COMP2PSYCH Ringberg Magda DUBOIS › 12363 › 36_comp2psych_ringberg_… · International Max...
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International Max Planck Research School COMP2PSYCH Apathy as aberrant maturational separation of dopamine pathways Magda Dubois Symposium and Advanced Course on Computational Psychiatry and Ageing Research 0
Transcript of COMP2PSYCH Ringberg Magda DUBOIS › 12363 › 36_comp2psych_ringberg_… · International Max...
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International Max Planck Research School COMP2PSYCH
Apathy as aberrant maturational separation ofdopamine pathways
Magda Dubois
Symposium and Advanced Course on Computational Psychiatry and Ageing Research
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• Diminished motivation
• Symptom in psychiatric and neurological
disorders
• Not well understood
• Impairs treatment success
Apathy
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Action
Motivation
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Effort Reward
Motivation
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Effort
Motivation
Reward
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Effort
Reward
Motivation
Apathy
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Reward
Prediction errors
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? ?
Effort and reward learning
ActionEffort??
? ?
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Reward Prediction Error
Effort Prediction Error
Effort and reward learning
[Hauser et al., PNAS, 2017]7
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DopamineEffort and reward learning
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Effort and reward learning
Project IEffort and reward learning ó different DA-ergic pathways?
[Hauser et al., PNAS, 2017]
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Effort and reward learning
Project IEffort and reward learning ó different DA-ergic pathways?
Striatal DA
Cortical DA
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Effort and reward learning
ApathyProject IEffort and reward learning ó different DA-ergic pathways?
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Effort and reward learning[Hauser et al., PNAS, 2017]
Project IEffort and reward learning ó different DA-ergic pathways?
Apathy
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Effort and reward learning
ApathyProject IEffort and reward learning ó different DA-ergic pathways?
Project IIDeficient DA-ergic pathways ó apathy?
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Effort and reward learning
Project IEffort and reward learning ó different DA-ergic pathways?
Project IIDeficient DA-ergic pathways ó apathy?
Project IIIWhen do those DA-ergic deficiencies emerge?
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[Hoops & Flores, Trends Neurosci, 2017]
Dopamine development
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[Hoops, 2017]
Dopamine development
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Project ILearning ó dopamine
Project IILearning ó apathy
Project IIILearning ó development
Question Cortical vs striatal DA Deficient pathways Learning during development
SubjectsHealthy adults o High vs low apathy
o NSPNo Children + adolescents
Studyo fMRIo Drug
• Istradefylline: striatal DA
• Tolcapone: cortical DA
o fMRI o Behavioral o Cross-sectional
Project
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[Hoops, 2017]
Thank you !
