Collagen based Drug Delivery
description
Transcript of Collagen based Drug Delivery
![Page 1: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/1.jpg)
Development of Collagen Based Drug Delivery
Systems
Ivy KanungoChemical Lab
![Page 2: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/2.jpg)
Background Information
Drug Delivery Systems
Biomaterials
Collagen
Current Drug Delivery Systems
Problems Associated with Collagen based Drug
Delivery
Aim and Objective
Design Constraints
Plan of Work
Presentation Outline
![Page 3: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/3.jpg)
Drug delivery is the method or process of
administering a pharmaceutical compound to
achieve a therapeutic effect in humans
Drug Delivery
![Page 4: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/4.jpg)
Intestinal
Intravenous/
Intraarterial
Intramuscular/
Subcutaneous
Oral
Buccal / Sublingual
Routes of Drug Administration
Rectal
Nasal
Pulmonary
Vaginal
Intrauterine
Transdermal
Ocular
![Page 5: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/5.jpg)
Methods of Drug Delivery
![Page 6: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/6.jpg)
Release rate dictated by the needs of the
body over the period of treatment
Constant, 0-order (clear PKPD)
Channel the drug to the active site, cell,
tissue, organ (drug targeting)
“No such DDS exists which combines
ABOVE …!!!”
Ideal Drug Delivery System
![Page 7: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/7.jpg)
Continuous maintenance of drug levels in
therapeutically desirable range
Potentially decreased amount of drug
needed
Decreased amount of dosage and possibly
less invasive dosing
Reduction of harmful side effects due to
targeted delivery to a particular site
Improved drug delivery include
![Page 8: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/8.jpg)
Sustain drug action at a predetermined rate by
maintaining a relatively constant, effective drug
level in the body with concomitant minimization
of undesirable side effects associated with a
sawtooth kinetic pattern
Localize drug action by spatial placement of a
controlled release system (usually rate
controlled) adjacent to or in the diseased tissue
or organ
Controlled Delivery Attempts
![Page 9: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/9.jpg)
Target drug action by using carriers
to deliver drugs to a particular
“target” cell type
![Page 10: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/10.jpg)
Targeted Drug Delivery
![Page 11: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/11.jpg)
Drug Release Profile
Plasma drug
concentration-profiles for
conventional tablet or
capsule formulation, a
sustained release
formulation, and a zero-
order controlled release
formulation
Concentration
![Page 12: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/12.jpg)
Solubility
Molecular weight
Chemical stability
Physical stability
Protein binding capability
Physicochemical Properties of a Drug Influencing Design and Performance
![Page 13: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/13.jpg)
Duration of action
Safety
Side effects
Margin of safety
Role of disease state
Biological Characteristics of a Drug Influencing Design and Performance
![Page 14: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/14.jpg)
Biomaterials
BioCompatibilty
Biodegradability
Issues to consider:
Viability
Placement
![Page 15: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/15.jpg)
Size of the carrier required
Inherent properties of the drugs i.e. aqueous
solubility or stability
Surface characteristics i.e. charge and permeability
Degree of biocompatibility, biodegradability and
toxicity
Drug release profile required
Routes of application of drugs
Antigenicity of the final product
Factors Influencing the Selection of the Carrier Material
![Page 16: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/16.jpg)
Development of collagen based
targeted drug delivery for sustained
release
Aim
![Page 17: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/17.jpg)
Chemical modification of collagen
without affecting its triple helical
conformation
Development of drug entrapped
collagen based biomaterials for
sustained release profile
Objective
![Page 18: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/18.jpg)
Collagen: Fibrous Protein
StabilizingInter-strandH-bonds
Gly-Pro-HyPro Repeat
![Page 19: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/19.jpg)
Collagen as a carrier for drug delivery
A three dimensional structure which works
as a natural distance barrier between the
drug is incorporated into the matrix and the
surroundings environment
A network which enhances cell penetration
and new tissue generation
![Page 20: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/20.jpg)
Adjustable bio degradability and bio
resorbability by cross linking
Good resistance and tensile properties
Compatible with synthetic polymers
High water absorbability
Partial open porosity
Partial close porosity
Tertiary release of the drugs
![Page 21: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/21.jpg)
Collagen based drug delivery
Sponge or Film
Hydrogel mediated drug delivery
Colloidal drug delivery
![Page 22: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/22.jpg)
Limitations
Sponge or film can be used for the treatment
of the incision of the outer part of the
body
The quantity and homogeneity of drug
loading into hydrogels
Colloidal based delivery system faces
dispersion and stability problem because of
their strong cohesiveness and high surface
areas
![Page 23: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/23.jpg)
Better Drug entrapment
Targeted delivery
Inexpensive
Sterile
Biocompatible
Sustained Delivery Profile
Scaled up
Design Constraints
![Page 24: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/24.jpg)
Goal: Design Autonomous Nano Medical Systems
Definition: Self-guiding, adaptive,
multicomponent systems on the nanoscale for
diagnostic and therapeutic prevention or
treatment of disease
Value: “smart” nanomedical systems can deal
with changing conditions, are error-correcting,
and can provide proper dose of therapeutic
response on a cell-by-cell basis
![Page 25: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/25.jpg)
Why nanoparticles are desired for drug delivery system?
![Page 26: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/26.jpg)
Questions?
?? ?? ??
![Page 27: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/27.jpg)
YY
Y
Y
YYYYY
YYY
Y
YY
YY
YY
Y
YY Y Y Cell targeting and
entry
Intracellular targeting
Biomolecular sensing
Gene/drug delivery
Concept: Smart Targeted, Programmed Sequence of Events, Nanomedicine Systems with Biomolecular Sensors for Control of Gene/Drug Delivery within Single Cells
Y
YY
YY
YYY
YY
YY
YY Y
Y
Biomolecular sensors
![Page 28: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/28.jpg)
Challenges: Optimal Drug Delivery to the Single Cell
Changing of collagen struture and shape
without affecting its amino acids sequences
Use and selection of crosslinking agent
Loading of drugs
Potential Solution: Delivery of a drug
manufacturing (in-situ) factory, not a drug
![Page 29: Collagen based Drug Delivery](https://reader033.fdocuments.in/reader033/viewer/2022061117/546827b3b4af9fdf3f8b5709/html5/thumbnails/29.jpg)
The Future
…….is full of
surprises
and
unintended
consequence
s