAM por sialização


22.1 Selectins and other CAMs participate in leukocyte extravasation

Figure 22-4


22.1 Cadherin-containing junctions connect cells to one another

Figure 22-5


A Matriz Extracelular (ECM)

Presente em todos os tecidos Organiza as células em tecidos Coordena a função as células Providencia um caminho para a migração celular Moléculas na matriz activam vias de trasdução

que regulam o crescimento, divisão e expressão génica das células

As células interagem com a ECM através de CAMPrincipalmente integrinasTambém selectinas e proteoglicanos


22.2 Integrins mediate weak cell-matrix and cell-cell interactions

Cell-matrix adhesion is modulated bychanges in the activity and number ofIntegrins (plaquetas; maturação S.I.)

De-adhesion factors promote cellmigration and can remodel the cell surface

• Desintegrinas (pequenos péptidos com RGD)

• Proteases que degradam a ECM

• Matrix specific Metaloproteinases

• Fibrinogen


22.2 Integrin-containing junctions connect cells to the substratum

Figure 22-9


22.3 Collagen: the fibrous proteins of the matrix


22.3 The basic structural unit of collagen is a triple helix

Figure 22-11

Collagen fibrils form by lateral interactions of triple helices

Gly-Pro-XGlycine (R=H)Proline


22.3 The side-by-side interactions of collagen helices are stabilized by covalent bonds

Figure 22-12


22.3 Assembly of collagen fibers begins in the ER and is completed outside the cell

Figure 22-14


22.3 Mutations in collagen reveal aspects of its structure and biosynthesis

Figure 22-15


22.3 Collagens form diverse structures

Figure 22-16


22.4 Fibronectins bind many cells to fibrous collagens and other matrix components

Copyright (c) by W. H. Freeman and Company Chapter 22 Integrating Cells into Tissues.

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