Commentary:Commentary:Memory for spatial locations, motor responses, and Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, objects: triple dissociation among the hippocampus,

caudate nucleus, and extrastriate visual cortexcaudate nucleus, and extrastriate visual cortex(Raymond P. Kesner, Bridget L. Bolland, Manoli Dakis, (Raymond P. Kesner, Bridget L. Bolland, Manoli Dakis,

1992)1992)

Courtney DawsonSamantha FabbriNish PaisCristian RochaAvik Sarkar

BackgroundIntroduction

Contradictory Evidence Recent StudiesFollow-up Study

Conclusion

1. Background2. Introduction3. Contradictory Evidence4. Recent Studies5. Follow-up Study6. Conclusions

Schedule

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-up Study ConclusionBackground

Hippocampus

Spatial Location Response Visual

Object Info

1. Hippocampus exclusively mediates all incoming informationINPUT

Samantha Fabbri

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-Up StudyConclusion

HippocampusCaudate Nucleus

Extra-striate Visual Cortex

INPUT

Spatial LocationResponse

Visual Object Info

2. Triple dissociation among the hippocampus, caudate nucleus and extra-striate visual cortex

Samantha Fabbri

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-up Study Conclusion

triple dissociation among: hippocampus caudate nucleus extra-striate visual cortex

Response Spatial location Visual object recognition

Introduction

Samantha Fabbri

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-up Study Conclusion

Spatial location controls received cortical lesions

Response and visual object controls received sham-operated control Lesions

The extent of each lesion was variable

Lesions ?

Courtney Dawson

Olfactory Cues One study regarding odor familiarity in a radial maze hypothesized

that such patterns of exploration would depend upon the olfactory environment

olfactory information can act as directional cues for animals exploring the radial maze.

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-up Study Conclusion

Avik Sarkar

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-Up StudyConclusionRecent Studies

Voermans et al. 2004. Interaction between the Human Hippocampus and the Caudate Nucleus during Route Recognition. Neuron. 43:427-435.

Courtney Dawson

Mizumori, S., Yeshenko, O., Gill, K., and Davis, D. 2004. Parallel processing across neural systems: Implications for a multiple memory system hypothesis. Neuro. Learning and Memory. 82:278-298.

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-Up StudyConclusion

Avik Sarkar

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-Up StudyConclusionFollow-Up StudyFollow-Up Study

Purpose Is there an interaction between the hippocampus, caudate nucleus and extra-striate visual cortex in mediating working memory?

Method Selectively lesion either: 1. The hippocampus and caudate nucleus 2. The hippocampus and extra-striate visual cortex 3. Extra-striate visual cortex and caudate nucleus 4. Only the hippocampus

Courtney Dawson

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-Up StudyConclusionConclusionConclusion

Our Revised Conclusion Multiple-memory systems exist and converge at a

higher processing level.

Avik Sarkar

IntroductionBackground

Methods / Results Supporting Evidence

Contradictory Evidence Further Research

Conclusion

Birke, L., Sadler, D., 1999. Effects of odor familiarity on the development of systematic exploration in the spiny mouse, Acomys cahirinus. Developmental psychobiology. 20(6):627-40

Cohen, Y., Reuveni, I., Barkai, E., Maroun, M. 2008. Olfactory learning-induced long-lasting enhancement of descending and ascending synaptic transmission to the piriform cortex. Journal of Neuroscience. 28(26):6664-9.

Kesner, P. Bolland, B. and Dakis, M. 1992. Memory for spatial locations, Motor responses and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex. Exp. Brain Res. 93:462-470.

Mizumori, S., Yeshenko, O., Gill, K., and Davis, D. 2004. Parallel processing across neural systems: Implications for a multiple memory system hypothesis. Neuro. Learning and Memory. 82:278-298.

Voermans et al. 2004. Interaction between the Human Hippocampus and the Caudate Nucleus during Route Recognition. Neuron. 43:427-435.

ReferencesReferences

BackgroundIntroduction

Contradictory Evidence Recent Studies

Follow-Up StudyConclusionThe End The End