Continuous Subcutaneous Insulin Management:...
Transcript of Continuous Subcutaneous Insulin Management:...
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H A Y L E Y M I L L E R , M D D I A B E T E S , P R E V E N T I O N A N D C O N T R O L P R O G R A M
T E L E - H E A L T H C O N F E R E N C E J U N E 1 9 , 2 0 1 3
Continuous Subcutaneous Insulin Infusion (CSII) in Diabetes
Management: Who, Why & How
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Evolution of Diabetes Technology and Treatments: Timeline
Insulin Injections
Urine Test Strips
• Glucose Sensors • Insulin Analogs • New Oral agents
Artificial Pancreas: “Closing the Loop” 1999 1978 1922 1900s 1977
Urine Tasting
1776
Glucose Meters
Insulin Pumps
• REAL- Time monitoring • Incretin-based Therapies • Inhaled Insulin
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Insulin Pumps: Overview
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0
50,000
100,000
150,000
'90 '91 '92 '93 '94 '95 '96 '97 '98 '99 2000 2001
6,600 8,700 11,400 15,000
20,000 26,500 35,000
43,000
60,000
81,000
120,000
162,000
U.S. Pump Usage
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Estimated Pump Use Around the World
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4:00 16:00 20:00 24:00 4:00
Breakfast Lunch Dinner
8:00 12:00 8:00 Time
Pla
sma
in
suli
n
Ideal Basal/Bolus Insulin
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Meal bolus
1
2
3
4
5
6
12 am 12 pm 12 am
Time of day
Basal rate
Pump Therapy
Boluses
Insulin needed pre-meal Pre-meal BG
Carbohydrates in meal
Activity level
Correction bolus for high BG
Units
Basal rate Continuous flow of insulin
Takes the place of glargine or detemir
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Pump Components
catheter
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Pump Components
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Pump Components
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Additional Features
Bolus Calculators: - Carbohydrates - Blood glucose - Insulin on board
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Insulin Pump Benefits
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HbA1c Reduction
5.0 5.5
6.0 6.5 7.0 7.5
8.0 8.5 .09 9.5
10.0
n = 58 n = 107 n = 116 n = 50 n = 25 n = 56 Mean dur. = 36
Adolescents Adults
Mean dur. = 36 Mean dur. = 54 Mean dur. = 42 Mean dur. = 12 Mean dur. = 12
Chantelau E, et al. Diabetologia. 1989;32:421–426; Bode BW, et al. Diabetes Care. 1996;19:324–327; Boland EA, et al. Diabetes Care. 1999;22:1779–1784; Bell DSH, et al. Endocrine Practice. 2000;6:357–360; Chase HP, et al. Pediatrics. 2001;107:351–356.
Bell Rudolph Chanteleau Bode Boland Chase
Pre-pump Post-pump
HbA
1c
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Copyright © The American College of Physicians.
All rights reserved. Ann Intern Med. 2012;():E-508. doi:10.7326/0003-4819-157-5-201209040-00508
Change from Baseline HbA1c: Comparing CSII with MDI
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Reduces Hypoglycemia
0
20
40
60
80
100
120
140
160
n = 55 Mean age 42
n = 107 Mean age 36
n = 116 Mean age 29
n = 25 Mean age 14
n = 56 Mean age 17
Chantelau E, et al. Diabetologia. 1989;32:421–426; Bode BW, et al. Diabetes Care. 1996;19:324–327; Boland EA, et al. Diabetes Care. 1999;22:1779–1784; Chase HP, et al. Pediatrics. 2001;107:351–356.
Bode Rudolph Chanteleau Boland Chase
Pre-pump Post-pump
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Incidence Rate Ratio Severe Hypoglycemia: CSII vs MDI
Ann Intern Med. 2012;():E-508. doi:10.7326/0003-4819-157-5-201209040-00508
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Quality of Life
Liberalization of diet — timing & amount
Increased control with exercise
Able to work shifts & through lunch
Less hassle with travel — time zones
Weight control
Less anxiety in trying to keep on schedule
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N = 165 Average Duration = 3.6 years Average Discontinuation <1%/yr
Continued 97%
Discontinued 3%
Continuation Rate
Bode BW, et al. Diabetes. 1998;47(suppl 1):392.
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Pros and Cons of Pump Therapy
Pros Cons
Insulin Pump Therapy
Slightly better glycemic control Cost
Fewer injections Superficial infection
Less variable insulin absorption day to day
Pump failure DKA
Lifestyle flexibility, improved QOL Inconvenience of wearing device 24/7
Capability to store history of bolus/basal: clinicians can assess adherence
Decreased frequency of hypoglycemia (in peds)
Multiple Daily Injections Lower cost Multiple injections
Freedom from wearing pump Inferior glycemic control
Less flexible
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Insulin Pumps: Indications
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Pump Therapy Indications
HbA1c >6.5%
Frequent hypoglycemia
Dawn phenomenon
Exercise
Pediatrics
Pregnancy
Gastroparesis
Hectic lifestyle
Shift work
Type 2???
Marcus. Postgrad Med. 1995.
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PUMP INDICATIONS
“Ideal CSII candidate is a patient with T1DM or absolutely insulin-deficient T2DM who. . .” Performs 4+ injections daily Is motivated to achieve tighter glycemic control Is willing & intellectually/physically able to comply with
initiation and maintenance of pup therapy Is emotionally mature with stable life situation Maintains frequent contact with health care provider
Eligible patients should be capable of Frequent SMBG and/or use of CGM Carb counting and insulin correction Troubleshooting problems
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Target Populations
Young children, especially infants and neonates
Adolescents with eating disorders
Children and adolescents with pronounced dawn phenomenon
Children with needle phobia
Pregnant women (before conception)
Ketosis-prone individuals
Competitive athletes
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When to Consider
Recurrent severe hypoglycemia
Wide fluctuations in blood glucose levels regardless of A1C
Suboptimal diabetes control
Microvascular complications and/or risk for macrovascular complications
Good metabolic control but insulin regimen compromises lifestyle
Gastroparesis
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Remember: The Smart Pump Arrives Dumb
Glycemic control depends on An accurate total daily dose
Appropriate basal rate (~50$ of total daily dose)
Accurate carb ratio
Accurate insulin sensitivity factor
Appropriate insulin on board
Appropriate correction target
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Insulin Pumps: Available Options
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Patch Pump vs Infusion Set
Patch Pump (Omni-Pod) Worn on body
No external tubing
Can loosen, leak, be knocked off
Lower start-up cost, greater monthly cost
Infusion set (tubed) More site options
Variety of needle and tubing lengths
Easy pump removal for showers, sports
Can loosen, leak, get ripped off
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Omni-Pod
Patch pump (no tubing)
Watertight up to 25 feet for 60 minutes
Color screen “Meter remote” Built-in FreeStyle blood
glucose meter Food library Future integration with
CGM (?)
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MiniMed Paradigm Revel
Tubed pump 2 different size
options available (523/723)
Only available pump with integrated CGM
Meter communicates to pump (not remote)
No food database No color screen Low basal rate increment
up to 1 unit Splash resistant (not
waterpoof)
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Animas OneTouch Ping
Tubed pump
Waterproof
Color Screen
Meter remote
Integrated food database
Future integration with Dexcom CGM (Animas Vibe)
Durable
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Tandem t:slim
Tubed pump Water resistant (3 feet 30
minutes) Color touch screen Smallest dimensions No integrated meter Rechargeable battery No returns Occlusion shuts off pump Cannot tolerate extreme
temperatures
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Accu-Check Combo
Tubed pump Water resistant Color screen on meter Meter remote ? Food database Must program basal rate
for each hour No bolus calculator on
pump Complicated
programming
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User Considerations
How much insulin does the patient use in 3 days?
How active is the patient?
Is tethering patient to pump practical?
Is the patient exposed to: Water?
Extremes of temperature?
Will the patient need a more durable device?
What does the patient want and why?
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Miscellaneous
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Misc. Points My BG is low again
Must. Get. More. Insulin.
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Insulin Absorption & Temp
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Air Travel & Insulin Pumps
• Study looked at 10 insulin pumps during flight & in hypobaric chamber with pressure simulating flight.
• Decrease in ambient pressure predictable unintended insulin delivery by:
• Air coming out of solution & forming bubbles • Expansion of existing bubbles in cartridge before takeoff increase by
36% in size
King et al. Diabetes Care 34: 1932-1933, 2011.
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Pumps in Young Women
Perceived body images & social acceptance
Increased self-consciousness
Greater body dissatisfaction
Decreased body esteem
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Pump Concealment
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Misc Points
Increased risk for DKA Pump volume should approximate total daily dose x 3
Infusion sets MUST BE CHANGED Q3 days Insulin on board 4-5 hours Close follow-up by specialist (CDE, Diabetologist) All rapid acting insulin analogues equivalent Infusion should never be stopped – loss of insulin during
a shower ~.25 units Bolus wizard should be used for ALL corrections Have a back-up plan for pump failure (glargine dose and
prescription)
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Most Important Factor when Prescribing Pump Therapy??
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References
Pickup JC, Hammond P. NICE guidance on continuous subcutaneous insulin infusion 2008: review of the technology appraisal guidance. Diabet Med. 2009 Jan;26(1):1-4.
Schwartz S, Scheiner G. The role of continuous glucose monitoring in the management of type 1 and type 2 diabetes. Chapter published in Evidence Based Management of Diabetes, 2012: 1-17.
Blevins TC et al. Statement by the American Association of Clinical Endocrinologists consensus panel on continuous glucose monitoring. Endocrine Practice, 2010. 16:440-56.
Aschner P, Horton E, Leiter A, Munro N, Skyler JS Practical steps to improving the management of type 1 diabetes: recommendations from the Global Partnership for Effective Diabetes Management. Int J Clin Pract, 2010, 64(3):305-315.
Dolgin E. Managed by a machine. Nature, 2012. 485: 56-58. Walsh J. PPT presentation: Emerging Technology Pumps and CGM. Children with Diabetes Concerence, Sept
4 2010. Hirsch IB, Bode BW, Garg S et al. Continuous subcutaneous insulin infusion (CSII) of insulin aspart versus
multiple daily injection of insulin aspart/insulin glargine in type 1 diabetes patients previously treated with CSII. Diabetes Care. 2005, 28(3): 533-539.
Yeh HC, et al. Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: a systematic review and meta-analysis. Ann Int Med, 2012; 157)5): 336-47
Handelsman Y et al. American Assocaition of Clinical Endocrinologists medical guidelines for clinical practice for developing a diabetes meliitus comprehensive care plan. Endocrine Practice, 2011 17(2): 1-53.
King BR, Goss PW, Paterson MA, Crock PA & Anderson DG. Changes in altitude cause unintended insulin delivery fro insulin pumps: mechanisms and implications. Diabetes Care, 2011; 34: 1932-1933.
Ritholz MD, Smaldone A, Lee J, Castillo A, Wolpert H, Weinger K. Perceptions of psychosocial factors and the insulin pump. Diabetes Care, 2007; 30(3): 549-554.