Complications of liver cirrhosis basic.ppt
Transcript of Complications of liver cirrhosis basic.ppt
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Complications of Liver
CirrhosisAyman Abdo
MD, AmBIM, FRCPC
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Objectives
1. Understand the basic mechanisms
of portal hypertension
2. Recognized the classicpresentations of portal hypertension
complications
3. Get an idea on the management ofthese complications
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What is Liver Cirrhosis?
Diffuse fibrosis of the liver with
nodule formation
Abnormal response of the liver toany chronic injury
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Causes of Cirrhosis1. Chronic viral hepatitis
2. Metabolic: hemochromatosis, Wilson dis,alfa-1-antitrypsin, NASH
3. Prolonged cholestasis (primary biliarycirrhosis, primary sclerosing cholangitis)
4. Autoimmune diseases (autoimmune
hepatitis)5. Drugs and toxins
6. Alcohol
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Anatomy of the portal venous system
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The Effect of The Liver Nodule
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Mechanism of Portal HTN
Cirrhosis
Resistance portal flow
MechanicalNodules DynamicNitric oxide
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Complications of Portal
Hypertension
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1. Varices
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Collaterals
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Varices
Esophagus
Gastric
Colo-rectal
Portal hypertensive gastropathy
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Varices
DiagnosisHistory : Hematemases, melena
Physical examination
Ultrasound abdomen
Endoscopy
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Varices
Management-GeneralABC
2 IV LinesType and cross match
Resuscitation
IVFBlood
Platelet transfusion (platelet
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Varices
Management-SpecificIV vasoconstrictors (Octreotide)
Endoscopic therapyBanding
Sclerotherapy
Shunting
Surgical
TIPS
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Variceal Banding
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Types of Shunts
TIPS (Transjugular intrahepaticportosystemic shunt)
Surgical shunt
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Varices
PreventionTreat underlying disease
Endoscopic banding protocol
B-blockers
Shunt surgery (only if nocirrhosis)
Liver transplantation
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2. Ascites
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Ascites
Definition: fluid in theperitonial cavity
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Mechanism of Ascites
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Causes of Ascites
1. Liver disease: cirrhosis
2. Right sided heart failure
3. Kidney disease (nephrotic syndrome)4. Low albumin (malnutrition, bowel loss)
5. Peritonial infection (TB)
6. Peritonial cancer
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PresentationHistory:
Increased abdominal girth
Increased wt
Physical exam:
Bulging flanks
Shifting dullness
Fluid wave
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DiagnosisPhysical examination
Ultrasound
Ascitic tap
WBC (>250 PMN: SBP)
RBC
SAAG (serum albumin to ascitic fluid
albumin gradient)
>11 mg/dl : portal hypertension
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Portal hypertension
or heart failure
Peritonial disease
or kidney disease
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Treatment-General
Treat the underlying disease
Salt restriction (
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Treatment-Resistant
Recurrent tapping
Peritoneal-venous shunt
TIPS
Liver transplantation
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Spontaneous Bacterial Peritonitis
Infection of ascitic fluid
Usually gram negative (E.Coli)
Presentation variableMortality is high
Dx: ascitic tap = PMN>250
Treatment : third generation
cephalosporin IV
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3. Hepatic
Encephalopathy
H ti
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Hepatic
EncephalopathyReversible decrease in
neurological function secondaryto liver disease
Acute: seen with acute liverfailure
Acute on chronic: established
cirrhosis
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Hepatic EncephalopathyMechanism
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Hepatic EncephalopathyClinical features
Reversal of sleep pattern
Disturbed consciousnessPersonality changes
Intellectual deterioration
Fetor hepaticus
Astrexis
Fluctuating
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Flapping Tremor
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Drawing Tests
H ti E h l th
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Hepatic EncephalopathyDiagnosis
Clinical (most important)
The drawing tests
EEG
CT/MRI may show cerebral atrophy
H ti E h l th
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Hepatic EncephalopathyExacerbating factors
H ti E h l th
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Hepatic EncephalopathyTreatment
Identify and treat precipitation factor
Treat underlying liver disease
Normal protein diet
Antibiotics (Neomycin, metronidazole)
LactoloseTransplantation
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4. Hepatorenal
Syndrome
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Hepatorenal Syndrome
Progressive renal failure
Type 1 : rapidly progressive, high
mortalityType 2: slower progression
R/O volume depletion secondary to
diuretics
IV vasoconstrictors
Liver transplantation
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Summary
1. Mechanical compression of blood flow
plus hemodynamic changes leads to
portal hypertension
2. Common complications of portal
hypertension are:
Collateral formation (Varices)
Ascites
Hepatic encephalopathy
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Summary
3. The most important step in variceal bleed
management is resuscitation
4. The most important step in management
of hepatic encephalopathy is the
identification of the precipitating factor