Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums,...
Transcript of Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums,...
![Page 1: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/1.jpg)
Cognivue®
Charles J. Duffy, MD, PhD
Founder and CEO
May 10, 2017
![Page 2: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/2.jpg)
Cognivue is an artificial intelligence neurological tool,
not a computerized psychological questionnaire
COGNIVUE ENABLES CARE
2
Cognivue promotes cost-effective dementia care
in primary care office practices
Cognivue aligns patients, families, and practitioners by
moving beyond dementia as an accusation
![Page 3: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/3.jpg)
3
LocalMotion
GlobalPattern
LocalMotion
GlobalPattern
LocalMotion
GlobalPattern
Psychophysics Distinguishes Aging and AD
Mo
tio
n C
oh
eren
ce T
hre
sho
ld
ORIGINS OF COGNIVUE
![Page 4: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/4.jpg)
4
UTILITY OF COGNIVUE
Year in Study (off treatment)
0
10
20
30
40
50
60
70
1 2
ON Radial IO
ON Radial Out
ON Planar
AD Radial IO
AD Radial Out
AD Planar
NAD = 12
NON = 31
One Year Longitudinal Study in Aging and AD M
oti
on
Co
heren
ce T
hresh
old
One Year Longitudinal Study in Aging and AD
Stability in normal aging
Decline in early Alzheimer’s
Detect and monitor disease neurological deficits
Monitor
Detect
![Page 5: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/5.jpg)
5
NEURAL MECHANISMS OF COGNIVUE
![Page 6: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/6.jpg)
6
LINKS TO AGING AND ALZHEIMER’S
Hyperactivity of soluble AβLoss od activity with Aβ plaques
Loss of signal coherencein aging and early AD
![Page 7: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/7.jpg)
SIX KEY POINTS
7
1. Detect functional impairment
2. Monitor disease progression
3. Assess therapeutic efficacy
4. Access neural mechanisms
5. Foundation of complex behaviors
6. Domain-specific impairment measures
![Page 8: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/8.jpg)
Shape Processing
Occipital
Language
Parietal
Temporal
Language Processing
cat
dal
daf
cbt
gca
erfltv
kif
ris
pfg
Visuo-Motor Function
Motion Processing
Dynamic Adaptation
Spatial Attention
Temporal Integration
Learning & Memory
Bottom-Up Processing
8
COGNIVUE COMMERCIALIZATION
![Page 9: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/9.jpg)
9
COGNIVUE PSYCHOPHYSICAL TESTING
Motor
Control Report Generation
Visual
Salience
Sensory-Motor Testing
Calibrate
to Patient
Perceptual Testing Shapes
Motion
Letters
Words
Calibrate
to Patient
Memory Testing Shapes
Motion
Letters
Words
Calibrate
to Patient
Cloud Archives
Post-hocAnalyses
Contextualized
F/U Testing
Practitioners& Researchers
![Page 10: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/10.jpg)
Doe, John02-01-1956
Secure access on Cognivue, desktops, and portable devices
10
THE COGNIVUE SYSTEM
![Page 11: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/11.jpg)
N = 356 subjects tested twice
Cognivue re-test correlation = .90
PPA = .89, NPA = .93, ICC = .94
SLUMs re-test correlation = .82
PPA = .87, NPA = .87, ICC = .87
11
COGNIVUE’S FDA VALIDATION
N = 401 subjects 55- 95 yo
impaired vs. unimpaired
Cognivue vs. SLUMS
PPA & NPA
.82 & .98
![Page 12: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/12.jpg)
1) Objective psychophysics
2) Neurological assessment
3) Linked to brain electrical activity
4) 10 minute testing in doctor’s office
5) Simple test interpretation algorithm
6) Easily explained to patients and families
12
COGNIVUE’S ADVANTAGES
![Page 13: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/13.jpg)
Cognitive Disorders – Dementias, Deliriums, Syndromes
Movement Disorders – Parkinsonism and overlap syndromes
Affective Disorders – Depressions, Manias, Psychoses
Acquired Disorders – Head injury and medicinal SEs
Developmental Disorders – Conditions and Pathopotential
PLATFORM TECHNOLOGY TARGETS
13
![Page 14: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/14.jpg)
14
COGNIVUE CONTINUING EXPANSION
Domain-specific cortical function
![Page 15: Cognivue - Critical Path Institute...2017/07/10 · Cognitive Disorders –Dementias, Deliriums, Syndromes Movement Disorders –Parkinsonism and overlap syndromes Affective Disorders](https://reader033.fdocuments.in/reader033/viewer/2022050612/5fb326af5141242e5c14ac8c/html5/thumbnails/15.jpg)
Bringing cognitive care to primary care
15