Communicable Disease Surveillance ~ Part of CD Law Seminar · Communicable Disease Surveillance ~...
Transcript of Communicable Disease Surveillance ~ Part of CD Law Seminar · Communicable Disease Surveillance ~...
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Communicable Disease Surveillance
~ Part of CD Law Seminar ~
Jean-Marie MaillardGCDC Branch
Epidemiology Section
Asheville, 7/27/2005
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Communicable Disease Laws
Most, but not all, communicable disease statutes are in Article 6 of Chapter 130A of the NC General Statutes(citation: e.g., GS 130A-135)
Communicable disease control rules are in Title 10A, chapter 41A of the North Carolina Administrative Code(citation: e.g., 10A NCAC 41A .0101)
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Reporting of Communicable Diseases
Expect changes– From paper (cards and forms) between MDs, LHDs, and state– To electronic system between LHDs and state (“NC-EDSS”)– Alerting and communication (NC-EDSS, HAN)
10A NCAC 41A .0101 - contains list of reportable diseases, conditions, and positive lab. tests– Note foodborne diseases– 24-hour vs. 7-day reporting requirements– CD report card
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Reportable Diseases and Conditions
List is modified as needed
Perceived public health importance
– High potential for spread
– Serious and/or severe illnesses
Effective control measures available
Special interest/study
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Who Reports?
Physicians (GS 130A-135)School principals & Day Care Center operators (GS 130A-136)Medical facilities may report(GS 130A-137)
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Who Reports? (continued)Operators of restaurants & other food or drink establishments must report foodborne disease (GS 130A-138):– Outbreak or suspected outbreak in
customers or employees– Infected food handler– Must call LHD within 24 hours– Not required to send CD report card
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Who Reports? (continued)
Laboratories:– List of reportable positive tests expanded
considerably in 1998
– Report direct to DPH rather than LHD(results other than STD)
– May report electronically(and not using CD report card)
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How to report (for physicians)
Telephone report –followed by card report within 7 days– for diseases reportable immediately (Bioterrorism potential) or within 24 hoursReport card (NC DHHS 2124), along with disease specific surveillance form when required
Method of reporting described in 10A NCAC 41A
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Disease Specific Surveillance Form
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Duties of LH Director, CD report
10A NCAC 41A .0103 (a) Upon receipt…(1) immediately investigate(2) determine control measures: needed, given, compliance(3) forward report: – (C) …to the Division of Public Health within 7 days– (D) Forward to other LHD within 24 hours for person
residing in another jurisdiction (and send copy to DPH)– (E) Forward to DPH within 24 hours for persons
residing outside of NC
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Flow of Surveillance Information
Physician
Local Health Department
State Health Department
National Surveillance (CDC)
Laboratory result
State Health Department
Local Health Department(have physician generate report if case definition criteria are met)
(Phone; mail)
(Phone; mail)
(Electronic)
(Mail, fax or electronic)
(Mail, phone, electronic)
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MD
MD
MDLHD
(Local)GCDC(State)
Lab LabLab
CDC(National)
NC Communicable Disease Surveillance- Current System -
DailyMail
WeeklyElectronic
Transmission
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NC Electronic Disease Surveillance- New System -
NC EDSS
LHD(Local)
Laboratories PHRST(Region)
GCDC(State)
CDC(National)
MD
MD MD
MD
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Functional Requirements of NC-EDSS
OMS
VPD
TB STD
HIV/AIDS
Lead
NVDS
Core
ContactTracing
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Epidemiologic Surveillance - AnalysisTime: – Trend (e.g., are we making progress, where are the
needs); Seasonality– Background, expected vs. observed: excess?
Place: clustering?– Listeriosis in W-S, 1999– Hepatitis A: Chapel Hill Winter 98, Meklenburg 2001
Person: Risk factors?– Rubella in NC Hispanic population in late 90’s– Hepatitis A in MSM, NC 2001-2002
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Interpretation
Taking into account:– Population changes– Changes in reporting procedure– Changes in personnel– Scientific progress: diagnostic techniques, control
measures– … or real change in disease pattern?
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Rubella - NC 1987-2003
0
20
40
60
80
100
87 88 89 90 91 92 93 94 95 96 97 98 99 '00 '01 '02 '03
All Non-Hispanic HispanicN=301. Hispanic cases: 80% aged 17-29 years old
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Measles – NC 1987-2003
020406080
100120140160180200
87 88 89 90 91 92 93 94 95 96 97 98 99 '00 '01 '02 '03
A vaccine Preventable DiseaseA childhood diseaseBackground rate: ~ 01989 outbreak:– Atypical age:
19% aged < 10 y.o.76% aged 10-24 y.o.
Use: Policy changes
N=318 Reported Cases - NC 1987-2003
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Hepatitis A
0
100
200
300
400
500
600
700
<10 10-19 20-29 30-39 40-49 50+
Male Female
Person-to-personFoodborneGender distribution:Male>Female (60%-40%)Age/Gender distribution:Young Males, 20-39 y.o.
Raises the question: STD in MSM
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Example of population change
Tuberculosis Cases in US-born vs. Foreign-born PersonsUnited States, 1992-2000
0
5000
10000
15000
20000
1992 1993 1994 1995 1996 1997 1998 1999 2000
US-born Foreign-born
No.
of C
ases
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Remember….
A disease does NOT have to be reportable to be investigable!
10A NCAC 41A(c)Whenever an outbreak of a disease... which is not required to be reported… but which represents a significant threat to the public health, the local health director shall give the appropriate control measures…
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Confidentiality
In general, records that identify a patient specifically are not public records and are to be treated confidentially
Surveillance data: at what level may a specific case become identifiable?
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Confidentiality (continued)Exceptions:
– When necessary for control of a disease representing a significant public health hazard [GS 130A-143(4) and rule .0211]
– When information is collected by a person other than a physician or nurse, it may not be protectable
– Others as specified in GS 130A-143
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Traditional vs. IndicatorSurveillance in Outbreak Detection
00.10.20.30.40.50.60.70.80.9
1
0 24 48 72 96 120 144 168
Incubation Period (Hours)
Pro
babi
lity
ofD
isea
se D
etec
tion
Time (days)
Num
ber
Dea
d
Sensor, Animal, or Human Indicators
105
t = 0
Fatalities WithEarly Warning
Military & CivilianFatalities With
Traditional Alerting
Gain of 2 days
Effective Treatment Period
Surveillance
Traditional DiseaseDetection
TIME!
Source: Johns Hopkins University / DoD Global Emerging Infections System
Syndromic/Electronic Surveillance
Anthrax
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Electronic Data Entry Screen
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Emergency Department Visits after Hurricane Isabel, NC 9/18/2003
0200400600800
100012001400
9/12
/200
39/
13/2
003
9/14
/200
39/
15/2
003
9/16
/200
39/
17/2
003
9/18
/200
39/
19/2
003
9/20
/200
39/
21/2
003
9/22
/200
39/
23/2
003
9/24
/200
39/
25/2
003
9/26
/200
39/
27/2
003
9/28
/200
3
Date
E.D
. Vis
its
N=11,707
12-day series available from 13 hospitals
Hurricane Isabel
(Data not collected)
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Injuries
05
101520253035404550
9/12
/200
39/
13/2
003
9/14
/200
39/
15/2
003
9/16
/200
39/
17/2
003
9/18
/200
39/
19/2
003
9/20
/200
39/
21/2
003
9/22
/200
39/
23/2
003
9/24
/200
39/
25/2
003
9/26
/200
39/
27/2
003
9/28
/200
3
CutFractureSprainBrainForeign BBurnBack Pain
Hurricane Isabel
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The new web of disease surveillance
NC PHIN
SyndromicSurveillance/ NC BEIPS
EMS/PreMIS
Hospital ED
Poison Center
Reportedcases
Hospital infectioncontrol practitioner
PhysicianLabResults
NC NEDSS
Local HD HospitalHosp.-based PH epidemiologists
Other
Other systems (HAN, Immunization
Registry, etc.)
PHRST
Other
SystemInformation flowData sourcePublic Health
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Attributes of a Surveillance System
TimelyUsefulRepresentativeAcceptableAffordable“Simple”
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Traditional vs. Enhanced SurveillanceAttribute Traditional
PassiveEnhancedSurveillance
Timely Somehow Yes, automation
Useful Yes – butlimitations(sensitivity,timeliness)
Better sensitivity; Thresholds;Timeliness
Representative Yes Yes
Acceptable Essential forcases to bereported
Agreements with reportingsources, unless mandatory
Affordable Low cost Set up expensive
“Simple” Yes No, but can be “user friendly”
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Hospital E.D. Surveillance
GS 130A-480 and rule .0105NCHA contracted for hospitals to provide ED surveillance data, to allow syndromic surveillance– Also supported passage of legislation for mandatory
reporting of de-identified data– Help small hospitals with grants to implement EMRs
DPH contracting with UNC-NCEDD project to build and deploy this complex system
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Annual ED Patient VolumePitt County MemorialNew Hanover RegionalCape Fear ValleyWake Med DukeUNCMoses Cone WFU-BaptistMission HospitalsCarolina’s Medical CenterVAMC
56,00071,00091,000119,000 56,00057,000102,00057,00080,000110,000NA
*Source: NC DHHS, Div. Facilities Services
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Hospital Selection for PH Epis
Geopolitical ConsiderationsRegionED Volume and Bed SizeHospital System or Network11 Hospitals ≈ 60% of NC Acute Care12th position: coordinator at NC SPICE
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PHE’s Role
Vital link between Public Healthand clinical medicine– Active surveillance– Investigation– Education and outreach
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Active Surveillance
Category A Agents– laboratory-based– weekly negative reporting
Syndromes– Influenza-like Illness– GI syndrome– Neurological syndrome– Rash + Fever
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Hospital-based Public Health Epidemiologists
Community-Acquired Infection– Outbreaks– Cases of special public health interest– Biological and chemical terrorism
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Investigation
Coordinate with Public Health– Local Health Department– PHRSTs– NC DPH GCDC Branch
Outbreaks– Norovirus in a hospital ward
Special interest cases– Influenza-associated pediatric
encephalopathy
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Division of Public Health
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Transition slide – to Investigation
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Communicable Disease Investigation
Jean-Marie MaillardGeneral Communicable Disease Control Branch
Epidemiology Section
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Investigation as required by Laws and Rules
GS 130A-144(a) The local Health director shall investigate, as required by the Commission, cases of communicable diseases and communicable conditions reported to the local health director…10A NCAC 41A .103 Duties of Local Health Director: (a) Upon receipt of a report… (1) immediately investigate…
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“Traditional” surveillance: lacks sensitivity and provides delayed information
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Contacts and social network of SARS index and special interest cases, NC 2003
Index caseOrange County
FamilyOrange County
HCWs3
FP ClinicOrange County
WorkplaceOrange County >100
ARDS1 InpatientWestern WakeWake County
ARDS FamilyWake County
HCWsWestern WakeWake County
CAP2
OutpatientDuke
Durham County
CAP FamilyDurham County
HCWsDuke
Durham County
Worriedwell
“Tent City”ScreeningUNC-CHNotes:
1. Acute respiratory distress syndrome2. Community acquired pneumonia3. Healthcare workers
EMS and other health care workers are among the first to benefit from better detection of communicable diseases.
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Remember….
A disease does NOT have to be reportable to be investigable!
10A NCAC 41A .0103(c)Whenever an outbreak of a disease... which is not required to be reported… but which represents a significant threat to the public health, the local health director shall give the appropriate control measures…
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Reasons for Investigating an Outbreak
Identify and eliminate source of infectionDefine the required control measuresDevelop strategies to prevent future outbreaks Describe new diseases and learn more about known diseasesEvaluate existing prevention strategiesAddress public concern about the outbreak
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Outbreak investigation: a collaborative enterprise
Epidemiology
EnvironmentalHealth
Laboratory
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Collaborative approachLocal public health professionals, cliniciansEpidemiologist(s) and disease expertsat the local, regional, state, national levelLaboratory techniciansEnvironmental health specialists;Industrial hygienistIndustry: restaurant, food supply, recreationothers as neededPublic information officerLaw enforcement officers
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Steps of an investigation1. Confirm diagnosis2. Confirm outbreak (linked cases, excess/expected)3. Convene epidemic team4. Plan investigation: epidemio, lab, environmental5. Case definition6. Collect data, standardized questionnaire7. Analyze data (time, place, person)8. Control measures (curative, prophylactic, preventive)
9. Increase surveillance and reporting10. Write report
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Outbreaks –Public Health Emergencies
Public Health Command CenterOffice of PH Preparedness and Response,PH Regional Surveillance Teams
Bioterrorism, e.g., anthrax, 2001Natural events– Infectious: SARS, Influenza, Monkeypox– Weather related: hurricane, flood, ice storm
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Phases of the NC Public Health Preparedness and Response Plan
Phase I BaselinePhase II Heightened ThreatPhase III Post-event, limited outbreakPhase IV Post-event, large outbreakPhase V Recovery
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Components of the NC Public Health Public Health Preparedness and Response Plan
SurveillanceDisease investigationVaccination/prophylaxisQuarantine and isolationMass careMass fatalityPublic informationCommand/Control/Communications
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V
RECOVERY
IV POST EVENT LARGE OUTBREAK
III POST EVENT LIMITED OUTBREAK
II HEIGHTENED THREAT
I
BASELINE
Planning Matrix for NC Public Health Preparedness & Response Plan
QUARANTINE LIMITED TO RESOLVING CASES
LTD. QUAR.MASS ISOLATION OF CASES/ AREAS
QUARANTINE/ISOLATION OF CASES/SUS-PECT AREAS
IDENTIFY & NOTIFY C,X,R FACILITIES
PLAN, TRAIN AND EDUCATE
QUARANTINE/ISOLATION
POSSIBLE CHANGE TO VAX POLICY
MASS VAX/PROPHY (SNS)
VAX/PROPHY OF CONTACTS (SNS?)
INCREASED PRE-EVENT (STAGE 3?)
CONTINUES UNTIL >1 INCUBATION PERIOD W/O CASE
CASE INTERVIEW/LAB STUDIES/SITE INVEST.
ACTIVE CASE FINDING
CONTINUES UNTIL > 1 INCUBATION PERIOD
ACTIVE –EXTENSIVE TRACKING & REPORTING
ACTIVE –TRACKING & REPORTING
ACTIVE – SHD ORDERS INCREASED REPORTING
ONGOING –PASSIVE
SURVEILLANCE
DISEASE INVESTIGATION
VACCINATION/PROPHYLAXIS
PRE-EVENT STAGES 1 & 2
PLAN, TRAIN AND EDUCATE
CASE TRACKING
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Planning Matrix for NC Public Health Preparedness & Response Plan
V.
RECOVERY
IV. EVENT LARGE OUTBREAK
III. EVENT LIMITED OUTBREAK
II. HEIGHTENED THREAT
I.
BASELINE
STAND DOWN AS EVENT CLOSES
ACTIVATED: JOC, SERT/EOC, PHCC & LOCAL EOCS
ACTIVATED: JOC, SERT/EOC, PHCC & LOCAL EOCS
ACTIVATED: RSTS, LHDS & PHCC (SERT?)
PLAN, TRAIN, EDUCATE,EXERCISE
COMMAND/CONTROL/COMMUNICA-TION
CONTINUES THRU > 1 INCUBATION PERIOD W/O CASE
ACTIVATED: SERT JIC; EVENT REPORTING; COORDINATE WITH FBI/SBI
ACTIVATED: SERT JIC; EVENT REPORTING; COORDINATE WITH FBI/SBI
ACTIVE RISK COMMUNI-CATION –COORDINATE WITH DHHS, PHP&R SERT
PLAN, TRAIN AND EDUCATE
PUBLIC INFORMATION
STAND DOWN AS FATALITIES RETURN TO NORMAL LVLS
ACTIVATE STATE & FED DMORT; EMAC ASSISTANCE
ACTIVATE STATE DMORT MED. EXAMRM.F. PLAN
ALERT NCEM, STATE DMORT OFF. MEDICAL EXAMINER
PLAN, TRAIN AND EDUCATE
MASS FATALITY
CONTINUES UNTIL PATIENT LOAD NORMALIZES
HOSPITALS EMER STATUS SERT /EMAC/ FED (SNS)
IMPACTED HOSPITALS EMER. STATUS(SNS?)
HOSPITALS ON ALERT -REVIEW EMER PLAN/STATUS
PLAN, TRAIN AND EDUCATE
MASS CARE
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Web-based Outbreak Questionnaire
Background– Statewide Triple Play exercise, October 2003– Pneumonic plague outbreak– Following exposure at animal show that attracted
statewide attendance– Multi-county outbreak; highly contagious disease
– Lack of method to capture case data in adequate manner, when faced with large outbreak or rapid increase of cases, scattered over wide area
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Solution (1)
Utilize Internet to collect information
– To provide standardized questionnaire– To make it rapidly available where needed– To securely collect information on reported cases– To pull case data in single database– To allow rapid analysis of all available data
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Solution (2)
Need: Survey builderUsers with Administrator rights can build outbreak questionnaire and analyze dataUsers with Reporter rights may report casesSecure access based on assigned user name and password to access Web site
PHCC briefing use: canned report for “snapshot” of main characteristics of cases:e.g., number of cases, County of residence, age, sex
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Prepare standardized questionnaire
Done by administrative users: epidemiologists at local, regional or state level (incl. PHRST, PHE, others)Make new outbreak investigationChoose questionnaire from existing templates with needed adaptation, or build new onePre-existing “blocks” of questions allow rapid design; these can be customized as needed
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Transition slide –To Control Measures
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Control Measures~ Part of CD Law Seminar ~
Jean-Marie MaillardGCDC Branch
Epidemiology Section
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Rule 10A NCAC 41A .0103
Upon receipt of a report of communicable disease… the local health director shall (1) investigate… determine identity of persons for whom control measures are required
(2) determine what control measures have been given and ensure that proper control measures… have been given and complied with
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Control Measures in 10A NCAC 41A
.0200 of 10A NCAC 41AGeneralHIVHepatitis BSTDTBHealth Care Settings
HIV and HBV infected health care workersSmallpox and vacciniaLaboratory TestingHandling and transportation of bodiesSARS
.0300 Special Control Measures (sale of turtles, sales of birds)
.0400 and .0500: Immunization and vaccines
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Control Measures –General
10A NCAC 41A .0201(a)– Except for a few diseases & conditions specifically
covered in the rules, control measures are those specified in APHA publication, Control of Communicable Diseases Manual
– Guidelines and recommendations from the CDC supercede those contained in the Control of CD Manual
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Guiding Principles
Rule 10A NCAC 41A .0201(b)– … reasonably be expected to decrease the risk of
transmission … consistent with recent scientific and public health information
– for diseases transmitted by the airborne route …physical isolation for the duration of infectivity
– …fecal oral route … exclusion from food handling, attendance or work in a day care center
– …sexual or blood-borne route… prohibit blood, organ or semen donation, needle-sharing, sexual contact
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Define control measuresas guided by available information
Unknown etiology or source– Adapt to circumstances, e.g., close a restaurant– Carefully thinking of potential consequences, e.g.,
exclusion of sick children or closure of DCC may increase risk of spread in the community
Diagnosed illness– Provide required prophylaxis with written order to
close contacts or otherwise exposed persons, e.g., rifampin for meningococcal disease, IG for hepatitis A
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