CELL DIVISION MITOSIS and the Cell Cycle MITOSIS and the Cell Cycle.
Controls of the Cell Cycle
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Transcript of Controls of the Cell Cycle
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Controls of the Cell Cycle
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Internal ExternalExternalChemical Chemical PhysicalPhysical
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Ex. At M phase checkpoint
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Chemical signals
essential nutrientgrowth factors
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1. Density-dependent inhibition
• crowded cells stop dividing
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Cells must be attached to a substratum
ex. inside of a culture jar or ECMof a tissue
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Don’t respond to body’s control mechanisms
Divide excessively
Don’t exhibit density-dependent inhibition
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“Immortal”
HeLa cells
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Diverse
Gene alteration
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Worst 5 Foods
www.copperwiki.org/index.
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HOW CANCER CELLS HOW CANCER CELLS SPREADSPREAD
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Transformation (normal cell to cancer cell)
Tumor (mass of abnormal cells w/in normal tissue)
Benign tumor
Malignant tumor / cancer
Metastasis
How
Cancer
Cells
Spread
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1. High-energy radiation
For localized tumor
Destroys DNA in cancer cells
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2.Chemotherapy
For metastatic tumors
For actively dividing cells
Side effects
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To summarize…To summarize…