Cold-Chain Monitoring, Custody Transfer & Security Sensors & High-IQ Networks 1. 1950 Mainframe ......

Confidential & Proprietary Information

Cold-Chain Monitoring, Custody Transfer &

Security


AGENDA

• From 30,000 Feet – What is “The Internet of Things”? – What Are the Implications for Cold-Chain

Monitoring Applications?

• On-the-Ground: What Are the Issues In Cold-Chain? – Where Are We in the Evolution of Cold-Chain Shipping? – Is There a New Definition of Cold-Chain? – What is Being Planned for CryoPort’s “Smart Monitoring” Products &

Services?

• The CryoPort + KLATU Collaboration Story • KLATU Products & Services • 5 Take-Away’s


Smart Sensors & High-IQ Networks

1. 1950 Mainframe 2. 1982 PC 3. 1992 Worldwide

Web 4. 2009 Smart

Sensors and High “IQ” Networks

Internet of Things is the Fourth Wave of Computing & Networks


CISCO and the “Internet of Things”

Source: Cisco 2011: Cisco Visual Networking Index: Forecast and Methodology, 2010-2015

2010 2015 CAGR % Connected Devices (Per capita) 1 2 100% Internet Traffic (GB/YR) 3 11 33% Non-PC Devices 3% 15% 50% Wireless Traffic < 1% 54% 258% Wired Traffic 63% 46% -8% TV’s 101% Smart Phones 144% Tablets 216% Wireless Devices 258%


Smart Sensors & High IQ Networks


Bob Metcalfe “The Network Effect”

Metcalfe's Law (1980) 1. The value of a telecommunications

network is proportional to the square of the number of connected users in the system (n2).

2. Now applied to social media (viral) although its original intent was to describe Ethernet purchases and connections.

3. Value depends upon the number of nodes in contact.

4. Forms the foundation of “High-IQ” Networks “anywhere” monitoring.

(22=$4 (Value is $2 ea)

(52=$25 (Value is $5 ea)

(122=$144 (Value is $12 ea)


Integrated Cold Chain Monitoring (Network Effect: Highest Value Architecture)

Standards Based

Wireless Sensors

High IQ Networks

10-Day Shipper

Carrier Integration


Cold-Chain Monitoring Requirements

Question/Issue Required Technology

Stor

age

Befo

re/A

fter

Dur

ing

Ship

men

t O

rder

Ar

chiv

e

4. Is the ship plan executing normally? 5. Where is and who has custody of the

shipment? 6. Will it be delivered on time? 7. Are the products in good condition?

• Location sensor • Route plan & lane profile • Carrier IT integration (data fusion) • Temperature, shock, vibration, tilt • High IQ wireless sensor network • Software-based tracking

1. Are the products/specimens stored properly at point of origin?

2. Will they be stored properly upon arrival at destination?

3. How to know if there was a storage problem –1 year from now?

• Enterprise grade remote monitoring system at point of origin and destination.

• Temperature & compressor health sensors to predict failure.

8. How to monitor Conformance to SOP’s?

9. How to access order history & sensor data archive –1 year from now?

• Single system for logistics, track & trace, and sensor data.

• Utilization of IT standards & security protocols

• CFR-21 Archive • Chain of custody management

New

Def

initi

on o

f Col

d-C

hain


Integration Risk (Regulatory & Technical Uncertainty)

• Changing Industry “Standards”: GxP, PDA, IATA, DOT • Changing Computer Standards

– Computer (Legacy): 3270, SNA, SDLC, Bi-Sync, IPX/SPX, Bell-103A/212, Apple Talk, MAP

– Today: TCP/IP

• Changing Cellular Standards – Cellular (Legacy): AMPS, 1xRTT, IDEN, Mobitex – Today: 3G, 4G, GSM

• Changing Wireless Sensor Standards – Wireless Sensor (Legacy): Zigbee, Zwave, BlueTooth, UWB,

DECT, WiMax, Wi-Bree, WirelessHart, ISA 100, 6LowWPAN, OneNet, Proprietary

– Tomorrow: Wi-Fi

• Many Vendors, Many Products –no interoperability.


Wireless Risk Factors RF Standards as Applied to

Frequency Spectrum

Standards Body

LF 125/134.2 kHz

HF 13.56 MHz +/- 7 kHz

HF 433 MHz

UHF 860-960MHz

UHF 2.45 GHz

ISO • ISO 11784 • ISO/IEC 18000-2A • ISO/IEC 18000-2B

• ISO/IEC 14443 • ISO/IEC 15693 • ISO 18000-3

• ISO 18000-7 • ISO 18000-6A • ISO 18000-6B • ISO 18000-6C

• ISO 18000-4 • ISO/IEC 24730-2

EPC Global • Class 0

• Class 1 • Class 1 Gen 2

IEEE

• Zigbee • Wi-Fi, • 6LoWPan • Zigbee • BlueTooth • WirelessHart • WiBree • 802.15.4

Proprietary

Implication: Which “Standard”? No Interoperability

9 million users of the most popular QR code scanner (iPhone) scanned only 4,000 QR codes per day (Forbes 8/04/11).


CryoPort/KLATU Collaboration

COLLABORATE 1. :Latin collaboratus, past participle of

collaborare to labor together, from Latin com- + laborare to labor

2. to work jointly with others or together especially in an intellectual endeavor


CryoPort/KLATU Collaboration

• Shared Vision For The Future Of Cold-chain Shipping & Management.

• Same Customers, Same Markets • Synergistic Products & Services. • Opportunity To Create A “Gen2”

Shipping Solution With Order Processing, Integrated Monitoring, Track/Trace And Custody Transfer …

• … and, Asset Monitoring At Point Of Origin And Destination.

CryoPort GEN2 LN2

Shipper (No Dry Ice)

KLATU TRAXX

Monitoring

CryoPort Express Portal (Biz Process

Optimization)


Amazon Elastic Compute Cloud

Shipping Services

FedEx Web Service Client

Scan Code Tracking Rules

Engine

Data Integration &

Validation Smart Module

Integration

FedEx

CryoPort Express Portal Design Overview

Replicated Database

Master DB

Slave DB

Web Server

End Users (CRO Partners)

CryoPort Internal

Logistics Partners

Users

End Users (Retail)

Web Server

Load Balancing

Web Server Unlimited Scaling

On Demand

Sm

art Modules

Portal

Back-Office Accounting

Forecasting & Contract

Management

Order Entry Wizard

Order Status & Monitoring

Alerting Work Flow Process

Access Control Reports


CryoPort Express Portal (Custody Transfer Events)

Scan Code Arrival


TRAXX Analytics Identical Assets

• Normal Temp • Normal kW Response

• Normal temp. • High kWh, abnormal

kWh response. • Probable high-stage

compressor problem


Rick Kriss, KLATU Networks, LLC [email protected]

(503) 802-0703 (619) 218-7000

www.klatunetworks.com

ULT-Cold Storage Assets Hidden Source of Wasted Energy

(Preliminary Research Results)

© 2011 KLATU Networks, LLC


The “Patient”

• ~ 30% Out-of-spec Averaging 10% -100% Energy Loss • > 250,000 In USA, ~ 47,000 Locations • Consume 15x More Energy Than A Home Refrigerator • kWh 1 ULT = kWh 1 House • Lack Of Visibility And Awareness • Problems Even When New and Well Maintained

Annual Energy Consumption (Identical Assets)


ULT Myths and Realities

• Stable -80

inside = Asset health OK • Setting a -80

to -60

will consume less energy

• New freezers are more energy efficient than old • Energy efficiency can be increased 15%-

30% by changing room temperature or line voltage

• Most ULT failures are unpredictable • Energy cost per ft can vary by 200%


4 Study Groups (n=32 of 59, 54%)

Bad Assets* 32 (54%) Avg Wasted kWh** $312 / 28% Wasted Energy** 77,182 kWh / $9,994 (14%) Avg Repair $218 Payback Repairs*** 8 Months Freezers in Failure Mode*** 6/59 (10%)

* Randomly Chosen, Well-Maintained, 2x / Yr. PM, ranked “C” or “F” ** @ $0.14/kWh, $0.09/kWh calculated on basis of all freezers (“A” – “F”) *** Note: Replacement Cost Not Included in Pay-back Analysis

Study Group Results

• Key Findings • Routine PM inspections cannot “see” most problems.

• “Out-of-spec” assets will eventually fail. Cheaper to maintain now.

• Condition based maintenance saves money.

• Make service provider a full partner, accountable to a result such as kWh metrics.

54% of ULT’s Waste 28% of Energy Consumed


ULT Repair Estimates (To Restore Efficiency)

Code Description of Fix Cost Count PCT D Defrost Cheap 8 31%

NFM New Filter Media on condenser coil

Cheap 8 31%

HSSC Replace High Stage Comp. Start Components

Affordable 3 12% LSC Replace Low Stage Compressor Expensive 2 8% CTS Change Temperature Setpoint Cheap 1 4%

M Move unit to cooler location/better circulation

Cheap 1 4% DG Replace Inner Door Gasket Cheap 1 4%

LSSC Replace Low Stage Comp. Start Components

Affordable 1 4% DCO Dual Compressor Overhaul Expensive 1 4%

n=16 (Some Assets Have Multiple Issues)


Quartile Asset Ranking

Annual kWh Consumption

6,000- 8,000

A

8,000- 10,000

B

10,000- 12,000

C

12,000- 15,000

F

Asse

t Cou

nt

No Skew

“Average”

25% 25% 25% 25%


Skewed “A”

6,000- 8,000

A

8,000- 10,000

B

10,000- 12,000

C

12,000- 15,000

F

30% 15% 20% 35%

Asse

t Cou

nt

“Better Than Peer Group”


Skewed “F”

6,000- 8,000

A

8,000- 10,000

B

10,000- 12,000

C

12,000- 15,000

F

15% 35% 30% 20%

Asse

t Cou

nt

“Worse Than Peer Group”


5 Take-Away’s 1. The Internet of Things is will have

a profound impact on Cold-Chain monitoring --millions of networked devices watching every move.

2. Everything will be monitored, tracked, traced and benchmarked for performance & optimization.

3. New monitoring applications will be designed around IT standards, tools, technologies and security models.

4. A new definition of supply chain monitoring will include close monitoring of shipments as well as the storage facilities at the beginning and end of the cold-chain.

5. New and highly integrated business automation solutions such as CryoPort Express Portal will manage all logistics as well as monitoring the entire cold-chain.


TRAXX kWh Analytics Identical Assets

Customized Floor-Plan. For Asset Status Visualization. Asset icons move & respond

to location & condition in real-time.

The End

Cold-Chain Monitoring, Custody Transfer & Security Sensors & High-IQ Networks 1. 1950 Mainframe ......

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Transcript of Cold-Chain Monitoring, Custody Transfer & Security Sensors & High-IQ Networks 1. 1950 Mainframe ......