Limb Development Matthew Velkey [email protected] 454A Davison, Duke South (Green Zone)
CNS Sequence CNS Histology March 10, 2008 S.K. Kim / J.M. Velkey.
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Transcript of CNS Sequence CNS Histology March 10, 2008 S.K. Kim / J.M. Velkey.
CNS Sequence
CNS Histology
March 10, 2008
S.K. Kim / J.M. Velkey
Spinal cord & peripheral
ganglia
Dorsal horns: InterneuronsVentral horns: Somatic motor neurons Lateral horns: • Sympathetic visceral motor neurons• Parasympathetic (S2-4) VM neurons
DRG: Sensory (pseudounipolar) neurons
Autonomic ganglia: Post ganglionic neurons with unmyelinated axons.
•Sympathetic: paravertebral & preaortic (celiac, superior mesenteric, etc.) ganglia•Parasympathetic: in organ walls
#65 Spinal cord and DRG#65 Spinal cord and DRG
Ventral Ventral hornhorn
Lateral hornLateral horn
Dorsal Dorsal hornhorn
Dorsal root Dorsal root ganglion (DRG)ganglion (DRG)
Motor neurons, glial cells and neuropil
Glial cells
Neuropil
Dorsal root ganglion
Motor and Sensory Neurons(Multipolar) (Pseudounipolar)
DHDH
DCDC
VHVH
LHLH
DH = dorsal hornDC = dorsal nucleus of Clarke
- thoracic spinal cord
LH = lateral hornVH = ventral horn
66a Spinal Cord (ventral horn motor neurons)
Thoracic cord lateral horn: preganglionic sympathetic neurons of intermediolateral cell column
Thoracic cord lateral horn: spinocerebellar neurons of Clarke’s nucleus (relay proprioceptive input up to cerebellar cortex:
e.g. from muscle spindle DRG spinocerebellar neuron cerebellum)
Thoracic cord: dorsal horn neurons (interneurons) short projections to other neurons at same level or nearby spinal level
Cerebrum
Sulcus (sulci) Gyrus (gyri)
Cerebellum
Pons Medulla oblongata
3rd ventricle
4th ventricle
Brain
Cerebrum and Cerebellum
Cerebellum Cerebrum
W W
CC
C
M
C: Cortex of gray matter W: White
matter
W/M = White matter of cerebellum also called “medulla”
#77 Cerebellum
Cortex
White matter
Slide 77a – luxol blue
white
mat
ter
cortex (gray matter)
#77 Cerebellum
WMWM
GLGL
MLML
PCPC
#76b Cerebrum – tol. blue & eosin
#76
Ross and Pawlina, p.311
Cereb
ral cortex
Layer III Layer III pyramidal pyramidal
cellscells
Layer V Layer V pyramidal pyramidal
cellscells
#NP004N Hippocampal regionCA: Cornus ammonis
CA1
CA3
CA2
Dentate Dentate gyrusgyrus
Hippocampus
CA4 (hilus)
choroid plexus
“typical” ependymal
cells (columnar, lining cells)
ependymal cells of choroid plexus (cuboidal, eosinophilic: produce CSF)
3 layers of Hippocampal region (CA1-CA3)
Molecular Molecular
layerlayer
Pyramidal cell
Pyramidal cell
layerlayer
Polymorphic
layer
Pyramidal cells
3 layers of Dentate gyrus
Molecular Molecular layerlayer
Granule cell layer
Granule cell layer (neurons)(neurons)
Polymorphic layerPolymorphic layer (interneurons and granule cell axons)
Molecular layer (dendrites of granule cells)
Cerebellum – H&E Cerebrum – TB&E
CC
W
W
Purkinje cells (neurons)
Layer V Layer V Pyramidal Pyramidal cells cells (neurons)(neurons)
C: Cortex of gray matter W: White matter
#77 Purkinje neurons #76b Pyramidal neurons
#74 Sympathetic ganglion cells
#75 Parasympathetic ganglion cells(in Seminal vesicle)
Sensory and Autonomic Neurons(Parasympathetic – e.g. from vaginal wall)(DRG)