Coagulation Just the basics.... Three steps Vasoconstriction Platelet plug formation Fibrin clot...
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Transcript of Coagulation Just the basics.... Three steps Vasoconstriction Platelet plug formation Fibrin clot...
![Page 1: Coagulation Just the basics.... Three steps Vasoconstriction Platelet plug formation Fibrin clot formation.](https://reader035.fdocuments.in/reader035/viewer/2022072005/56649cef5503460f949bd0b7/html5/thumbnails/1.jpg)
Coagulation
Just the basics...
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Three steps
• Vasoconstriction• Platelet plug formation• Fibrin clot formation
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Essentially all interconnected and all occurring at the same time.
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Platelet plug formation
Step 1 – covering the exposed surfaces
Mechanism:Adherence of platelet GP1b to von Willebrand
factor. vWF is in turn bound to collagen.
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Step 2: Platelet activation
• Shape change – discoid to spiny• Membrane flip-flop – become negatively
charged• Assemble GPIIb IIIa receptors for fibrinogen • Release some coagulation factors from alpha
granules• Release ADP from dense granules
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Platelet aggregation
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Initiation of coagulation cascade
Tissue factor
+Factor VII
=firelighter
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The coagulation cascade
“Intrinsic” pathway=
Main fuel of fire
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Interactions
Platelets• Shape change• Membrane flip flop
• Alpha granule release
• Platelet activation
• ADP release
Coagulation cascade• Surface area for reaction• Negative charge for docking
factors• Increased concentration of
factors• Thrombin production
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Inhibition of coagulation
• Tissue factor pathway inhibitor (TFPI)
• Antithrombin
• Protein C/ Protein S
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Role of the endothelium in inhibition of thrombosis
• Antithrombin and heparin• Thrombomodulin and Protein C• Prostacyclin• Nitric oxide• Release of fibrinolytic activators (TPA)
• Blood flow in intact vessels washes away thrombin
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