COMPOSITION OF LIPIDS Lipoproteins Apolipoproteins Lipoproteins Apolipoproteins Cholesterol Protein...

of 54 /54

Embed Size (px)

Transcript of COMPOSITION OF LIPIDS Lipoproteins Apolipoproteins Lipoproteins Apolipoproteins Cholesterol Protein...

  • Slide 1
  • Slide 2
  • Slide 3
  • Slide 4
  • Slide 5
  • Slide 6
  • Slide 7
  • Slide 8
  • COMPOSITION OF LIPIDS Lipoproteins Apolipoproteins Lipoproteins Apolipoproteins Cholesterol Protein Triglyceride Phospholipid
  • Slide 9
  • Slide 10
  • Slide 11
  • Chylomicron Very Low Density Lipoprotein Low Density Lipoprotein Intermediate Density Lipoprotein High Density Lipoprotein Chylomicron Very Low Density Lipoprotein Low Density Lipoprotein Intermediate Density Lipoprotein High Density Lipoprotein
  • Slide 12
  • Slide 13
  • Slide 14
  • Slide 15
  • Slide 16
  • CHOLESTEROL METABOLISM Exogenous Endogenous Reverse Cholesterol Transport LDL Uptake Exogenous Endogenous Reverse Cholesterol Transport LDL Uptake
  • Slide 17
  • Slide 18
  • Slide 19
  • Slide 20
  • Slide 21
  • Slide 22
  • Slide 23
  • Slide 24
  • HMG CoA Reductase Inhibitors
  • Slide 25
  • Fibric Acids TG synthesis lipoprotein synthesis excretion of lipoproteins from liver; primarily VLDL synthesis of cholesterol production of sterols HDL
  • Slide 26
  • Bile Acid Binding Resins Nicotinic Acid Bind bile salts in gut Cholesterol eliminated in the feces Liver uses other sources of cholesterol (LDL) to make more bile
  • Slide 27
  • Nicotinic Acid Inhibits liver secretion of VLDL Reduced serum LDL Inhibits removal of HDL Increases excretion of sterols in the feces
  • Slide 28
  • Fibric Acids LDL VLDL TG Bile Acid Binding Resins HDL LDL VLDL TG HMG CoA Reductase Inhibitors Nicotinic Acid
  • Slide 29
  • Slide 30
  • Dufaux, International Journal of Sports Medicine, 1982 TRIGLYCERIDES & TRAINING Increase Decrease No Change Numbers of Studies
  • Slide 31
  • Dufaux, International Journal of Sports Medicine, 1982 CHOLESTEROL & TRAINING Increase Decrease No Change Numbers of Studies
  • Slide 32
  • Dufaux, International Journal of Sports Medicine, 1982 LDL & TRAINING Increase Decrease No Change Numbers of Studies
  • Slide 33
  • Dufaux, International Journal of Sports Medicine, 1982 HDL & TRAINING Increase Decrease or No Change Numbers of Studies
  • Slide 34
  • Tolfrey K, et al Sports Medicine 29:99-112, 2000 Pediatric Triglyceride response to Exercise Increase Decrease No Change
  • Slide 35
  • Increase Decrease No Change Numbers of Studies Pediatric Total Cholesterol response to Exercise Tolfrey K, et al Sports Medicine 29:99-112, 2000
  • Slide 36
  • Increase Decrease No Change Numbers of Studies Pediatric LDL response to Exercise Tolfrey K, et al Sports Medicine 29:99-112, 2000
  • Slide 37
  • Increase Decrease No Change Numbers of Studies Pediatric HDL response to Exercise Tolfrey K, et al Sports Medicine 29:99-112, 2000
  • Slide 38
  • Hurley, B.F., MSSE 21:689-693, 1989. RESISTANCE TRAINING
  • Slide 39
  • Hurley, B.F., MSSE 21:689-693, 1989.
  • Slide 40
  • CHOLESTEROL & TRAINING Whaley et al, J Cardiopulm Rehab 12:42-50, 1992 Pre Post Total Cholesterol
  • Slide 41
  • Lipid Research Clinics, JAMA 251:356-374, 1984. Reduction in Risk related to Reduction in Cholesterol
  • Slide 42
  • Risk reduction associated with a 20.7 mg/dL reduction in Total Cholesterol Lipid Research Clinics, JAMA 251:356-374, 1984.
  • Slide 43
  • Lehmann, R, et al. European J Clin Invest 31:37-44, 2001. HDL Subfractions and Physical Activity
  • Slide 44
  • Lehmann, R, et al. European J Clin Invest 31:37-44, 2001. HDL Subfractions and Physical Activity
  • Slide 45
  • Kraus, WE, et al. N Eng J Med 347:1483-1492, 2002 Exercise & Lipid Subfractions
  • Slide 46
  • Kraus, WE, et al. N Eng J Med 347:1483-1492, 2002 Exercise & Lipid Subfractions
  • Slide 47
  • Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993. HDL Subfractions and Physical Activity
  • Slide 48
  • Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993. HDL Subfractions and Physical Activity
  • Slide 49
  • Lp(a) and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.
  • Slide 50
  • Lopez, A, et al Atherosclerosis 20:1-9, 1974. How does HDL change with exercise?
  • Slide 51
  • Lopez, A, et al Atherosclerosis 20:1-9, 1974. How does HDL change with exercise?
  • Slide 52
  • Grandjean, et al J Applied Physiology 89:472-480, 2000
  • Slide 53
  • Hyper Normo Grandjean, et al J Applied Physiology 89:472-480, 2000
  • Slide 54
  • CETP and Physical Activity Seip, RL. Et al. Arteriosclerosis and Thrombosis 13:1359-1367, 1993.