Collaborative Program in Neuroscience (CPIN) …Digital+Assets/...2015-16 CPIN Distinguished...

2015-16 CPIN Distinguished Lectureship Series

CPIN Office

[email protected]

Tel.: 416 978 8637

Lead Faculty

Faculty of Medicine

CPIN Participating Units

Applied Psychology & Human

Development

Biochemistry

Biomaterials & Biomedical

Engineering

Cell & Systems Biology

Computer Science

Dentistry

Laboratory Medicine &

Pathobiology

Medical Biophysics

Medical Science

Music

Pharmaceutical Sciences

Pharmacology & Toxicology

Physiology

Psychology

Rehabilitation Science

Contributors:

Heart & Stroke/Richard Lewar

Centre of Excellence in

Cardiovascular Research

Human Biology Program

Krembil Research Institute

St. Michael’s Neuroscience

Research Program

Zhong-Ping Feng

Director

CPIN

Graduate Studies

Suhail Asrar

Administrator

CPIN Office

Collaborative Program in Neuroscience (CPIN)

University of Toronto Newsletter – Vol. 32, No. 10 – June 2016

http://www.neuroscience.utoronto.ca/communications/newsletter.htm

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Featured In This Issue CPIN Newsletter

The 2016 CPIN Research Day on May 19 was a rousing success with more than 200 people

participating in the events. 5 CPIN faculty members presented Distinguished lectures. 24 oral

and 79 poster presentations by CPIN trainees were evaluated by 33 judges. 4 Excellence in

Oral Presentation and 12 Excellence in Poster Presentation Awards were recognized by the

presentation judges. CPIN would like to thank our generous event sponsors. For further

details, please see Pages 4 to 8 for the event summary.

Jonathan Dostrovsky Award in Neuroscience The deadline for this year’s award application

is Thursday, June 30. Please visit the award webpage for further information: http://www.neuroscience.utoronto.ca/award_opportunities/jonathan_dostrovsky_award.htm

News – CPIN Faculty Members Congratulations to Dr. Freda Miller (Prof., Molecular

Genetics, Physiology & the Institute of Medical Science) on being elected as the new President

of the Canadian Association for Neuroscience. Congratulations to Dr. Steven Prescott

(Associate Prof., Physiology & the Institute for Biomaterials & Biomedical Engineering) on the

innovative research from his laboratory on mechanisms underlying the development of touch-

evoked pain involving a reduced inhibition of pain signal transmission. We would also like to

welcome Dr. Blake Richards (Assistant Prof., Biological Sciences and Cell & Systems

Biology) as a new faculty member to the CPIN community. Please see page 2 for details.

Congratulations CPIN Graduating Students Please see page 3 for details.

Welcome New CPIN Students Please see page 3 for details.

CPIN Neurotalk Please see page 9 for details.

Canadian Association for Neuroscience (CAN) Student Social Event We would like to

acknowledge the CPIN graduate students who volunteered at this year’s CAN Student Social

event held on May 30 at The Ballroom that was organized in collaboration between CPIN and

Dr. Melanie Woodin (Chair of the Local CAN Organizing Committee): Ekaterina Turlova

(group leader), Andrew Barszczyk, Celeste Leung and Dulcie Vousden.

Call for CPIN 2016-2017 Distinguished Lecturer Nominations CPIN trainee & faculty

members are welcome to nominate potential speakers for the 2016-2017 Neuroscience

Distinguished Lectureship Series. Please submit your nominations at the following link: http://www.neuroscience.utoronto.ca/events/lectureship/distinguished_lecturer_nominations.htm

Nominations will be reviewed by the CPIN Academic/Executive Committees for approval.

CPIN on Twitter Follow us on Twitter for the latest program information and updates:

https://twitter.com/CPIN_UofT

Neuroscience Opportunities Please see page 9 for details

Speaker | Dr. Stafford Lightman, Professor of Medicine, University of Bristol; Henry

Wellcome Laboratories for Integrative Neuroscience & Endocrinology, Bristol, United

Kingdom

Title | Shining a light on rhythms of the hypothalamic-pituitary-adrenal axis

Date | Thursday, June 16, 2016

Time | 4:00 pm

Location | Rm. 2172, Medical Sciences Building, 1 King's College Circle, U of T

Host | Dr. Graham Collingridge, Chair and Professor, Department of Physiology, U of T

Sponsor | Department of Physiology, U of T

Note: A wine and cheese reception will be held at the Medical Sciences Building C.

David Naylor Student Commons (Stone Lobby) at 5:00pm following the lecture.

http://www.neuroscience.utoronto.ca/events/lectureship.htm

mailto:[email protected]



http://www.neuroscience.utoronto.ca/award_opportunities/jonathan_dostrovsky_award.htm












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News - CPIN Faculty Members http://www.neuroscience.utoronto.ca/home.htm

Congratulations to Dr. Freda Miller (Professor, Departments of Molecular Genetics, Physiology and the

Institute of Medical Science; Senior Scientist, Neurosciences & Mental Health, Hospital for Sick Children)

on being recently elected as the new President of the Canadian Association for Neuroscience.

Dr. Miller obtained her undergraduate degree at the University of Saskatchewan and her Ph.D. at the

University of Calgary, and held faculty positions at the University of Alberta and the Montreal Neurological

Institute at McGill prior to coming to Toronto in 2002. Her research has focused upon growth factor

signaling in the developing nervous system, with a particular focus on how neurotrophic factors regulate the genesis, survival and growth of neurons. In particular, her laboratory has defined an interplay between the TrkA and

p75 neurotrophin receptors that regulates the biology of developing neurons, has defined key roles for the p53 family in the

brain, has identified and characterized the first dermal stem cell, and has defined how growth factors encountered in the

embryonic environment regulate the self-renewal and differentiation of developing neural precursors.

In recognition of this work, she has won numerous awards, and is an HHMI Senior International Research Scholar, and an

elected fellow of the AAAS and of the Royal Society of Canada. In addition, this work has led to her role as a founder in two

different biotechnology companies. Dr. Miller also has significant experience in administrative roles. She was previously a

Councillor and Secretary for the Society for Neuroscience, and President of the International Society for Developmental

Neuroscience, and is currently the Treasurer-Elect of the Society for Neuroscience.

Congratulations to Dr. Steven Prescott (Senior Scientist, Hospital for Sick Children; Associate Professor,

Department of Physiology and the Institute for Biomaterials and Biomedical Engineering) on the innovative

research from his laboratory on mechanisms underlying the development of touch-evoked pain involving a

reduced inhibition of pain signal transmission.

This work is featured as a press release from the recent Canadian Neuroscience Meeting in Toronto

(http://www.eurekalert.org/pub_releases/2016-06/cafn-npu052716.php).

Research in Dr. Prescott’s lab focuses on how the nervous system processing information, especially how that processing

goes awry in neurological disorders such as neuropathic pain.

His lab combines experiments (electrophysiology, optogenetics, calcium imaging, etc.) with computer simulations and

mathematical analysis to uncover how changes in neuronal excitability and synaptic transmission affect information

processing by single neurons and neural circuits in the spinal cord and brain.

We would like to welcome Dr. Blake Richards (Assistant Professor, Departments of Biological Sciences

and Cell & Systems Biology) as a new faculty member to the CPIN community.

His research examines the neurobiology of learning and memory with a focus on testing hypotheses about

learning generated by models in computational neuroscience. He originally obtained his Hon. B.Sc. in

Cognitive Science and Artificial Intelligence at the University of Toronto, before going on to do a M.Sc. and

D.Phil. in Neuroscience at the University of Oxford.

After his graduate work, Dr. Richards was awarded a Banting Postdoctoral Fellowship to work with Dr. Paul Frankland at

SickKids hospital, where he studied memory consolidation. His lab started in 2014, and currently has funding from

NSERC, HFSP and Google. More information about Dr. Richards' current research and trainees can be found at his lab

website: linclab.org


http://www.neuroscience.utoronto.ca/home.htm

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http://linclab.org/

http://linclab.org/

http://linclab.org/




Congratulations CPIN Graduating Students

Last Name First Name Home Unit Degree Supervisor

Beera Kiran Medical Biophysics MSc Brian Nieman

Compagnone Jordana Institute of Medical Science MSc Mario Masellis

De Barros Freitas Carina Patricia Institute of Medical Science PhD Evdokia Anagnostou

D'Souza Abigail Pharmaceutical Sciences MSc Robert Bonin

Kim Junseok Institute of Medical Science PhD Karen Davis

MacKay-Clackett Isabel Institute of Medical Science MSc Derek van der Kooy

Patel Ingita Pharmaceutical Sciences MSc Robert Bonin

Yini Virginia Pharmaceutical Sciences MSc Robert Bonin

Welcome New CPIN Students

Last Name First Name Home Unit Degree Supervisor (s)

Brunec Iva Psychology MA Morris Moscovitch & Morgan

Barense

Butcher Nancy Institute of Medical Science PhD Anne Bassett

D'Souza Samantha Rehabilitation Science MSc Darcy Fehlings

Elliott Brittany Physiology MSc Elise Stanley

Hou Yi Bo Physiology MSc Paul Frankland

Joseph Michael Physiology MSc Lyanne Schlichter

Morrissey Mark Psychology PhD Kaori Takehara-Nishiuchi

Ng Enoch Institute of Medical Science PhD Albert Wong & John Roder

Poon Alan Institute of Medical Science MSc Carol Westall

Pressey Jessica Cell and Systems Biology PhD Melanie Woodin

Qiu Lily Institute of Medical Science MSc Jason Lerch & Mark Palmert

Renton Tian Rehabilitation Science MSc Jane Topolovec-Vranic & Angela

Colantonio

Santoro Adam Institute of Medical Science PhD Paul Frankland

Shulyakova Natalya Physiology PhD James Eubanks & Linda Mills

Terpstra Alexander Rehabilitation Science MSc Robin Green

Yalnizyan-Carson Annik Cell and Systems Biology MSc Blake Richards & Melanie

Woodin


CPIN Research Day (http://neuroscience.utoronto.ca/events/CPIN_Research_Day.htm)

The 2016 University of Toronto CPIN Research Day was held on May 19 at the Medical Sciences Building of the University of

Toronto. Over 200 graduate, postdoctoral and faculty members as well as friends attended the CPIN Research Day.

CPIN Trainee Oral Presentations were delivered by 24 trainees and evaluated by 11 judges from 9:00 to 10:15am. Students in

each group were competing for Excellence in Oral Presentation Awards (see page 7 for the list of winners).

• Group 1 (MSB 2173): Chair: Dr. Lili-Naz Hazrati (Assistant Professor, Laboratory Medicine and Pathobiology; CPIN Executive

Committee member); Student Chair: Frances Xia

• Group 2 (MSB 3227): Chair: Dr. Lu-Yang Wang (Professor & Director, The BRAIN Platform, Physiology; Interim Head & Senior

Scientist, Neurosciences and Mental Health, SickKids; CPIN Executive Committee member); Student Chair: Celeste Leung

• Group 3 (MSB 4171): Chair: Dr. Vincent Tropepe (Associate Professor and Chair, Cell and Systems Biology); Student Chair:

Ekaterina Turlova

• Group 4 (MSB 4279): Chair: Dr. Kaori Takehara-Nishiuchi (Associate Professor, Psychology); Student Chair: Vladislav

Sekulic

CPIN Research Day Sponsorship The 2016 CPIN Research Day Organizing Committee wish to acknowledge the following

sponsors: the Heart and Stroke Richard Lewar Centre of Excellence, the U of T Human Biology Program, the Krembil Research

Institute, the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Parkinson Canada, the SickKids Neurosciences

& Mental Health Program and the St. Michael’s Neuroscience Research Program; as well as the 16 CPIN participating

Departments and their faculties: the Departments of Cell & System Biology, Psychology, and Computer Science from Faculty of

Arts and Science; Graduate Department of Dentistry from Faculty of Dentistry; Departments of Biochemistry, Laboratory

Medicine & Pathobiology, Medical Biophysics, Pharmacology, Physiology, Rehabilitation Science, Institute of Biomaterials &

Biomedical Engineering, and Institute of Medical Science from Faculty of Medicine; Graduate Department of Pharmaceutical

Sciences from Faculty of Pharmacy; the Dalla Lana School of Public Health from Faculty of Public Health; Department of Applied

Psychology & Human Development from Ontario Institute For Studies in Education; the Graduate Department of Music from

Faculty of Music. See page 8 & our website for details (http://neuroscience.utoronto.ca/events/CPIN_ Research_Day.htm).



4

Research Day Welcome and Opening Remarks (MSB 2158, JJR Macleod Auditorium) All attendees were welcomed by Dr.

Zhong-Ping Feng (CPIN Director; Professor, Physiology). The opening remarks were delivered by Dr. Allan S. Kaplan (Vice

Dean, Graduate and Academic Affairs, Faculty of Medicine; Professor of Psychiatry).

New Award Announcement Dr. Zhong-Ping Feng announced the establishment of the annual Jonathan Dostrovsky Award

in Neuroscience (http://www.neuroscience.utoronto.ca/award_opportunities/jonathan_dostrovsky_award.htm). Due to the

generosity of Dr. Dostrovsky, this new annual award recognizes and supports excellence amongst graduate students enrolled in

the Collaborative Program in Neuroscience.

(CPIN Research Day Photos credit: Vladislav Sekulic)


http://neuroscience.utoronto.ca/events/CPIN_Research_Day.htm

http://neuroscience.utoronto.ca/events/CPIN_ Research_Day.htm


























5

Morning Session Distinguished Neuroscience Lectures (JJR Macleod Auditorium) Two Distinguished

Neuroscience Lectures were delivered at the Research Day by CPIN faculty members during the morning

session between 11:10am to 12:10pm. The session Chair was Dr. Amy Ramsey (Assistant Professor,

Pharmacology; CPIN Academic Committee member).

The first lecture was presented by Dr. Sandra Black (Professor and Brill Chair in Neurology, Department of

Medicine; Professor, Institutes of Medical Science, of Rehabilitation Sciences, and of Biomaterials and

Biomedical Engineering; Executive Director, Toronto Dementia Research Alliance; Director, Hurvitz Brain

Sciences Research Program, Sunnybrook Research Institute) entitled “Brain Networks and Network Science”.

The second lecture was delivered by Dr. John S. Floras (Professor, Division of Cardiology, Department of

Medicine and Institute of Medical Science; Canada Research Chair Tier 1 in Integrative Cardiovascular

Biology; Senior Clinical Scientist, Lunenfeld-Tanenbaum Research Institute) entitled “Disturbances of

neurogenic control of the human heart and circulation in heart failure and sleep apnea”.

Poster Presentations (MSB Stone Lobby) Following the lunch break at 12:10pm, 79 poster presentations in 12 groups were

given by trainees at the MSB Stone Lobby from 12:30 to 2:00pm. The poster presentations were evaluated by 22 judges.

Students in each group were competing for Excellence in Poster Presentation Awards (see page 7 for the list of winners).





Afternoon Session Distinguished Neuroscience Lectures (JJR Macleod Auditorium) Three

Distinguished Neuroscience Lectures were presented at the Research Day by CPIN faculty members

during the afternoon session between 2:40 to 4:10pm. The session was co-chaired by Dr. Jeffrey

Henderson (Associate Professor, Pharmacy, CPIN Academic and Executive Committees’ member) and

Dr. Zhengping Jia (Professor, Physiology; Senior Scientist, Neurosciences and Mental Health, SickKids).

The first lecture was presented by Dr. Michael H. Thaut (Professor and Director of the Music and Health

Research Collaboratory,MaHRC, Faculty of Music) entitled “Music and rhythm based interventions for

neurorehabilitation – research translations from the basic neuroscience of music perception and music

performance”.

The second lecture was delivered by Dr. Janice Robertson (Associate Professor, Department of

Laboratory Medicine and Pathobiology; Tanz Centre for Research in Neurodegenerative Diseases)

entitled “Uncovering Disease Mechanisms in Amyotrophic Lateral Sclerosis”.

The final lecture of the session was presented by Dr. Graham Collingridge (Professor and Chair,

Department of Physiology; Senior Scientist, Lunenfeld-Tanenbaum Research Institute) entitled “Is

Alzheimer’s caused by LTD gone awry”.




CPIN Activity Summary (JJR Macleod Auditorium) At 2:30pm following the poster presentation

session, Dr. Zhong–Ping Feng overviewed the major educational and outreach activities undertaken by

CPIN in the 2015-2016 academic year and acknowledged the CPIN trainees and CPIN faculty members,

CPIN Academic and Executive Committees, CPIN Board of Directors, CPIN Participating Graduate Units

and the CPIN Research Day sponsors for their support. For more information, please visit

http://www.neuroscience.utoronto.ca/

(CPIN Research Day Photos credit: Vladislav Sekulic)













Congratulates to Awardees Following the afternoon lecture session, the winners of the Excellence in Poster and Oral

Presentation Awards were announced by CPIN Student Co-Chairs Vladislav Sekulic (Student Organizer) and Ekaterina

Turlova (Student Organizer). In addition, the winners of the Best in Show awards at the CPIN NeuroCentricArts competition that

was held on April 29 at UofT were also announced by Suhail Asrar (CPIN Alumnus and Administrator). The winners received

their awards from Dr. Zhong-Ping Feng.



7

CPIN Excellence in Oral Presentation Awards

Colleen Gillon, Physiology, Sheena Josselyn lab

Charissa Poon, Institute of Biomaterials and Biomedical Engineering, Kullervo Hynynen lab

Husain Shakil, Physiology, Steven Prescott lab

Yohan Yee, Medical Biophysics, Jason Lerch lab

CPIN Excellence in Poster Presentation Awards

Dhekra Al-Basha, Physiology, Steven Prescott lab

Jessica Arsenault, Psychology, Bradley Buchsbaum lab

Kiran Beera, Medical Biophysic, Brian Nieman lab

Alexandra Chatzikalymniou, Physiology, Frances Skinner lab

Fenika Kapadia, Pharmacology & Toxicology, Etienne Sibille lab

Tsukiko Miyata, Medical Biophysics, Jim Woodgett lab

Temitope Olanbiwonnu, Pharmacology & Toxicology, Laurie Zawertailo lab

Alicia Paniccia, Rehabilitation Sciences Institute, Sally Lindsay lab

Vinoja Sebanayagam, Institute of Medical Science, Jennifer Ryan & Randy McIntosh labs

Chesarahmia Dojo Soeandy, Pharmaceutical Sciences, Jeffrey Henderson lab

Petri Takkala, Institute of Medical Science, Steven Prescott lab

Neuroscience Undergraduate Excellence in Poster Presentation Award

Priscilla Chan, Michael Fehlings lab (Human Biology, Neuroscience Program)

CPIN NeuroCentricArts Best in Show Award Winners

Eric Chung, Category: Original Computer Animation, Title: Optogenetics: Controlling the brain with light

Zahra Emami, Category: Acrylic Painting, Title: Universal Minds

Stephanie Holbik, Category: Photography, Title: The Shadow We Cast on Nature

Shraddha Pai, Category: Fabric Appliqué, Title: Room with a View




Event Sponsors




The immense success of the 2016 CPIN Research Day is attributable to a enormous team effort by the CPIN faculty members,

postdoctoral fellows and graduate students as well as the CPIN Research Day Organizing Committee, session chairs, judges,

volunteers and event sponsors. CPIN would also like to thank the Distinguished Lecturer speakers in both the morning and

afternoon sessions for their educational and inspirational talks!

8

Trainee Presentation Judges

Deryk Beal, Robert Bonin, Colleen Dosckstader, Jonathan Downar, Zhong-Ping Feng, Leon French, Karen A. Gordon, Ariel

Graff, Anne-Marie Guerguerian, Lili-Naz Hazrati, Jeffrey Henderson, Zhengping Jia, William Ju, Julie Lefebvre, Donald

Mabbott, Kei Masani, Jose Nobrega, Mohan Pabba, John Peever, Peter Pennefather, Stephen Perry, Amy Ramsey, Ali

Salahpour, Iman Sarvastani, Gerold Schmitt-Ulms, Frances Skinner, Shuzo Sugita, Hong-Shuo Sun, Kaori Takehara-

Nishiuchi, Anurag Tandon, Vincent Tropepe, Lu-Yang Wang and Carol Westall

Special Acknowledgements

Artur Cane, Angela Colantonio, Jonathan Dostrovsky, Michael Farkouh, Lili-Naz Hazrati, Karen A. Gordon, Allan Kaplan, Darina

Landa, Mingyao Liu, Tom Schweizer, Kaori Takehara-Nishiuchi, Vincent Tropepe, Lu-Yang Wang, Donald Weaver, Jim

Woodgett, Melanie Woodin and Julie Wysocki

Event Program Design

Alexandre Guet-McCreight (Cover Art)

Vladislav Sekulic (Abstracts)

Distinguished Speakers

Sandra Black, Graham Collingridge, John S. Floras, Janice Robertson and Michael H. Thaut

Trainee Volunteers

Julianne Baarbe, Alexandra Chatzikalymniou, Ayda Ghahremani, Alexandre Guet-McCreight, Sammen Huang, Feiya Li, Tsukiko

Miyata, Sarah Peters, Sofia Raitsin, Raymond Wong, Frances Xia and Yohan Yee

CPIN Research Day Organizing Committee

Vladislav Sekulic (Student Organizer), Ekaterina Turlova (Student Organizer), Zhong-Ping Feng (CPIN Director), Jeffrey

Henderson, Amy Ramsey and Suhail Asrar (CPIN Office)

Administration

Suhail Asrar


Event Organizers and Contributors






https://www.facebook.com/groups/CPINneurotalk/

http://www.neuroscience.utoronto.ca/events/Neurotalk.htm

2015-16 CPIN Neurotalk

Grad Room, northeast corner of Spadina & Harbord, in the Second Cup,

downstairs.

Date & time: Thursday, June 23 at 5:30pm

Moderated by: Vladislav Sekulic, Physiology The rise of ever growing data sets in neuroscience has resulted in the ushering of a new era of

"Big Data". From neuroimaging data, diffusion tensor imaging (DTI), multiunit recordings, and

gene sequencing, modern techniques for studying the brain increasingly possess the capability of

gathering huge amounts of data. This presents special challenges not only in terms of the

significant technical feats required to acquire the data, but also the non-trivial issues in analyzing,

synthesizing, and generating understanding from the data. This month we will broadly explore

issues related to Big Data in Neuroscience and society. In general, how do we make sense of all

the data? What are some of the additional challenges that large data sets create above and

beyond the "standard" difficulties in deciphering neural activity? How does the collection and

public dissemination of large data sets as well as the development of portable EEG equipment

affect how non-scientists participate in the study of the brain? We will also go over some well

known "Big Data" projects in Neuroscience, from the microcircuit level all the way up to publicly

available clinical datasets, all of which are changing the landscape of neuroscience research.

Join us for a discussion of these Big issues!

Neuroscience Opportunities http://www.neuroscience.utoronto.ca/communications/Positions_Available.htm

Postdoctoral Fellow Position

Department of Cell and Systems Biology, University of Toronto

Toronto, Canada

Description: The Woodin Lab is focused on understanding inhibitory synaptic function and plasticity. A key protein underlying

inhibitory transmission is the chloride extruder KCC2. We are currently discovering and characterizing KCC2 protein

interactions, in order to determine how they regulate KCC2 function. We are recruiting a postdoctoral fellow to identify and

characterize KCC2-protein interactions that can be targeted for KCC2 enhancement in the treatment of autism spectrum

disorder (ASD). The ideal candidate will have expertise and/or education in a combination of proteomics, biochemistry, and

neuroscience. The initial appointment will be for one-year, and is renewable for a second year. Salary will be commensurate

with experience. Applications for the position can be made by emailing a cover letter, resume, and the contact information for

two academic references to Melanie Woodin at [email protected]

For further information, please visit the CPIN website:

http://www.neuroscience.utoronto.ca/communications/Positions_Available.htm

The CPIN Newsletter will resume in September 2016 following the summer break

Reminders

Submissions for News Updates The CPIN Office requests trainee and faculty members to submit updates in research

discoveries, events, and other achievements involving CPIN members. Please send your submissions to

[email protected]

CPIN Student Completion Form CPIN graduate students who have completed both their home department and CPIN

trainee requirements must fill in the online completion form located at the link below:

http://www.neuroscience.utoronto.ca/students/cpin_student_completion_form.htm



https://www.facebook.com/groups/CPINneurotalk/

https://mail.med.utoronto.ca/owa/redir.aspx?C=PmWMTxBfYkm2sYJH03O7xzyR5ZMEC9MIhaIfLtgOAhTm8Ui9n3eTQV4-b06lYykApAEuw7plND0.&URL=http%3a%2f%2fwww.neuroscience.utoronto.ca%2fevents%2fNeurotalk.htm

































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