Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin...

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Conference on Diabetes • Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent • Experiment with type 1 genetic or environmental w/immuno-supp • Assay development radioimmunoassay – insulin concentrations histologic evaluation with Bata cell detection blood glucose measurement blood antibodies measurement

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Transcript of Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin...

Page 1: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

Conference on Diabetes• Types of diabetes mellitus

type 1 -- insulin dependent type 2 – insulin independent

• Experiment with type 1 genetic or environmental w/immuno-supp

• Assay developmentradioimmunoassay – insulin concentrationshistologic evaluation with Bata cell detectionblood glucose measurementblood antibodies measurement

Page 2: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

ISLETS Of LANGERHANS in pancreas

Page 3: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

Acinar cells

islet

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Page 5: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

ISLETS OF LANGERHANS stained with aldehyde-fuchsin, which selectively stains secretory granules of insulin-secreting Beta cells

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kidney

Page 7: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.
Page 8: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.
Page 9: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.
Page 10: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

Blood sugar concentrations

• Normal range 80 – 120 mg/dl• Diabetic range >120 mg/dl

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Page 12: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

ROLES AND SPECIFIC ACTIONS OF ANTIOBODIES IN IMMUNITY

COMPLEMENT - MEDIATED LYSISOPSONIZATION - PROMOTE PHAGOCYTOSISTOXIN NEUTRALIZATION

PREVENTION OF MICROBIAL BINDING TO MUCOSAL SURFACE

VIRUS NEUTRALIZATION - INTERFERES WITH CELL PENETRATION

Page 13: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

EFFECTOR T CELLS•DELAYED - TYPE HYPERSENSITIVITY T CELLS

CYTOTOXIC CELLS DESTROYS TRANSPLANTED ORGANS

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Measure antibodies in blood

Page 15: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

radioimmunoassay for insulin blood concentrations

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Page 17: Conference on Diabetes Types of diabetes mellitus type 1 -- insulin dependent type 2 – insulin independent Experiment with type 1 genetic or environmental.

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Type-I Diabetes. Background Information Diabetes mellitus type-1 -Also called Insulin dependent diabetes or Juvenile diabetes. -Autoimmune destruction.

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Insulin Diabetes Outreach (June 2011). 2 Insulin Learning outcomes >Understand the difference between insulin therapy in type 1 diabetes as compared to.

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Prevention Of Diabetes. Type 2 Diabetes: Hyperglycemia Insulin Resistance Relative Impairment of Insulin Secretion Pathogenesis: Poorly Understood Genetic.

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Table of contents · 2013-11-09 · Type 1 diabetes • The pancreas does not make any insulin. • People with Type 1 diabetes must inject insulin to survive. Type 2 diabetes •

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Molecular biology of Type 1 (insulin-dependent) diabetes ... · Molecular biology of Type I (insulin-dependent) diabetes mellitus* ,~. Lernmark Hagedorn Research Laboratory, Gentofte,

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Human Muscle Fiber Type Specific Insulin ... - Diabetes · Human Muscle Fiber Type– Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes Diabetes 2015;64:485–497

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