Complete References Clin Chem 2002 48: 1620-1622 fileCambridge Healthtech Institute's Third Annual...

Complete References Clin Chem 2002 48: 1620-1622

I. ANALYTICAL MICROCHIPS

(1-33) 1. Bergaud C, Nicu L. Viscosity measurements based on experimental investigations of composite cantilever beam eigenfrequencies in viscous media. Review of Scientific Instruments 2000;71:2487-91. 2. Brooks SA, Dontha N, Davis CB, Stuart JK, O'Neill G, Kuhr WG. Segregation of micrometer-dimension biosensor elements on a variety of substrate surfaces. Analytical Chemistry 2000;72:3253-9. 3. Burggraf N, Krattiger B, de Mello AJ, de Rooij NF, Manz A. Holographic refractive index detector for application in microchip-based separation systems. The Analyst 1998;123:1443-1447. 4. Cheng J, Kricka LJ. Biochip Technology.Philadelphia: Gordon and Breach Scientific Publishers, 2001 5. Chiu Daniel T, Pezzoli E, Wu H, Stroock Abraham D, Whitesides George M. Using three-dimensional microfluidic networks for solving computationally hard problems. Proceedings of the National Academy of Sciences of the United States of America. [ print] 2001;98:2961-2966. 6. Chou C-F, Austin Robert H, Bakajin O, et al. Sorting biomolecules with microdevices. Electrophoresis 2000;21:81-90. 7. Eijkel JCT, Stoeri H, Manz A. A molecular emission detector on a chip employing a direct current microplasma. Analytical Chemistry 1999;71:2600-2606. 8. Eijkel JCT, Stoeri H, Manz A. An atmospheric pressure dc glow discharge on a micro chip and its application as a molecular emission detector. J. Anal. At. Spectrom. 2000;15:297-300. 9. Jain KK. Cambridge Healthtech Institute's Third Annual Conference on Lab-on-a-Chip and Microarrays. 22-24 January 2001, Zurich, Switzerland. Pharmacogenomics 2001;2:73-7. 10. Jain Kewal K. Biotechnological applications of lab-chips and microarrays. Trends in Biotechnology. [ print] 2000;18:278-280. 11. Jakeway SC, de Mello AJ, Russell EL. Miniaturized total analysis systems for biological analysis. Fresenius Journal of Analytical Chemistry 2000;366:525-39. 12. Jensen KF. The impact of MEMS on the chemical and pharmaceutical industries. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:105-10. 13. Kricka LJ, Ji X, Nozaki O, Wilding P. Imaging of chemiluminescent reactions in mesoscale silicon-glass microstructures. Journal of Bioluminescence and Chemiluminescence 1994;9:135-138. 14. Kricka LJ, Wilding P. Micromachining: A new direction for clinical analyzers. Pure and Applied Chemistry 1996;68:1831-1836. 15. Kricka LJ, Wilding P. Micromechanics and nanotechnology. In: Kost GJ, ed. Clinical Automation, Robotics, and Optimization. New York: Wiley, 1996: 45-77. 16. Kricka LJ, Wilding P. Microminiaturization of laboratory analyzers. LabMedica 1998;May-June:2-15. 17. Kricka LJ. Revolution on a square centimeter. Nature Biotechnology 1998;16:513-514. 18. Kricka LJ. Miniaturization of analytical systems. Clin Chem 1998;44:2008-14. 19. Krishnan M, Namasivayam V, Lin RS, Pal R, Burns MA. Microfabricated reaction and separation systems. Curr. Opin. Biotechnol. 2001;12:92-98.


20. Kwok YC, Manz A. Characterisation of Shah convolution Fourier transform detection. Analyst 2001;126:1640-1644. 21. Lee Luke P. Biomedical Polymer-Opto-Electro-Mechanical-Systems (BioPOEMS) for advanced biochips. Abstracts of Papers American Chemical Society. 2001;221:125. 22. Mitchell MC, Spikmans V, Bessoth FG, Manz A, de Mello A. Towards organic synthesis in microfluidic devices: multicomponent reactions for the construction of compound libraries. In: van den Berg A, Olthuis W, Bergveld P, ed. Micro Total Analysis Systems 2000,. Dordrecht: Kluwer Academic Publishers, 2000: 463-465. 23. Murakami Y, Tamiya E. [Department of microbiosensing system using micromachine techniques]. Rinsho Byori 1999;47:1105-12. 24. Pan D, Mathies RA. Chromophore structure in lumirhodopsin and metarhodopsin I by time-resolved resonance Raman microchip spectroscopy. Biochemistry 2001;40:7929-36. 25. Rossi C, Esteve D, Mingues C. Containment sensors for the determination of L-lactate and glucose. Biosensors & Bioelectronics 1999;14:27-32. 26. Roulet JC, Volkel R, Herzig HP, Verpoorte E, de Rooij NF, Dandliker R. Microlens systems for fluorescence detection in chemical microsystems. Optical Engineering 2001;40:814-21. 27. Rummler Z, Bacher W, Saile V, Schomburg WK. Mass separation using thin PTFE membranes. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 28. Tantra R, Manz A. Integrated potentiometric detector for use in chip based flow cells. Analytical Chemistry 2000;72:2875-2878. 29. Wilding P, Kricka LJ. Micro-microchips: just how small can we go? Tibtech 1999;17:465-468. 30. Wilkinson M. Microsystems: applications in catheters and endoscopes. Medical Device Technology 2000;11:34-6. 31. Woolley AT. Biomedical microdevices and nanotechnology. Trends in Biotechnology 2001;19:38-39. 32. Xiao-Feng Z, Burt JP, Talary MS, Goater AD, Pethig R. Development of biofactory-on-a-chip technology. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:241-50. 33. Xu Y, Bessoth FG, Eijkel JCT, Manz A. On-line monitoring of Chromium(III) using a fast micromachined mixer / reactor and chemiluminescence detection. Analyst 2000;125: 677-683.

FABRICATION

(1-97) 1. Andersson H, Van der Wijngaart W, Enoksson P, Stemme G. Limiting factors in the production of deep microstructures. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3892:242-52. 2. Andersson H, Jonsson C, Moberg C, Stemme G. Patterned self-assembled beads in silicon channels. Electrophoresis 2001;22:3876-3882. 3. Armani D, Liu C, Aluru N. Silicon as tool material for polymer hot embossing. Technical Digest. IEEE International MEMS 1999;:228-31. 4. Becker H, Ropke W. Fabrication of microarrays on an industrial scale with TopSpot. Mst News, no 2000;4:22-3.


5. Beebe DJ, Moore JS, Yu Q, et al. Microfluidic tectonics: a comprehensive construction platform for microfluidic systems. Proceedings of the National Academy of Sciences of the United States of America 2000;97:13488-93. 6. Beluze L, Bertsch A, Renaud P. Microstereolithography: a new process to build complex 3D objects. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 7. Bhansali S, Han A, Patel M, Oh KW, Ahn CH, Henderson HT. Integratible process for fabrication of fluidic microduct networks on a single wafer. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:110-18. 8. Bhusari D, Reed HA, Wedlake M, Padovani AM, Allen SAB, Kohl PA. Fabrication of air-channel structures for microfluidic, microelectromechanical, and microelectronic applications. Journal of Microelectromechanical Systems 2001;10:400-8. 9. Blom MT, Tas NR, Pandraud G, et al. Advances in MEMS using SFB and DRIE technology. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3876:64-73. 10. Bousse L. Optically programmable assembly of ordered bead arrays: a novel technology for on-chip biochemical analysis. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:36-42. 11. Bousse L, Minalla A, Deshpande M, Greiner KB, Gilbert JR. Micro concentrator with opto-sense micro reactor for biochemical IC chip family. 3D composite structure and experimental verification. Technical Digest. IEEE International MEMS 1999;:376-81. 12. Bousse L, Cohen C, Nikiforov T, et al. Electrokinetically controlled microfluidic analysis systems. Annual Review of Biophysics & Biomolecular Structure 2000;29:155-81. 13. Bousse L. Biochemical IC chip: towards artificial cellular device. Review of Laser Engineering 2000;28:422-7. 14. Buriak JM. Functionalization of silicon surfaces for device applications. Jala Journal of the Association for Laboratory Automation 1999;4:36-9. 15. Caton PF, White RM. MEMS microfilter with acoustic cleaning. Technical Digest. MEMS 2001;:479-82. 16. Chabinyc ML, Chiu DT, McDonald JC, et al. An integrated fluorescence detection system in poly(dimethylsiloxane) for microfluidic applications. Analytical Chemistry 2001;73:4491-8. 17. Chau C, Banerjee S, Seul M. From batch to continuous manufacturing of micro-biomedical and micro-analytical devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:44-53. 18. Che-Hsin L, Gwo-Bin L, Yen-Heng L, Guan-Liang C. Fabrication of microchannels using polycarbonates as sacrificial materials. Journal of Micromechanics & Microengineering 2001;11:733-7. 19. Chiu DT, Pezzoli E, Wu H, Stroock AD, Whitesides GM. From the Cover: Using three-dimensional microfluidic networks for solving computationally hard problems. Proc Natl Acad Sci U S A 2001;98:2961-6. 20. Cooney C, Towe B. Fabrication of integrated microanalytical chambers and channels for biological assays using flame hydrolysis deposition glass. Elsevier. Microelectronic Engineering 1999;46:1-4. 21. Edwards TL, Mohanty SK, Edwards RK, Thomas CL, Frazier A. Rapid tooling using SU-8 for injection molding microfluidic components. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:82-9. 22. Ehlert A, Dauer S, Buttgenbach S. Rapid prototyping of microfluidic structures with Nd:YAG-laser-ablation. MICRO SYSTEM Technologies 1998;98:439-44.


23. Folch A, Ayon A, Hurtado O, Schmidt MA, Toner M. Molding of deep polydimethylsiloxane microstructures for microfluidics and biological applications. J Biomech Eng 1999;121:28-34. 24. Fuqua P, Janson SW, Hansen WW, Helvajian H. Fabrication of true 3D microstructures in glass/ceramic materials by pulsed UV laser volumetric exposure techniques. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3618:213-20. 25. Fuqua PD, Taylor DP, Helvajian H, Hansen WW, Abraham MH. A UV direct-write approach for formation of embedded structures in photostructurable glass-ceramics. Materials Development for Direct Write Technologies. Symposium 2000;624:79-86. 26. Furuki M, Kameoka J, Craighead HG, Isaacson MS. A fast prototyping process for fabrication of microfluidic systems on soda-lime glass. Journal of Micromechanics & Microengineering 2001;11:726-32. 27. Galambos P, Benavides G. Electrical and fluidic packaging of surface micromachined electromicrofluidic devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:200-7. 28. Gardeniers H, Schasfoort R, van den Berg A. Microfluidic devices for biomedical applications. Mst News 2000;4:14-15. 29. Gorges-Schleuter M, Jakob W, Suss W. Microfabrication using synchrotron radiation. Reports on Progress in Physics 1998;61:313-51. 30. Grosse A, Grewe M, Fouckhardt H. Deep wet etching of fused silica glass for hollow capillary optical leaky waveguides in microfluidic devices. Journal of Micromechanics & Microengineering 2001;11:257-62. 31. Guijt RM, Baltussen E, van der Steen G, et al. New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection. Electrophoresis 2001;22:235-41. 32. Gwo-Bin L, Chen IH, Bin-Jo K, Guan-Ruey H, Bao-Herng H. Micromachined pre-focused 1*N flow switches for continuous sample injection. Journal of Micromechanics & Microengineering 2001;11:567-73. 33. Hayes MA, Polson NA, Garcia AA. MEMS: from classic sensors to RF applications. Revue Hf. Electronique, Telecommunications, no 2001;2:27-38. 34. Henning AK, Fitch J, Harris JM, Arkilic EB, Cozad B, Dehan B. Fabrication of a stainless steel microchannel microcombustor using a lamination process. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3514:386-92. 35. Higdon WR. Deep plasma silicon etch for microfluidic applications. Elsevier. Surface & Coatings Technology 1999;116:461-7. 36. Holke AD, Pilchowski J, Henderson HT, et al. Quartz channel fabrication for electrokinetically driven separations. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:164-71. 37. Hostis EL, Michel PE, Fiaccarbinno GC, Strike DJ, de Rooij NF, Koudelka-Hep M. Surface-tension-driven microactuation based on continuous electrowetting. Journal of Microelectromechanical Systems 2000;9:171-80. 38. Ikuta K, Maruo S, Fujisawa T, Yamada A. Palladium based micromembranes for hydrogen separation and hydrogenation/dehydrogenation reactions. Technical Digest. IEEE International MEMS 1999;:382-7. 39. Jackman RJ, Floyd TM, Ghodssi R, Schmidt MA, Jensen KF. Microfluidic systems with on-line UV detection fabricated in photodefinable epoxy. Journal of Micromechanics & Microengineering 2001;11:263-9. 40. Jin-Woo C, Ahn CH, Henderson HT. Design and fabrication of variable focusing lens. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:270-7.


41. Jo BH, Van Lerberghe LM, Motsegood KM, Beebe DJ. Micromachining of buried micro channels in silicon. Journal of Microelectromechanical Systems 2000;9:94-103. 42. Jr-Hung T, Liwei L. Micro-to-macro fluidic interconnectors with an integrated polymer sealant. Journal of Micromechanics & Microengineering 2001;11:577-81. 43. Juncker D, Schmid H, Bernard A, et al. Soft and rigid two-level microfluidic networks for patterning surfaces. Journal of Micromechanics & Microengineering 2001;11:532-41. 44. Kilgo MM, III, Williams C, Constantinide D. Economic fabrication of microscale features in thick resists using scanning projection lithography. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3874:305-11. 45. Kim WJ, Rife JC, Horwitz JS, et al. Movable microstructures made by two-photon three-dimensional microfabrication. MHS'99. Proceedings of 1999;:173-8. 46. Kim Y-D, Park Chan B, Clark Douglas S. Stable sol-gel microstructured and microfluidic networks for protein patterning. Biotechnology & Bioengineering. [ print] 2001;73:331-337. 47. Kramer KD, Oh KW, Ahn CH, Bao JJ, Wehmeyer KR. MEMS based micro-fluidic system for chromatographic analysis of liquid samples. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:86-93. 48. Krijnen GJM, Lammerink TSJ, Lambeck PV, Elwenspoek M. The design and fabrication of microfluidic flow sensors. ISCAS'99. Proceedings of the 1999;:136-9. 49. Kruusing A, Leppavuori S, Uusimaki A, Uusimaki M. Rapid prototyping of silicon structures by aid of laser and abrasive-jet machining. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 50. Kuebler SM, Rumi M, Watanabe T, et al. Optimizing two-photon initiators and exposure conditions for three-dimensional lithographic microfabrication. Journal of Photopolymer Science & Technology 2001;14:657-68. 51. Kugelmass SM, Lin C, DeWitt SH. Laminated ceramic components for microfluidic applications. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:95-100. 52. Lao AIK, Lee TMH, Hsing IM, Ip NY. Application of fluorine based plasma etching processes in microfluidic device fabrication. Journal of Solid State Devices & Circuits 2000;8:5-9. 53. Love JC, Anderson JR, Whitesides GM. Fabrication of three-dimensional microfluidic systems by soft lithography. MRS Bulletin 2001;26:523-8. 54. Maas D, Karl B, Saile V, Schulz J. Manufacturing of microcomponents in a research institute under DIN EN ISO 9001. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4174:416-26. 55. Madou M, Zhang YS, Xu T, Kellogg GJ, Duffy DC. Fabrication of polymer high aspect ratio structures with hot embossing for microfluidic applications. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:74-9. 56. Manginell RP, Rosato DA, Benson DA, Frye-Mason GC. Sputtered silicon carbide thin films as protective coating for MEMS applications. Surface & Coatings Technology 2000;125:1-3. 57. Martinoia S, Bove M, Tedesco M, Margesin B, Grattarola M. A simple microfluidic system for patterning populations of neurons on silicon micromachined substrates. Journal of Neuroscience Methods 1999;87:35-44.


58. Maruo S, Ikuta K, Hayato K. Light-driven MEMS made by high-speed two-photon microstereolithography. Technical Digest. MEMS 2001;:594-7. 59. Mastrangelo CH, Palaniappan S, Man PF, Burns MA, Burke DT. Fabrication and characterization of three-dimensional microfluidic arrays. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:88-94. 60. Matson DW, Martin PM, Bennett WD, Stewart DC, Bonham CC. Resolving chemical/bio-compatibility issues in microfluidic MEMS systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:101-9. 61. McDonald JC, Duffy DC, Anderson JR, et al. Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 2000;21:27-40. 62. Morishima K, Arai F, Fukuda T, Matsuura H, Yoshikawa K. Coherent macro porous silicon as a wick structure in an integrated microfluidic two-phase cooling system. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:154-62. 63. Moser I, Jobst G, Svasek P, Varahram M, Urban G. Ultraprecision microelectroforming of metals and metal alloys. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1997;3223:168-75. 64. Nam-Trung N, White RM. Three-dimensional microfabrication using two-photon activated chemistry. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;3937:97-105. 65. Paul O, Westberg D, Hornung M, Ziebart V, Baltes H. Formation of hollow microcylinders from sputtered erbium-doped glass films. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1997;2996:86-92. 66. Quake S. Taguchi optimization for SU-8 photoresist and its applications in microfluidic systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3899:440-7. 67. Quake SR, Scherer A. From micro- to nanofabrication with soft materials. Science 2000;290:1536-40. 68. Quanbo Z, Zhenfeng W, Rongming L, et al. SOI on buried cavity patterns using ion-cut layer transfer. 1998;:165-6. 69. Rainey PV, Mitchell SJN, Gamble HS. Flow-rate measurement via conductivity monitoring in microfluidic devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:185-93. 70. Rasmussen A, Zaghloul ME. Biochemical IC using micro stereolithography-towards artificial cellular device. Digest of Papers Microprocesses and Nanotechnology 2000;:26-7. 71. Rasmussen A, Gaitan M, Locascio LE, Zaghloul ME. Fabrication techniques to realize CMOS-compatible microfluidic microchannels. Journal of Microelectromechanical Systems 2001;10:286-97. 72. Rife JC, Bell MI. Selective hydrophobic and hydrophilic texturing of surfaces using photolithographic photodeposition of polymers for microfluidic sample control. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:136-43. 73. Rogers JA. Micromachined metallic pipettes and bioanalysis systems. 1997;:5-12. 74. Roulet JC, Volkel R, Herzig HP, Verpoorte E, de Rooij NF, Dandliker R. Fabrication of multilayer systems combining microfluidic and microoptical elements for fluorescence detection. Journal of Microelectromechanical Systems 2001;10:482-91. 75. Salimi-Moosavi H, Szarka R, Andersson P, Smith R, Harrison DJ. Silicon membrane nanofilters from sacrificial oxide removal. Journal of Microelectromechanical Systems 1999;8:34-42.


76. Schlautmann S, Wensink H, Schasfoort R, Elwenspoek M, van den Berg A. Powder-blasting technology as an alternative tool for microfabrication of capillary electrophoresis chips with integrated conductivity sensors. Journal of Micromechanics & Microengineering 2001;11:386-9. 77. Sheu TS, Ding PP, Chen PH. Characterizing the process of cast molding microfluidic systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:303-11. 78. Shoji S, Akahori K, Tashiro K, Sato H, Honda N. Novel microchannel system for monodispersed microspheres. Inst. Phys. Chem. Res. 2001;36:21-3. 79. Si-Hong A, Yong-Kweon K. Microgasketing and adhesive wicking techniques for fabrication of micro fluidic devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:286-91. 80. Srinivasan U, Liepmann D, Howe RT. Microstructure to substrate self-assembly using capillary forces. Journal of Microelectromechanical Systems 2001;10:17-24. 81. Sy-Hann C, Heh-Nan L, Chii-Ron Y. Sputtered coatings for microfluidic applications. AIP for American Vacuum Soc. Journal of Vacuum Science & Technology A Vacuum Surfaces & Films 2000;18:1-2. 82. Talary MS, Burt JPH, Rizvi NH, Rumsby PT, Pethig R. Microfabrication of biofactory-on-a-chip devices using laser ablation technology. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 83. Thaysen J, Marie R, Boisen A. Cantilever-based bio-chemical sensor integrated in a microliquid handling system. Technical Digest. MEMS 2001;:401-4. 84. van Rijn CJM, Nijdam W, Kuiper S, Veldhuis GJ, van Wolferen H, Elwenspoek M. Design and fabrication of a microfluidic circuitboard. Journal of Micromechanics & Microengineering 1999;9:176-9. 85. Veenstra TT, Lammerink TSJ, Sanders RGP, Elwenspoek M, Van den Berg A. Laser machined components for microanalytical and chemical separation devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3519:200-7. 86. Walsh K, Norville J, Yu-Chong T. Micromachining techniques for liquid crystal polymer. Technical Digest. MEMS 2001;:126-30. 87. Wego A, Richter S, Pagel L. Fluidic microsystems based on printed circuit board technology. Journal of Micromechanics & Microengineering 2001;11:528-31. 88. Whitesides GM, Ostuni E, Takayama S, Jiang X, Ingber DE. Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 2001;3:335-73. 89. Whitesides GM, Stroock AD. Flexible methods for microfluidics. Physics Today 2001;54:42-8. 90. Wong CC, Adkins DR, Frye-Mason GC, et al. Laminated microfluidic structures using a micromolding technique. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:139-46. 91. Xu Z, Tran E, Weichih W, Eun Sok K, Soo Young L. Sacrificial aluminum etching for CMOS microstructures. Proceedings IEEE. The Tenth Annual International Workshop on Micro Electro Mechanical Systems. An Investigation of Micro Structures, Sensors, Actuators, Machines and Robots 1997;. 92. Xuan-Qi W, Desai A, Yu-Chong T, Licklider L, Lee TD. Fabrication and characterization of a micro turbine/bearing rig. Technical Digest. IEEE International MEMS 1999;:529-33.


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INTEGRATION

(1-38) 1. Accoto D, Nedelcu OT, Carrozza MC, Dario P. A modular integrated pressure control unit for gases. Technical Digest. IEEE International MEMS 1999;:77-81. 2. Becker H, Dietz W. Novel monolithic and multilevel integration of high-precision 3-D microfluidic components. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:183-91. 3. Becker H, Heim U. Integrating microfabricated fluidic systems and NMR spectroscopy. IEEE Transactions on Biomedical Engineering 2000;47:3-7. 4. Dempsey E, Diamond D, Smyth MR, et al. Design and development of a miniaturised total chemical analysis system for on-line lactate and glucose monitoring in biological samples. Anal. Chim. Acta 1997;346:341-349. 5. Eijkel JCT, Prak A, Cowen S, Craston D, Manz A. A micromachined heated chemical reactor for pre-column derivatisation. J.Chromatogr. A 1998;:265-271. 6. Eijkel JCT, de Mello AJ, Manz A. A miniaturized total chemical analysis system: m-TAS. In: H.Masuhara H, Schryver FC, ed. Organic Mesoscopic Chemistry. Geneva: IUPAC, 1999: 185-219. 7. Erbacher C, Bessoth FG, Busch M, Verpoorte EMJ, Manz A. Towards integrated continuous-flow chemical reactors. Mikrochim. Acta 1999;131:19-24. 8. Eteshola E, Leckband D. Integrated optical measurement system for fluorescence spectroscopy in microfluidic channels. Review of Scientific Instruments 2001;72:1-2. 9. Fettinger JC, Manz A, Lüdi H, Widmer HM. Stacked modules for micro flow systems in chemical analysis: concept and studies using an enlarged mode. Sensors Actuators 1993;B17:19-25. 10. Flgeys D, Aebersold R. Micro total analysis system ( mu TAS). Electronics & Communications in Japan, Part 1999;82:21-9. 11. Freaney R, McShane A, Keaveny TV, et al. Novel instrumentation for real-time monitoring using miniaturised flow systems with integrated biosensors. Annals of Clinical Biochemistry 1997;34:291-302. 12. Keoshkeryan R, Dressler L, Schwesinger N. Microfluidic system for the integration of gas sensors. MICRO SYSTEM Technologies 1998;98:577-82.


13. Kopp MU, Crabtree HJ, Manz A. Developments in technology and applications of microsystems. Current Opinion in Chemical Biology 1997;1: 410-419. 14. Kutter JP, Mogensen KB, Friis P, et al. Integration of waveguides for optical detection in microfabricated analytical devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:98-105. 15. Liu RH, Chen H, Luehrsen KR, et al. Highly parallel integrated microfluidic biochannel arrays. Technical Digest. MEMS 2001;:439-42. 16. Manz A, Graber N, Widmer HM. Miniaturized total chemical analysis systems: a novel concept for chemical sensing. Sensors and Actuators 1990;B1:244-248. 17. Manz A, Fettinger JC, Verpoorte EMJ, Haemmerli S, Widmer HM. A stacked modular device for use in miniaturized total chemical analysis systems. In: Krahn R, Reichl H, ed. Micro System Technologies 91. Berlin: VDE-Verlag, 1991: 49-54. 18. Manz A, Fettinger JC, Verpoorte EMJ, Lüdi H, Widmer HM, Harrison DJ. Micromachining of monocrystalline silicon and glass for chemical analysis systems - A look into next century's technology or just a fashionable craze ? Trends Analytical Chemistry 1991;10:144-149. 19. Manz A, Harrison DJ, Verpoorte EMJ, Widmer HM. Planar chips technology for miniaturization of separation systems: A developing perspective in chemical monitoring. Advances in Chromatography 1993;33:1-66. 20. Manz A, Becker H, eds. Micro system technology in chemistry and life sciences. Berlin: Springer, 1998:252. 21. McCaman MT, Murakami P, Pungor E, Jr., Hahnenberger KM, Hancock WS. Analysis of recombinant adenoviruses using an integrated microfluidic chip-based system. Analytical Biochemistry 2001;291:262-8. 22. Miki N, Shimoyama I. A micro-channel heat sink with integrated temperature sensors for phase transition study. Technical Digest. IEEE International MEMS 1999;:159-64. 23. Quiram DJ, Jensen KF, Schmidt MA, et al. Package level integration of silicon microfabricated reactors to form a miniature reactor test system. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:166-9. 24. Rong Y, Minxian W, Guofan J. Integrated micro-optical and microfluidic system for micro total analysis system. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:208-11. 25. Sanders GHW, Manz A. Chip-based microsystems for genomic and proteomic analysis. Trends Analytical Chemistry 2000;19:364-378. 26. Santiago JG, Wereley ST, Meinhart CD, Beebe DJ, Adrian RJ. Integration of micropump and microflow sensor. Journal of Functional Materials & Devices 1998;4:101-4. 27. Smith JS. High density, low parasitic direct integration by fluidic self assembly (FSA). International Electron Devices Meeting 2000;:201-4. 28. Tolfree DWL. Micro total analysis system ( mu TAS) chemical analysis. Transactions of the Institute of Electronics, Information and Communication Engineers C I 1998;:385-93. 29. Trumbull JD, Glasgow IK, Beebe DJ, Magin RL. Specific bio-recognition reactions observed with an integrated Mach-Zehnder interferometer. Biosensors & Bioelectronics 1999;14:405-11. 30. Verpoorte EMJ, Manz A, Lüdi H, Widmer.H.M. A novel optical detector cell for use in miniaturized total chemical analysis systems. Transducers '91, Digest of Technical Papers 1991;: 796-799.


31. Verpoorte EMJ, Manz A, Lüdi H, et al. A silicon flow cell for optical detection in miniaturized total chemical analysis systems. Sens. Actuators 1992;B6:66-70. 32. Verpoorte EMJ, Manz A, Widmer HM, van der Schoot BH, de Rooij NF. A three-dimensional micro flow system for a multi-step chemical analysis. In: Transducers '93 Digest of Technical Papers. Tokyo: Institute of Electrical Engineers of Japan, 1993: 939-942. 33. Verpoorte EMJ, van der Schoot BH, S.Jeanneret S, Manz A, Widmer HM, de Rooij NF. Three-dimensional micro flow manifolds for miniaturized chemical analysis systems. J. Micromech. Microeng. 1994;4:246-256. 34. Verpoorte EMJ, van der Schoot BH, Jeanneret S, Manz A, de Rooij NF. Silicon-based chemical microsensors and microsystems. ACS Symposium Series 1994;561:244-254. 35. Wang PC, DeVoe DL, Lee CS. Integration of polymeric membranes with microfluidic networks for bioanalytical applications. Electrophoresis 2001;22:3857-67. 36. Warren ME, Sweatt WC, Wendt JR, et al. Novel, highly sensitive chemical and biological sensors based on integrated MOEM and MEMS technologies. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3878:193-8. 37. Yang Z, Matsumoto S, Goto H, Matsumoto M, Maeda R. Design of integrated microfluidic device for sorting magnetic beads in biological assays. IEEE. IEEE Transactions on Magnetics 2001;37:2621-3. 38. Zhou S, Kilgo MM, III, Williams C. Integration of microfluidics/electrochemical system for trace metal analysis by stripping voltammetry. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:248-56.

PLASTIC MICROCHIPS

(1-34) 1. Anderson JR, Chiu DT, Jackman RJ, et al. Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Analytical Chemistry 2000;72:3158-64. 2. Bauer C, Dietrich S. Design rules for polyimide solvent bonding. Sensors & Materials 1999;11:269-78. 3. Becker H, Gartner C. Polymer microfabrication methods for microfluidic analytical applications. Electrophoresis 2000;21:12-26. 4. Becker H, Gaertner C. Polymer microfabrication methods for microfluidic analytical applications. Electrophoresis 2000;21:12-26. 5. Becker H, Roetting O, Roepke W, Heim U. Polymer microfluidics: The technology chain. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:106-11. 6. Blankenstein G. Microfluidic applications of polymer microsystems. Mst News 2000;4:20-1. 7. Chen YH, Chen SH. Analysis of DNA fragments by microchip electrophoresis fabricated on poly(methyl methacrylate) substrates using a wire-imprinting method. Electrophoresis 2000;21:165-70. 8. Chen Y, Chen Z, Zhao Y, et al. Test channels for flow characterization of processed plastic microchannels. Materials Science of Microelectromechanical Systems 2000;605:253-9. 9. Dharmatilleke S, Henderson HT, Bhansali S, Ahn CH. Three-dimensional silicone microfluidic interconnection scheme using sacrificial wax filaments. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:90-7.


10. Dickey CK, Elmore BB, Jones F. Enzyme catalyzed biochemical production in a polydimethylsiloxane microreactor. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:56-64. 11. Duffy DC, Schueller OJA, Brittain ST, Whitesides GM. Rapid prototyping of microfluidic switches in poly(dimethyl siloxane) and their actuation by electro-osmotic flow. Journal of Micromechanics & Microengineering 1999;9:211-17. 12. Glasgow IK, Beebe DJ, White VE. Polymer hot embossing with silicon master structures. Sensors & Materials 1999;11:297-304. 13. Golubovic NC, Qinghua K, Henderson HT, Pinto N. Integrated capillary electrophoresis using glass and plastic chips for multiplexed DNA analysis. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:94-103. 14. Gwo-Bin L, Shu-Hui C, Guan-Ruey H, Yen-Heng L, Wang-Chou S. Microfabricated plastic chips by hot embossing methods and their applications for DNA separation and detection. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:112-21. 15. Hofmann O, Niedermann P, Manz A. Modular approach to fabrication of three-dimensional microchannel systems in PDMS – application to sheath flow microchips. Lab on a Chip 2001;1:108-114. 16. Janshoff A, Kunneke S. Micropatterned solid-supported membranes formed by micromolding in capillaries. European Biophysics Journal 2000;29:549-54. 17. Johnson RD, Badr IH, Barrett G, et al. Development of a fully integrated analysis system for ions based on ion-selective optodes and centrifugal microfluidics. Anal Chem 2001;73:3940-6. 18. Kameoka J, Craighead HG, Zhang H, Henion J. A polymeric microfluidic chip for CE/MS determination of small molecules. Analytical Chemistry 2001;73:1935-41. 19. Kwok YC, Jeffery NT, Manz A. Velocity measurement of particles flowing in a microfluidic chip using Shah convolution Fourier transform detection. Analytical Chemistry 2001;73:1748-53. 20. Linder V, Verpoorte E, Thormann W, de Rooij NF, Sigrist H. Surface biopassivation of replicated poly(dimethylsiloxane) microfluidic channels and application to heterogeneous immunoreaction with on-chip fluorescence detection. Analytical Chemistry 2001;73:4181-9. 21. Lorenzen D. Chemical mapping of hot-embossed and UV-laser-ablated microchannels in poly(methyl methacrylate) using carboxylate specific fluorescent probes. Applied Surface Science 2001;181:1-2. 22. Martin PM, Matson DW, Bennett WD, Hammerstrom DJ. Microfluidic devices for mu -TAS applications fabricated by polymer hot embossing. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:177-82. 23. Martynova L, Locascio LE, Gaitan M, Kramer GW, Christensen RG, MacCrehan WA. Fabrication of plastic microfluid channels by imprinting methods. Analytical Chemistry 1997;69:4783-9. 24. Matzke CM, Arnold DW, Ashby CIH, Kravitz SH, Warren ME, Bailey CG. Fabrication of plastic microfluidic components. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:172-6. 25. McNeely MR, Spute MK, Tusneem NA, Oliphant AR. Fabrication of three-dimensional microfluidic systems by stacking molded polydimethylsiloxane (PDMS) layers. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:222-9. 26. Meinhart CD, Zhang H. Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer. Journal of Microelectromechanical Systems 2000;9:76-81.


27. Monahan J, Gewirth AA, Nuzzo RG. A method for filling complex polymeric microfluidic devices and arrays. Analytical Chemistry 2001;73:3193-7. 28. Niggemann M, Ehrfeld W, Weber L, Gunther R, Sollbohmer O. Miniaturized plastic micro plates for applications in HTS. Microsystem Technologies 1999;6:48-53. 29. Robertson JK, Wise KD. Polymerization optimization of SU-8 photoresist and its applications in microfluidic systems and MEMS. Journal of Micromechanics & Microengineering 2001;11:20-6. 30. Sethu P, Yu H, Grodzinski P, Mastrangelo CH. Fabrication of genetic analysis microsystems using plastic microcasting. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:175-8. 31. Van Drieenhuizen BP. Polymers-an excellent and increasingly used material for microsystems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3876:172-84. 32. Wu S, Mai J, Tai YC, Ho CM. Re-configurable fluid circuits by PDMS elastomer micromachining. Technical Digest. IEEE International MEMS 1999;:222-7. 33. Yu-Cheng L, Hsiao-Ching H, Chien-Kai T, Shao-Qin H. A poly-methylmethacrylate electrophoresis microchip with sample preconcentrator. Journal of Micromechanics & Microengineering 2001;11:189-94. 34. Zhao M, Boone TD, Qiu XC, Ricco AJ. Distribution and mixing of reagents on multichannel plastic chips. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:183-6.

SIMULATION AND MODELING

(1-42) 1. Aktas O, Aluru NR, Ravaioli U. Application of a parallel DSMC technique to predict flow characteristics in microfluidic filters. Journal of Microelectromechanical Systems 2001;10:538-49. 2. Anduze M, Colin S, Caen R, Camon H, Conedera V, Do Conto T. Mixing characteristics of T-type microfluidic mixers. Journal of Micromechanics & Microengineering 2001;11:126-32. 3. Bau HH, Jihua Z, Mingqiang Y. Automated generation of compact models for fluidic microsystems. Analog Integrated Circuits & Signal Processing 2001;29:1-2. 4. Becker H, Heim U. Optimization of sample injection components in electrokinetic microfluidic systems. Technical Digest. IEEE International MEMS 1999;:309-14. 5. Bohringer KF, Srinivasan U, Howe RT. Modeling of capillary forces and binding sites for fluidic self-assembly. Technical Digest. MEMS 2001;:369-74. 6. Cooper EB, Fritz J, Wiegand G, Wagner P, Manalis SR. Electro-viscous effects on pressure-driven liquid flow in microchannels. Colloids & Surfaces A Physicochemical & Engineering Aspects 2001;195:1-3. 7. Darlo P, Carrozza MC, Benvenuto A, Menciassl A. Modelling of micropumps using unimorph piezoelectric actuator and ball valves. Journal of Micromechanics & Microengineering 2000;10:277-81. 8. Deshpande M, Greiner KB, West J, Gilbert JR, Bousse L, Minalla A. Predictive design of reverse injection mechanism for electrokinetic DNA sample injection. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:128-31. 9. Ducree J, de Heij B, Sandmaier H, Zengerie R. Automated generation of compact models for fluidic microsystems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4019:30-8.


10. Enchao Y, DeMing W, Sura K, Przekwas A. Acoustic streaming in micromachined flexural plate wave devices: numerical simulation and experimental verification. IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 2000;47:1463-71. 11. Evan Kamholz A, Schilling EA, Yager P. Optical measurement of transverse molecular diffusion in a microchannel. Biophysical Journal 2001;80:1967-72. 12. Giridharan MG, Krishnamoorthy S, Krishnan A. Computational simulation of microfluidics, electrokinetics, and particle transport in biological MEMS devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 13. Grasegger JM. Optimal design of a microfluidic system with piezoactuator for droplets generation. MICRO SYSTEM Technologies 1998;98:551-6. 14. Harley J. Advances in computer-aided design of microfluidics for applications in biotechnology. Abstracts of Papers American Chemical Society. [ print] 2001;221:210. 15. Hegab HE, Liu G. Fluid flow modeling of micro-orifices using micropolar fluid theory. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:271-81. 16. Huff MA, Benard WL. Design optimization using evolutionary algorithms at hand of a micropump. Atp, Automatisierungstechnische Praxis 1998;40:50-5. 17. Jang J, Lee SS. A modified direct simulation Monte Carlo method for low-speed microflows. Journal of Micromechanics & Microengineering 2000;10:21-7. 18. Jie D, Chakrabarty K, Fair RB. Scheduling of microfluidic operations for reconfigurable two-dimensional electrowetting arrays. IEEE Transactions on Computer Aided Design of Integrated Circuits & Systems 2001;20:1463-8. 19. Jun-Bo Y, Chul-Hi H, Euisik Y, Choong-Ki K. Simulation of fluid-structure interaction in micropumps by coupling of two commercial finite element programs. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:194-204. 20. Kamholz AE, Schilling EA, Yager P. Optical measurement of transverse molecular diffusion in a microchannel. Biophysical Journal 2001;80:1967-72. 21. Kamholz AE, Yager P. Theoretical analysis of molecular diffusion in pressure-driven laminar flow in microfluidic channels. Biophysical Journal 2001;80:155-60. 22. Klein A, Gerlach G. First principles based approach to modeling of microfluidic systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:205-16. 23. Ledezma GA, Folch A, Bhatia SN, Balis UJ, Yarmush ML, Toner M. Cad tools for lab-on-a-chip systems. IEE Seminar Microengineering, Modelling and Design 1999;2:1-4. 24. Lowe H, Ehrfeld W, Diebel J. Design and modelling for a thermal flow sensor. 1997;:511-14. 25. Maruo S, Ikuta K. Thermal ink jet dynamics: modeling, simulation, and testing. Microelectronics & Reliability 2000;40:525-32. 26. Matzke CM, Ashby CIH, Bridges M, Griego L, Wong C. Modeling transport in gas chromatography columns for the Micro-ChemLab/sup TM. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:120-9.


27. Mehta A, Helmicki AJ. Numerical framework for the modeling of electrokinetic flows in microfluidic devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:217-27. 28. Molho JI, Herr AE, Mosier BP, et al. A low dispersion turn for miniaturized electrophoresis. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:132-7. 29. Nagel DJ. Design of MEMS and microsystems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 30. Rasmussen A, Zaghloul ME. A hierarchical approach to stochastic discrete and continuous performance simulation using composable software components. Microelectronics Journal 2000;31:95-104. 31. Rebenklau L, Wolter KJ, Howitz S. Navier-Stokes simulation of gas flow in micro devices. Journal of Micromechanics & Microengineering 2000;10:372-9. 32. Russell GB, Black WZ, Glezer A, Hartley JG. Computer modeling of flow and heat transfer in a MEMS based air microjet array impingement cooling device. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3906:201-6. 33. Sbalzarini IF, Muller S, Koumoutsakos P. Microchannel optimization using multiobjective evolution strategies. Evolutionary Multi Criterion Optimization. First International Conference, EMO 2001;1993:516-30. 34. Sharipov F. The pumping effect of growing and collapsing bubbles in a tube. Journal of Micromechanics & Microengineering 1999;9:402-13. 35. Shrewsbury PJ, Muller SJ, Liepmann D. Meshless analysis of steady-state electro-osmotic transport. Journal of Microelectromechanical Systems 2000;9:435-49. 36. Sugiura S, Nakajima M, Seki M. Modeling a microfluidic system using Knudsen's empirical equation for flow in the transition regime. Journal of Vacuum Science & Technology A Vacuum Surfaces & Films 2001;19:358-64. 37. Tianhao Z, Feng C, Dewey AM, Fair RB, Chakrabarty K. Performance analysis of microelectrofluidic systems using hierarchical modeling and simulation. IEEE Transactions on Circuits & Systems II Analog & Digital Signal Processing 2001;48:482-91. 38. Vargo SE, Muntz EP. Prediction of mixing of two parallel gas streams in a microchannel using the direct simulation Monte Carlo method. AIP. American Institute of Physics Conference Proceedings, no 2001;585:510-17. 39. Veijola T, Turowski M. Compact damping models for laterally moving microstructures with gas-rarefaction effects. Journal of Microelectromechanical Systems 2001;10:263-73. 40. Wagner F, Hoffmann PW. Taylor dispersion of a solute in a microfluidic channel. Journal of Applied Physics 2001;89:4667-9. 41. Wilkinson M. Microsystems: how to access the technology. Medical Device Technology 2000;11:24, 28, 30. 42. Xu D, Ng TY, Pan LS, Lam KY, Hua L. Numerical simulations of fully developed turbulent liquid flows in micro tubes. Journal of Micromechanics & Microengineering 2001;11:175-80.

THERMAL CONTROL DEVICES

(1-11) 1. Bayt RL, Breuer KS. A silicon heat exchanger with integrated intrinsic-point heater demonstrated in a micropropulsion application. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:56-9.


2. Dai J, Xu D, Khoo Boo C, Lam Khin Y. Transient temperature performance of an integrated micro-thermal system. Journal of Micromechanics & Microengineering 2000;10:466-76. 3. Hestroni G, Mosyak A, Segal Z. Nonuniform temperature distribution in electronic devices cooled by flow in parallel microchannels. IEEE Transactions on Components & Packaging Technologies 2001;24:16-23. 4. Kuan C, Jing-Yu C. A Joule-Thompson cooler fabricated from micro tubes of different diameters. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3795:248-58. 5. Linan J, Man W, Zohar Y. Micro jet array heat sink for power electronics. Technical Digest. IEEE International MEMS 1999;:165-70. 6. Ling Z, Banerjee SS, Jae-Mo K, et al. A micro heat exchanger with integrated heaters and thermometers. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:275-80. 7. Pan LS, Liu GR, Khoo BC, Song B. Heat-transfer analysis of microfabricated thermocapillary pumping and reaction devices. Journal of Micromechanics & Microengineering 2000;10:42-55. 8. Qiao R, Aluru NR. Design and fabrication of a cross flow micro heat exchanger. Journal of Microelectromechanical Systems 2000;9:502-8. 9. Shulin Z, Chuan-Hua C, Mikkelsen JC, Jr., Santiago JG. Active cooling of integrated circuits and optoelectronic devices using a micro configured thermoelectric and fluidic system. Itherm 2000;:134-9. 10. Stefanescu S, Mehregany M, Leland J, Yerkes K. Micro heat exchanger by using MEMS impinging jets. Technical Digest. IEEE International MEMS 1999;:171-6. 11. Unger K, Muller D, Lorenzen D, Daiminger F. Controlling diode laser bar temperature by micro channel liquid cooling. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3825:80-91.

II. MICROFLUIDICS

GENERAL

(1-142) 1. Abrantes M, Magone MT, Boyd LF, Schuck P. Adaptation of a surface plasmon resonance biosensor with microfluidics for use with small sample volumes and long contact times. Anal Chem 2001;73:2828-35. 2. Bachman M, Chiang YM, Chu C, Li GP. Effects of rectangular microchannel aspect ratio on laminar friction constant. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:147-58. 3. Baechi D, Buser R, Dual J. From micro- to nanoparticle manipulation. Journal of Nanoparticle Research 2000;2:393-9. 4. Baldock SJ, Goddard NJ, Fielden PR. Development and characterization of microfluidic devices and systems for magnetic bead-based biochemical detection. Biomedical Microdevices 2001;3:191-200. 5. Barbic M, Mock JJ, Gray AP, Schultz S. Electromagnetic micromotor for microfluidics applications. Applied Physics Letters 2001;79:1399-401. 6. Barker SL, Ross D, Tarlov MJ, Gaitan M, Locascio LE. Control of flow direction in microfluidic devices with polyelectrolyte multilayers. Anal Chem 2000;72:5925-9. 7. Beard DA. Response to "Comment on `Taylor dispersion of a solute in a microfluidic channel' [J. Appl. Phys. 90, 6553 (2001)]". Journal of Applied Physics 2001;90:6555-6.


8. Blom MT, Chmela E, Gardeniers JGE, et al. Local anodic bonding of Kovar to Pyrex aimed at high-pressure, solvent-resistant microfluidic connections. Journal of Micromechanics & Microengineering 2001;11:382-5. 9. Bohm S, Olthuis W, Bergveld P. Micro-systems in biomedical applications. Journal of Micromechanics & Microengineering 2000;10:235-44. 10. Bousse L. Electrokinetic microfluidic systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3874:2-8. 11. Brahmasandra SN, Johnson BN, Webster JR, Burke DT, Mastrangelo CH, Burns MA. Design of microfluidic sample preconditioning systems for detection of biological agents in environmental samples. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:252-9. 12. Brazzle JD, Mohanty S, Frazier AB. A micro fluidic system of microchannels with on-site sensors by silicon bulk micromachining. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:267-72. 13. Brazzle J, Bartholomeusz D, Davies R, Andrade J, van Wagenen RA, Frazier AB. Active microneedles with integrated functionality. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:199-202. 14. Cabrera CR, Finlayson B, Yager P. Formation of natural pH gradients in a microfluidic device under flow conditions: model and experimental validation. Analytical Chemistry 2001;73:658-66. 15. Cai H, Zhou Z, Li Y, Ye X, Yang Y. Screening of single Escherichia coli by electric field and laser tweezer. 1997;:155-60. 16. Chang-Jin K. Chemo- and biosensor microsystems for clinical applications. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3539:46-50. 17. Chang-Jin K. Microfluidics using the surface tension force in microscale. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:49-55. 18. Chi-Hoon J, Chang-Auck C, Won-Ick J, Youn Tae K. Silicon surface micromachining of a deep vacuum cavity structure and its application to a microflow sensor. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4174:164-71. 19. Chiang YM, Bachman M, Chu C, Li GP. Electrokinetic microfluidic systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3879:2-8. 20. Chu ZK-H. A low-pressure encapsulated resonant fluid density sensor with feedback control electronics: Slip flow in an annulus with corrugated walls. Measurement Science & Technology 2000;11:205-11. 21. Chuang-Chia L, Ghodssi R, Ayon AA, et al. Manipulation of a round jet with electromagnetic flap actuators. Technical Digest. IEEE International MEMS 1999;:534-40. 22. Conway P. Microfluidics enabled drug discovery-high throughput synthesis and screening. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 1997;371997:388. 23. Cousseau P, Hirschi R, Frehner B, Gamper S, Maillefer D. Improved micro-flow regulator for drug delivery systems. Technical Digest. MEMS 2001;:527-30. 24. Cui L, Morgan H. The flow structure inside a microfabricated inkjet printhead. Journal of Microelectromechanical Systems 2000;9:67-75.


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MIXING

(1-14) 1. Bertsch A, Heimgartner S, Cousseau P, Renaud P. 3D micromixers-downscaling large scale industrial static mixers. Technical Digest. MEMS 2001;:507-10. 2. Bessoth FG, de Mello AJ, Manz A. Microstructure for efficient continuous flow mixing. Anal. Comm. 1999;36:213-215. 3. Desmukh AA, Liepmann D, Pisano AP. Continuous micromixer with pulsatile micropumps. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:73-6. 4. Franz AJ, Jensen KF, Schmidt MA. Droplet-based nano/picoliter mixer using hydrophobic microcapillary vent. Technical Digest. IEEE International MEMS 1999;:388-93. 5. He B, Burke BJ, Zhang X, Zhang R, Regnier FE. A picoliter-volume mixer for microfluidic analytical systems. Analytical Chemistry 2001;73:1942-7. 6. Jin-Woo C, Ahn CH. Active microfluidic mixer for mixing of microparticles and liquids. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:154-61. 7. Jin-Woo C, Ahn CA. An active micro mixer using electrohydrodynamic (EHD) convection for microfluidic-based biochemical analysis. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:52-5. 8. Junghoon L, Chang-Jin K. Passive mixing in a three-dimensional serpentine microchannel. Journal of Microelectromechanical Systems 2000;9:190-7. 9. Kakuta M, Bessoth FG, Manz A. Microfabricated devices for fluid mixing and their application for chemical synthesis. Chemical Record 2001;1:395-405. 10. Liu Y, Wipf DO, Henry CS. Conductivity detection for monitoring mixing reactions in microfluidic devices. Analyst 2001;126:1248-51. 11. Ruano JM, Ortega D, Bonar JR, et al. Improved characterization technique for micromixers. Journal of Micromechanics & Microengineering 1999;9:156-8. 12. Schabmueller CGJ, Koch M, Evans AGR, Brunnschweiler A. Characterization method for a new diffusion mixer applicable in micro flow injection analysis systems. Journal of Micromechanics & Microengineering 1999;9:199-202.


13. Stremler MA, Olsen MG, Jo BH, Adrian RJ, Aref H, Beebe DJ. Chaotic mixing in microfluidic systems. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:187-90. 14. Yang Z, Goto H, Matsumoto M, Maeda R. Active micromixer for microfluidic systems using lead-zirconate-titanate (PZT)-generated ultrasonic vibration. Electrophoresis 2000;21:116-9.

VALVES

(1-23) 1. Alarie JP, Jacobson SC, Culbertson CT, Ramsey JM. Effects of the electric field distribution on microchip valving performance. Electrophoresis 2000;21:100-6. 2. Baechi D, Dual J, Buser R. A high density microchannel network with integrated valves and photodiodes. Technical Digest. MEMS 2001;:463-6. 3. Chaudhari AM, Woudenberg TM, Albin M, Goodson KE. Development of a MEMS microvalve array for fluid flow control. Journal of Microelectromechanical Systems 1998;7:395-403. 4. Christel LA, Petersen K, McMillan W, Kovacs GTA. Contoured elastic-membrane microvalves for microfluidic network integration biochemical/biological processing application. Journal of Biomechanical Engineering 1999;121:2-6. 5. Feustel A, Krusemark O, Muller J. Piezoelectric membrane pump with integrated ball valves. Actuator 1998;98:39-42. 6. Gravesen P, Branebjerg J, Jensen OS. Active valves and pumps for microfluidics. Journal of Micromechanics & Microengineering 1993;3:216-18. 7. Jiang L, Wong M, Zohar Y. An integrated liquid mixer/valve. Journal of Microelectromechanical Systems 2000;9:295-302. 8. Jun X, Xing Y, Xuan-Qi W, Yu-Chong T. Surface micromachined leakage proof Parylene check valve. Technical Digest. MEMS 2001;:539-42. 9. Matsumoto S, Klein A, Maeda R. A practical thermopneumatic valve. Technical Digest. IEEE International MEMS 1999;:147-52. 10. Papavasilliou AP, Liepmann D, Pisano AP. Electrolysis-bubble actuated gate valve for insulin injection application. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:48-51. 11. Przekwas AJ, Yang HQ, Athavale MM. Computational design of membrane pumps with active/passive valves for microfluidic MEMS. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3680:1-2. 12. Rich CA, Wise KD. Development of bi-directional valve-less micropump for liquid. Technical Digest. IEEE International MEMS 1999;:141-6. 13. Roberts DC, Hagood NW, Su Y, Li H, Carretero JA. Design of a piezoelectrically-driven hydraulic amplification microvalve for high-pressure, high-frequency applications. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;3985:616-28. 14. Sadler DJ, Liakopoulos TM, Cropp J, Ahn CH, Henderson HT. Liquid and gas-liquid phase behavior in thermopneumatically actuated microvalves. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:53-63.


15. Schaible J, Messner S, Muller M, Fuchs N, Sandmaier H, Zengerle R. An 8-bit microflow controller using pneumatically-actuated microvalves for semiconductor process gases. Technical Digest. IEEE International MEMS 1999;:130-4. 16. Schwesinger N, Bechtel S. Prototype microvalve using a new magnetic microactuator. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:46-52. 17. Takahashi K, Yoshino K, Hatano S, Nagayama K, Asano T. Responsive biomimetic hydrogel valve for microfluidics. Applied Physics Letters 2001;78:2589-91. 18. Tesar V. Microfluidic valves for flow control at low Reynolds numbers. Journal of Visualization 2001;4:51-60. 19. Unger MA, Chou HP, Thorsen T, Scherer A, Quake SR. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 2000;288:113-6. 20. Whelan J. Microscale valves drive progress in microfluidics. Drug Discov Today 2001;6:1134-1135. 21. Wu CH, Scampavia L, Ruzicka J, Zamost B. Micro sequential injection: fermentation monitoring of ammonia, glycerol, glucose, and free iron using the novel lab-on-valve system. Analyst 2001;126:291-7. 22. Young AM, Bloomstein TM, Palmacci ST. Contoured elastic-membrane microvalves for microfluidic network integration. Journal of Biomechanical Engineering 1999;121:2-6. 23. Yuen PK, Kricka LJ, Wilding P. Semi-disposable microvalves for use with microfabricated devices or microchips. Journal of Micromechanics and Microengineering 2000;:401-409.

PUMPS

(1-15) 1. Accoto D, Carrozza MC, Dario P. Experimental study on thermally actuated micropump. Journal of Functional Materials & Devices 2000;6:65-70. 2. Ajdari A. Pumping liquids using asymmetric electrode arrays. Physical Review E. Statistical Physics, Plasmas, Fluids, & Related Interdisciplinary Topics 2000;61. 3. Brazzle JD, Papautsky I, Frazier AB. Acousto- and electroosmotic microfluidic controllers. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:125-35. 4. Harada T, Sasaki Y, Kouno A. Development of high-power micropump. Transactions of the Institute of Electronics, Information & Communication Engineers C II 1999;:551-6. 5. Harrison DJ, Manz A, Glavina PG. Electroosmotic pumping within a chemical sensor system integrated on silicon. Transducers '91, Digest of Technical Papers 1991;:792-795. 6. Ikuta K, Hasegawa T, Adachi T. SMA micro pumps and switching valves for biochemical IC family. MHS2000. Proceedings of 2000;:169-74. 7. Kashani R, Kang S, Hallinan KP. Electrohydrodynamic pumped hydraulic actuation with application to active vibration control. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3675:180-9. 8. Kashani R, Kang S, Hallinan KP. Micro-scale electrohydrodynamic pumped high performance actuation. Technomic Publishing. Journal of Intelligent Material Systems & Structures 2000;11:343-50.


9. Laritz C, Pagel L. An intelligent micro-fluidic system for drug delivery. Proceedings of IEEE International Conference on Industrial Technology 2000;:70-5. 10. Linnemann R, Richter M, Leistner A, Woias P. A full-wafer mounted self-priming and bubble-tolerant piezoelectric silicon micropump. Actuator 1998;98:78-81. 11. Lissorgues G, Sevely L, Francais O, et al. Initial results from the first MEMS fabricated thermal transpiration-driven vacuum pump. AIP. American Institute of Physics Conference Proceedings 2001;585:502-9. 12. Manz A, Harrison DJ, Fettinger JC, Verpoorte EMJ, Lüdi H, Widmer HM. Integrated electroosmotic pumps and flow manifolds for total chemical analysis systems. Transducers '91, Digest of Technical Papers 1991;:939-941. 13. McKnight TE, Culbertson CT, Jacobson SC, Ramsey JM. Electroosmotically induced hydraulic pumping with integrated electrodes on microfluidic devices. Analytical Chemistry 2001;73:4045-9. 14. Xiaohao Z, Zhaoying Z, Xiongying Y, Yong L, Wendong Z. A PZT-driven micropump. MHA'98. Proceedings of the 1998;:269-72. 15. Xu N, Hu W-L, Guo Z-Y. Study on the efficiency of thermal actuated micropump. Journal of Functional Materials & Devices 2001;7:121-4.

III. APPLICATIONS

AMPLIFICATION REACTIONS

(1-53) 1. Belgrader P, Benett W, Hadley D, et al. Rapid pathogen detection using a microchip PCR array instrument. Clin Chem 1998;44:2191-4. 2. Belgrader P, Hansford D, Kovacs GT, et al. A minisonicator to rapidly disrupt bacterial spores for DNA analysis. Anal Chem 1999;71:4232-6. 3. Belgrader P, Okuzumi M, Pourahmadi F, Borkholder DA, Northrup MA. A microfluidic cartridge to prepare spores for PCR analysis. Biosensors & Bioelectronics 2000;14:849-52. 4. Brdicka R. [Bird's eye view of laboratories--report on symposia]. Cas Lek Cesk 1998;137:700-1. 5. Cantafora A, Blotta I, Bruzzese N, Calandra S, Bertolini S. Rapid sizing of microsatellite alleles by gel electrophoresis on microfabricated channels: application to the D19S394 tetranucleotide repeat for cosegregation study of familial hypercholesterolemia. Electrophoresis 2001;22:4012-5. 6. Chen Y-H, Wang W-C, Young K-C, Chang T-T, Chen S-H. Plastic microchip electrophoresis for analysis of PCR products of hepatitis C virus. Clinical Chemistry 1999;45:1938-1943. 7. Cheng J, Shoffner MA, Hvichia GE, Kricka LJ, Wilding P. Thermal cycling and surface passivation of micromachined devices for PCR. Clinical Chemistry 1995;41:1367-1368. 8. Cheng J, Shoffner MA, Hvichia GE, Kricka LJ, Wilding P. Chip PCR. II. Investigation of different PCR amplification systems in microbabricated silicon-glass chips. Nucleic Acids Res 1996;24:380-5. 9. Cheng J, Shoffner MA, Mitchelson KR, Kricka LJ, Wilding P. Analysis of ligase chain reaction (LCR) products amplified in a silicon chip using entangled solution capillary electrophoresis (ESCE). Journal of Chromatography A 1996;732:151-158.


10. Cheng J, Waters LC, Fortina P, et al. Degenerate oligonucleotide primed-polymerase chain reaction and capillary electrophoretic analysis of human DNA on microchip-based devices. Analytical Biochemistry 1998;256:101-106. 11. Foedinger M, Sunder-Plassmann G, Wagner Oswald F. Trends in molecular diagnostics. Wiener Klinische Wochenschrift 1999;111:315-319. 12. Fortina P, Cheng J, Kricka LJ, et al. DOP-PCR amplification of whole genomic DNA and microchip-based capillary electrophoresis. Methods Mol Biol 2001;163:211-9. 13. Fujita S-I, Senda Y, Nakaguchi S, Hashimoto T. Multiplex PCR using internal transcribed spacer 1 and 2 regions for rapid detection and identification of yeast strains. Journal of Clinical Microbiology 2001;39:3617-3622. 14. Gao DQ, Makroglou G, Liu S, et al. High-throughput di-nucleotide short tandem repeats (STR) genotyping by electrophoresis on microchip. International Genome Sequencing & Analysis Conference 1220;:60-61. 15. Giordano BC, Ferrance J, Swedberg S, Huhmer AFR, Landers JP. Polymerase chain reaction in polymeric microchips: DNA amplification in less than 240 seconds. Analytical Biochemistry 2001;291:124-132. 16. Giordano BC, Copeland ER, Landers JP. Towards dynamic coating of glass microchip chambers for amplifying DNA via the polymerase chain reaction. Electrophoresis 2001;22:334-40. 17. Henning AK, Firch JS, Harris JM, et al. Transient liquid crystal thermometry of microfabricated PCR vessel arrays. Journal of Microelectromechanical Systems 1998;7:345-55. 18. Hofgartner WT, Huhmer AF, Landers JP, Kant JA. Rapid diagnosis of herpes simplex encephalitis using microchip electrophoresis of PCR products. Clin Chem 1999;45:2120-8. 19. Hong JW, Fujii T, Seki M, Yamamoto T, Endo I. Integration of gene amplification and capillary gel electrophoresis on a polydimethylsiloxane-glass hybrid microchip. Electrophoresis 2001;22:328-33. 20. Huhmer AF, Landers JP. Noncontact infrared-mediated thermocycling for effective polymerase chain reaction amplification of DNA in nanoliter volumes. Anal Chem 2000;72:5507-12. 21. Ibrahim MS, Lofts RS, Jahrling PB, et al. Real-time microchip PCR for detecting single-base differences in viral and human DNA. Anal Chem 1998;70:2013-7. 22. Jiang G, Harrison DJ. mRNA isolation in a microfluidic device for eventual integration of cDNA library construction. Analyst 2000;125:2176-9. 23. Jing G, Zhang J, Zhu X, et al. Temperature control system for biochemical reactions in microchip-based devices. Tsinghua Science & Technology 2001;6:269-72. 24. Jovanovich S, Hadd A, Liu S, et al. Nanoscale preparation of DNA samples for a microchip-based DNA analysis system. International Genome Sequencing & Analysis Conference. [ print] 1220;:70. 25. Jovanovich Stevan B, Salas O, Hadd A, et al. Nanoscale preparation of DNA samples for a microchip-based DNA analysis system. Abstracts of Papers American Chemical Society. [ print] 2001;222. 26. Khandurina J, McKnight TE, Jacobson SC, Waters LC, Foote RS, Ramsey JM. Integrated system for rapid PCR-based DNA analysis in microfluidic devices. Analytical Chemistry 2000;72:2995-3000. 27. Kopp MU, Mello AJ, Manz A. Chemical amplification: continuous-flow PCR on a chip. Science 1998;280:1046-8. 28. Lagally ET, Medintz I, Mathies RA. Single-molecule DNA amplification and analysis in an integrated microfluidic device. Analytical Chemistry 2001;73:565-70.


29. Medintz I, Wong WW, Berti L, et al. High-performance multiplex SNP analysis of three hemochromatosis-related mutations with capillary array electrophoresis microplates. Genome Res 2001;11:413-21. 30. Mikhailovich VM, Lapa SA, Gryadunov DA, et al. Detection of rifampicin-resistant Mycobacterium tuberculosis strains by hybridization and polymerase chain reaction on a specialized TB-microchip. Bull Exp Biol Med 2001;131:94-8. 31. Mitchelson Keith R, Cheng J, Kricka Larry J. The use of capillary electrophoresis for point-mutation screening. Trends in Biotechnology 1997;15:448-458. 32. Munro NJ, Snow K, Kant JA, Landers JP. Molecular diagnostics on microfabricated electrophoretic devices: from slab gel- to capillary- to microchip-based assays for T- and B-cell lymphoproliferative disorders. Clin Chem 1999;45:1906-17. 33. Munro NJ, Huhmer AF, Landers JP. Robust polymeric microchannel coatings for microchip-based analysis of neat PCR products. Anal Chem 2001;73:1784-94. 34. Nemoda Z, Ronai Z, Szekely A, et al. High-throughput genotyping of repeat polymorphism in the regulatory region of serotonin transporter gene by gel microchip electrophoresis. Electrophoresis 2001;22:4008-4011. 35. Proudnikov D, Timofeev E, Mirzabekov A. Immobilization of DNA in polyacrylamide gel for the manufacture of DNA and DNA-oligonucleotide microchips. Anal Biochem 1998;259:34-41. 36. Ross PL, Davis PA, Belgrader P. Analysis of DNA fragments from conventional and microfabricated PCR devices using delayed extraction MALDI-TOF mass spectrometry. Anal Chem 1998;70:2067-73. 37. Shoffner MA, Cheng J, Hvichia GE, Kricka LJ, Wilding P. Chip PCR (I). Surface passivation of micromachined devices for PCR. Nucleic Acids Research 1996;24:375-379. 38. Soper SA, Ford SM, Xu Y, et al. Nanoliter-scale sample preparation methods directly coupled to polymethylmethacrylate-based microchips and gel-filled capillaries for the analysis of oligonucleotides. J Chromatogr A 1999;853:107-20. 39. Strizhkov BN, Drobyshev AL, Mikhailovich VM, Mirzabekov AD. PCR amplification on a microarray of gel-immobilized oligonucleotides: detection of bacterial toxin- and drug-resistant genes and their mutations. Biotechniques 2000;29:844-8, 850-2, 854 passim. 40. Sung WC, Lee GB, Tzeng CC, Chen SH. Plastic microchip electrophoresis for genetic screening: the analysis of polymerase chain reactions products of fragile X (CGG)n alleles. Electrophoresis 2001;22:1188-93. 41. Tan H, Zhang N, Yeung ES. On-line coupling DNA amplification reactions with capillary array electrophoresis through fully automated microfluidics. Abstracts of Papers American Chemical Society 1998;215:37. 42. Tillib SV, Strizhkov BN, Mirzabekov AD. Integration of multiple PCR amplifications and DNA mutation analyses by using oligonucleotide microchip. Anal Biochem 2001;292:155-60. 43. Tillib SV, Mirzabekov AD. Advances in the analysis of DNA sequence variations using oligonucleotide microchip technology. Curr Opin Biotechnol 2001;12:53-8. 44. Turowski M, Chen Z, Przekwas A. Design, fabrication, and packaging of closed chamber PCR-chips for DNA amplification. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4019:362-9. 45. Vissing H, Nielsen AT, Noerholm M, et al. High throughput multiplex genotyping using chimeric LNA (Locked Nucleic Acids)/DNA oligos immobilized on a polymer microchip. American Journal of Human Genetics 2001;69:470. 46. Waters LC, Jacobson SC, Kroutchinina N, Khandurina J, Foote RS, Ramsey JM. Multiple sample PCR amplification and electrophoretic analysis on a microchip. Anal Chem 1998;70:5172-6.


47. Waters LC, Jacobson SC, Kroutchinina N, Khandurina J, Foote RS, Ramsey JM. Microchip device for cell lysis, multiplex PCR amplification, and electrophoretic sizing. Anal Chem 1998;70:158-62. 48. Woolley AT, Lao K, Glazer AN, Mathies RA. Capillary electrophoresis chips with integrated electrochemical detection. Anal Chem 1998;70:684-8. 49. Xie W, Yang R, Xu J, Zhang L, Xing W, Cheng J. Microchip-based capillary electrophoresis systems. Methods Mol Biol 2001;162:67-83. 50. Yasuda K, Okano K, Ishiwata S. Focal extraction of surface-bound DNA from a microchip using photo-thermal denaturation. Biotechniques 2000;28:1006-11. 51. Yershov G, Barsky V, Belgovskiy A, et al. DNA analysis and diagnostics on oligonucleotide microchips. Proc Natl Acad Sci U S A 1996;93:4913-8. 52. Zasedateleva OA, Krylov AS, Sharonov AY, Mirzabekov AD. Double biological microchip: Use for investigation of biochemical reactions. Sensornye Sistemy. [ print] 2001;15:85-92. 53. Zhang N, Tan H, Yeung ES. Automated and integrated system for high-throughput DNA genotyping directly from blood. Analytical Chemistry 1999;71:1138-45.

CHROMATOGRAPHY

(1-15) 1. Blom MT, Tas NR, Pandraud G, et al. Failure mechanisms of pressurized microchannels: model and experiments. Journal of Microelectromechanical Systems 2001;10:158-64. 2. Bousse L. Integrated micro-optical fluorescence detection system for microfluidic electrochromatography. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3878:185-92. 3. Deshpande M, Ghaddar C, Gilbert JR, et al. Electrical conductivity particle detector for use in biological and chemical micro-analysis systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:230-41. 4. Eijkel JCT, Stoeri H, Manz A. A dc microplasma on a chip employed as an optical emission detector for gas chromatography. Analytical Chemistry 2000;72:2547-2552. 5. Gawron AJ, Martin RS, Lunte SM. Microchip electrophoretic separation systems for biomedical and pharmaceutical analysis. European Journal of Pharmaceutical Sciences 2001;14:1-12. 6. Henning AK. Biological transport in a microfabricated device: active immunochromatography with motorized antibodies. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:66-75. 7. Manginell RP, Frye-Mason GC, Kottenstette RJ, Lewis PR, Channy Wong C. Microfabricated planar preconcentrator. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:179-82. 8. Manz A, Miyahara Y, Miura J, Y.Watanabe Y, Miyagi H, Sato K. Design of an open-tubular column liquid chromatograph using silicon chip technology. Sens. Actuators 1990; B1:249-255. 9. O'Neill AP, O'Brien P, Alderman J, et al. On-chip definition of picolitre sample injection plugs for miniaturised liquid chromatography. J Chromatogr A 2001;924:259-63. 10. Ocvirk G, Verpoorte EMJ, Manz A, Grasserbauer M, Widmer HM. High performance liquid chromatography partly integrated onto a silicon chip. Anal. Methods Instrum. 1995;2:74-82.


11. Regnier FE, He B, Lin S, Busse J. Chromatography and electrophoresis on chips: critical elements of future integrated, microfluidic analytical systems for life science. Ophthalmic Genetics 1999;17:101-6. 12. Rocklin RD, Ramsey RS, Ramsey JM. A microfabricated fluidic device for performing two-dimensional liquid-phase separations. Anal Chem 2000;72:5244-9. 13. von Heeren F, Verpoorte EMJ, Manz A, Thormann W. Rapid micellar electrokinetic chromatography separations on planar microstructures. Analytical Chemistry 1996;68,:2044-2053. 14. Wiranto G, Soegandi TMS, Muljono M, Widodo S, Hermida IDP. The design of a miniature injector for microengineered GC system. ICSE 2000;:85-9. 15. Yu C, Svec F, Frechet Jean MJ. Towards stationary phases for chromatography on a microchip: Molded porous polymer monoliths prepared in capillaries by photoinitiated in situ polymerization as separation media for electrochromatography. Electrophoresis 2000;21:120-127.

DNA ANALYSIS

(1-28) 1. Baba Y. [Ultrafast analysis of DNA by microchip and nanochip technology]. Tanpakushitsu Kakusan Koso 2000;45:76-85. 2. Becker H, Heim U, Rotting O. Microchips for DNA sequencing. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3877:82-7. 3. Buchholz BA, Doherty EA, Albarghouthi MN, Bogdan FM, Zahn JM, Barron AE. Microchannel DNA sequencing matrices with a thermally controlled "viscosity switch". Analytical Chemistry 2001;73:157-64. 4. Cheng J, Fortina P, Surrey S, Kricka LJ. Microchip-based devices for molecular diagnosis of genetic diseases. Molecular Diagnosis 1996;:1-18. 5. Cheng J, Fortina P, Surrey S, Kricka LJ, Wilding P. Microchip-based devices for molecular diagnosis of genetic diseases. Mol Diagn 1996;1:183-200. 6. Cheng J, Kricka LJ, Sheldon EL, Wilding P. Sample preparation in microstructured devices. Topics in Current Chemistry 1997;194:215-231. 7. Chou HP, Spence C, Scherer A, Quake S. A microfabricated device for sizing and sorting DNA molecules. Proceedings of the National Academy of Sciences of the United States of America 1999;96:11-13. 8. Craighead HG, Han J, Turner SW. Separation of DNA in microfluidic systems. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:26-8. 9. Eggers M, Ehrlich D. A review of microfabricated devices for gene-based diagnostics. Hematol Pathol 1995;9:1-15. 10. Esch MB, Locascio LE, Tarlov MJ, Durst RA. Detection of viable Cryptosporidium parvum using DNA-modified liposomes in a microfluidic chip. Analytical Chemistry 2001;73:2952-8. 11. Fan ZH, Mangru S, Granzow R, et al. Dynamic DNA hybridization on a chip using paramagnetic beads. Analytical Chemistry 1999;71:4851-9. 12. Forster AH, Krihak M, Swanson PD, Young TC, Ackley DE. A laminated, flex structure for electronic transport and hybridization of DNA. Biosensors & Bioelectronics 2001;16:187-94. 13. Frazier AB, Gale BK, Papautsky I. Cell-free mRNA translation in a microbiochemical reactor. 1997;:91-5.


14. Gale BK, Caldwell KD, Frazier AB. On-chip DNA band detection in microfabricated separation systems. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1998;3515:242-51. 15. Gilles PN, Wu DJ, Foster CB, Dillon PJ, Chanock SJ. Single nucleotide polymorphic discrimination by an electronic dot blot assay on semiconductor microchips. Nat Biotechnol 1999;17:365-70. 16. Han J, Craighead HG. From microfluidics to nanofluidics: DNA separation using nanofluidic entropic trap array device. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:42-8. 17. Hou-Pu C, Unger MA, Scherer A, Quake SR. Integrated elastomer fluidic lab-on-a-chip-surface patterning and DNA diagnostics. Technical Digest. Solid State Sensor and Actuator Workshop 2000;:111-14. 18. Koutny L, Schmalzing D, Salas-Solano O, et al. Eight hundred-base sequencing in a microfabricated electrophoretic device. Analytical Chemistry 2000;72:3388-91. 19. LeClair T, Harper A, Graham S, Ackley D. Flip chip interconnection of DNA chip devices. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 1999;3582:732-6. 20. McGlennen RC. Miniaturization technologies for molecular diagnostics. Clin Chem 2001;47:393-402. 21. Meldrum K. Microfluidics-based products for nucleic acid analysis. American Laboratory 1999;31:20-22. 22. Minalla AR, Bousse L. Characterization of microchip separations. SPIE Int. Soc. Opt. Eng. Proceedings of Spie the International Society for Optical Engineering 2000;4177:134-41. 23. Mizukami Y, Rajniak D, Nishimura M. ACAPELLA-1K: a biomechatronic fluid handling system for genome analysis that processes 1000 samples in 8 hours. IEEE/ASME Transactions on Mechatronics 2000;5:212-20. 24. Mueller O, Hahnenberger K, Dittmann M, et al. A microfluidic system for high-speed reproducible DNA sizing and quantitation. Electrophoresis 2000;21:128-34. 25. Rusu C, van't Oever R, de Boer MJ, et al. Direct integration of micromachined pipettes in a flow channel for single DNA molecule study by optical tweezers. Journal of Microelectromechanical Systems 2001;10:238-46. 26. Schmalzing D, Koutny L, Adourian A, Belgrader P, Matsudaira P, Ehrlich D. DNA typing in thirty seconds with a microfabricated device. Proceedings of the National Academy of Sciences of the United States of America 1997;94:10273-8. 27. Sundberg SA, Chow A, Nikiforov T, Wada HG. Microchip-based systems for target validation and HTS. Drug Discov Today 2000;5:92-103. 28. Zhang J, Jing G, Xu J, Cheng J, Zhou Y. Effect of flow on complex biological macromolecules in microfluidic devices. Biomedical Microdevices 2001;3:225-38.

ELECTROPHORESIS

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4. Arora A, De Mello Andrew J, Manz A. Sub-microliter electrochemiluminescence detector: A model for small volume analysis systems. Analytical Communications 1997;34:393-395. 5. Arora A, Eijkel JCT, Morf WE, Manz A. A wireless electrochemiluminescence detector applied to direct and indirect detection for electrophoresis on a microfabricated glass device. Anal. Chem. 2001;73:3282-3288. 6. Arundell M, Whalley PD, Manz A. Indirect fluorescence detection of phenolic compounds by capillary electrophoresis on a glass device. Fresenius J. Anal. Chem. 2000;367:686-691. 7. Attiya S, Jemere AB, Tang T, et al. Design of an interface to allow microfluidic electrophoresis chips to drink from the fire hose of the external environment. Electrophoresis 2001;22:318-27. 8. Becker H, Lowack K, Manz A. Planar quartz chips with submicron channels for two-dimensional capillary electrophoresis applications. J. Micromech. Microeng. 1998;8:24-28. 9. Berrill MG, McKenzie JS, Clark C. Design and fabrication of travelling wave dielectrophoresis structures. Journal of Micromechanics & Microengineering 2000;10:72-9. 10. Bousse L, Mouradian S, Minalla A, Yee H, Williams K, Dubrow R. Protein sizing on a microchip. Anal Chem 2001;73:1207-12. 11. Bruin GJ. Recent developments in electrokinetically driven analysis on microfabricated devices. Electrophoresis 2000;21:3931-51. 12. Cabrera CR, Yager P. Continuous concentration of bacteria in a microfluidic flow cell using electrokinetic techniques. Electrophoresis 2001;22:355-62. 13. Chiem NH, Harrison DJ. Monoclonal antibody binding affinity determined by microchip-based capillary electrophoresis. Electrophoresis 1998;19:3040-4. 14. Colyer CL, Mangru SD, Harrison DJ. Microchip-based capillary electrophoresis of human serum proteins. J Chromatogr A 1997;781:271-6. 15. Colyer CL, Tang T, Chiem N, Harrison DJ. Clinical potential of microchip capillary electrophoresis systems. Electrophoresis 1997;18:1733-41. 16. Colyer Christa L, Tang T, Chiem N, Harrison DJ. Clinical potential of microchip capillary electrophoresis systems. Electrophoresis 1997;18:1733-1741. 17. Crabtree HJ, Kopp MU, Manz A. Shah function convolution Fourier Transform detection: A concept applied to capillary electrophoresis and laser-induced fluorescence. Analytical Chemistry 1999;71: 2130-2138. 18. Crabtree HJ, Cheong EC, Tilroe DA, Backhouse CJ. Microchip injection and separation anomalies due to pressure effects. Anal Chem 2001;73:4079-86. 19. Cui L, Holmes D, Morgan H. The dielectrophoretic levitation and separation of latex beads in microchips. Electrophoresis 2001;22:3893-3901. 20. Dolnik V, Liu S, Jovanovich S. Capillary electrophoresis on microchip. Electrophoresis 2000;21:41-54. 21. Duke TAJ, Austin RH. Microfabricated sieve for the continuous sorting of macromolecules. Phys. Rev. Lett. 1998;80:1552-1555. 22. Effenhauser CS, Manz A, Widmer HM. Glass chips for high speed capillary electrophoresis separations with sub-micron plate heights. Analytical Chemistry 1993;65:2637-2642.


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61. Raymond DE, Manz A, Widmer HM. Continuous sample pretreatment using a free-flow electrophoresis device integrated onto a silicon chip. Analytical Chemistry 1994;66:2858-2865. 62. Raymond DE, Manz A, Widmer HM. Continuous separation of high molecular weight compounds using a microlitre volume free-flow electrophoresis microstructure. Analytical Chemistry 1996;68:2515-2522. 63. Salimi-Moosavi H, Jiang Y, Lester L, McKinnon G, Harrison DJ. A multireflection cell for enhanced absorbance detection in microchip-based capillary electrophoresis devices. Electrophoresis 2000;21:1291-9. 64. Seiler K, Harrison DJ, Manz A. Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation and separation efficiency. Analytical Chemistry 1993;65:1481-1488. 65. Starkey DE, Han A, Bao JJ, et al. Fluorogenic assay for beta-glucuronidase using microchip-based capillary electrophoresis. J Chromatogr B Biomed Sci Appl 2001;762:33-41. 66. Suzuki S, Shimotsu N, Honda S, Arai A, Nakanishi H. Rapid analysis of amino sugars by microchip electrophoresis with laser-induced fluorescence detection. Electrophoresis 2001;22:4023-31. 67. Tian H, Brody Lawrence C, Fan S, Huang Z, Landers James P. Capillary and microchip electrophoresis for rapid detection of known mutations by combining allele-specific DNA amplification with heteroduplex analysis. Clinical Chemistry. [ print] 2000;47:173-185. 68. Tian H, Brody Lawrence C, Landers James P. Rapid detection of deletion, insertion, and substitution mutations via heteroduplex analysis using capillary- and microchip-based electrophoresis. Genome Research. [ print] 2000;10:1403-1413. 69. Tian H, Jaquins-Gerstl A, Munro N, Trucco M, Brody Lawrence C, Landers James P. Single-strand conformation polymorphism analysis by capillary and microchip electrophoresis: A fast, simple method for detection of common mutations in BRCA1 and BRCA2. Genomics 2000;63:25-34. 70. Tian H, Huhmer AF, Landers JP. Evaluation of silica resins for direct and efficient extraction of DNA from complex biological matrices in a miniaturized format. Anal Biochem 2000;283:175-91. 71. Tian H, Brody LC, Fan S, Huang Z, Landers JP. Capillary and microchip electrophoresis for rapid detection of known mutations by combining allele-specific DNA amplification with heteroduplex analysis. Clin Chem 2001;47:173-85. 72. von Heeren F, Verpoorte EMJ, Manz A, Thormann W. Characterization of electrophoretic sample injection and separation in a gel-filled cyclic planar microstructure. Journal of Microcolumn Separations 1996;8:373-381. 73. Wakida S, Chiba A, Matsuda T, et al. High-throughput characterization for organic pollutants in environmental waters using a capillary electrophoresis chip. Electrophoresis 2001;22:3505-8. 74. Wang J, Chatrathi Madhu P, Tian B, Polsky R. Capillary electrophoresis chips with thick-film amperometric detectors: Separation and detection of hydrazine compounds. Electroanalysis 2000;12:691-694. 75. Wilding P, Kricka Larry J, Cheng J, Hvichia G, Shoffner Mann A, Fortina P. Integrated cell isolation and polymerase chain reaction analysis using silicon microfilter chambers. Analytical Biochemistry 1998;257:95-100. 76. Xu C, Wang Y, Cao M, Lu Z. Dielectrophoresis of human red cells in microchips. Electrophoresis 1999;20:1829-1831. 77. Yang Q, Hidajat K, Li SF. Trends in capillary electrophoresis: 1997. J Chromatogr Sci 1997;35:358-73. 78. Yu-Cheng L, Ming-Yuan H. Electroporation microchips for in vitro gene transfection. Journal of Micromechanics & Microengineering 2001;11:542-7.


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IMMUNOASSAY

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MASS SPECTROMETRY


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PROTEIN ANALYSIS

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Complete References Clin Chem 2002 48: 1620-1622 fileCambridge Healthtech Institute's Third Annual...

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