Conference and Exhibition · 2007. 3. 16. · PENETRATION ENHANCER: EFFECTS OF VEHICLES AND ......

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UB/TIB Hannover 16.Pharmaceutical

TechnologyConference and Exhibition

Divani Caravel HotelAthens, Greece

Volume 2

WednesdayApril 16th 1997

April 15th, 16th and 17th 1997, Athens, Greece

PharmaizeuflbalfTechnBlogg

Conference and. ExhibitionRthens,' 'Greece:,

Plenary Lecture: OLYMPIA HALL

8.30-9.30 COMPARISON BETWEEN FLUID BEDGRANULATORS AND HIGH SHEARGRANULATORSDr Ole Worts, Glatt Norden ApS, Allerod,Denmark.

9.30-9.50 COFFEE

Research Papers

CONTROLLED DRUG DELIVERY:OLYMPIA HALL

9.50-10.20 AN INVESTIGATION OF POLY- 12CAPROLACTONE COPOLYMER BLENDSS. Berrill, K. Viras, J.P.A. Fairclough, C. Booth, S.Brown, D. Attwood and J.H. Collett, Universities ofManchester, U.K. and Athens, Greece, UMIST,Manchester and Sanofi Winthrop, U.K.

10.20-10.50 EVALUATION OF PEMULEN TR-1, A 22POLYACRYLIC ACID COPOLYMER ASMUCOADHESIVE AGAINST LICHEN PLANUSMUCOSAE ORIS USING A COMPOSITE DESIGNAS AN OPTIMISATION TECHNIQUEM. Brisaert & J.A. Plaizier-Vercammen, FreeUniversity of Brussels, Belgium.

10.50-11.20 HOT-MELT COATING TECHNOLOGY: 31INFLUENCE OF COMPRITOL 888 ATO ANDGRANULE SIZE ON THEOPHYLLINE RELEASEA. Faham, P. Prindere, E. Cauture, G. Kalantzis, N.Farah, Ph. Barthelemy & J. Joachim, University ofMarseille, Gattefosse, Saint Priest, France andHoechst Hellas ABEE, Athens, Greece.

11.20 -11.50 NEW TABLET DESIGN FOR THE BIMODAL 38RELEASE OF DRUGSL. Maggi and U. Conte, University of Pavia, Italy.

11.50 -12.20 A DEFINITIVE METHOD TO EVALUATE 46ENTERIC DELIVERY SYSTEMS TARGETINGTHE PROXIMAL SMALL INTESTINEE.P. Sandefer & G.A. Digenis, University ofKentucky, U.S.A.

UB/TIB Hannover 89119 055 848

InternationalAdvisory Board

F. CarliTrieste, Italy.

O.I. CorriganDublin, Ireland

j . CucalaBarcelona, Spain.

M.A. DonsmarkCopenhagen, Denmark

J.L. FordLiverpool, United Kingdom

M.J. GrovesChicago, USA.

A.M. Guyot-HermannLille, France.

T.M. JonesLondon, United Kingdom.

K.A. KhanNottingham, United Kingdom.

|.W. McGinityAustin, USA.

|. RakBratislava, Slovak Republic

D.M. RekkasAthens, Greece ' •

H. RupprechtRegensbuig, Germany.

A. StammStrasbourg, France.

Conference Co-ordinator

M.H. RubinsteinLiverpool, United Kingdom.

Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2E],United Kingdom

Telephone:National 0151 737 1993,lnternational+44 151 737 1993

FaxNational 0151 737 1070,International +44 151 737 1070

April 15th, 16th and 17th 1997, Athens, Greece

•"•';• f f A R G E T E D DRUG DELIVERY:0'.. OLYMPIA HALL

12.20-12.50 PECTIN/CHITOSAN COATINGS FOR COLONIC 70DRUG DELIVERYM.J. Femandez-Hervas & J.T. Fell, University ofSeville, Spain and University of Manchester, U.K.

12.50 -14.00 LUNCH: ATHENS VIEW ROOM

9.30-12.50 TABLE-TOP EXHIBITION:14.00 -17.00 OLYMPIA FOYER

14.00 - 16.00 POSTER-SESSION: OLYMPIA HALL

16.00-16.30 STUDIES ON PHYSICAL PROPERTIES OF 80MIXED PECTIN/ETHYLCELLULOSE FILMSINTENDED FOR COLONIC DRUG DELIVERYG.S. Macleod, J.T. Fell & J.H. Collett, University ofManchester, U.K.

TRANSDERMAL DRUG DELIVERY:OLYMPIA HALL

16.30-17.00 EFFECT OF FATTY ACIDS ON THE 95ALBUTEROL SULPHATE DIFFUSIONTHROUGH CELLULOSE MEMBRANE,HAIRLESS MOUSE SKIN AND HUMANCADAVER SKINN. Ali Chisty, R.A. Bellantone, D.R. Taft & F.M.Plakogiannis, Long Island University, U.S.A.

17.00-17.30 N-DODECYL-2-PYRROLIDONE AS A DERMAL 97PENETRATION ENHANCER: EFFECTS OFVEHICLES AND MODEL DRUGSB.B. Michniak, D.A. Godwin & J.W. Sowell Sr.,University of South Carolina, U.S.A. >

17.30-18.00 THE EFFECT OF DIFFERENT ENHANCERS ON 107THE TRANSDERMAL DELIVERY OFMETAPROTERENOL SULPHATE THROUGHHAIRLESS MOUSE SKIN AND CADAVER SKINA. Komessariou, N. Nicolettos, R. Morgan & F.M.Plakogiannis, Long Island University, U.S.A.

18.00-18.30 IN VITRO EVALUATION OF NIFEDIPINE 108PERMEATION THROUGH HUMAN EPIDERMISUSING EXPERIMENTAL DESIGN TECHNIQUESS.A. Giannakou, P.P. Dallas, DM. Rekkas & N.H.Choulis, University of Athens, Greece.

18.30-19.00 TRANSDERMAL DELIVERY OF TRICYCLIC 124ANTIDEPRESSANTS: AN IN-VITRO STUDYN. Nicolettos, A. KomessariouA F.M. Plakogiannis,

PharmaceuticalTechnology

Conference and ExhibitionRthens,. Greece


F. CarliTrieste, Italy

O.I. CorriganDublin, Ireland.

J. Cucala >

Barcelona, Spain


J.L FordLiverpool, United Kingdom



T.M. JonesLondon, United Kingdom


J.W. McGinityAustin, USA.

j . RakBratislava, Slovak Republic

D.M. RekkasAthens, Greece

H. RupprechtRegensburg, Germany

A. StammStrasbourg, France


M.H. RubinsteinLiverpool, United Kingdom

Conference Address

24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom

TelephoneNational 0 I5I 737 1993,International +44 151 737 1993

FaxNational 01 51 737 1070,International 444 151 737 107C

9.30-12.5014.00-17.00

TABLE-TOP EXHIBITION:OLYMPIA FOYER

PharmaceoijcafTephrtplggy

. Conference arid Exhibition

Research Papers

GRANULATION: VERGINA ROOM

9.50 -10.20 DROPLET SIZE MEASUREMENT IN A 125FLUIDISED BED GRANULATORL. Juslin, O. Antikainen, P. Merkku & J. Yliruusi,University of Helsinki and Leiras Oy, Turku,Finland.

10.20-10.50 EVALUATION OF NIR-ABSORPTION FOR 141MOISTURE CONTENT MONITORING OFGRANULES IN A FLUIDISED BEDGRANULATORS. Lehtola, J-P. Mannermaa, P. Ramet & J.Yliruusi, University of Helsinki, Finland.

10.50-11.20 PREPARATION AND EVALUATION OF RAPID- 153RELEASE GRANULES USING A NOVEL HOT-MELT EXTRUSION TECHNIQUEJ.W. McGinity & J.J. Koleng, The University ofTexas at Austin, U.S.A.

11.20-11.50 EVALUATION OF THE MIXTURES OF DIBASIC 155CALCIUM PHOSPHATE ANDMICROCRYSTALLINE CELLULOSE FORPREPARING INITIAL BEADS IN ACENTRIFUGAL GRANULATING PROCESSMd. Harum Ar. Rasid, J. Heinamaki, J. Menna & J.Yliruusi, University of Helsinki, Finland.

11.50-12 20 THE EFFECT OF COLLOIDAL GRADE OF 169MICROCRYSTALLINE CELLULOSE ON THEEXTRUSION RHEOLOGY ANDSPHERONISATION OF CYSTEAMINEHYDROCHLORIDE FORMULATIONSB. Owen, G. Rowley, I.M. Strarkey & M.G.Coulthard, University of Sunderland and RoyalVictoria Infirmary, Newcastle upon Tyne, U.K.

12.20-12.50 RELEASE OF PARACETAMOL FROM 176MICROCRYSTALLINE CELLULOSE UNCOATEDPELLETS PREPARED BY EXTRUSION-SPHERONISATIONB. Bataille, M. Jacob, G. Baylac & P. Yapo,Universities of Montpellier and National CoteD'lvoire, France.

12.50 - 14.00 LUNCH: ATHENS VIEW ROOM

Rthens, Greece




j . CucalaBarcelona, Spain


).L. FordLiverpool, United Kingdom.





|.W. McGinityAustin, USA.

j . RakBratislava, Slovak Republic

D.M. RekkasAthens, Greece.

H. RupprechtRegensburg, Germany.




Conference Address:


lelephone.National 0151 737 1993,International +44 151 737 1993


Pharmaceytiital

18.30-19.00 THE EFFECT OF SILICON DIOXIDECONCENTRATION ON DRUG RELEASE FROMTRIGLYCERIDE GEL FORMULATIONS, LIQUIDFILLED IN HARD GELATIN CAPSULEST. Benedict, G. Rowley & P.A. Walters, Universityof Sunderland, U.K.

Conference and ExhibitionRthens'Greece•

14.00 - 16.00 POSTER-SESSION: OLYMPIA HALL

GRANULATION: VERGINA ROOM

16.00-16.30 SCALE-UP ON TWO PRODUCTION SCALE 187FIXED BOWL MIXER-GRANULATORSA. Faure, M. Landin, I.M. Grimsey, P. York, M.J.Cliff, R.C. Rowe & A.J. Wigmore, University ofBradford, Zeneca Pharmaceuticals, Macclesfieldand Aeromatic-Fielder Ltd., Eastleigh, U.K.

EXCIPIENTS: VERGINA ROOM

16.30-17.00 STARCH ACETATES: MULTIFUNCTIONAL 192EXCIPIENTS FOR TABLETINGP. Raatikainen, P. Paronen, S. Peltonen, J. Nakari& A. Urtti, University of Kuopio and Primalco Ltd.,Rajamaki, Finland.

17.00-17.30 WATER UPTAKE OF HYDROCOLLOIDS 194G. Bhaskar, J.L. Ford & D.A. Hollingsbee,Convatec (WHRI) and Liverpool John MooresUniversity, U.K.

CAPSULES: VERGINA ROOM

17.30-18.00 RHEOLOGICAL CHARACTERISATION OF 217POLOXAMERS AND POLOXAMER/SILICONDIOXIDE GELS IN RELATION TO LIQUIDFILLING OF HARD GELATIN CAPSULEST. Saeed, G. Rowley & P.A. Walters, University ofSunderland, U.K.

18.00-18.30 EMULSIFYING EFFICIENCY OF SEMI-SOLID 225LIPID EMULSIFYING MATRICES AND ITSIMPLICATION IN DRUG RELEASEL. Halbaut, C. Barbe & M. Aroztegui, University ofBarcelona, Spain.

237




J. CucalaBarcelona, Spain.


J.L FordLiverpool, United Kingdom.




K.A. KhanNottingham, United Kingdom

J.W. McGinityAustin, USA

J. Rak

Bratislava, Slovak Republic






Conference Address:


TelephoneNational 0151 737 1993,International+44 151 737 1993.



Conference and Exhibition •

POSTERS

ON DISPLAY 14.00 - 16.00Olympia Foyer

BIOADHESION

49. CONTINUOUS SHEAR AND TEXTURAL 242ANALYSIS OF BIOADHESIVEPHARMACEUTICAL SEMISOLIDS CONTAININGTETRACYCLINE FOR THE TREATMENT OFPERIODONTITISA.F. Brown, D.S. Jones & A.D. Woolfson, TheQueen's University of Belfast, U.K.

DRUG RELEASE

50. IN-VITRO DISSOLUTION OF CONVENTIONAL 245DILTIAZEM TABLETS IN VARIOUS BUFFERSOLUTIONSI. Ahopelto, J. Yliruusi & E. Kristoffersson,University of Helsinki, Finland.

51. SLOWING DOWN THE RELEASE OF 259DIMEPHOSPHONE INCREASES THEEFFICIENCY OF A DERMATO-COSMETICCREAMS.N. Egorova, L.E. Ziganshina & E.A. Kadirova,Kazan Medical University, Russia.

52. FACTORS INFLUENCING THE DISSOLUTION 264RATE OF NIFEDIPINE/POLYVINYL-PYRROLIDONE CO-PRECIPITATESG. Kalantzis, E. Cauture, P. Prinderre, G. Joachim,Ph. Piccerelle, J.P. Reynier & J. Joachim,University of Marseille, France and Hoechst HellasABEE, Athens, Greece.

53. EFFECT OF DIFFERENT FILLERS ON THE 273DRUG RELEASE OF NITRENDIPINE FROMTABLETSI. Homsek & R. Popovic, ICN Galenika, Belgrade,Yugoslavia

Rthens, ̂ Greece"


F. CarliTneste, Italy


J. CucalaBarcelona, Spain

M.A. DonsmarkCopenhagen, Denmark.


M.J. GrovesChicago, USA





J. Rak

Bratislava, Slovak Republic






Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2EJ,United Kingdom

Telephone.National 0151 737 1993,International +44 151 737 1993

FaxNational 0151 737 1070,International + 44 151 737 1070

Conference andExhibition[•'•'-'•• ''''•<•"•'.'\ •••••" Rthens.'thfeece--

54. THE INFLUENCE OF pH AND AGITATION 277INTENSITY ON DRUG RELEASE FROMTABLETS EVALUATED BY MEANS OFFACTORIAL DESIGNJ. Radovanovic, Z. Duric, M. Jovanovic, L. Nikolic& S. Ibric, Institute For Pharmaceutical Technology,Belgrade, Yugoslavia

55. EVALUATION OF THE PHYSICAL PROPERTIES 286OF A TOLBUTAMIDE/HYDROXYPROPYL-BETA-CYCLODEXTRIN INCLUSION COMPLEXE. Suihko, O. Korhonen, T. Jarvinen, J. Ketolainen,E. Paine & P. Paronen, Universities of Kuopio andTurku, Finland.

56. PHYSICOPHARMACEUTICAL CHARACTER- 295ISATION OF TOLBUTAMIDE/ BETA-CYCLODEXTRIN INCLUSION COMPLEXESF. Veiga & A. Sousa, University of Coimbra,Portugal.

DRUG STRUCTURE

57. DESIGN OF THYROTROPIN ANALOGS USING 297SITE-DIRECTED MUTAGENESIS AND GENETRANSFERF.A. Fares, Carmel Medical Centre and TheRappaport Family Institute for Research in MedicalSciences, Haifa, Israel.

BIOAVAILABILITY

58. A NEW ALGORITHM TO PREDICT DRUG 308BLOOD LEVELS FROM IN VITRO DISSOLUTIONDATA: INTEREST IN PREFORMULATIONP. Odou, C. Barthelemy & H. Robert University ofLille II, France.

STABILITY






J.L. FordLiverpool, United Kingdom.


A.M. Guyot-HermannLille, France

T.M. |onesLondon, United Kingdom.



J. RakBratislava, Slovak Republic.






59. STUDIES OF DIFFERENT INCLUSION 316PROCESSES OF CARBAMAZEPINE WITHHYDROXYPROPYL BETA-CYCLODEXTRIN ANDTHE CHARACTERISATION OF THECOMPLEXESLj. Tasic, J. Milic-Askrabic & D. Rajic, BelgradeUniversity and Military Technical Institute,Belgrade, Yugoslavia.

Conference Address:

24 Menlove Gardens North, •Liverpool LI 8 2EJ,United Kingdom j

telephone. ,'National 0151 737 1993, \International +44 151 737 1993

FaxNational 0151 737 1070, \International +44 151 737 1070


Conference and ExhibitionRthens: Gret

60. SOLUBILISATION OF TRETINOIN WITH 320SURFACTANTS AND CYCLODEXTRINS ANDTHEIR INFLUENCE ON PHOTO-DEGRADATIONOF TRETINOINM.Brisaert & J. Plaizier-Vercammen, FreeUniversity of Brussels, Belgium

61. THERMAL ANALYSIS IN THE PREDICTION OF 328COMPATIBILITY: RIGHT, WRONG OR NEWAPPROACHES?M. E. Gil Alegre & J.L. Ford, University ofComplutense, Madrid, Spain and Liverpool JohnMoores University, U.K.

62. EFFECT OF SOLVENT ADDITION ON THE 338CHARACTERISTICS OF FREEZE-DRIEDSYNTHETIC PENEM PREPARED USING ANAUTOMATIC PROCESSC. Vecchio, S. De^Luigi Bruschi, M. Varallo & A.gazzaniga, Pharmaceutical Technologies, Veruno,University of Milan and Edwards Alto Vuoto,Trezzano, Italy.

63. CHARACTERISATION OF DRUG/ADDITIVE 346INTERACTIONS USING MODERN ANALYTICALMETHODSL. Colliere, H. Giraud, V. Lavastre & H. Mifsud,Sanofi Recherche, Toulouse, France.

TRANSDERMAL DRUG DELIVERY

64. THE EFFECT OF SKIN PENETRATION 347ENHANCERS ON THE PERMEATION OFDIDEOXYCYTIDINE THROUGH HAIRLESSMOUSE SKIN IN-VITROT.K. Fincher, S.D. Yoo & B.B. Michniak, Universityof South Carolina, U.S.A.

65. IN-VITRO PENETRATION OF ANIONIC, 353CATIONIC AND ZWITTERIONIC LIPOSOMALLYENCAPSULATED ANTISENSEOLIGONUCLEOTIDE INTO HAIRLESS MOUSESKINT.W. Ocheltree, R.C. Mehta, B.B. Michniak & J.C.Shah, ISIS Pharmaceuticals, Carlsbad, Universityof South Carolina and Medical University of SouthCarolina, U.S.A.




j . CucalaBarcelona, Spain.







|.W. McGinityAustin, USA

J. RakBratislava, Slovak Republic






Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2E),United Kingdom

TelephoneNational 0151 737 1993,International +44 151 737 1993


TechnologyConference and Exhibition'

• :: Rthens'r Greece I

66.

67.

68.

69.

70.

71.

TRANSDERMAL (DIADERMATIC) DELIVERY OF 366DICLOFENAC SODIUMD. Parashos, F.M. Plakogiannis, M. Mesiha & A.Babar, Long Island University, U.S.A.

EMULSION AND VESICLE FORMATION OF 367ALPHA-TOCOPHEROL AND ALLOPURINOLWITH EGG YOLK PHOSPHATIDYLCHOLINES. Braha, I. Paduraru, M. Pavelescu, E. Brailoiu &E. Braha, lasi University, Rumania.

EMULSIONS

OF 372

382

391

FORMULATION AND RHEOLOGYSUCROESTER EMULSIONSM.F. Bobin, G. Perraud, N. Claudel, J. Pelletier &M.C. Martini, University Claude Bernard, Lyon,France.

FORMULATION AND EVALUATION OF A O/WEMULSION USING EXPERIMENTAL DESIGNP. Prinderre, Ph. Piccerelle, E. Cauture, G.Kalantzis, J.P. Reynier & J. Joachim, University ofMarseille, France and Hoechst Hellas ABEE,Athens, Greece.

OCULAR DELIVERY

INFLUENCE OF PENETRATION ENHANCERSON THE WEIGHT OF DROPS DELIVEREDFROM FLEXIBLE DROPPER BOTTLESL. Van Santvliet & A. Ludwig, University ofAntwerp, Belgium.

NON-IONIC SURFACTANT BASED TIMOLOL 402MALEATE DISCOMES FOR CONTROLLEDOCULAR DELIVERYS.P. Vyas & N. Mysore, Doctor Harisingh GourVishwavidyalaya, Sagar, India.

72. IN-VITRO AND IN-VIVO EVALUATION OF SOME 405ANTIFUNGAL DRUGS FOR OPHTHALMICAPPLICATIONSS.A. Ibrahim, S.S. Tous, A.K. Al-Hussaini, A.A. El-Shanawany, E.A. Daef, A.S. Aly & M. Mahmoud,Assiut University and Al-Azhar University, Egypt.




J. CticalaBarcelona, Spain





T.M. (onesLondon, United Kingdom



J. RakBratislava, Slovak Republic






Conference Address:



FaxNational 01 51 737 1070,International +44 151 7 i7 1070

PharmaceuticalTechnolqgy

Conference and ExhibitionRthens, Greece

ANALYSIS

73. SPECTROPHOTOMETRIC DETERMINATION OF 424MOCLOBEMIDE BY CHARGE-TRANSFERCOMPLEXATIONM.U. Adikwu & K.C. Ofokansi, University of Nigeria,Nstikka, Nigeria.

74. MOBILE PHASE OPTIMISATION AND ASSAY 433OF CALCIPOTRIOL USING HIGHPERFORMANCE LIQUID CHROMATOGRAPHYJ.J.N. Cirunay, Y.V. Heyden & J. Plaizier-Vercammen, Free University Brussels, Belgium.

75. CHARGE TRANSFER COMPLEXATION FOR 443SPECTROPHOTOMETRIC ASSAY OF CERTAINIMIDAZOLE ANTIFUNGAL DRUGSS.R. El-Shabouri, K.E. Emara & A.M. Mohamed,Assiut University, Egypt.

76. DETECTION POSSIBILITIES AND SEPERATION 455OF SODIUM ARTESUNATE AND ARTELINICACID WITH CAPILLARY ZONEELECTROPHORESISM. Gabriels, M. Jimidar & J.A. Plaizier-Vercammen,Free University Brussels, Belgium.

77. DEVELOPMENT AND COMPARISON OF UV- 465SPECTROPHOTOMETRIC AND THIN LAYERCHROMATOGRAPHIC TECHNIQUES APPLIEDTO ARTELINIC ACID AND SODIUMARTESUNATEM. Gabriels & J.A. Plaizier-Vercammen, FreeUniversity Brussels, Belgium.

78. SIMULTANEOUS DETERMINATION OFACETAMINOPHEN AND CODEINE INPHARMACEUTICAL PREPARATIONS BYDERIVATIVE SPECTROPHOTOMETRYJ. Hanaee, Medical Sciences University of Tabriz,Iran.

474








A.M. Guyot-HermannLille, France










DRYING

79. DRYING OF LACTOSE AND MANNITOLGRANULES MADE IN A LABORATORY SCALEHIGH SHEAR MIXERT. Niskanen, M. Niskanen & J. Yliruusi, OrionCorporation, Espoo and University of Helsinki,Finland.

476 Conference Address:



Fax.National 0151 737 1070,International +44 151 737 1070

80.

81.

82.

83.

84.

85. COMPARISON OF DIFFERENT METHODS FORMEASURING THE PARTICLE SIZE OFMETERED DOSE INHALERSM. Nagy, Z. Bokros, E. Barczai, Z. Szabados & M.Gora, EGIS Pharmaceuticals Ltd., Hungary.

SUPPOSITORIES

Conference and Exhibition' ' .'..:.. .r. "Rthehs,- G'reece-

508

UNUSUAL DRYING BEHAVIOUR OF GLUCOSEGRANULESM. Niskanen, T. Niskanen, I. Mattila & J. Yliruusi,Orion Corporation, Espoo and University ofHelsinki, Finland.

EXCIPIENTS

A COMPARISON OF THE COMPRESSIONPERFORMANCE OF AN ALTERNATIVESOURCE OF MICROCRYSTALLINECELLULOSE TO AVICELM.J. Elmer, Abbott Laboratories, U.K.

COMPUTATIONAL ELASTICITY OF 509ANHYDROUS BETA-LACTOSEJ. Paivarinta, A. Poso, J. Gynther, E. Suihko & J.Ketolainen, University of Kuopio, Finland.

PHYSICAL CHARACTERISATION OF SPRAY- 517DRIED LACTOSEY. von Scholz, S.A. Merkle & F.U. Flother, TheR.W. Johnson Pharmaceutical Research Institute,Schaffhausen, Switzerland.

INHALATION TECHNOLOGY

TRIBOELECTRIFICATION AND ADHESION 523DURING THE MIXING OF DRY POWDERINHALER FORMULATIONSF. Bennett, G. Rowley, P. Carter & Y. Dandiker,University of Sunderland, U.K.

528


F. CarliTries te , Italy




J.L FordLiverpool, United Kingdom





|.W. McGinityAustin, USA







86. GELLING OF A RECTAL SOLUTION 530CONTAINING SHORT-CHAIN FATTY ACIDSV. Astre, C. Tuleu, C. Charrueau & J.C. Chaumeil,University Rene Descartes, Paris, France.

87. RELEASE CHARACTERISTICS OF 538METRONIDAZOLE FROM FATTY AND WATERSOLUBLE BASEST. Kovacevic, M. Zivkovic, S. Popovic & T. Milic,ICN Institute, Belgrade, Yugoslavia.

Conference Address:

24 Menlove Gardens North,Liverpool L18 2E|,United Kingdom



PharmaceuffcMTectihtiltigff

Conference-and Exhibition.thens," Greece'

88. EFFECT OF MODERN ADDITIVES ON THE IN- 541VITRO DRUG RELEASE OF DIURETIC RECTALSUPPOSITORIESG. Regdon Jr., D. Deak, S. Berko & I. Eros, AlbertSzent-Gyorgyi Medical University, Szeged,Hungary.

MICROBIOLOGY

89. THE INTERACTION OF OPHTHALMIC 547ADHESIVES WITH A QUATERNARYAMMONIUM ANTI-MICROBIAL PRESERVATIVEN. Castellic-Munier, M. Boix & I. Maroteaux,Allergan R & D, Vallauris, France.

90. VAPOUR PHASE HYDROGEN PEROXIDE 548STERILISATION TECHNOLOGY FOR STERILITYTESTINGI. Maroteaux, C. Leccia & L. Foucher, Allergan R &D, Vallauris, France.

91. ANTIBIOTIC RESISTANCE AND THE ROLE OF 549MICROBIAL BIOFILMD.S. Jones, J.G. McGovern, A.D. Woolfson & S.P.Gorman, The Queen's University of Belfast, U.K.

92. NEW MICROBIOCIDAL MECHANISMS WITH 552SKIN PEPTIDES TO TREAT AND PREVENTPARASITIC INFECTIONS: NOVELPHARMACEUTICAL APPROACHI. Vouldoukis, M.C. Venier-Julienne, D. Mazier, M.Gentilini & L. Monjour, School of Medicine Paris VI,CNRS Paris and University of Angers, France


F. CarliTrieste, Italy.




J.L. FordLiverpool, United Kingdom.






|. RakBratislava, Slovak Republic






Conference Address:



Fax.National 0151 737 1070,International +44 151 737 1070

Conference and Exhibition · 2007. 3. 16. · PENETRATION ENHANCER: EFFECTS OF VEHICLES AND ......

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