coagulation2-

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PART IV Drugs used in disorders of coagulation

001. All of the following physiologic reactions are

involved in the control of bleeding EXCEPT:

a) Platelet adhesion reaction

b) Platelet release reaction

c) Activation of the antifibrinolytic system

d) Triggering of the coagulation process

002. Which of the following substances is

synthesized within vessel walls and inhibits

thrombogenesis ?

a) Thromboxane A2 (TXA2 )

b) Prostacyclin (PGI2 )

c) Prostaglandin ((PGE )

d) None of the above

003. All of the following groups of drugs are for

thrombosis treatment EXCEPT:

a) Anticoagulant drugs

b) Antifibrinolitic drugs

c) Fibrinolitic drugs

d) Antiplatelet drugs

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c

b

b


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004. Pick out the drug belonging to anticoagulants of

direct action :

a) Aspirin

b) Heparin

c) Dicumarol

d) Phenprocoumon

005.

Which of the following drugs has low-molecularweight ?

a) Dicumarol

b) Enoxaparin

c) Phenprocoumon

d) Heparin

006. Indicate the drug belonging to antagonists of

heparin :

a) Aspirin

b) Dicumarol

c) Dalteparin

d) Protamine sulfate


indirect action !!!

b

b

d


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007. Tick the drug used as an oral anticoagulant :

a) Heparin

b) Daltreparin

c) Dicumarol

d) Enoxaparin

008. All of the following drugs are indirect acting

anticoagulants EXCEPT:

a) Dicumarol

b) Warfarin

c) Dalteparin

d) Phenindione

009. Which of the following drugs belongs to

coumarin derivatives?

a) Heparin

b) Enoxaparin

c) Dalteparin

d) Warfarin


NOT INcluded

c

c

d


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010. Heparin is effective when administred orally.

This consideration is :

a) True

b) False

011. All of these drugs are antiplatelet agents

EXCEPT:

a) Aspirin

b) Urokinase

c) Ticlopidine

d) Clopidogrel

012. The use of heparin is recommended for

treatment of deep venous thrombosis. Thisstatement is :

a) True

b) False


b

b

a


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013. Mechanism of aspirin action is :

a) Converts inactive plasminogen into active plasmin

b) Inhibits COX and thus thromboxane synthesis

c) Enhances the interaction between antitrombin III

and both thrombin and the factors involved in the

intrinsic clottingcascade

d) Inhibits the glycoprotein IIb/IIIa complex

014. Which doses of Aspirin may be more effective

in inhibiting Tromboxane A2 ?

a) Low

b) High

015. Which of the following drugs is an inhibitor ofplatelet glycoprotein IIb/IIIa receptors ?

a) Aspirin

b) Clopidogrel

c) Ticlopidine

d) Abciximab

016. Ticlopidine is an inhibitor of ADP-induced

platelet aggregation. Its :

a) True

b) False


b

a

d

a


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017. Which of the following drugs is fiibrinolytic ?

a) Ticlopidine

b) Streptokinase

c) Aspirin

d) Warfarin

018. Mechanism of urokinase action is an inhibition

of Thromboxane A2. This statement is:

a) True

b) False

019. Fibrinolytic drugs are used for following

EXCEPT:

a) Central deep venous thrombosis

b) Multiple pulmonary emboli

c) Heart failure

d) Acute myocardial infarction


Not Included

b

b

c


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020. Indicate the drug belonging to fibrinoliytic

inhibitors :

a) Aminocapronic acid

b) Ticlopidine

c) Streptokinase

d) Vitamin K

021.

Aminocapronic acid is a drug of choice fortreatment of :

a) Acute myocardial infarction

b) Bleeding from fibrinolytic therapy

c) Heart failure

d) Multiple pulmonary emboli

022. Tranexamic acid is an analog of aminocapronic

acid. Its :

a) True

b) False


a

b

a

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