CME ON: Bio implant & Biomedical devices- Application, Recent advancement and Bio-medical science:

Application Adverse effects.

Recent Advancement Current Priority

Research Conclusion.

Clinical Application of -

S E C T I O N S -

Application Of Bio-materials/ medical devices. Adverse effects of Biomaterials/Bio-devices. Recent Advancement of Bio-materials/ Bio- medical Science. Current Priority Research on Biomaterial/ bio-medical science.

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Prepared By-Dr. Md Nazrul Islam.MBBS, M.sc.(BME).

Supervised By-Associate Prof. Ziaul Haq -MBBS, MS (Orthopedic).

1. Implants for Eye, ENT, Brain2. Implants for Heart, Liver and Kidney.3. Implants for Orthopedic and Dental.

Biodegradable cranial implant made of PLA-β-TCP produced using SLM.

Application Of Bio-implant & Biomedical Devices-

Implants for Eye, ENT, Brain-

Hydroxyapatite Ocular implant

Retinal Prosthesis

ARTIFICIAL-CORNEA

Lens(ocular) Prosthesis


implanted device to treat balance disorder


Cochlear Implant:Most Commonly Used Ear Implant.

Implants for Eye, ENT, Brain-

Implants for Heart, Liver and Kidney.

Implantfor Heart:.

Implant for Kidney:

Stent for Heart:.

Metallic Heart Valve:.

Collagen Heart Valve:.


First Implantableartificial kidney / Technology .

Implants for Dental and Orthopedic-

• Bone Repair • Joint Implants• Joint Replacements

Biomaterial For Hard Tissue-

Collagen Bone Graft

Resorbable Tricalcium Phosphate (β-TCP) Implants for bone void

Osteoset—calcium sulfate pellets.

β-tricalcium synthetic bone product.


Dental Biomedical Implants:

Metallic Glass-New BioabsorbableOption for Bone Implants

Timeline of the recent past, near future, and far future for the use of synthetic dental biomaterials versus truly biological materials

Glass Orthopedic Bone Graft Material For New Bone Growth,

An artificial dental crown


Orthopedic Biomedical Implants:

• Bone Repair • Joint Implants• Joint Replacements

Biomaterial For Hard Tissue- Limbs

Orthopedic Implant Finger Plate


Biomaterial For Hard Tissue- Lower Limbs

ANKLE- prosthesis.

KNEE- prosthesis.HIP- prosthesis.

Application Of Bio-implant & Biomedical Devices-Orthopedic Biomedical Implants:

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Biomaterial-For Hard Tissue- Lower Limbs: Application


Composite–(Metal ,PolymerAnd Ceramic) Hip prostheses. Composite–(Metal ,Polymer

And Ceramic) Knee prostheses.

Ankle-Replacement-Prosthesis

Biomaterial-For Hard Tissue- Limbs

Synthetic Biomaterial for Tendon Replacement


Patellar Augmentation implant.

Orthopedic Biomedical Implants:

Biomaterial For Hard Tissue- Limbs: Application


Biomaterial:For Hard Tissue- Spine


Baguera L - Lumbar Disc Prosthesis. MRI compatible

Biomaterial-For Hard Tissue- Spine: Application


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Biomaterial- Biodegradable:For Hard Tissue- Limbs & Spine


Tissue Engineering Of Skin - Withy Polymer Scaffold

Polyform® Synthetic Mesh

Biomaterial-For Soft Tissue-

Bio-Engineering Hydro-gel for Tissue Repair


Biomaterials-regeneration-tissue Small intestinal submucosa (SIS) is a biomaterial that can induce host tissue proliferation and regeneration when it is implanted at various tissue sites.

Tissue Engineering Of Skin – for Burn Patients

Application Of Bio-implant & Biomedical Devices-Biomaterial-For Soft Tissue-

1. Artificial Device / Organs for Eye, ENT, Brain2. Artificial Device / Organs for Heart, Lungs, Liver and Kidney. 3. Artificial Device/Organs for Dental, Maxillofacial and Orthopedic.

Application of Artificial Device/ Organs


Insulin Pumps - Diabetes

Cancer detectionfrom an implantable device,

Human Biomedical Devices.

Class I: General controls.

Class II: General controls with special controls

(infusion pumps, and surgical drapes…).

Class III: General controls and premarket approval (implantable pacemaker, pulse generators, automated external defibrillators).

Classification:

Biomaterial, Bio-implant / Biomaterial device:

Artificial Device/ Organs for Eye, ENT, Brain

Scientists Set Sights on an Implantable Prosthetic for the Blind .

Implantable Miniature Telescope for Macular Degeneration

implantable-device- seizureImplantable Smart Chip

Fights Chronic Pain -


Artificial Device/ Organs For Heart,Lungs,Liver,Kidney and Stomach.

ivad

Artificial Heart

Device blocking stomach nerve signals shows promise in obesity


Artificial Lung Without Need for Extra Oxygen

First_pacemaker_Siemens-Elema_19581

Application: Pace-maker in-situ.


Blood-power-hydroelectric-turbine... devices that use Small turbines designed to fit inside a human artery.

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Liver device helps man survive until transplant – FGate


Artificial Device/ Organs For Heart, Lungs, Liver and Kidney.

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Artificial mechanical kidney


Artificial Device/ Organs For Heart, Lungs, Liver and Kidney.

Artificial Device/ Organs for Dental and Orthopedic Implantation.

Orthopedic /Dental Implants Pulse Generators (CRMs) .

Flexible (nylon) dental prostheses.

Composite– (Metal andCeramic) dental prostheses.


Surgically implanted titanium And stainless steel plates

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Remote Control-Microchips...

Wireless Implantable Chip Delivers Osteoporosis Drug- When It Is Needed.

Application Of Bio-implant & Biomedical Devices-Artificial Device/ Organs for Dental and Orthopedic Implantation.

Hemolysis,Thrombosis & Coagulation. (Exaggerated) Inflammation Acute Inflammation (Exaggerated) Chronic Inflammation (Specific for foreign

body) Immunogenicity and toxicity Infection Corrosion/ Wear/ Tear Loosening Fracture of implant and bone Rejection of Implant Tumorogenesis /Carcinogenesis.

Adverse Effects Of Biomaterial/Bio-device:

Recent AdvancementOf Biomaterial/Biomedical Science.

Biodegradable Biomaterial.

Bioactive Biomaterials.

Biologic Biomaterials.

Antibiotic coated Bio-

implants/device.

Aesthetic/ Cosmetic

Biomaterial.

Micro-chip controlled Bionic

Devices.

Molecular Imaging Technique.Mesh_Titanium_orthopedic implant.

Biodegradable Biomaterial.

Recent AdvancementOf Biomaterial Science.

Biomaterials that form bonds with the living tissues and perform specific biological response at the interface -

• Capable of direct chemical bonding with the host tissue.

• Stimulatory effects on bone-building cells.

o Bioglass SiO2, o CaO and Na2O, o Calcium Phosphate.Bone ingrowth around

synthetic hydroxyapatite


Ideal as bone cement filler and coating due to its biological activity– Cannot be used for load bearing applications-

Biologic Biomaterials.

Implantation of cell / tissue / fluid for regeneration. Restorable Collagen- Based Medical Implant/ tissue. Tissue Engineering for Tissue and Organ Regeneration.

Are Biological components- either from- Natural (Plant), or xeno, allo or auto biological components- Whole /part of Cell- adult /stem, Cell-secreted extracellular matrix or fluid, Living Tissue Components (e.g. Collagen, liver or pancreatic tissue) or Lab grown biological cell, fluid/ tissue or organ to augment, regenerate, replace or implantation in the living biological system.

Research of interest -


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Tissue Engineering For Tissue and Organ Regeneration.Stem Cell Researchers –A Step Closer to Growing New Organs-

An artificial human trachea implanted in Sweden: A cancer patient has received the first synthetic windpipe transplant.

The synthetic scaffold of an ear sits bathed in cartilage-producing cells, part of an effort to grow new ears for wounded soldiers.


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Restorable Collagen-Based Medical

Implant.

Collagen is an important ECM molecule and is the major structural component in the body.It is biocompatible and degrades into harmless products that are metabolized or excreted. a very poor antigen , non-toxic.


Pulpal Regeneration -

Antibiotic-coated Bio-implants/device -

New multifunctional ciprofloxacin-releasing

SR-PLGA 80/20 screws (A). Screws that do not contain ciprofloxacin (B).


Aesthetic/ Cosmetic Biomaterial.

Porous-polyethylene-implant-Reconstruction of the total external ear has two major approaches- alloplastic prosthesis implantation.

Nose implants

Cosmetic-dentistry-

Popular- cosmetic-dental-treatments-


http://www.qualitymedicalsupplies.com/page/QMS/PROD/111-BA-SFC/57-165818




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Aesthetic Biomaterial.

Popular- Aesthetic Replacement of Testis-


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Cosmetic Biomaterial.Biomaterials in plastic - surgery-

Silicone-breast implant in-situ


Saline-breast implant

Autogenous-cartilage-graft

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Micro-chip Controlled Bionic Devices.

Bionic bodies have been depicted in science fiction for decades. Now, researchers are making bionics the new frontier of medical science, by creating hi-tech devices to help people walk, see and hear again.


Innovation- Molecular Imaging Technique›


Molecular imaging is a new biomedical research discipline enabling the visualization, characterization, and quantification of biologic processes taking place at the cellular and sub-

cellular levels.

It provides a number of unique advantages over more traditional tools such as histology: Non-Invasive Real-Time Physiological Conditions Intact Tissue Living Subject Longitudinal and Quantitative Assessments Complementary to Histology.

Human Bone Osteosarcoma Cells (Fluorescent Digital Image technology)

Bimolecular Image of Chest-

• Positron emission tomography (PET)• Single photon emission computed tomography (SPECT)• Magnetic resonance imaging (MRI)• Computed tomography (CT)• Optical bioluminescence imaging• Optical fluorescence imaging• Ultrasound.

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Current Priority Research On Biomedical/ Biomaterial Science.

Application: Genomic and personalized medicine. Nano -technology oriented Medical science and Regenerative Medicine. 3rd And 4th Generation Biomaterial –• Tissue Engineered- Cell and

Gene activating Biomaterials.

• Adult/Stem Cell derived cell, tissue/Organ and Medication.

Innovation: Biodegradable and Bioactive- biomaterial /drug delivery system. Biocompatible and comfortable bionic limbs/ Organs. Newer technology for Aesthetic,Cosmetic,Dental,Orthopedic & Maxillofacial Surgery. Bio-fuel/auto-fueled/ Self controlled Biomedical devices.

Advanced Biomaterial-Regenerative medicine,

able to interact with

living cells, and to

promote tissue repair.

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Live human lungs grown in lab using stem cells in potential transplant breakthrough -

Current Priority Research On Biomedical/ Biomaterial Science-

Stem Cell Research:

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Live human heart grown in lab using stem cells in potential transplant breakthrough-


Stem Cell Research:

Tissue Engineered Bladder


Stem Cell Research:

Dr. Anthony Ata-la and his team has grownbladders and blood vessels using Stem Cell.

Spray On Stem Cells for Treating Burns and Open Wounds–Regenerative


Stem Cell Research:

Most current applications of biomaterials /biomedical device involve structural functions, or very simple chemical or electrical functions.

Complex chemical functions (e.g., those of liver), and

Complex electrical or electrochemical functions (e.g., those of brain and sense organs) – cannot be carried out by biomaterials.

Transplantation of organs and tissues is inevitable when biomaterials are not available.

Regenerative Medicine In 2012- Assessing Predictions

Conclusion And Our Consensus :

Conclusion

Tissue engineering will change the face of biomaterials. Regenerative medicine will reduce the need for synthetic materials in the body. In the near-future, biomaterials will be incorporated with biological factors (such as bone growth) directly into an implant’s surface to improve biocompatibility and bioactivity. Bionic device- Now researchers are making bionics, the new frontier of medical science, by creating hi-tech devices to help people walk, see and hear again.

Conclusion

Conclusion And Our Consensus:

We Are

Grateful To : Professor Shamimul Haq Associate Prof. Dr. Ziaul Haq Associate Prof. Dr Paritosh Chandra Debenath Associate Prof. Dr. Sheikh Abbas Uddin Ahmed Associate Prof. Dr. Md Golam Kabir Miah Associate Prof. Dr. Monoarul Islam Associate Surgeon Dr. Aminur Rahman Assistant Prof. Kazi Shamim uzzaman Assistant Prof. S.M. Quamrul Akther Sanju Assistant Prof. Bahar Uddin Dr. Ibnul Hasan of Department of Orthopedic And Mr Sanouar Hossain & Kazi Afsar Uddin of THE ACME Laboratories, Dhaka, Bangladesh.

Sponsored By:THE ACME- Laboratories Ltd,Dhaka, Bangladesh.

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CME ON: Bio implant & Biomedical devices- Application, Recent advancement and Bio-medical science:

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Transcript of CME ON: Bio implant & Biomedical devices- Application, Recent advancement and Bio-medical science: