CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENT File...

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- vvu9 -------------------------------------------------------------------------------- bpa5 -------------------------------------------------------------------------------- bja4 -------------------------------------------------------------------------------- msp9 -------------------------------------------------------------------------------- gsu1 -------------------------------------------------------------------------------- dde4 -------------------------------------------------------------------------------- dde3 -------------------------------------------------------------------------------- pmu6 -------------------------------------------------------------------------------- psp19 -------------------------------------------------------------------------------- msp12 -------------------------------------------------------------------------------- psp25 -------------------------------------------------------------------------------- oih3 -------------------------------------------------------------------------------- rpa6 -------------------------------------------------------------------------------- bja7 -------------------------------------------------------------------------------- spo20 -------------------------------------------------------------------------------- tfu1 -------------------------------------------------------------------------------- rsp10 -------------------------------------------------------------------------------- msp15 -------------------------------------------------------------------------------- cgl1 -------------------------------------------------------------------------------- spo21 -------------------------------------------------------------------------------- reu5 -------------------------------------------------------------------------------- psp6 -------------------------------------------------------------------------------- bbr8 -------------------------------------------------------------------------------- bpe1 -------------------------------------------------------------------------------- bpa9 -------------------------------------------------------------------------------- ssp5 -------------------------------------------------------------------------------- bja6 -------------------------------------------------------------------------------- rsp8 -------------------------------------------------------------------------------- msp6 -------------------------------------------------------------------------------- msp10 -------------------------------------------------------------------------------- bbr10 -------------------------------------------------------------------------------- spo22 -------------------------------------------------------------------------------- bpa14 -------------------------------------------------------------------------------- bbr12 -------------------------------------------------------------------------------- psp16 -------------------------------------------------------------------------------- bbr7 -------------------------------------------------------------------------------- bpa3 MSSIEMPAPVMPIEPAELAGASPYPLAIDQDFCLIRWMAAISRACGALATVALLLMALSMCYEIFSRYLFNAPTAWATEI 80 mma5 -------------------------------------------------------------------------------- dar4 -------------------------------------------------------------------------------- mma4 -------------------------------------------------------------------------------- sme1 -------------------------------------------------------------------------------- spo12 -------------------------------------------------------------------------------- mde3 -------------------------------------------------------------------------------- ssp12 -------------------------------------------------------------------------------- bbr13 -------------------------------------------------------------------------------- pma1 -------------------------------------------------------------------------------- cau1 -------------------------------------------------------------------------------- tde1 -------------------------------------------------------------------------------- bpa19 -------------------------------------------------------------------------------- mlo1 -------------------------------------------------------------------------------- rsp13 -------------------------------------------------------------------------------- bme1 -------------------------------------------------------------------------------- reu6 -------------------------------------------------------------------------------- bja13 -------------------------------------------------------------------------------- atu4 -------------------------------------------------------------------------------- apo1 -------------------------------------------------------------------------------- wsu4 -------------------------------------------------------------------------------- vvu8 -------------------------------------------------------------------------------- msp11 -------------------------------------------------------------------------------- rsp12 -------------------------------------------------------------------------------- sme15 -------------------------------------------------------------------------------- spo15 -------------------------------------------------------------------------------- spo16 -------------------------------------------------------------------------------- tth1 -------------------------------------------------------------------------------- rge2 -------------------------------------------------------------------------------- spo18 -------------------------------------------------------------------------------- dha3 -------------------------------------------------------------------------------- ssp7 -------------------------------------------------------------------------------- bpa10 -------------------------------------------------------------------------------- spo11 -------------------------------------------------------------------------------- atu10 -------------------------------------------------------------------------------- mma6 -------------------------------------------------------------------------------- ruler 1.......10........20........30........40........50........60........70........80

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- vvu9 -------------------------------------------------------------------------------- bpa5 -------------------------------------------------------------------------------- bja4 -------------------------------------------------------------------------------- msp9 ----------MVLDQFALWAGFLLLGLAVVVCADVVLRLGADLPMAGLYEISALVAAMAMAASFVRPTLLSDHIGMDLLA 70 gsu1 -------------------------------------------------------------------------------- dde4 -------------------------------------------------------------------------------- dde3 -------------------------------------------------------------------------------- pmu6 -------------------------------------------------------------------------------- psp19 -------------------------------------------------------------------------------- msp12 -------------------------------------------------------------------------------- psp25 -------------------------------------------------------------------------------- oih3 -------------------------------------------------------------------------------- rpa6 -------------------------------------------------------------------------------- bja7 -------------------------------------------------------------------------------- spo20 -------------------------------------------------------------------------------- tfu1 -------------------------------------------------------------------------------- rsp10 -------------------------------------------------------------------------------- msp15 -------------------------------------------------------------------------------- cgl1 -------------------------------------------------------------------------------- spo21 -------------------------------------------------------------------------------- reu5 -------------------------------------------------------------------------------- psp6 -------------------------------------------------------------------------------- bbr8 -------------------------------------------------------------------------------- bpe1 -------------------------------------------------------------------------------- bpa9 -------------------------------------------------------------------------------- ssp5 -------------------------------------------------------------------------------- bja6 -------------------------------------------------------------------------------- rsp8 -------------------------------------------------------------------------------- msp6 -------------------------------------------------------------------------------- msp10 -------------------------------------------------------------------------------- bbr10 -------------------------------------------------------------------------------- spo22 -------------------------------------------------------------------------------- bpa14 -------------------------------------------------------------------------------- bbr12 -------------------------------------------------------------------------------- psp16 -------------------------------------------------------------------------------- bbr7 -------------------------------------------------------------------------------- bpa3 SGYLLVATVFFGLAAAQASNSHVQVELWIDRLSAPVRLRVELLCQWLALLFCVVLGWQMASFNVREYLNDTRDWGLLSTP 160 mma5 -------------------------------------------------------------------------------- dar4 -------------------------------------------------------------------------------- mma4 -------------------------------------------------------------------------------- sme1 -------------------------------------------------------------------------------- spo12 -------------------------------------------------------------------------------- mde3 -------------------------------------------------------------------------------- ssp12 -------------------------------------------------------------------------------- bbr13 -------------------------------------------------------------------------------- pma1 -------------------------------------------------------------------------------- cau1 -------------------------------------------------------------------------------- tde1 -------------------------------------------------------------------------------- bpa19 -------------------------------------------------------------------------------- mlo1 -------------------------------------------------------------------------------- rsp13 -------------------------------------------------------------------------------- bme1 -------------------------------------------------------------------------------- reu6 -------------------------------------------------------------------------------- bja13 -------------------------------------------------------------------------------- atu4 -------------------------------------------------------------------------------- apo1 -----MSHIIDKTTKYIGKILALLSLALAFLITYDAFMRYIFSEGSIALQELEWHIFDIIFLLGLSYALKHKKHVRVDIF 75 wsu4 -------------------------------------------------------------------------------- vvu8 -------------------------------------------------------------------------------- msp11 -------------------------------------------------------------------------------- rsp12 -------------------------------------------------------------------------------- sme15 -------------------------------------------------------------------------------- spo15 -------------------------------------------------------------------------------- spo16 -------------------------------------------------------------------------------- tth1 -------------------------------------------------------------------------------- rge2 -------------------------------------------------------------------------------- spo18 -------------------------------------------------------------------------------- dha3 -------------------------------------------------------------------------------- ssp7 -------------------------------------------------------------------------------- bpa10 -------------------------------------------------------------------------------- spo11 -------------------------------------------------------------------------------- atu10 -------------------------------------------------------------------------------- mma6 -------------------------------------------------------------------------------- ruler ........90.......100.......110.......120.......130.......140.......150.......160

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- vvu9 -------------------------------------------------------------------------------- bpa5 -------------------------------------------------------------------------------- bja4 -------------------------------------------------------------------------------- msp9 ERGDFLSRLIPAAVTSIFIGLATWALFRMAMHAFASAETTLVVRWPTWPFWFAALFLLFPALLTMAVNFGAVREKLPAWD 150 gsu1 -------------------------------------------------------------------------------- dde4 -------------------------------------------------------------------------------- dde3 -------------------------------------------------------------------------------- pmu6 -------------------------------------------------------------------------------- psp19 -------------------------------------------------------------------------------- msp12 -------------------------------------------------------------------------------- psp25 -------------------------------------------------------------------------------- oih3 -------------------------------------------------------------------------------- rpa6 -------------------------------------------------------------------------------- bja7 -------------------------------------------------------------------------------- spo20 -------------------------------------------------------------------------------- tfu1 ---------------------------------------------------METTMTSATETSATLDNTNPARSTESTGT 29 rsp10 -------------------------------------------------------------------------------- msp15 -------------------------------------------------------------------------------- cgl1 -------------------------------------------------------------------------------- spo21 -------------------------------------------------------------------------------- reu5 -------------------------------------------------------------------------------- psp6 -------------------------------------------------------------------------------- bbr8 -------------------------------------------------------------------------------- bpe1 -------------------------------------------------------------------------------- bpa9 -------------------------------------------------------------------------------- ssp5 -------------------------------------------------------------------------------- bja6 -------------------------------------------------------------------------------- rsp8 -------------------------------------------------------------------------------- msp6 -------------------------------------------------------------------------------- msp10 -------------------------------------------------------------------------------- bbr10 -------------------------------------------------------------------------------- spo22 -------------------------------------------------------------------------------- bpa14 -------------------------------------------------------------------------------- bbr12 -------------------------------------------------------------------------------- psp16 -------------------------------------------------------------------------------- bbr7 -------------------------------------------------------------------------------- bpa3 QWMPELAVSVGIVVFCMSILVDIYRLSPPAQAWRRWLTPTLLALLAAALVALGANAVPMAAGGRFDWGMALIVAALLACA 240 mma5 -------------------------------------------------------------------------------- dar4 -------------------------------------------------------------------------------- mma4 -------------------------------------------------------------------------------- sme1 -------------------------------------------------------------------------------- spo12 -------------------------------------------------------------------------------- mde3 -------------------------------------------------------------------------------- ssp12 -------------------------------------------------------------------------------- bbr13 -------------------------------------------------------------------------------- pma1 -------------------------------------------------------------------------------- cau1 -------------------------------------------------------------------------------- tde1 -------------------------------------------------------------------------------- bpa19 -------------------------------------------------------------------------------- mlo1 -------------------------------------------------------------------------------- rsp13 -------------------------------------------------------------------------------- bme1 -------------------------------------------------------------------------------- reu6 -------------------------------------------------------------------------------- bja13 -------------------------------------------------------------------------------- atu4 -------------------------------------------------------------------------------- apo1 FVHFKKETKAIIEILSILFLLIPFGLFLVVGSFEMTTQSFLQHEISSDPGGLKYRFLIKGVAFLGFLLLVLQGISEIIKA 155 wsu4 -------------------------------------------------------------------------------- vvu8 ----------------------------------MVSACFFIHSIKS--------------------------------- 13 msp11 -------------------------------------------------------------------------------- rsp12 -------------------------------------------------------------------------------- sme15 -------------------------------------------------------------------------------- spo15 -------------------------------------------------------------------------------- spo16 -------------------------------------------------------------------------------- tth1 -------------------------------------------------------------------------------- rge2 -------------------------------------------------------------------------------- spo18 -------------------------------------------------------------------------------- dha3 -------------------------------------------------------------------------------- ssp7 -------------------------------------------------------------------------------- bpa10 -------------------------------------------------------------------------------- spo11 -------------------------------------------------------------------------------- atu10 -------------------------------------------------------------------------------- mma6 -------------------------------------------------------------------------------- ruler .......170.......180.......190.......200.......210.......220.......230.......240

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------MTASLIGFGAVLALILLRVPIAFAMGFVGMVG--FMTETSFRASISMVA 47 vvu9 -------------------------------MIESIVGFSVLIALILLRLPLAFAMGVIGFIGFWYINDYNWTAAMSMAA 49 bpa5 -------------------------------MIESLSALGAMLALVFMRVPVAFAMALVGFVGLGLLRG--WPPAYAMAG 47 bja4 --------------------------MST--DAVAVIGFVSLFALMLLRVPVGMAMGLVGVSGFSYLVG--ATPALKLVG 50 msp9 RGALIVPFFLLLAIGILVAIFVYQDQLGP--VAKGGLLFGAVYALAMAQVPIGISMGIVGVTGVWALLS--TRAAERVLQ 226 gsu1 ----------------------------------------MFFMLFVLRIPAAFTLMMVGFLGIATVTT--WDAALAMLG 38 dde4 -------------------------MEPV--TLGVLSVGVLLAAILASRIPVGFAMAVTGLGGYAAAMG--PAAAWSMLG 51 dde3 -------------------------MDPT--IAGICGI-AAMMVLFMLRMPVAYAMLLVGVAGFSMLTS--VTGGLNMLG 50 pmu6 -------------------------MMSG--LEMGIVGFFILLTLLLIRIHISIAMFLAAAGLYAYLGQGDLNALMYTLN 53 psp19 --------------------------MSS--LSLTLLIFGSMLALMAVRVPIAVSMFGAGA--IGYVTQTGWAPFASFLN 50 msp12 --------------------------MNS--LVLGLVGLGLLLGLIVVRVPIAYTMLLVGIG--GVAIQSGPFIVLNQLK 50 psp25 --------------------------MSP--EIIGAIGLLCMIAMVMLRVPVALAMLGVGLV--GFGAVTAPIGALHMLK 50 oih3 --------------------------MSP--ELIGFLGIIAILILFFLKIPIAVSLILVSLL--GTSFIRGWEVAFAQLG 50 rpa6 --------------------------MTT------LIVLGLLFVLLAIGTPVGFAMAFSGSVGLLMVG----GTG-TLFG 43 bja7 --------------------------MTP------FIVLALLFGLLALGTPVGFAMAFSGSVGLVMVG----GWG-TLFG 43 spo20 --------------------------MTMDSIDIGLWVTGGLLVLVLTGMRVAFAAALAGLVGLVWIFWAKFGYDPDRFG 54 tfu1 VKEGRRPWIVAAVTLIVLGGSAVCVFLPLVPEAIGAMACVMMLALLFLRVPVAVAMLIPSLLGLYALRG-MPLIESTFSK 108 rsp10 ----------------------------MSNVAIGFTGIGIGLILLALRVQIGVALGLVSFVGIGILLS-WRAAWGIVTA 51 msp15 --------------------------------------------MVYAGLHVPVAFILVSFFGVFLVRGSFDVAANSLVI 36 cgl1 ----------------------------MEWYIFLPIYILALIVVLLLRIPVAFGIFGVGIVASLIIFG-------DIET 45 spo21 ----------------------------MEWYEALVFLLGMILFFMALGVPVALAFLAANMIGAAYFMGGRGDIASQMAR 52 reu5 ----------------------------MSTVLVALILLLVMIAFLAIGAWIP---VAIAVTSWVGLVIFSDHDALVNLA 49 psp6 ----------------------------MDILTIGGILLFLMLLLLSGGVWIA---MTLAICGWVGQAFFTTTQPGLNLF 49 bbr8 ----------------------------MGELAQSLVLIASLLLLLAAGVWVS---LALVASGLVALLLFTDAPAGIIFA 49 bpe1 ----------MNSCGASVGRASQNRSKSMNEILIVTLLVVSIFALLGCGVWVG---LTLAGTAWIGMEVLSSRPAGDAMA 67 bpa9 ------------------------------------------------------------------------------MA 2 ssp5 ----------------------------MSEIYTTVIFLFVLFALLGGSVWIG---LALMGVAWVGMELFTTRPAGDAMI 49 bja6 ------------------------------MTIEVVALFGILFALLAGGVWIG---LTLALTATLLLAMFRSIPLDKLLP 47 rsp8 -----------------------------------------------------------------LRSSGRTCRGLKLLA 15 msp6 ---------------------------MEPEFARGLIIVAVLLVLLGSGIWIFGAIFLISLGGLFFLQDFSFVRIGTLMK 53 msp10 ------------------------------------MWIFLALTFLG-------------ALGLWWVAGFPIDRIGLLLQ 31 bbr10 --------------------------------MIATALILLLVLIGIS-IPVGA---ALGVLGLILDPLYSMLPLTRAIG 44 spo22 --------------------------------MIGYVTVGLLGLLAMS-IPVGI---VLFLLGFGVDAFFSPFPLIRGLG 44 bpa14 -------------------------------MLLGALYFGGLVLFLMAGIHVAS---AIFMTAVVSD-WMSMQVLPSMIG 45 bbr12 -------------------------------MLLGALYFGGLVLFLMAGIHVAS---AIFMTAVVSD-WMSMQVLPSMIG 45 psp16 ----------------------------MSIGLFGIAFVVMLGMMLVG-IPIAV---SMAAVGIVGGIAAYGIPFMDSIA 48 bbr7 -------------------------------MTQFVLVIAVFLVLLLAGMWIPF---AIFLSASLYIVLYAGWDGLSGFG 46 bpa3 WAWSGVRTLAHVVLVVGGCAVLYGLARGQSLGWVAFLLVASMMLLLFLGVRIGV---ALGLVGLFGVYFLLSRPQLSLLA 317 mma5 -------------------------------------------------------------------------------- dar4 ----------------------------MAESSIGILYGLGTLAVMFSGIPIAFA--LGSIAVLFMLLFM-PAAATDTIT 49 mma4 -------------------------------------------------------------------------------- sme1 -------------------------------------------------------------------------------- spo12 ----------------------------MEWYVVGLGLLGLLMLFISIGLPIPFA--LAAASLPFLWQIQGWKTSIVSSE 50 mde3 ---------------------------MLEYLPLIMFG--VVCAVLMLGYPVAFTLAGVSLIFAGIGIYAGIFE------ 45 ssp12 ---------------------------MTSSLDLIMFA--ALMAAILMGFPVAFSIAGIAVFFAYLGWMLGVMD------ 45 bbr13 -------------------------MSLSDVLCLLMFA--TVMGTMMFGFPVAFTLSGVGVAFALLGSALDVFE------ 47 pma1 -------------MIEIELLDHVISFDPATTLGPGMFI--ALVFALLSGYPVAFCLGGIAVIFALLGMALGVID------ 59 cau1 ------------------------MYD---WLGPTMFL--GALVILGIGYPVAFSLGATAIVFGIIGVSLGIFD------ 45 tde1 ---------------------------MTEILVPLMFV--GLVAFLLIGYPVAFALAANGLLFAAIGIAAGLFD------ 45 bpa19 ------------------------MEFLIANLAPIMFA--TLVLFLLLGFPVAFALAANGILYGLVGIELDLLS------ 48 mlo1 -------------------------------MAPIMFA--SLIIFLLIGYPVAFSLAANGLMFFFIGVLLSPYSGG---- 43 rsp13 ------------------------MEFIAVNMAPIMFA--SLVIFLLLGYPVAFALAANGLLFFFIGVELAPLSEG---- 50 bme1 ---------------------MRKPRRSEGNGYGCFFCGKSRTPDVPVAGGRAAARLSRGFRACFRGLCFGFIGIE---- 55 reu6 -------------------------------MPPLMFG--GLVVFMLIGFPVAFSLSAVGLAFGFLAIEWGYFP------ 41 bja13 -------------------------MITLEMMPPLMFG--GLVLAMLIGFPVAFTLAAVGLSFGFLAIHLGFFD------ 47 atu4 -------------------------MFEYGILPPLMFL--GMIIFMLYGFPVAFSLATVGLVFGVIGIFTEHFS------ 47 apo1 YKRIENRKLLFSLIFGLILIFIISLFHIPFLIDPIWLMFLLTLILLMSGFEVAFVFGGVALLFALISEEL---------- 225 wsu4 -------------------------------MLTSILLFVVAFLFLFVGIPVAFAFGGAALLVALLSPEA---------- 39 vvu8 --------------LTRILCINLHQISRKEIRMIGIVMFFVALFALLLGFPVAFTFGGIALLFGVWAEG----------- 68 msp11 --------------------------MTDPQIAIMMLG--IFILCIFLGFPIAFTLMALGVGFGYYAYFDASRMWRSYNR 52 rsp12 -------------------------------------------------------------------------------- sme15 --------------------------MSEPFLGLTMLG--LIVVVIMMGFPTAFTLMGLGMLFGFYAFYNP--------- 43 spo15 -----------------------------------MFV--MLLGLLLTGMPLAFVTLLVALIFALGWFG----------- 32 spo16 --------------------------MESSFVLLFMFT--SLVAFMLSGAGLAFVLGAIAFISTILLWG----------- 41 tth1 --------------------------MPIETLTWLMFG--ALFVLLLTGYPLAFLVGGLSVVFIAWLWS----------- 41 rge2 ---------------------------MSDYLPFFMLP--LAFTLMFLGVQVAFAMMLTAAAFGLAIFGPN--------- 42 spo18 ------------------------------MAPLLMFA--ALFVLVFAGVPVAFSLIIIAVVFGYTVFGDL--------- 39 dha3 -----------------------------------MMV--VFISILLLGHPLSWILGGLGVIFGVFFWGDLN-------- 35 ssp7 --------------------------MSQEYIAIFMFA--SMMLMLFTGQRVFGAIGAVGAVAALLLWGVG--------- 43 bpa10 --------------------------------MTIAILSFSFVLLVLVGMPISFAMGISSLLAMLYQSDLPINLLVHRTV 48 spo11 -----------------------MSKREGRGQMEIVLLVVCFVVLVLLGAPVALAMILMPTTYILLTDAAPLLTVPHQMY 57 atu10 ------------------------MLESLGNLNLAIFLGLFVAVFLVLGVPIAFCFGLGTLAYLTFTTWVPTIVMIGRMD 56 mma6 -----------------------------MEAVGLIMLAAVAALLGLTGLPVFVVLVGVSVLAAVFGLGAGIFTLPVLTA 51 ruler .......250.......260.......270.......280.......290.......300.......310.......320

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 R-------------------------------LIIDTSQDYGLSVVPLFILMGLFVNKGGISRELYAASNAFLGHLRGGL 96 vvu9 R-------------------------------RIIDTGQDYGLSVIPLFILMGNFVTKAGISNELYKACNAFVGHRRGGL 98 bpa5 S-------------------------------VIYESGFQYLLSVLPLFILMGNFVTESRMSRELYAAAHALLGHRRGGL 96 bja4 Q-------------------------------TSMRTVTDYTFGVIPMFLLMGSFVSNSGMSRELFRAANGFVGHLRGGL 99 msp9 N-------------------------------EVRDVLSSNELIAIPLFLMMGSFAIRAGLAARIFTAARAIFGPVRGGL 275 gsu1 S-------------------------------ELWGSFSNYGLTVIPLFILVGEIVHYAGYNNSLYHATYKWFGHKRGGL 87 dde4 G-------------------------------EVWEVFSSYGLTVIPFFIFMGQICFYSGVNERLYRAVYAWMGHIRGGI 100 dde3 R-------------------------------SVYSTFASHELSTIPLFILMGQIAFNAGISRRLYDTAYCFLGHVRGGL 99 pmu6 G-------------------------------LAYARLSNYDLAVVPLFIFMGQLASHGGMSKALFQAASSFIGHWRGGL 102 psp19 T-------------------------------QAFARFAGYDLSVIPLFILMGHFATKGGISKSLFEFAAGVMGRFKGGL 99 msp12 D-------------------------------LAYAQFANYDLSVLPMFLLMGGLAARSGLSTDLFRAAHAWFGRFRGGV 99 psp25 D-------------------------------LPVDVLAKYDFSAIPLFILMGVFASHSGMAGKLFEATRTIFGGVRGSL 99 oih3 R-------------------------------TPFDTSSNYSLSVIPLFILMGMILSYTGIGKDLYRLVDTWIGHLRGGL 99 rpa6 -------------------------ILETA---PLSTVSSYELITIPMFLLMAELVLLSGVADALFKTASAWVGRIPGGL 95 bja7 -------------------------ILQTA---PLSTVSSYELITIPMFLLMADLVLLSGVADDLFKTASAWVGRIPGGL 95 spo20 KALT--------------------VAVKTAGQVPHSKVSSQALSLIPTFILIGYLAYYAGLTRALFEAAKRWMAWVPGGL 114 tfu1 L--------------------------------VYNGVAEWTLSVVPMFVLMGLLLWRSGMTDSIYLAGRHWLNWLPGGL 156 rsp10 I--------------------------------PFNFVGDWNLTAIPMFLLMGFVASEAGLSSGLFRAMRILLSWLPGGL 99 msp15 A--------------------------------ATDSISSYTFATVPVFVFMGLLVVLAGMGRSTFDVAAHATRRLPGGL 84 cgl1 TSR-------------------------LISLSVLSSVNSFTFTAIPLFILMGEVLFRSRIAQDAIVEISKMLHRVPGRL 100 spo21 GIG-------------------------QLANNAIPTVTSFNLMPVPMFLLMGEIFFFTGLANRMFGAVDRLMGKLPARL 107 reu5 N-------------------------------SWWSSSASYTLASLPLFVWMGEILFRTKLSEQMFNGLSPWLNWLPGRL 98 psp6 S-------------------------------AFWESNASWELAALPLFIWMGEILFRTKLSEEMFTGLAPWLGRVPGRL 98 bbr8 T-------------------------------KSWDASANWALTALPLFIWMGEILYRTRLAEDMFSGLGPWVRRLPGRL 98 bpe1 V-------------------------------TIWGASSSWTLTALPLFLWMGEILFRTRLSEDLFKGLAPWLNRLPGRL 116 bpa9 V-------------------------------TIWGASSSWTLTALPLFLWMGEILFRTRLSEDLFKGLAPWLNRLPGRL 51 ssp5 T-------------------------------TIWSGASSWTLTALPLFIWMGEILYRTRLSEDMFRGLAPWMRFLPGGL 98 bja6 Q-------------------------------YAWNILTTQELLALPLFILMGELLFRTRLSRSLFQGLAPWAGLLPGRL 96 rsp8 Q-------------------------------QTYNVVVSPELLALPLFILMAEILFRTKISEALFTGLSPWLRRVPGRL 64 msp6 T-------------------------------VSWRALTSYELASLPLFVWMAEILFRTRLSEQIFRGVSPWVDWVPGRL 102 msp10 T-------------------------------TFWNSSKMWELSAVPLFVWMGEIYYRTNLAAELFRGIAPLIKWLPGKL 80 bbr10 E-------------------------------VTWSANNEFLLVAIPLFIMLGEVLLRAGFAERMYAAMSLWLSWLPGGL 93 spo22 N-------------------------------LVWSTSNNATLIAIPFFVLLGEILVRSGIATRTYAALDRWVSWLPGGL 93 bpa14 N-------------------------------TMWSTMNKFLLVAIPLFILLGEILTRSGVADRMYKALAAWLQWLPGGL 94 bbr12 N-------------------------------TMWSTMNEFLLVAIPLFILLGEILTRSGVADRMYKALAAWLQWLPGGL 94 psp16 P-------------------------------VVWGVHNENLLTSIPLFILLGELLLRSGIADRMYIALSAWLGRLPGGL 97 bbr7 L-------------------------------SSWGSMNSFTLTAIPLFILMAEIMLESGLSQRVYRGLARIVRRLPGGL 95 bpa3 E-------------------------------RAWSSTNTFTLTAVPMFIFMGGLLLRSGITAGMFDALVRWFGRAPGGL 366 mma5 -------------------------------------------------------------------------------- dar4 Q-------------------------------NVFEEMANITLLSIPLFILKGAAIGRSRAGADLYLAIHAWMHKIPGGL 98 mma4 -------------------------------------------------------------------------------- sme1 ---------------------------------MFSGIANLAYVSIPMFVLMGAAVASSPAGSDLYTSLDRWLNRIPGGL 47 spo12 L-------------------------------KLWGVWIDYILLAVPLFVFLGELIGKSKIGPNLYQFLHQGVR-LRGSA 98 mde3 ---------------------LQEMLAYTERAYG--IMTNTSLIAVPMFIFMGVMLERSKIAEALLHNLAHACGRAPAGL 102 ssp12 ---------------------ISLLGAFGQRVFG--LLSNEVLIAIPLFVLMGAILEKSRIAEELLDTMGRLFGQLKGGL 102 bbr13 ---------------------WRTMGGVMGRLYG--IMSNEMLVAIPLFVFMGIMLEKSKAAERLLVTTSSLFGSLSGGL 104 pma1 ---------------------PLFVTALPQRILG--IMANFTLLAIPAFVFMGAMLETSGIAERLLESMGRLLGKLRGGL 116 cau1 ---------------------PIIIRAMPSRIFN--VMSNYTLLAIPYFIFLGSMLEKSGLAEDLLDTMGILFGPVRGGL 102 tde1 ---------------------LSLLHALPERVYG--IVANPTLLAIPFFALMGLILERSGMAEDLLDTVGQLFGSARGGL 102 bpa19 ---------------------PALFQALPQRVFG--IISNDTLLAVPFFTLMGLVLERSGMAEDLLETIGQVFGPLRGGL 105 mlo1 ----------------SINLAWPLLHALPDNFYGSRVMSNDTLLAIPFFTFMGIVLERSGMAEDLLDTIGQLFGPIRGGL 107 rsp13 ----------------TISLGWNLLGTMPDRFWG--VLSNETLLAIPFFTFMGIVLERSGMAEDLLDTIGQLFGPIRGGL 112 bme1 ----------------LGLLPVNLFGAIPDRIFG--QMSNETLLAIPFFTFMGLILERSGMAEDLLDTIGQLFGPVRGGL 117 reu6 ---------------------VQFLQAVPSRVFGS-VLSNELLLAIPFFTFMGAILEKCGLAEDMLDSMGQLFGPVRGGL 99 bja13 ---------------------LNFLQAIPGRVFGS-VLSNELLLAIPFFTFMGAILERCGLAEDMLDSMGQLFGPIRGGL 105 atu4 ---------------------PAFLQALPLRIFG--IISNDLLLAIPFFTFMGAILERCGLAEDLLEGTGKLFGAIPGGL 104 apo1 --------------------GLEVLEMLPYRVYG--IMGNITLMSIPLFILMGLILEKSKIAEDLLLSMGKLFGGVRGGL 283 wsu4 --------------------SLSILSLLPSRIYG--IMSNATLMAMPLFIFMGLVLEKSGMAEKLLRNIGRLFGSIRGGM 97 vvu8 ---------------------IEMFAFMPYRIQS--IMENTVLMAVPLFVFMGLVLQKTRLAEQLLESMGKLFGSVRGGL 125 msp11 AVEDGADSWTLIQTWIDGFFNNRIFDLFVNQTYS--VMANEVLTAVPLFLFMGYVVERANIVDKLFSTLYIAARRVPGAM 130 rsp12 -------------------------------------------------------------------------------M 1 sme15 -----------VEPWID----NRVFDLMVQRTYG--AMTNDVLISIPLFVLMGYVMERGALVDKMFYSIQLSFRRVPASL 106 spo15 ---------------------PMAVPLITSRIFS--FVNSFVFVSVPMFVLMASILDRSGIAKDLFDAMRVVGGRLRGGV 89 spo16 ---------------------PAALIVAVLNTFE--TMTSEALMAIPLYVLMASILQKSAIIDALYDAMETWFSRLNGGL 98 tth1 ---------------------PDALALVPQRVWN--NMTQYLLAAIPLFIFMASMLEKSGVIEEVFDVAYKWLGRIPGGL 98 rge2 -----------------------VIHQFVEKIDD--LSSNFVFAAVPLFVFMGAMLEKSGIADRLFEAIHIWTRRLPGGL 97 spo18 -----------------------IFLQLYGPLLS--TASNFVLAAIPLFIFMGAVLERSGIARRLFHALQLWLGGFPGGL 94 dha3 -----------------------VLNIFTRAVYK--VVTTSSYVCIPLFIFMGALLEKSGSADKLFDSLYIVFGRLKGGL 90 ssp7 -----------------------GYDIPFSAAMK--LMKWYPLLTLPMFIFMGYVLSESRLADDLYKMFHVWMGPINGGL 98 bpa10 MG-----------------------------------IDSFVLLAIPLFIFAGSIMEQGGISERLVRFAYTLLGRFRGGL 93 spo11 EG-----------------------------------IAHFPLVAVPFFMLTGELMNGSSVTQRIMRLSRVIVGRMRGGL 102 atu10 EG-----------------------------------MSGIILLSVPVFVLLGCVLDATGMGKAIVELLSSMFGHIRAGM 101 mma6 LPN-----------------------------RLTGLLENDLLQALPLYVLMGALLDRLPLAETLFGGAAAMVRRWRAAP 102 ruler .......330.......340.......350.......360.......370.......380.......390.......400

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 AMATIVACGGFAAISGSSLATAATMAKVAMPEMRRFGYSDALSTASIAAGGTLGILIPPSVILVIYGLLTE--------- 167 vvu9 SMSTILACGGFSAICGSSLATSATMSKVAMPPMRKYGYSDGLASASIAAGGTLGILIPPSVMLVIYGLLTE--------- 169 bpa5 AMSTIAACGGFGAICGSSLATAATMAKVAYPEMRRMGYSEKLAAGSIAAGGTLGVLIPPSIIMVVYCLLTE--------- 167 bja4 GIATVGACGGFAAICGSSVATAATFSAVAYPEMRRFGYPQSFATGVIAAGGTLGAMLPPSTVLAVYGIITE--------- 170 msp9 AIATVVGCGGFGAVSGSSVATTATLGRVAFDEMRVNGYRQSFACGTIAAGGTLGALIPPSVILIIYCVVAE--------- 346 gsu1 AMTTILASAAFSAISGSNTATAATMSAVAIPAMKEYKYHPLLNAGSVAAGATLGVLIPPSIVLVVYGLYTG--------- 158 dde4 AYATVLACAGFSAICGSNTATAATMSAVALPEMKKYGYAPVLSTGCVAAGATLGVLIPPSVVLIVIGLQTG--------- 171 dde3 AMATVSACTAFGAVCGSSPATAATMATVGLPEMKRFGYSDELAAGAVASGGGLGMIMPPSVVLLVYGVLTE--------- 170 pmu6 AMASVGSCAAFGAICGSSLATAATMGQVAIPELKKRRYSGELSTATLAAGGTLGILIPPSVPLIIYAVLTQ--------- 173 psp19 AMASLLACAAFGAISGSSVATAATITGVALPEMQRHGYSGRLATGTLAAGGTLGIQLPPSIVLVIYAILTE--------- 170 msp12 AMAAVAACAGFGAVCGSSTATASTMGQVALPELRRYKYSDALATGTLAAGGTLGILIPPSVVLIVYAIIVE--------- 170 psp25 GIAGIGSSGIFASISGSSLATASTMTKVALPQMEKYGYQPGFACGILAAGGTLGIMIPPSIALLVYAILTQ--------- 170 oih3 AMATIGTAAIFSSISGSLNATTATVAKIALPEMDKYNYKPGLSTSSVAAGGTLGILIPPSVILILYGILTR--------- 170 rpa6 GMATALAGAGFGAICGTSTASAATLSSTSLPAMIKQGYEPKMAAGVVAISGTLAMLIPPSVALVIFGLLAE--------- 166 bja7 GMATALAGAGFGAICGTSTASAATLSSTSLPAMIRQGYEPKMAAGVVAISGTLSMLLPTSVALVIFGLLAE--------- 166 spo20 AVSTVFATAGFAAVSGASVATSAVFARIAIPEMLAIGYNKRFAAGVVAAAGTLASLIPPSAILVIYAIIVE--------- 185 tfu1 AVGTNVAGTGLAAVSGSSVGTAYALARMGIPEMLKAGYDRRMAIGAVIVAGLPGQLIPPSIMLVIYAGIAE--------- 227 rsp10 AVSSVGANAVLAAASGSSVATASAFARIATPEMLRYGYHPGLATGVIAAAGTLGALIPPSILMVLYGYLAE--------- 170 msp15 AIGSVGANAIFAATIGVGIAAAAIFSKLAIPEMQRYGYSLRRSAGVVAAASLLGPLIPPSLLLILFGVMTF--------- 155 cgl1 PMVAVAGGSAFGLLSGSSLANTALLSRTLLPQMKKAGYSTHISAGSILAAGGLAMVFPPSALAILWGGVAN--------- 171 spo21 SFVTVAGGTAFATLSGSSMGSTALLGSLMVPEMQKRGYKKHMAIGPILGTGGLAMLIPPSALAVLLATLAE--------- 178 reu5 MHVNILGCGIFGSVSGSSAATCATIAKSALPELTRRGYDERITLGSLSTAGTLGILIPPSITMVVYAVSAD--------- 169 psp6 FHTTILGCGIFGSVSGSSAATCATIAKVSLPELKKRGYNEKIALGSLATAGTLGILIPPSITMVVYAVAAD--------- 169 bbr8 VHVNVLGCGIFAAVSGSSAATAATIGRISLPELKARGYDDGLAIGSLAGAGTLGLLIPPSIVMIVYGVAAQ--------- 169 bpe1 LHTNVIGCAIFAAVSGSSAATCATVGKMTIPELTRRGYPEDKILGTLSGAGTLGLLIPPSIIMIVYGVAAD--------- 187 bpa9 LHTNVIGCAIFAAVSGSSAATCTTVGKMTIPELTRRGYPEDKILGTLSGAGTLGLLIPPSIIMIVYGVAAD--------- 122 ssp5 LHTNIAGCTIFAAVSGSSAATLNMVGKMSIPELRARGYPEYMIIGTLAGAATLGLMIPPSLTLIVYGVTIN--------- 169 bja6 LHVNVIGCTIFAAISGSSAATTQVIGRMSLNELLRRGYSRDIAIGSLAGAGTLGFLIPPSNIMIIYGVLGD--------- 167 rsp8 SHLTVLGCTMFASVCGSSAATTATVGRITAKELIDRGYNRDLVTGSLAGAGTLGFLIPPSTIMIIYGVMAE--------- 135 msp6 LHVVIVACGLFGAVSGSSTATCATGSKIALPELRKRGYDDGVIIGALSAGGTLGIMIPPSIAMVIYAVVAE--------- 173 msp10 LHSNVIGCTAFAAVSGSSAATTATIARITLPVLAASGYSRNLALGSLAGAGTLGILIPPSTALIIYGVLAE--------- 151 bbr10 MHANIGASTLFSATSGSSVATAATVGTVAIPQIKKYGYNEPLFLGSLAAGGTLGILIPPSINLVIYGVLTN--------- 164 spo22 VHANIATATMFSATSGSSVATAATVATVAMPQAEKLGYDPKLFSGAIAAGGTLGIMIPPSINLIVYGFLTQ--------- 164 bpa14 LHTNIATCALFAATSGSSVATSATVGTVALPTLQRLGYRERLVLGSIAAGGTLGILIPPSINMVVYGALAE--------- 165 bbr12 LHTNIATCALFAATSGSSVATSATVGTVALPTLQRLGYRERLVLGSIAAGGTLGILIPPSINMVVYGALAE--------- 165 psp16 LHTNIGSCALFAATSGSSVATAATVGTVALPSLQKRGYPMRASLGTLAAGGTLGILIPPSVNMIVYGSLTN--------- 168 bbr7 LQTNIAGCAAFSAISGSSVATAAAIGSVALPQLEARGYCLKLSTGTLAAGGTLGILIPPSIAMIIYGTFTE--------- 166 bpa3 AHASAGASAVFAAVSGSSLATAATLGKVACPDMIERGYSPRLTYGVAAAGATLGILIPPSIPMIIYGTTVG--------- 437 mma5 -------------------------------------------------------------------------------- dar4 GIANVFACALFAAMAGSSPATCSAIGGAGIPEMRARGYSPGFAAGIIAAGGTLGILLPPSITMILFAVAAE--------- 169 mma4 -MSNTIACGLFAAMAGSSPATCSAIGSAGIPEMRARGYSPGFAAGIIAAGGTLGILLPPSVTMLLYAVAAE--------- 70 sme1 ILSNIGACAIFSGMTGSSPATCAAIGKMGIPEMMRRGYPASVASGSIAAGGTLGILIPPSVTLIVYGIATE--------- 118 spo12 AYGSIGASAGFGAVCGSSMVGALTIGGVALPEMLRLGYGKRLSSGVLAAGGTLSVLIPPSLILLFYGIVTD--------- 169 mde3 AISVVLVGTLMAASTGIVGATVVTMGLMSLPTMLKRGYDPALACGTICATGTLGQIIPPSIALVLLGDVLSSAYQQAQLN 182 ssp12 GISVVLVGALLAASTGIVGATVVAMGMIALPAMLRAGYDPRVASGIVCTAGTLGQIIPPSTLLIILADVMSNAYQQVQYE 182 bbr13 AFTVVMVGTLLSAATGMVAATVATLALISVPAMRRAGYQPSYMAGSICASGTLSQLIPPSTVLILIGDMLRGVTPPDRPG 184 pma1 ALAVVLVGSLLAATTGVVAATVTTMGLISLPAMLRAGYDRSLATGVIAASGTLGQIIPPSIVLVVLGDQLG--------- 187 cau1 AIAVVAVGALLAATTGVVAATVVAMGLISLPIMLRYNYNKELACGVICAAGTLGQIIPPSVVLVVLGDQIG--------- 173 tde1 AYAVVLVGGLLAATTGVVAATVIAMGLISLPVMLRYGYDKRLAAGVIAASGTLAQIIPPSLVLIVLADQLG--------- 173 bpa19 AIAVVFVGAMLAATTGVVSASVISMGLISLPIMLRYGYDRRLASGVIAASGTLSQIIPPSLVLIILADQLG--------- 176 mlo1 AYAVIFVGALLAATTGVVAASVIAMGLISLPIMLRYGYDRRLAAGVIAASGTLAQIIPPSLVLIVLADQLG--------- 178 rsp13 AYAVIIVGALLAATTGVVAASVIAMGLISLPIMLRYGYDRRIASGVIAASGTLAQIIPPSLVLIVLADQLG--------- 183 bme1 AYAVIIVGALLAATTGVVAASVISMGLISLPIMLRYGYDRKVASGTIAAAGTLAQIIPPSLVLIVLADQLG--------- 188 reu6 GYSVIIVGFILGAITGTVAAQVIAMAMISLPVMMRYRYNMKYATGVLAASGTITQLVPPSLVLVVLADQLKTPAGS---- 175 bja13 GYSVIIVGFILGAITGTVAAQVIAMALISMPVMIRYGYNMRYITGVLAASGTITQLVPPSLVLIVLADQLG--------- 176 atu4 AYAVIIVGAILGAITGTVAASVITMGVISLPIMLKYGYNPRLATGVIAASGTITQVIPPSLVLIVLADQLG--------- 175 apo1 AISVVVVGAILAASTGIVGASVVMMSLIALPLMLKHNYKPELATGSIVASGTLGQIIPPSIVLIVLGDQMH--------- 354 wsu4 AIGVVAVGVLLAASTGVVGASVVMMGVIAVPAMLKSGYSPALSSGVVAASGTLGQIIPPSIVLILLGDVMQ--------- 168 vvu8 AISTVLVGALLAASTGVVGASVVAMGLISLPVMLKYNYDKGLACGTICASGTLGQIIPPSIVLILLGDVLG--------- 196 msp11 AVAALITCTLFATATGIVGAVVTLMGLLAFPAMLKARYDTSFASGVICAGGTLGILIPPSIMLIVYAAASG--------- 201 rsp12 GVAALVTCALFATATGIVGAVVTLMGLLALPAMLKSRYDHAFASGIICAGGTLGILIPPSIMLIVYAASSG--------- 72 sme15 AVTTLIVCTFWGIASGLVGAVVVLMGVIAMNPMLRAGYDVKLASGVITAGGTLGILIPPSVMIIVYAAVAG--------- 177 spo15 AIQTLLVAVVLAAMSGIIGGEVVLLGLLALPQMLRLGYDRRLAIGVCCAGGALGTMIPPSIVLIIYGLTAS--------- 160 spo16 AVGTIAICTILAAMTGVVGAAVAAMGILALPSMLSRGYHPPLALGAICAGGTLGILIPPSVVTIVYAITAQ--------- 169 tth1 AVATVVASTVLAAMVGVIGAAVVTMALVALPSMLRRGYSPVLAVGTVMAGGTLGILIPPSVLAIVYGLVAN--------- 169 rge2 AIATVLMCIVFAASSGVIGATESVVGLLTIPIMLRYGYNKSLISGTICAGGSLGTIIPPSVVVVVMGPLAN--------- 168 spo18 SLSTIAMCAIFAAASGVVGAVEIVVGLMAIPPMMKAGYRNDLIAGTICAGGSLGTIIPPSVIVVVYASIAQ--------- 165 dha3 ALATVVISALMGAATGIIGASISIMAMLALPTMLKHRYEEKLACGTVMAAGSLGTLIPPSVILVIYGSLSN--------- 161 ssp7 AIGTIGLMVLVSAMNGLSVAGMAIGATIALPELLRRGYDKTMVTGVIQAGSSLGILVPPSVVLVLYAMIAR--------- 169 bpa10 PMVVVGSTMLQSGISGSTVADVSAMSAMTLKPLENEGYPRPYSLSVIGASCAFSILIPPCILMVVVAAVAN--------- 164 spo11 AQVNIVASMFFAGMNGSAVADTATIGTIMIPDMKRKGYTPAYAAAITAIGSTIGGIIPPSIAMIVLASSVN--------- 173 atu10 SYVLLGSLFLVSGISGSKVSDMATVAPALFPEMKRRGHKPKEMIALLATGAAMADTVPPSIVLIVLGSAAG--------- 172 mma6 LLAALGVGALIAPMNGSVAASASTLGRVVAPRLKDAGVGPERSLAVICLASTMGVVVPPSLVLLLLGDAMMRAHTEALNA 182 ruler .......410.......420.......430.......440.......450.......460.......470.......480

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 --------TSIGKLFVAGIVPGMLGILLYLCAVRWTVWRNPAAGP----------------------------------- 204 vvu9 --------TSIRELFAAGFLPGLLGIVLYLLAVQWVVSRKPESAP----------------------------------- 206 bpa5 --------QSIGKMFAAGVLPGVLAILCYMAAVAWVVRRDPAAGP----------------------------------- 204 bja4 --------QDIGKLFIAGIIPGLLAMTMYMITIALIGYFRPDFLP----------------------------------- 207 msp9 --------QSIERAFAAALFPGLLAILLYAATIAVMVRLRPDVAP----------------------------------- 383 gsu1 --------QSIGKLFFGNVIPSAILTILILLTVVWICRRHPDWGP----------------------------------- 195 dde4 --------LSISTLFMAGIMPGLLLTGLFLAVVWLLCRRHPQWGP----------------------------------- 208 dde3 --------QSIGALFVAGILPALLLTLLFIAAVAVQCLLYPQHGP----------------------------------- 207 pmu6 --------ESIGKLFVAAIIPGILALLGYVFVIKVLVSLHPEAGP----------------------------------- 210 psp19 --------QNISKLFAAAVIPGIIAMCGYMIAVAIYVRVVPGHAP----------------------------------- 207 msp12 --------VNIVTMFAAALIPGLIATAMFLATVALYSRFVSGAGP----------------------------------- 207 psp25 --------QSVGDMFIAGFLPGMLGMVMYSITVMIMVRWKPHLAQ----------------------------------- 207 oih3 --------EPIGALLISGIIPGVLQITIFIITIYILVRKDPSIAPP---------------------------------- 208 rpa6 --------VNIGQLLIGGIIPAALVTATIMATIYILVWLDPSRAP----------------------------------- 203 bja7 --------VNIGKLLISGIIPAILVTITIMATIYFLVWQDPSRAP----------------------------------- 203 spo20 --------QDVGKLLLAGFVPGAFSAVIYVALIVGIAVVFKSVGP----------------------------------- 222 tfu1 --------VPIGPQLLAGIGPGLLVAVMFTLMIVGFAVVRPELVGKTKGAAV---------------------------- 271 rsp10 --------VSIAQLFAAGIVPGILTALAFSAMIVVRCLVNPRLAPR---------------------------------- 208 msp15 --------TSIGSLFLAAVIPGLLLAAAYVLFIVLEARFRPAIYGGTDADRP---------------------------- 199 cgl1 --------VSIGPLLIAGIVPGVMMAIGYVILILWHSKKKGDPGAAT--------------------------------- 210 spo21 --------LDIGDLLIAGIMPGLMLAIFYAVMILGMALYDPSAAPAY--------------------------------- 217 reu5 --------VSIIRVFLAGFLPGLLLMILFSGYIVVWALMNPEKTPAAETFG----------------------------- 212 psp6 --------ASIIRIFLAGFLPGIVLMLLFSGYIAWWSMRNKAQMPPAEPVTS---------------------------- 213 bbr8 --------VSLIKLFIAGILPGLLLMALFSGYIGVWSLRNPARVPPREPAVP---------------------------- 213 bpe1 --------VSIAKLFIAGIFPGLLLALLFMGYIAWWAIRHPGAVPAADPGIS---------------------------- 231 bpa9 --------VSIAKLFIAGIFPGLLLALLFMGYIAWWAIRHPGAVPAADPGIS---------------------------- 166 ssp5 --------ESITKLFMAGVFPGLVLAGLFMLYIVGWHFFGPGERPKPEPRLT---------------------------- 213 bja6 --------VSILKLFTAGVLPGLLLAATFMGWVMLHTTLKPSMVPETEAKLSQ--------------------------- 212 rsp8 --------ESILRLFIAGIVPGLMLAASYMGYLAIRSWLNPALVGATPPRTS---------------------------- 179 msp6 --------VSLVKLMLAGFLPGLLMMGLFSGYICGWSVLNPHRTPDDPEPMR---------------------------- 217 msp10 --------VSIADLFVAGIVPGLMVAGLSSLFIMIVALINPSVAGSVQSERGD--------------------------- 196 bbr10 --------SSVPKLYLAGIIPGFAMAALFMMTVVVACVA-KPSWGGHRIQAS---------------------------- 207 spo22 --------TSIPRLFLAGLLPGLALALGFMLITVIICLI-RPALGGTRRVFS---------------------------- 207 bpa14 --------VSVGKLFAAGIVPGIIVLLLMMAVIVIMALLGKVAPDNEKLIIP---------------------------- 209 bbr12 --------VSVGKLFAAGIVPGIIVLLLMMAVIVIMALLGKVAPDNEKLIIP---------------------------- 209 psp16 --------NSIGKLFIAGIIPGLMLTGCFMLYIAVSSLMSGNAMREPK--VP---------------------------- 210 bbr7 --------TSIAKLFMAGVVPGLALVVLFMCYVAVRCLVNPRLAPPPEQDTP---------------------------- 210 bpa3 --------ASVTHLFLAGMLPGLLLMACFMLGALVWALAVPGSAPVAR-AYT---------------------------- 480 mma5 ---------------------------------MFRFRSEFAAAKRAYERDGTQHPIL---------------------- 25 dar4 --------QSLGRLFLAGIFPGLLLVFLFAGYAVFRFKVEYNSALDVWHSGGAKSAYL---------------------- 219 mma4 --------VSLGRLFLAGIGPGLLLITLFAAYSVLRYRHEYRLAERAAAAHGTHSALL---------------------- 120 sme1 --------TSIGRLFMAGILPGILLTIMFMTWAVIDCKRKGYEFEARLVR------------------------------ 160 spo12 --------QSIGDLFIAGVIPGIILVSSFVVVVLIWGILRPEDIPGSEDA------------------------------ 211 mde3 LGVFNATPISVGDLFIGAMVPGIVLVLLYLLYLAWIGVFKPELAPPNP-DDTP-PP------------------------ 236 ssp12 QGKFAVEALSVGQFFAAALIPGLVLVVLYLLYILIRGLLRPEDMPSAP-AGIARPH------------------------ 237 bbr13 ------GPVTVSDLFAGAVLPSVLLVVLFLGYVLYRALLRPDTCPPLPRSAGQRVG------------------------ 234 pma1 --------VSVGDLFLGSLIPGVLMAGAFATYVLVISHLKPHLAPQLNP-ADLIP------------------------- 233 cau1 --------VSVGKLFLGSLIPGLLLAAALAFYCWIVALLKPEMAPALPLSARSISG------------------------ 221 tde1 --------TSVGAMYKGALVPGLVLVAAYLAYVFGVSLLRPHAAPAVPTSARTLRG------------------------ 221 bpa19 --------RSIGDMYRAAMVPGFVLAGLYIAYVVVVSLVKPSAAPALPEEARRFREPNGSRGGR---------------- 232 mlo1 --------RSVGDMYAGALIPGLVLTGLYALYILIMSIVRPKSVPALPLEARTLGHGVLS-------------------- 230 rsp13 --------RSVGDMYKGALIPGLILTGIYMGYVLVMSILKPKSMPALPLEARTLGSGVMS-------------------- 235 bme1 --------RSVGDMYKGALVPGLLLVGVYVGFIVVMSILRPNSVPALPLQARTLKG------------------------ 236 reu6 --------ADVGSMYLGAWGPSVIQIALFALYTFVLTRIKPDWLPPVPEEARTLRG------------------------ 223 bja13 --------KSVGDMYLGAWGPSVFQIMLFAGYTFILGLIKPGHVPPVPKEARTLTG------------------------ 224 atu4 --------KSVGDMYLGAIGPSILQVTIFMLFILLMSIVRPKDLPALPPEARGELN------------------------ 223 apo1 --------LSVGDLFKGALAPSLILVILYILYILIYSRLDESVAPAIKTK--ETYKE----------------------- 401 wsu4 --------VSVGDLFAAAIVPSLILVLFYVFFILALAFLKPALAPALKGEEGESLRG----------------------- 217 vvu8 --------VPVGDLFQAAVWPGIVLVGVYVIYILIYAKLNPEAAQPMERDDTISRKQ----------------------- 245 msp11 --------VSIVRLYAGALLPGLLLAGLYLVYVIGRAILQPSVAPKPSKE------------------------------ 243 rsp12 --------VSIVRLYAAALLPGLTLVGLYLVYIIGRAILQPHVAPRPAPG------------------------------ 114 sme15 --------QSVVKLYAATMFPGFFLALLYLAYVLGWAMLNPKIAPRLPEEQTRVPVPPWMKHFAEVYSSNMLAGLLVALV 249 spo15 --------VSIGDLFTASFLPGLMLASFYIAYVLIRAYLNPDIAPIPEPDE-IPTKEK---------------------- 209 spo16 --------ISIGQMFAAGIVPGLMLAGSYMAYVLVRTWFNPALAPKPVHLKPIPLAVK---------------------- 219 tth1 --------QSVGELYLGSVFPGLVLSGLYILFSVGYALLNPKAAPRLSPEETPTWSER---------------------- 219 rge2 --------LSVGDLMYGMVLPGFLMAGLYLAYIFVLCIVKPEMGRRIPPEPGD-PTFMQK-------------------- 219 spo18 --------LSIGQLFAASIMPGFLMVVFFVGYILIRSLRNPADAPPLPIHDRA-IPLKEK-------------------- 216 dha3 --------LSIAKLFAGGMGAGICLAAIYSIYVVVLSYIKPSYGPPISKEESQKYSAGQK-------------------- 213 ssp7 --------QPVGQLWLAGVIPGLMMAGLFIIYIWLRCKANPALGPAMEDAHEVPRAEK---------------------- 219 bpa10 --------TSVVAVFAAGVVPAVVIGLMFFAFIHIQARLQNMPRGEAYS------------------------------- 205 spo11 --------LSVGALFAGGILPGILIGLLLMLTAWIIAKAKDHERGDEP-------------------------------- 213 atu10 --------VSIAGLFTSGFMIAMVLLLVLAVLARWKARDENMEGAKRTP------------------------------- 213 mma6 TG-QLTRILNTQDLFRGAVIPAALLLGLFLAAALWTGRTSERGTVP---------------------------------- 227 ruler .......490.......500.......510.......520.......530.......540.......550.......560

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- 204 vvu9 -------------------------------------------------------------------------------- 206 bpa5 -------------------------------------------------------------------------------- 204 bja4 -------------------------------------------------------------------------------- 207 msp9 -------------------------------------------------------------------------------- 383 gsu1 -------------------------------------------------------------------------------- 195 dde4 -------------------------------------------------------------------------------- 208 dde3 -------------------------------------------------------------------------------- 207 pmu6 -------------------------------------------------------------------------------- 210 psp19 -------------------------------------------------------------------------------- 207 msp12 -------------------------------------------------------------------------------- 207 psp25 -------------------------------------------------------------------------------- 207 oih3 -------------------------------------------------------------------------------- 208 rpa6 -------------------------------------------------------------------------------- 203 bja7 -------------------------------------------------------------------------------- 203 spo20 -------------------------------------------------------------------------------- 222 tfu1 -------------------------------------------------------------------------------- 271 rsp10 -------------------------------------------------------------------------------- 208 msp15 -------------------------------------------------------------------------------- 199 cgl1 -------------------------------------------------------------------------------- 210 spo21 -------------------------------------------------------------------------------- 217 reu5 -------------------------------------------------------------------------------- 212 psp6 -------------------------------------------------------------------------------- 213 bbr8 -------------------------------------------------------------------------------- 213 bpe1 -------------------------------------------------------------------------------- 231 bpa9 -------------------------------------------------------------------------------- 166 ssp5 -------------------------------------------------------------------------------- 213 bja6 -------------------------------------------------------------------------------- 212 rsp8 -------------------------------------------------------------------------------- 179 msp6 -------------------------------------------------------------------------------- 217 msp10 -------------------------------------------------------------------------------- 196 bbr10 -------------------------------------------------------------------------------- 207 spo22 -------------------------------------------------------------------------------- 207 bpa14 -------------------------------------------------------------------------------- 209 bbr12 -------------------------------------------------------------------------------- 209 psp16 -------------------------------------------------------------------------------- 210 bbr7 -------------------------------------------------------------------------------- 210 bpa3 -------------------------------------------------------------------------------- 480 mma5 -------------------------------------------------------------------------------- 25 dar4 -------------------------------------------------------------------------------- 219 mma4 -------------------------------------------------------------------------------- 120 sme1 -------------------------------------------------------------------------------- 160 spo12 -------------------------------------------------------------------------------- 211 mde3 -------------------------------------------------------------------------------- 236 ssp12 -------------------------------------------------------------------------------- 237 bbr13 -------------------------------------------------------------------------------- 234 pma1 -------------------------------------------------------------------------------- 233 cau1 -------------------------------------------------------------------------------- 221 tde1 -------------------------------------------------------------------------------- 221 bpa19 ---------------------------------------------------SLLVLMLISSLSAYVLGQWLENDTAPVDE 261 mlo1 -----------------------------------------------------LLVALVVAVAISYAAYRYLAPAHG-DN 256 rsp13 -----------------------------------------------------LIVALAVAAGVGVATHYWLAGAYGAEN 262 bme1 -------------------------------------------------------------------------------- 236 reu6 -------------------------------------------------------------------------------- 223 bja13 -------------------------------------------------------------------------------- 224 atu4 -------------------------------------------------------------------------------- 223 apo1 -------------------------------------------------------------------------------- 401 wsu4 -------------------------------------------------------------------------------- 217 vvu8 -------------------------------------------------------------------------------- 245 msp11 ---------------------------------------------------DVGDTPIG--------------------- 251 rsp12 ---------------------------------------------------EVPDVPGG--------------------- 122 sme15 SPSRALGIKAGEGRLTYWKLVKNLAAAFVPLLLTASTLGLLWWYVVIHQQAAATEAPEGLEELGAPLADAGPATADGPAT 329 spo15 -------------------------------------------------------------------------------- 209 spo16 -------------------------------------------------------------------------------- 219 tth1 -------------------------------------------------------------------------------- 219 rge2 -------------------------------------------------------------------------------- 219 spo18 -------------------------------------------------------------------------------- 216 dha3 -------------------------------------------------------------------------------- 213 ssp7 -------------------------------------------------------------------------------- 219 bpa10 -------------------------------------------------------------------------------- 205 spo11 -------------------------------------------------------------------------------- 213 atu10 -------------------------------------------------------------------------------- 213 mma6 -------------------------------------------------------------------------------- 227 ruler .......570.......580.......590.......600.......610.......620.......630.......640

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 . . spo8 ----------------------AGERVPLRGRLAALREVWAVILLFFLVIGGLYGLFDIPPLNINFSPTEAAGMGAMGAF 262 vvu9 ----------------------PGERVSWKGRLIALKGIFSTLLLFVIVMGGIY----IG----AFTPTEAAGIGACGAF 256 bpa5 ----------------------RGPRSTWPHTLHALRQVWMVLALIGMLLGGIYGG--------LFTPAEAAGVGAFLSF 254 bja4 ----------------------KGKVLPWRERFAGLKEIWAPVLLFVFVIGGLYGLPFLP----RFTPTEAGGVGATGAF 261 msp9 ----------------------QMAQKPLREILRDVLGAWPPALLFIIVLAGLYGG--------LFTSSEAAAVGCILAL 433 gsu1 ----------------------EGPRSGWGERFAALPEAIDILILFAIIMYALFTG--------VVTATEAAAVSCFLAL 245 dde4 ----------------------AGEKSSWRSRMRALPGAGEILILFVLVIGGLFMG--------VFTPTEAGAAGSAIAL 258 dde3 ----------------------AGRRSSWRCRLCSLMGLVDTLLVFALVIGGMFYG--------WFTPTEAASIGVLGVF 257 pmu6 ----------------------TSEKVPFLQALKSQVKVLPIFIVFAVVIISIYGG--------WANPTEAASIGAASCG 260 psp19 ----------------------EVQADRQGVTMHSLIGVTPIVVIFLLVFGGIYGG--------FFTPTEGAAVGAASTF 257 msp12 ----------------------KGEPVSAAELWSASINVIPVLVVFAIVIGGIYAG--------IYNPTAAAAIGVFLVL 257 psp25 ----------------------RGEPTSWKQKLISLTGLIPFSFIFIVIIAGIFLG--------LFTPTEGAAVGAFVSW 257 oih3 ----------------------REEKASILEKLHSLKNIWPFMGLFLVSIGGIYLG--------IFTPTEAAGVGAFGAL 258 rpa6 ----------------------RVASVPWRERFVLLWQIGPMLALFSLVTGTIY--LG------VATPTEASALGAAGAL 253 bja7 ----------------------AAKSVPWREKFALLWQVSPMVVLFSIVTGTIY--LG------VATPTEASAFGAFGAF 253 spo20 ----------------------PVTGFTWRQRFASLPGALPIVFVVVIIISFVYNPFGGDA---WGTPTEGGALGAFVVF 277 tfu1 ----------------------AQDQTTWKERLVSLVRIWPVPLLIVLIIAGMFSG--------VFTATEVGAAAALFSL 321 rsp10 ----------------------VEDRFTRAEKLAAFQETWPLPVIILGVLCGIFVG--------FFTPTAAGAVGAALAI 258 msp15 ----------------------CGPAMTWREIILKIG---PITVLVFLIFGGLYGG--------IFTANEAGAMGAFGAL 246 cgl1 ----------------------SDEHRPLAETFRGIAKNLLLPGVLALTVLVIIFTG-------IATPTEAAAFGAVAAI 261 spo21 ----------------------EVESSDWVEKLRLLFVDILPMVSIVIGVILVIMFG-------IATPSESAAFGCLGVI 268 reu5 ----------------------------WSARLASIRQLMPCIILIAFITWIMMAG--------YSTATEAAAYGVVASL 256 psp6 ----------------------------FREKLRLSKNLIPCALLIIFICWSLLAG--------WATATECAAYGVVGAL 257 bbr8 ----------------------------WLTMLARLRLLLPVVALIAGVIGSIYAG--------IATATEAATIGVIGAL 257 bpe1 ----------------------------FMQKLKQSRHLIPVLLLIGAVLGSIYTG--------IATATEAAAVGVVGAL 275 bpa9 ----------------------------FMQKLKQSRHLIPVLLLIGAVLGSIYTG--------IATATEAAAVGVVGAL 210 ssp5 ----------------------------FGERIAESRFLLPLFGLVFVVIGSMYMG--------FATATEAAAVGVLGAL 257 bja6 --------------------------VPWGERFAALKDLAPALFLIACVLGSMYGG--------LATPSEAAAVGVLGAG 258 rsp8 ----------------------------FREKMVALKDLGPLLLLIAGVIGSMYGG--------IASPTEAATVGVVVSM 223 msp6 ----------------------------LIERFARLFELAPVAVLFIFIFGALFAG--------YITATECAAWGVAGAL 261 msp10 --------------------------SDRVSFLSLLSDVVPTASVFVVIMGSIYLG--------LATPSESAAIGLAMTV 242 bbr10 ----------------------------WAQRIASLVHLGPPMAIFFLVVGSIYAG--------LATPTEAAALGVLGAL 251 spo22 ----------------------------GGEMLRALLQLVPIVLLFTIIIGTIYKG--------WATPTEAAAVGVAGAI 251 bpa14 ----------------------------LAMRLKLLIDVLPVVFIFGLVMGGIYLG--------IATPTEAAALGVVGAI 253 bbr12 ----------------------------LAMRLKLLIDVLPVVFIFGLVMGGIYLG--------IATPTEAAALGVVGAI 253 psp16 ----------------------------MADKLRSLVHLVPPMVVFGIVMGSLYFG--------IATTTESAALGVIAAL 254 bbr7 ----------------------------PPLR-QTLADLLPFGALIVGVMGSLYAG--------LATPTEAAGVGACLAA 253 bpa3 ----------------------------LREKLSASRGMVPFVAIIGAVLGSMYTG--------VATPTEAAAIGAVSAF 524 mma5 ----------------------KEEAYSMRERFSTLPRVLPFVVLLTGVMVALYGG--------YATPSETAGLGGLLAL 75 dar4 ----------------------DEMRMTRADKTRMLPRVIPFVLLLIGVMLALYGG--------YATPSETAGLGGILAL 269 mma4 ----------------------AGEHYGLGEKIRMVVWVAPFVTILAGVMVVLYAG--------WATPSETAGVGAVLAL 170 sme1 --------------------------YSMKERLAVLPRILPFLLIIAGTLYVLYGG--------IATPSEAAGAGAFLTL 206 spo12 ---------------------------AKMPMRMIVATVGPVMLIGLVITVAIYAG--------IATPTEAAAVAASLTV 256 mde3 -------------------------------ASELIKSIVPPILLMVLVLGSIITG--------QATPTEASGVGALAAT 277 ssp12 -------------------------------RTEVLRAVVPPILLIFAVLGAILGG--------VATPTEAASVGAIGAL 278 bbr13 -------------------------------LRQLLVDAVAPLALIIAVLGSILAG--------IATPTESAAVGAMGAV 275 pma1 -----------------------------MQPGQLLRVIIPPLGLILLVLGSIFFG--------IATPTEAGVLGATGAM 276 cau1 ----------------------------AALAKRVVQVMIPPLLLIVAVLGSIFFG--------ISTATEAGAVGALGAT 265 tde1 ----------------------------SALALRVLTTLLPPLVLIFLVLGTIFLG--------VATPTEGGAMGAVGAL 265 bpa19 QVVVSLLLWGLTAFVIAIANKVFRLKMLSALAERVTFVMIPPLFLIFLVLGTIFIG--------VATPTEGGAMGAVGAI 333 mlo1 ADILGATVGVLFIYIVAIADKRLNFNMMSRLAQQVVIVLIPPLALIFLVLGTIFLG--------IATPTEGGAMGSVGAL 328 rsp13 ADILGAVAGIAVIYIAAILDRAAGGKLMSRLAQQVIIVLIPPLALIFLVLGTIFLG--------IATPTEGGAMGAVGAL 334 bme1 ----------------------------WKLARRVVLSLVPPLVLIFLVLGTIFIG--------VATPTEGGAMGAVGAL 280 reu6 ----------------------------WALWRTCLRGIIPCAVLIFLVLGTIMLG--------IATPTESGAMGAVGAL 267 bja13 ----------------------------WPLWKKCLMGIIPSAVLIFVVLGTMMMG--------LATPTEAGAMGAVGAI 268 atu4 ----------------------------RALVFRVLAGMIPSIVLIFLVLGTIFLG--------LATPTEAGALGVVGAM 267 apo1 ------------------------------VAVEAIRVIIPPLILILTVLGSIFAG--------IASPTESAGVGVVGAL 443 wsu4 ------------------------------VILETLQTSLPPIGLIIIVLGGIFLG--------VVTPTEAAALGAMGSI 259 vvu8 ------------------------------EVVKALKAVIPPLALIVVVLGSIFAG--------VATPTESAALGGAGAI 287 msp11 -----------------------------TLLFMIVTSFLPLAFLILAVLGSILFG--------LATPTEAASAGALGGL 294 rsp12 -----------------------------KLFLMLLTSFFPLAVLILAVLGSILFG--------LATPTEAASIGALGGM 165 sme15 SFYVWFGLAAAVAVFALLRYYRNMTAERLQVVKLLVSSVMPLAILTVVVLGVILFG--------ITTATESAAVGAAGAF 401 spo15 --------------------------------LRLLKGLILPILVVFMVLGSIYGG--------IASVTEASAMGVLGVA 249 spo16 --------------------------------LGKLKSLILPALVVIGVLGSIYAG--------IATPTEAAAVGVLGAM 259 tth1 --------------------------------WRALRSIWSPLVLIFLVLGTIFLG--------LAAPTEAAAIGAFGAM 259 rge2 -------------------------------LAITTRNLVPPLGMIVAVLGSILLG--------LASPTEAAAIGALCSV 260 spo18 -------------------------------MTISLTAMLPPLALIVMVLGSLLAG--------IASATEAAAVGAAGTL 257 dha3 -------------------------------AAMILVSVVPTLSLILLVLGSILLG--------AATPNEASALGCVGAM 254 ssp7 --------------------------------LRLLGSGALPLLIFAAMMVPFVNG--------WTSLVESSAIGALTAL 259 bpa10 ----------------------------FVAILKGLKDALFALGVPILIFGGIRMG--------VATVTEMAAFAVVYSL 249 spo11 --------------------------FTFRAFLSAAWGASLALCVPLILVVGIFGG--------WFSSVEAGAITALVAL 259 atu10 ----------------------------WPQVGKAALIAAPALVLPFLIRSLVGGG--------VATATEVSTIAVLYAM 257 mma6 -----------------------------KMSGKGLLLAGATAAFIALLLGGVALG--------RFYAVEAAAMGAFALA 270 ruler .......650.......660.......670.......680.......690.......700.......710.......720

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 LIALARRRLSL-------------------------------------------------------------KDTLEVLL 281 vvu9 ALAGVRGKLNY-------------------------------------------------------------TVLREILI 275 bpa5 LFACSRRAMTW-------------------------------------------------------------RRFLDVVV 273 bja4 IIGVFTGRLDR-------------------------------------------------------------EKILASLL 280 msp9 IFWVVGGSFTF-------------------------------------------------------------GALSASLL 452 gsu1 VICGLRRKLTW-------------------------------------------------------------KKLTGALV 264 dde4 LLSLAGRRLSL-------------------------------------------------------------RGLVDAVN 277 dde3 VLAVSRGHLGW-------------------------------------------------------------RGFVKAVD 276 pmu6 IISWLSGGLTW-------------------------------------------------------------KGLVDSIL 279 psp19 LTALLKGEMTL-------------------------------------------------------------DKFKECFY 276 msp12 AYGLVARRLSL-------------------------------------------------------------AGIRDSLL 276 psp25 AYAFAKG-MRM-------------------------------------------------------------KGLKQSLI 275 oih3 LFALISRKLTW-------------------------------------------------------------ETLKDSLS 277 rpa6 VLAISKGKVTP-------------------------------------------------------------RTLYKALL 272 bja7 LLAIVKGKITP-------------------------------------------------------------SSLYRTLL 272 spo20 CMAVFRG-MKW-------------------------------------------------------------AEFKSALL 295 tfu1 IVALMWKRKNRPF-----------------------------------------------------------AAVVESAV 342 rsp10 LLGLLRGKID--F-----------------------------------------------------------AVMKRATE 277 msp15 LFALFKVRNP--------------------------------------------------------------KTYWRLLT 264 cgl1 IIAFGAGRFSF-------------------------------------------------------------RDLLGASM 280 spo21 VLAALYRSLTW-------------------------------------------------------------EGIVKSVA 287 reu5 ALAWAGGSLTR-------------------------------------------------------------KAFWESLM 275 psp6 ALALWSRSLTW-------------------------------------------------------------ANFNEALM 276 bbr8 AIAAWGKSLNR-------------------------------------------------------------RSFIDSLM 276 bpe1 ILSALQGSLTR-------------------------------------------------------------TSFMTSLL 294 bpa9 ILSALQGSLTR-------------------------------------------------------------TSFMTSLL 229 ssp5 GLSLMQGSLSW-------------------------------------------------------------GTFVESLM 276 bja6 LVAWAQGSMSQ-------------------------------------------------------------QVMRDVLI 277 rsp8 IIGFAQRTLTL-------------------------------------------------------------GGLLSAAR 242 msp6 LIAAQQRLLTW-------------------------------------------------------------ETFKLSIR 280 msp10 VIAALKRRFSF-------------------------------------------------------------AVLAQALA 261 bbr10 ILAAWFRRLTW-------------------------------------------------------------TMLREAIE 270 spo22 LIAGFFGGISV-------------------------------------------------------------QMFIDSIL 270 bpa14 AIAAANRTLSV-------------------------------------------------------------AMLHAAFL 272 bbr12 AIAAANRTLSV-------------------------------------------------------------AMLHAAFL 272 psp16 GFVVHSGKMSR-------------------------------------------------------------ELLRTCFI 273 bbr7 LIARIWGDCSI-------------------------------------------------------------ATLRRSLA 272 bpa3 VLCLVRRQLSW-------------------------------------------------------------RALFEIAH 543 mma5 ALIAVIYGVWRF------------------------------------------------------------RDLDPILT 95 dar4 ALIAGIYGVWRP------------------------------------------------------------SQLKPILN 289 mma4 AVIGMMYGIWRP------------------------------------------------------------RLLMPILT 190 sme1 AVVIVAYRLFRF------------------------------------------------------------RPVAGIFG 226 spo12 LLAFWVGGLTWQ------------------------------------------------------------GFKEAIFS 276 mde3 LLAVARR-------------------------------------------------------QFSLKA------LASVVR 296 ssp12 LMAGLRTGGPLRSILLGAGALIALGILSGLHPVRLQRNDLSSMDLVIGLFYALLAAAGAIAVLLSLRAGLKKRILHDAVT 358 bbr13 LIALLYK-------------------------------------------------------ALSWPV------LKQVCM 294 pma1 VLAALNG---------------------------------------------------------GFS----RSSLSKVCD 295 cau1 LLAAANR---------------------------------------------------------RLT----WKNFVAVCD 284 tde1 ALAAARG---------------------------------------------------------RLT----RLQLTQAVD 284 bpa19 IMALIRR---------------------------------------------------------RLT----LELLKQAMD 352 mlo1 IMAAAKG---------------------------------------------------------RLS----LDVIKQALT 347 rsp13 LLAGIKG---------------------------------------------------------RLN----LAVVTQALA 353 bme1 LLAIING---------------------------------------------------------RLN----LKMLTSALY 299 reu6 VLAVIRDKGFNKI----DRNIYRLGLLATLVAAAVGVFAFGSHAFRIPLAIAYLVVLWLLIRAGQLTD--LRLLIVDAYQ 341 bja13 VLAAIHHKDFTST----DRKILITGVIAAGVGTIVAMMMSENLIFKLAFALTYLAVAWICIRAARIPD--LRDLITQGYQ 342 atu4 VLAAAHR---------------------------------------------------------RLS----WDLVKQGMH 286 apo1 ILAKING---------------------------------------------------------ELS----LKLIKYASI 462 wsu4 LLTLFLR---------------------------------------------------------SFS----LELLRYAAI 278 vvu8 VLAILYK---------------------------------------------------------QFS----WGMVYDSAK 306 msp11 ILAVAYR---------------------------------------------------------ALT----WQRLRESVY 313 rsp12 VLAVLYR---------------------------------------------------------AMT----FERLRESVY 184 sme15 LLALQAR---------------------------------------------------------TLD----WQRTKEAVF 420 spo15 LSAVIRG---------------------------------------------------------EFN----WELLKGASL 268 spo16 LSALVTG---------------------------------------------------------KLR----LSVLSDAAT 278 tth1 VVAAIHR---------------------------------------------------------RLS----WTILRLALE 278 rge2 GLTVLYG---------------------------------------------------------RFT----WPGLYESLL 279 spo18 LLTLMFR---------------------------------------------------------ELT----LKLVMDSLG 276 dha3 IIAIMYK---------------------------------------------------------NFN----WKMFKESCF 273 ssp7 AASIAKR---------------------------------------------------------RMT----WKIFESCTK 278 bpa10 LVGGLVYRRLS------------------------------------------------------------WRGIYQALV 269 spo11 ILGTVVYRDLD------------------------------------------------------------LASFLGALN 279 atu10 IVGAVLYGGIS------------------------------------------------------------LRKLYSMLV 277 mma6 LGGALSGHLTL-------------------------------------------------------------KVLNDVLA 289 ruler .......730.......740.......750.......760.......770.......780.......790.......800

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 : . . spo8 ETSITAASLFAVLIGAWIFSNFVNIAGLPAA-LSEIITAYELRPWQVMAVILAIYIALGCVFESLSMLLLTVPIFFPLVT 360 vvu9 DTAKTSASLFAVVISALILSNFVNRAGLPTA-LVELIQTANVTPMMALGLILVIYIILGCVFESMSMMLLTVPIFYPVIV 354 bpa5 ESAKTTGMIFVVMIGALMLANFINFTSLPQD-LLDVVARHQLSPLTVILAICVIYIVLGCVLESMSMILLTVPVFYPLVQ 352 bja4 QATRTAAAVFTVLIGALIFGYFLTVTQTPQK-VTEFLTGLGLGPYGVLALIMVMYLVLGCLMDAMAMIILTVPIIFPVIM 359 msp9 DAMTSSAKLYMVILGASLFAALLNLTGLARV-VLTWADPATTPQIVVLLAFVAVYLILGAIFDSVAALLVTAPIVIPVIE 531 gsu1 DTLRISCMVFMIVAGAVIFAKFLTITRLPYE-TAEWISSLDLPRWMVLWVILACYIIGGCIMDALAFLLVSLPIFYPLVT 343 dde4 DTLRISSMIMVIILGAVLYGRFLAVTRLPFA-VAEWTASLPLPPLGILLLICGVYIVGGMMMDALALLLVTIPIFFPVVQ 356 dde3 ETLRTSCMVMLLIAGATVFGKFLAVTRIPFD-IAGWVGGFDLPAFAVMGLVVAVYFVGGCFMDSLALVMLTIPVFYPLVL 355 pmu6 QTAMASAMIFMVLIGADLLNSALALTQMPAQ-LANWVVEQQYAPLLVLFCILMIYLVLGCVMDSLAMILLTIPIFYPIIL 358 psp19 GTAVSAAMIFLIFIGADLMNSALALTQVPNQ-LAALVGGWGLSPLVVVVAILLFYVLLGAVMDELSMLLLTIPIFFPMVM 355 msp12 DTARTGGMIFLILLGAELLKIFMSRAGVPQA-GAEMLQASGLQPMAILLLVIFAFLLLGCLMDSLSMIILAIPFFWPVIA 355 psp25 ETLALSAVVFFMLLGAEALGYFISVSRMSYT-LASWIGTLAVSPMIVLICILIMYFLLGLFMDALAMLVITIPVVFPIIL 354 oih3 ESIRLTAFIFFILIGANLFGQFLAISRIPVM-LTTYVGNLDLHAYIILIGILAVLLVLGCFIESLALIVITLPILYPIIT 356 rpa6 SASYGTCMIVTILVGASIFGYFFTLTHVTQD-LVAWVGSLETSRWVIITLILCGYIVLGSFMDQIAILVLTVPIVMPLIK 351 bja7 RACHGTCMIIMILVGASIFGYFFTLTHVTQD-LVAWIGSLPTSRWVIITLILCGYIVLGSFMDQIAILVLTVPIVLPLIK 351 spo20 ETAKLTVMIFTIIWGVLIYVRFLGFADLPGA-FSDWITSLQMSPMLILVCILLAYAVLGMFMDAIGMLLLTLPVVYPAVM 374 tfu1 ATVSSVGAIFFILIAAAALTSLLTLTGISTG-MADAVESLGLGRVQFLLVMVVVYLILGMFMDPMAIMVLTIPILIPTLN 421 rsp10 ATLMSTASIFLVIIGTSLLGKFMAISGVPAY-AASLLIEFGTTQLMVLLAVSLLYIFLGMFLDSMGILLLTMPIILPMAR 356 msp15 ETGQVTASILLLVIGASIYTRMLALTGVPAA-LVGLFSDLGLGVVGTLVIYVTIILLLGTLIDSASIILLVVPLMYPIFQ 343 cgl1 SSVRITGTIFILVMASTLYSQIMAYMGATTG-LVSWVSSSIANGVIMLFLIVFLLVLLSCFIDQASIMLITAPLLMPIAM 359 spo21 GALKVTTMALLIIFGSATFSALLAFSGASSG-LIRWATGFDLEPITMLLIMFGILLVLGMFMDQLSMMLLTVPIFFPLAQ 366 reu5 SATRLTAMIMFVLGATSFLSVTMSFTGIPRA-LAEWVAALHLSPWALIAVLTIIYILLGTALDGISMIALTTATVLPMVQ 354 psp6 GSARTSCMIMFILAGAAFLTKTMAFTGVPRE-LAEWVGSLNLSPYSLIACLVVVYLVLGTALDGISMIVLTAAVVMPMIQ 355 bbr8 GATRTSCMISFILLGAAYLTSAMSFTGLPAN-LAEWISSLGLSQYGLIAVLTVFFILMGAFLDGISIVVLTTAVLMPAIQ 355 bpe1 GATRLYCMIALILAGAQFLPGHGLHRPAPRAGRVDRRAGP-------------VPVRPDHGLDG----VLRRAGLLP--- 354 bpa9 GATRLYCMIALILAGAQFLTLAMGYIGLPRA-LAEWIGGLGLSQFGLIMALMVFFVVLGCFLDGISIVVLTMGVLLPTVQ 308 ssp5 GATRTSAMIAFILMGAAFLSLSMGFTGLPRA-LAGMIESYNLSPIALIAVLTVFYLILGMFMDGLSSVVLTMAIVEPMIR 355 bja6 GSVVTCSMIALIVLGASILGNAAAFLGIPQA-VAAFVKGLGLSPFMLIVVLIIFYLILGCFLDGFSMIVMTLPIVLPIVK 356 rsp8 QAAESCAMIGLIMIGAMFLSTMIGYLGVPRY-IATEIQSWGMSPLMLVVVLLIFYVLLGTVMEGLGIIVMTLPITLPLAV 321 msp6 GTVRTTSMLVMLIGMAAIMSSFVALAGIPNA-MSRAVDSLGVGPFGLVAILMLVFIVLGMFLDGMSMILLTLPVTLPMVV 359 msp10 SAIRTSCMVCILLVSAAFLTSAMSFMHLPNQ-IADAIGQMHLPPLQLILILAVFYLVLGIVVDGLPIMVMTLPFVYPLVT 340 bbr10 GTMRSTAMIMLIVLAASFLNFVMSATGLTDA-LVQSITGLGLSPGWMLLIVVIFYLVLGCFMETLSMMITTIPIVAPIMI 349 spo22 GTVKITSMIMLVVIGASFLNFTLASAGLGRE-LESFLGGLGLSPLGTILVVVVIYIVLGFFIETLSLMVVTIPIIVPLVV 349 bpa14 SALRTTAMVVLVVTTAFVLNFSLSLAGIPQA-LSEYIGQLGWSPTATIWVLVAFYLILGCFLEAIAMMVTTVGVVVPLI- 350 bbr12 SALRTTAMVVLVVTTAFVLNFSLSLAGIPQA-LSEYIGQLGWSPTATIWVLVAFYLILGCFLEAIAMMVTTVGVVVPLIV 351 psp16 STARVSGMILLIITAAFILNLTISLTGVAEA-MTKWVAGLGLSATGLILALIVFYLILGMFMDVLSMQVATIPITYPIAT 352 bbr7 KTVKACGAILFIVYAAFLFSYAIAMTGLTDS-LTDLLDAWQLSRLELLLAVVLLYTVLGFLMDSIGMMVITVPILHPILA 351 bpa3 DSAKVTALLLLIVVGAGIFSWVFDYLRLPRE-VVNLIQGADLSPALIVAAMVLAYLVLGMFVESIAMMLMTLPVTYPIAM 622 mma5 ATLRESTMLMLIIGMSLLYAYVMSYLHISQA-AAQAIVAMQLSPWLLLATILALVIALGFFLPPVSIILMTAPIILPPLK 174 dar4 STLKESTMLMFIIGMSLLYSYVMSYLHISQS-AAEWIVAMHLSKWLLLAAILIFVVILGFFLPPVSIILMTAPIILPPLK 368 mma4 GTLRESTMLLMIIGMSLLYAYVMSYLHISQA-AADWIIGLALSKWFLLAAVLLFTVVLGFFLPPVSIILMTAPIILPPLK 269 sme1 SAMKESVMIMMIMAAAELFAFALSSLFITQT-VAAAIADMEVNRWVLMAVINVFLLICGMFLPPVAVIVMTSPMLFPIVT 305 spo12 -TMRTMGYLGLLLSAGVLFGFVLTYYRVPQQ-FTELFLSFDLSPYTVLAIVLVFYIILGMFLEPVSMTFITLPTIYPLMS 354 mde3 STAKVTTMVFAILLGSALFSLVFRDLGGEQLIHGFFHDLP-GGTFMAVLIVMLVIFLLGFILDFIEITFVVVPIIAPTLL 375 ssp12 STATMTSMIFATMLAASMFSLVFIGLGGEDRVAHILSELP-GGPSGALLFSMLFIFVLGFFLDFVEISVIVLPLVTPTLI 437 bbr13 ATGHLVAMVFTIMIGAAIFSLVFKGLGGEHLARELLSSVP-GDLYGALLLVLLIAFVLGFFLDSFEIIFVVIPIFGPPLL 373 pma1 ETLRTTAMVMAILLGSTAFSLVFRGVGGDQLIADLLLNLP-GGKVGFMAVSMLTIFGLGFFIDFFEIAFIAVPLLLPAAR 374 cau1 ATMRATTMVLFILIGSTAFALVFRALSGDKFVFDLMANLP-GGAWGFLVVSMLIVFFLGFFIDFFEICFIVIPLFVPVA- 362 tde1 STTRLTTFVIFILIGSTIFTLVFRGLDGDAAVEHVFAQLP-GGVLGFLIVVNLLVFVLAFFLDFFEIAFIVVPLVGPVAA 363 bpa19 TTTKLSCFVVFILVGSTVFGLTFRGVNGDLWVEHLLIGLP-GGEWGFLIVVSVLTFVLAFFLDFFELAFIIVPLLGPVAD 431 mlo1 STTRLSSFVLFILIGARVFSLTFYGVNGHIWVEHLLISLP-GGEVGFLIGVNILVFFLAFFLDFFELAFIIVPLLAPAAD 426 rsp13 STTRLSAFVMFILLGARMFSLTFYGVNGHIWVEHLLTSLP-GGEYGFLIAVSVLVFFLAFFLDFFELAFIIVPLLAPAAE 432 bme1 ATTKLSSFVIFILLGARVFSLTFYGVNGHVWVEHLMTSVP-GGEVGFLIVANILVFFLAFFLDYFELAFIIIPLLAPVAD 378 reu6 STARITAMVVFILIGSTCFSVVFQGVDGGAWVEHLFTSLP-GGWIGFLIVVNLFIFFLAFFLDFFEIAFIVVPMLAPVAV 420 bja13 STMRLTCMVTFILIGSTCFSVVFLGVSGGVWLEHLLTSLP-GGVWGFLIFINLFIFFLAFFLDFFEIAFIILPMIAPIAQ 421 atu4 STMHITSMVVFILVGATCFSLVFQGMDGSLWIEHMLSGIP-GGPIGFLIFVNIFIFFLAFFLDFFEIAFIVIPMLAPIAQ 365 apo1 ETVKLTAMIFMILIGATAFSLVFNELGGQDLAMEFFANDI-GDKWSFILLSMALIFILGFFIDFIEIAFVVVPILVPIVH 541 wsu4 QTVVFSGMIFAILIGASAFTLVFNDAGGGDLIFDFFSDHL-GSPWAFIWVAMGVVFLLGFFIDFIEICFVVVPLFVPLVG 357 vvu8 ETVKVTAMVFAILLGATAFSMAFTYTGGDELVEEWMLAIP-GDKWGFLIITMLVILILGFFIDFVEICFIIVPILAPVAE 385 msp11 LTMKTTAMVCWLFVGSWVFSSVFSYLGGEGLIRDFVTGLD-MSPIMFLILAQIIIFLLGWPLEWSEIIIIFVPIFLPLLA 392 rsp12 LTVRTTAMVCWLFVGSYTFSAVFSYLGGEQVIADFVGSLD-LTPFQFLILAQIIIFLLGWPLEWSEIIIIFVPIFLPLLR 263 sme15 LTAKTTAMVCWLFVGSALFSAVFAILGGQALVEQWVLALN-LTPVQFMILSQAIIFILGWPLEWTEIIIIFVPIFLPMLH 499 spo15 QTLSTVGMIVWIGIGATALVGVFNLMGGINFVSGLIIGVS-DNPTVIVLVMMLILFVLGMFLDWVGIALLTMPIFVPIIR 347 spo16 DTLRVTAMILWITIGARAFISVFVATGGADSILTFVETLE-ASRWVVLGAMVLILIFLGLFLDEIGIILLCVPVFLPIVD 357 tth1 QTAKATAMVMWIVFGANAFVGFYIAQGGDRYVSELLLGTG-LSPWGILLLMQGILIVLGMFLDWVGILLLAVPVFVPIIR 357 rge2 KTLRVTAMIMFVLLGGTLFTGVFIGGGGINLASSMITHLD-LSPWALLGMMLFILFIAGFFLDWISIVLIFLPIFTPLVT 358 spo18 VTLRITAMIMLIVAGGTMFTSIFAVTGGGGLVRDAVESIG-YGNFGIIAFFLTVVFFSGFVLDWVSIVLIFVPIFAPIVK 355 dha3 STMKTTSMIMWIIVCATMFTSIFIGLGGDKVIADMVVGVG-ENKWVILSVILVLLVAMGMLLDSYGVLLIGVPLFTPIVY 352 ssp7 NTLAISCMFMWIILAALGFGAVFDGLGAVKAIDSLFTEQLGLSPWVILILMQLSFIIMGTFLDDTAMLVIVAPLYVPLVA 358 bpa10 DTCVATGVICLLMGFAMIFGYLLATEGVPGA-VAQWIRDNHISPWGVMLITALIFVFIGAVLEGAPAVLIFVPILLPVVR 348 spo11 RTVRMSASVFVIIAAAGPFTWLLARLG-ALEMLQNWLLGFAETPFFFALMLLGLILLAGMIMDAAANIIVLGPLLVAACE 358 atu10 ETAALSGAILLILGCASAMAWGLTQSGFAFQ-LTAMITDLPGGWMTYMVVSILIFMILGCVLEGLPAIVLLAPIMFPIAR 356 mma6 DTMAVSGALFALFAGATTFTLVFRLFESDRL-LARLVEALPWGTTGALGGVLVILALSALVLDAFEIIFVLVPVLMPPLL 368 ruler .......810.......820.......830.......840.......850.......860.......870.......880

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 GLGYD-----------------PIWFGIVVVVVTEISLITPPVGLNVFVLKG-------------VVG-DVSTGTIFRGV 409 vvu9 ELGFD-----------------PIWFGIIVVVVTEISLITPPVGLNVFVLSG-------------LIK-DINTATIFRGV 403 bpa5 SLGFD-----------------LIWFGVIVVVVTEISFITPPFGMNVFVLRG-------------LLP-GVSTPTIFRGV 401 bja4 HLGFD-----------------PIWFGVIIVMTVELGLIHPPVGMNVFVIKS-------------VVK-DVSFSTIFKGV 408 msp9 GYGLD-----------------LVWWGIVTLSMIETGMITPPIGMNVFVLRG-------------VLGGEIRLQDIYRGI 581 gsu1 QLGYD-----------------PIWFGQVITIVTTMGSIMPPIGICCYVVSG--------------MSG-IPLGTVFRSG 391 dde4 AMGYD-----------------PVWFSVFITVITTMGAITPPVGVTAFVVAS--------------AAGDVGVQDVFRGV 405 dde3 NLGYD-----------------PVWFGIIIVLVTEMGVITPPVGINVYVVYGIAQQ---------VVPGGIALESVFKGV 409 pmu6 GLDFWG----------LSAQDKTIWFGIVALMVVEIGLITPPVGMNLFIINK--------------MDKDTPLLATSKWV 414 psp19 ALDFG-----------MAKDLVAIWFGIMVLMTVGFGLIAPPVGLNVYIVNG--------------LAKNVPMSETYRGV 410 msp12 GLDFG-----------LTPNDTKIWFGIIILIVVELGLITPPVGLNVFIISA--------------MAKDVPMRETFKGV 410 psp25 ALGFD-----------------PIWFGIIAVLTVELGLITPPMGMNIFVIKA--------------MAPHIKLSDMFKGV 403 oih3 ELGFN-----------------GIWFGVIMIMVINIGALTPPLGISVYVIKG--------------VARNIPIQSIFRGV 405 rpa6 SLG-----------------FDPIWFGVIKIVTAEVGMITPPVGLNCFIVARY---------------AKRPVAEVFHGT 399 bja7 TLG-----------------FDPIWFGVIKIVTAEVGMITPPVGLNCFIVARY---------------AKRPVAEVFHGT 399 spo20 ALNGGEAVSAADSAFGMSGPMCAIWFGILVVKMAEFCLITPPIGLNCFVVAGVR--------------PDLSVQDVFRGV 440 tfu1 SLDIS-----------------LMWFGVFTVFMGELAVVTPPVGILAFIIHGMVKDPDV------NMGHKISLKDVFVSV 478 rsp10 EAGLD-----------------LIFFGIILVKLLEIGLLTPPVGLNVYIIKG-------------ALGDRVSLTTIFKGV 406 msp15 SMNVD-----------------PIWLGIITVMSVEVGLLTPPFGMAAFVVKAT------------SEQKELKVEDVYWGA 394 cgl1 QFSWD-----------------PVWFSIIVLITLQIGNISPPFGMSLFVMK--------------STAPWIPMLTLYRAA 408 spo21 TLGFD-----------------LIWFGVIVLLALEISFTTPPFGLLLFVMKG-------------VSAPGTSMRDIYVSA 416 reu5 AAGFD-----------------LVWFGIFIVLLVEIAEVTPPVGFNLFVLQSMTGK---------------DSNYIARVS 402 psp6 KAGFD-----------------LVWFGIFVILLVEIAEVTPPVGFNLFVLQNMTGK---------------DSNVIARAA 403 bbr8 AADID-----------------PIWFGIYLILVVEMAQITPPVGFNLFVIQGITGR---------------NLFELVRMA 403 bpe1 ---------------------------------GRHFHRRPDHGRAAAHRAGR--R---------------HRPDLVRH- 383 bpa9 AAGID-----------------LIWFGIFIVFVVEMAQITPPVGFNLFVLAGMSGR---------------ELPYIARAS 356 ssp5 QAGID-----------------VIWFGIFLVVVIETAQVTPPIGFNLFVLQGMTRH---------------EISYIAKTA 403 bja6 GAGFD-----------------EIWFGIFLVLAVEMAQITPPVGFNLFVIQGLTED---------------GLGYIARVT 404 rsp8 AAGYD-----------------KVWFGIFLVIVVEMAQITPPVGFNLTVIQRLTGD---------------SMGRITRAT 369 msp6 AAGFD-----------------PIWYGIFLILMIEIGELTPPVGFNLFVLQNITGK---------------NIFSIGRMS 407 msp10 ALGYD-----------------PLWLGIFIILNIEMGMISPPVGLNLFVLKGLTGE---------------SIGRIGFAA 388 bbr10 ALGYD-----------------PIWLGILIIVLVEAALITPPVGLNLFVVQSLRKS--------------GSMTAVINGA 398 spo22 AQGYD-----------------PIWFGILMIVLIEMALITPPVGLNLYVVQGARQS--------------GKMSEVMLGT 398 bpa14 -------------------------------------------------------------------------------- 350 bbr12 SLGFD-----------------PLWFGIFMTMMMELALITPPVGLNLFVAQNIRLSR-------------GGISDVYIGV 401 psp16 ALGVD-----------------PIWFGIFIVLMCELGLITPPVGMNLFVVHGIRPDK-------------GGIEDAIWGA 402 bbr7 SYGVD-----------------PIWFGVLLVVLIELGQITPPVGMNLFVVKSVSPS--------------ARLKDVVVGS 400 bpa3 SLGLD-----------------PIWFGVFLVLMIELGLITPPVGMVLFVLRSMNEK--------------ARFTDIIRGA 671 mma5 AAGFD-----------------LVWFGVVMTITMEMGLIHPPVGLNIFVIKNIAP-D-------------IPLKDIIWGT 223 dar4 AAGFD-----------------LIWFGIVMTVVMEMGLIHPPVGLNIFVIKNVAP-D-------------IPLKDIVWGV 417 mma4 AAGFD-----------------LIWFGVVMTIVMEMGLIHPPVGLNIFVIKNIAP-D-------------IPLRDIIWGT 318 sme1 QAGFD-----------------PYWFAIVLTINMEVGLITPPIGLNLFVINAIAP-Q-------------IPTKDILWGS 354 spo12 AAGFD-----------------LIWFGVVYTITMEIAVLTPPVGLNLYVIQAISRDQ-------------VTIGDVIMGC 404 mde3 MMG-----------------VDPIWLGIMIAINLQTSFLTPPFGFALFYLRGVAPQ-------------TVATSAIYKGV 425 ssp12 LMG-----------------HDPVWLGILIAINLQTSFLTPPFGFSLFYLRGAAPK-------------EITTRHIYQGV 487 bbr13 SLG-----------------VDPLLFGVLLAVTLQTSYLTPPFGFAIFYLQGVY-K-------------DIGAETAYRGV 422 pma1 QILGP---------------EALIWLGVVIGANLQTSFLTPPFGFALFYLRGVAPK-------------TITTQEIYKGA 426 cau1 QALG----------------FDLIWFGVLLGANLQTSFLTPPFGFALFYLRGVAPP-------------GITTADIYRGV 413 tde1 KLG-----------------IDPIWFGVMLAVNMQTAFMHPPFGFALFYLKSVAPK-------------AVRTGDIYRGA 413 bpa19 KMG-----------------IDLIWFGIILAVNMQTSFMHPPFGFALFYLRSVAPKDAYKDKITGKVIQPVTTGQIYWGS 494 mlo1 KLG-----------------IDLIWFGVLLGVNMQTSFMHPPFGFALFYLRSVAARVPYLDRLTGKQIAPVTTGQIYWGA 489 rsp13 ALG-----------------IDLIWFGIILGVNMQTSFMHPPFGFALFYLRSVAPRQSYIDPVTKARMAPVTTGQIYWGA 495 bme1 SLG-----------------IDLIWFGVMLAMNMQTSFMHPPFGFSLFYLRSVAPSRPYKDKVTGATIPPVTSGQIYMGS 441 reu6 KVLAPVVADSMGGNPEAAATAALVWFGVMLCVNMQTSFMHPPFGFALFYLRGIAPK-------------EVKSSDIYWGA 487 bja13 KILAPVVG----------PDAALIWFGVMLCVNMQTSFLHPPFGFALFYLRGVAPK-------------EVKSSDIYWGA 478 atu4 SLG-----------------IDLIWFGVLICINMQTSFMHPPFGFALFYLRSIAPR-------------SVKTSDIYMGA 415 apo1 SFG-----------------IDPVWFAILIALNLQASFLTPPFGFALFYLKGSAKD-------------LVTTKEIYKGV 591 wsu4 HFG-----------------IDPIWFAMLLAINLQTSFLTPPFGFALFYLKGAVGD-------------KLKTSAIYQGA 407 vvu8 ILG-----------------INMTWFAILIAMNLQTSFLTPPFGFSLFYLKGVAPA-------------GVTTRDIYRGV 435 msp11 HFD-----------------VDPLFFGILVALNLQTSFLTPPMAMSAYYLKGIAPP-------------QVRLTQIFAGC 442 rsp12 IFD-----------------IDPLFFGVLVALNLQTSFLTPPMAMSAYYLKGIAPA-------------QVRLTQIFAGS 313 sme15 HFD-----------------IDPILWGVLVFVNLQAAFLSPPVAMSAYYLKGVSPP-------------QVTLNQIFAGM 549 spo15 ELG-----------------LDPVWFGVVFAMNMQVSFLSPPFGPAAFYLKSVAPEG-------------ISLGEIFRSL 397 spo16 TLG-----------------FDPLWFGVLFMITAQMAYITPPFGYTLFYLKGVLPEG-------------IGIGQVYRGV 407 tth1 DLG-----------------FDPLWFGVLYLVNMQISFLSPPFGYALFYVRGVAPQ--------------VPMGTIYKAA 406 rge2 AAG-----------------FDPVWFCILFLIMIQTSYLTPPMAPAIFYLRAVAPP-------------EITMRHMYWGM 408 spo18 SAG-----------------IDPIWFAMMVLVVIQTSYLTPPMAPSIFYLRSIAPR-------------SMTYGQMYRGV 405 dha3 SLG-----------------FDPIWFGIIFTLMIQVSVLSPPVAYAVFYMKGFVP--------------HIPIGKLYWAV 401 ssp7 ALG-----------------FDLVWYGVLYTITTQIAYMTPPFGYNLFLMRAMAPP-------------EISLTDIYRSI 408 bpa10 ELGID-----------------VVHWLTVVVLASGIGLFVPPTGLAVLVACSVG---------------RVSMQAIIRPL 396 spo11 TAGYE-----------------PVQAALVVVVGFLLGTVTPPVGVCYFTATAIAG---------------CRLEQSAAAL 406 atu10 TLGIN-----------------DIHYSMVVVVAMNIGLMAPPIGIGFYIACKIGN---------------VSPDEAMGAI 404 mma6 VRVPD-----------------TLWVAVAALLTLQASFLVPPLGQAVLMARRAVPQ-------------ALGIGRLMRAL 418 ruler .......890.......900.......910.......920.......930.......940.......950.......960

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 TPFWMVDIIRLALLLAVP-ALALYLPGQM--------------------------------------------------- 437 vvu9 LPFWVADMVRLALIVLVP-AIALYLPNMLY-------------------------------------------------- 432 bpa5 MPFVVSDVVRLAILVLFP-SISLLLPSYVR-------------------------------------------------- 430 bja4 IPFVATDLVRLVILIAFP-LLATWLPTRMMAH------------------------------------------------ 439 msp9 WPFVCADLVRLALLLAIP-SIALWLPSAIG-------------------------------------------------- 610 gsu1 LYYMPSYIASIAILMVSPYWTVLVLADLVK-------------------------------------------------- 421 dde4 TFFLAAYAVCALLLLLVP-QIVLFIPSLM--------------------------------------------------- 433 dde3 LPFLVAVIAGIALLLCFP-QIVTLLPSLMY-------------------------------------------------- 438 pmu6 LPFIASDLIRIAVIACVP-GIALWLVHLF--------------------------------------------------- 442 psp19 MPFLFSDVLRTMLFLFFP-IIPLWLVGFIK-------------------------------------------------- 439 msp12 MPFFGAEVVRIALLIAFP-AITLFLPHLLR-------------------------------------------------- 439 psp25 MPFIVSDLVRLVILVAFP-AISLVLLS----------------------------------------------------- 429 oih3 VPMIIAMIVCVAILVVFP-QIVTVLPDLMK-------------------------------------------------- 434 rpa6 FPHFIAHLIAIAIMVAFP-SIILWLPSQMAP------------------------------------------------- 429 bja7 FPHFIAHLIAIAILVAFP-SIILWLPSQMGR------------------------------------------------- 429 spo20 MPFFVADAVTIALLVAFP-QIVLWLPTLAG-------------------------------------------------- 469 tfu1 GWFLPMAIAVAVILILVP-EIATFIPDMAAAQK----------------------------------------------- 510 rsp10 GWFIAVDLVLLAILVEWP-VLVTGLPSLMF-------------------------------------------------- 435 msp15 APFAIITIGVVGLLILFP-QLTTVLLR----------------------------------------------------- 420 cgl1 IPWIISDLVVILILCIFP-SIVLFLPQLMAN------------------------------------------------- 438 spo21 LPFIGCSMLLVALLIIFP-GIALWLPGLGQ-------------------------------------------------- 445 reu5 LPFFMMMVLAIGIITVWP-SVVTWLPDVVMAKELK--------------------------------------------- 436 psp6 IPFFMCLVVCIALITLFP-QIVTIVPDLVMGKVK---------------------------------------------- 436 bbr8 FPFFLLLVLATAIITIFP-AIVTALP-LAMR------------------------------------------------- 432 bpe1 -------------LHRVR-G------------------------------------------------------------ 389 bpa9 LPMFFLMIVAVLLLYYLP-GIATWLPQHMTL------------------------------------------------- 386 ssp5 VPMVALMLLMVVILVVWP-ELATWLPNNIR-------------------------------------------------- 432 bja6 MPYLMIMVGFVLLLTLWP-GIVTILPRVLYG------------------------------------------------- 434 rsp8 MPFFLIMAAFVLLIAVFP-GIIGFLPDLIRGN------------------------------------------------ 400 msp6 FPFFLMMVICIFVLVASP-QIVMVLPNLYH-------------------------------------------------- 436 msp10 LPFFAVMCVVTALISIFP-ELVLWLPSLAIN------------------------------------------------- 418 bbr10 LPFVLAMFVMLALLAFFP-DLALWLPRVFG-------------------------------------------------- 427 spo22 IPYVIAMLVMVAALIAFP-AIALFLPSALGG------------------------------------------------- 428 bpa14 -------------------------------------------------------------------------------- 350 bbr12 LPFAFAMMVFVTLLIYFP-QIALWLPNRLF-------------------------------------------------- 430 psp16 LPYALIMILFTLLIMVWP-QIVTWLPAHM--------------------------------------------------- 430 bbr7 LPFCLLMYVLIAWLIYSP-QLALWFPGRMTG------------------------------------------------- 430 bpa3 LPFVLIILLFLCLIYIYP-QIVMWLPQQVK-------------------------------------------------- 700 mma5 LPFVILMAVAIVALCLVP-GIALWLPDLLLPSTR---------------------------------------------- 256 dar4 FPFVGLMFLAVILLCIFP-GIATWLPDVVMGVAS---------------------------------------------- 450 mma4 IPFVLIMMVAVVLCSVLP-GIATWLPAAVMG------------------------------------------------- 348 sme1 LPYVLVMFLAIILLCVFP-DVATWLPNQMLGDRPMNTTSFFSDMLQSIAERGRRFLSLGPARNGDVNPVGTMEALCDTLL 433 spo12 LPFIGAMILLIAVLIVAP-DVALWLPEQMR-------------------------------------------------- 433 mde3 IPFIILQVLLMVCLALWP-SLATWLPNLLR-------------------------------------------------- 454 ssp12 IPFIGLQVLGVILVWFIP-GLATWLPEAIF-------------------------------------------------- 516 bbr13 LPYIALQVGAVAALLSFP-ALATWLPTVLY-------------------------------------------------- 451 pma1 LPFVGLQIAVLVLIIAAP-PLVDWLPNLAAS------------------------------------------------- 456 cau1 VPFIAIQLTIVVVLIFFP-QLALYLPAISFGQ------------------------------------------------ 444 tde1 IPFLVIQLLMVAVVLGFP-QIVLRDVAGDASSVREIPIDVDPD------------------------------------- 455 bpa19 VPFIVIQLFMVAAVMLFP-GMVMHYKGG-QSTVDPASVKIEVE------------------------------------- 535 mlo1 VPFVLIQVVMIGLTISFP-QMVMRYKS---TVIDPGTIDYKVPEVPGLSP---------------------------LGV 538 rsp13 VPFVCIQIVMVALVILFP-QMVMHYKG---APVDTSNVTITLPQMPGLGGGLGGGLGGGLGGGLGAPGAQPAPGAGGLGA 571 bme1 IPFLLIQVVAVGVIIAFP-GLVTHYKGN-HPQVDPASIQINVP-MPDAGG----------------------------GN 490 reu6 LPWVGLQLVMVLLVMFWP-GMVTGLLDK-GSLKHSNSAEVSIPLGGQDDG----------------------------KP 537 bja13 MPWIGLQLIMVMLVIIFP-ITVTGLLDK-PLNVDLDKVKIEVPQ------------------------------------ 520 atu4 IPWLGMQLILVAIVIFWP-ESVTYWLDK-APDVDLNSIKIEIPAFGNQ-------------------------------- 461 apo1 VPFILLQLLALVIVLLFP-DIIYIFWG----------------------------------------------------- 617 wsu4 VPFILLQLLLLGIVVAFP-AVIVY-------------------------------------------------------- 430 vvu8 MPFIGLQILVLASLLVFP-SFYGMG------------------------------------------------------- 459 msp11 MPFLVMVILSMIIVYIFP-GTVYTLPELVYGR------------------------------------------------ 473 rsp12 LPYVGMVFVCMALMYLFP-QIVFALPEFVYGAR----------------------------------------------- 345 sme15 MPYMLIVILCMIMMYIWP-GMTLWLPEYLYG------------------------------------------------- 579 spo15 LPFIAMQVLALAILIAFP-GVTGRW------------------------------------------------------- 421 spo16 IPFFLIQVAILILFALFP-ALVTWLPELLTQNAR---------------------------------------------- 440 tth1 LPFLFLQLVGLALVMLFP-GLATWLPSVVYGR------------------------------------------------ 437 rge2 IPFIALQVITLACTLMWP-QLVTWLPSVAMQMR----------------------------------------------- 440 spo18 LPFVGAQMLVLVVIVFFP-ATVTWLPSILVGLVSLGFDPLWFGIFMTMMMELALITPPVGLNLFVAQNIRLSRGGISDVY 484 dha3 IPFMAMQIICIILCCIFP-DIIMFLPNRMQ-------------------------------------------------- 430 ssp7 VPFVAIMVVALAIIMVFP-QIALWLPETIYGQ------------------------------------------------ 439 bpa10 IPFLLLLLAGLAVIMAFP-VISIGLPRAMGIPW----------------------------------------------- 428 spo11 LPFLAVEILVLLLMLFLA-PLTLFLPALLGFL------------------------------------------------ 437 atu10 WPYLAAMIIGLLLIAAIP-GFSTILL------------------------------------------------------ 429 mma6 APFLALQMAVLALVLAFPALVHLTEPAAQMAPVSSGSADWSPVQLYSPEEQR---------------------------- 470 ruler .......970.......980.......990......1000......1010......1020......1030......1040

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- 437 vvu9 -------------------------------------------------------------------------------- 432 bpa5 -------------------------------------------------------------------------------- 430 bja4 -------------------------------------------------------------------------------- 439 msp9 -------------------------------------------------------------------------------- 610 gsu1 -------------------------------------------------------------------------------- 421 dde4 -------------------------------------------------------------------------------- 433 dde3 -------------------------------------------------------------------------------- 438 pmu6 -------------------------------------------------------------------------------- 442 psp19 -------------------------------------------------------------------------------- 439 msp12 -------------------------------------------------------------------------------- 439 psp25 -------------------------------------------------------------------------------- 429 oih3 -------------------------------------------------------------------------------- 434 rpa6 -------------------------------------------------------------------------------- 429 bja7 -------------------------------------------------------------------------------- 429 spo20 -------------------------------------------------------------------------------- 469 tfu1 -------------------------------------------------------------------------------- 510 rsp10 -------------------------------------------------------------------------------- 435 msp15 -------------------------------------------------------------------------------- 420 cgl1 -------------------------------------------------------------------------------- 438 spo21 -------------------------------------------------------------------------------- 445 reu5 -------------------------------------------------------------------------------- 436 psp6 -------------------------------------------------------------------------------- 436 bbr8 -------------------------------------------------------------------------------- 432 bpe1 -------------------------------------------------------------------------------- 389 bpa9 -------------------------------------------------------------------------------- 386 ssp5 -------------------------------------------------------------------------------- 432 bja6 -------------------------------------------------------------------------------- 434 rsp8 -------------------------------------------------------------------------------- 400 msp6 -------------------------------------------------------------------------------- 436 msp10 -------------------------------------------------------------------------------- 418 bbr10 -------------------------------------------------------------------------------- 427 spo22 -------------------------------------------------------------------------------- 428 bpa14 -------------------------------------------------------------------------------- 350 bbr12 -------------------------------------------------------------------------------- 430 psp16 -------------------------------------------------------------------------------- 430 bbr7 -------------------------------------------------------------------------------- 430 bpa3 -------------------------------------------------------------------------------- 700 mma5 -------------------------------------------------------------------------------- 256 dar4 -------------------------------------------------------------------------------- 450 mma4 -------------------------------------------------------------------------------- 348 sme1 SSRGEASGMALAKNILDRWQGFDQDKRRDFMLALLSRFGPDIERLERAIDAYRADPTPKALLEMSMAAEPRRQELIRRLN 513 spo12 -------------------------------------------------------------------------------- 433 mde3 -------------------------------------------------------------------------------- 454 ssp12 -------------------------------------------------------------------------------- 516 bbr13 -------------------------------------------------------------------------------- 451 pma1 -------------------------------------------------------------------------------- 456 cau1 -------------------------------------------------------------------------------- 444 tde1 -----ANYLPAEWR------------------------------------------------------------------ 464 bpa19 -----GGYGGSVYGGG-------------------DATPFK--------------------------------------- 552 mlo1 PP--ANGTAPANGGS-------------------APAAPGTP----DLSQPPSFGETPPA-------------KPAAPAP 580 rsp13 PPGLAPGQAPAPGGLGAPPGLAPAPGGLGTPPGLAPVAPGSAPAPGGLGVPPGLAPATPAPAPGEAPAPGALEVPAAPAP 651 bme1 PF----GNAPAPFGAP------------------SPAVEPLP--------APSFGSPAPS---------------FGQGA 525 reu6 GGASSPGTLELPSGGD----------------SSEPVAPSFQFEKSK--------------------------------- 568 bja13 --------IELPP---------------------LDLGPPQK-------------------------------------- 533 atu4 -GGNTMPNFGQPGGLP----------------GMPNLGEPPKVGP----------------------------------- 489 apo1 -------------------------------------------------------------------------------- 617 wsu4 -------------------------------------------------------------------------------- 430 vvu8 -------------------------------------------------------------------------------- 459 msp11 -------------------------------------------------------------------------------- 473 rsp12 -------------------------------------------------------------------------------- 345 sme15 -------------------------------------------------------------------------------- 579 spo15 -------------------------------------------------------------------------------- 421 spo16 -------------------------------------------------------------------------------- 440 tth1 -------------------------------------------------------------------------------- 437 rge2 -------------------------------------------------------------------------------- 440 spo18 IGVLPFAFAMMVFVTLLIYFPQIALWLPNRLF------------------------------------------------ 516 dha3 -------------------------------------------------------------------------------- 430 ssp7 -------------------------------------------------------------------------------- 439 bpa10 -------------------------------------------------------------------------------- 428 spo11 -------------------------------------------------------------------------------- 437 atu10 -------------------------------------------------------------------------------- 429 mma6 -------------------------------------------------------------------------------- 470 ruler ......1050......1060......1070......1080......1090......1100......1110......1120

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- 437 vvu9 -------------------------------------------------------------------------------- 432 bpa5 -------------------------------------------------------------------------------- 430 bja4 -------------------------------------------------------------------------------- 439 msp9 -------------------------------------------------------------------------------- 610 gsu1 -------------------------------------------------------------------------------- 421 dde4 -------------------------------------------------------------------------------- 433 dde3 -------------------------------------------------------------------------------- 438 pmu6 -------------------------------------------------------------------------------- 442 psp19 -------------------------------------------------------------------------------- 439 msp12 -------------------------------------------------------------------------------- 439 psp25 -------------------------------------------------------------------------------- 429 oih3 -------------------------------------------------------------------------------- 434 rpa6 -------------------------------------------------------------------------------- 429 bja7 -------------------------------------------------------------------------------- 429 spo20 -------------------------------------------------------------------------------- 469 tfu1 -------------------------------------------------------------------------------- 510 rsp10 -------------------------------------------------------------------------------- 435 msp15 -------------------------------------------------------------------------------- 420 cgl1 -------------------------------------------------------------------------------- 438 spo21 -------------------------------------------------------------------------------- 445 reu5 -------------------------------------------------------------------------------- 436 psp6 -------------------------------------------------------------------------------- 436 bbr8 -------------------------------------------------------------------------------- 432 bpe1 -------------------------------------------------------------------------------- 389 bpa9 -------------------------------------------------------------------------------- 386 ssp5 -------------------------------------------------------------------------------- 432 bja6 -------------------------------------------------------------------------------- 434 rsp8 -------------------------------------------------------------------------------- 400 msp6 -------------------------------------------------------------------------------- 436 msp10 -------------------------------------------------------------------------------- 418 bbr10 -------------------------------------------------------------------------------- 427 spo22 -------------------------------------------------------------------------------- 428 bpa14 -------------------------------------------------------------------------------- 350 bbr12 -------------------------------------------------------------------------------- 430 psp16 -------------------------------------------------------------------------------- 430 bbr7 -------------------------------------------------------------------------------- 430 bpa3 -------------------------------------------------------------------------------- 700 mma5 -------------------------------------------------------------------------------- 256 dar4 -------------------------------------------------------------------------------- 450 mma4 -------------------------------------------------------------------------------- 348 sme1 LAPNGIATLVRMRADLLELKAQNPDLEAVDTDFAHLFGSWFNRGFLVLRPISWSTPADILEKIIRYEAVHHIGGWDELRR 593 spo12 -------------------------------------------------------------------------------- 433 mde3 -------------------------------------------------------------------------------- 454 ssp12 -------------------------------------------------------------------------------- 516 bbr13 -------------------------------------------------------------------------------- 451 pma1 -------------------------------------------------------------------------------- 456 cau1 -------------------------------------------------------------------------------- 444 tde1 -------------------------------------------------------------------------------- 464 bpa19 -------------------------------------------------------------------------------- 552 mlo1 DLSQP---------------------PSFN-------------------------------------------------- 589 rsp13 ATPSPGAVPGAPPGLAPGGLPPGLAPPAQN-------------------------------------------------- 681 bme1 DQKEK---------------------PAQ--------------------------------------------------- 533 reu6 -------------------------------------------------------------------------------- 568 bja13 -------------------------------------------------------------------------------- 533 atu4 -------------------------------------------------------------------------------- 489 apo1 -------------------------------------------------------------------------------- 617 wsu4 -------------------------------------------------------------------------------- 430 vvu8 -------------------------------------------------------------------------------- 459 msp11 -------------------------------------------------------------------------------- 473 rsp12 -------------------------------------------------------------------------------- 345 sme15 -------------------------------------------------------------------------------- 579 spo15 -------------------------------------------------------------------------------- 421 spo16 -------------------------------------------------------------------------------- 440 tth1 -------------------------------------------------------------------------------- 437 rge2 -------------------------------------------------------------------------------- 440 spo18 -------------------------------------------------------------------------------- 516 dha3 -------------------------------------------------------------------------------- 430 ssp7 -------------------------------------------------------------------------------- 439 bpa10 -------------------------------------------------------------------------------- 428 spo11 -------------------------------------------------------------------------------- 437 atu10 -------------------------------------------------------------------------------- 429 mma6 -------------------------------------------------------------------------------- 470 ruler ......1130......1140......1150......1160......1170......1180......1190......1200

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- 437 vvu9 -------------------------------------------------------------------------------- 432 bpa5 -------------------------------------------------------------------------------- 430 bja4 -------------------------------------------------------------------------------- 439 msp9 -------------------------------------------------------------------------------- 610 gsu1 -------------------------------------------------------------------------------- 421 dde4 -------------------------------------------------------------------------------- 433 dde3 -------------------------------------------------------------------------------- 438 pmu6 -------------------------------------------------------------------------------- 442 psp19 -------------------------------------------------------------------------------- 439 msp12 -------------------------------------------------------------------------------- 439 psp25 -------------------------------------------------------------------------------- 429 oih3 -------------------------------------------------------------------------------- 434 rpa6 -------------------------------------------------------------------------------- 429 bja7 -------------------------------------------------------------------------------- 429 spo20 -------------------------------------------------------------------------------- 469 tfu1 -------------------------------------------------------------------------------- 510 rsp10 -------------------------------------------------------------------------------- 435 msp15 -------------------------------------------------------------------------------- 420 cgl1 -------------------------------------------------------------------------------- 438 spo21 -------------------------------------------------------------------------------- 445 reu5 -------------------------------------------------------------------------------- 436 psp6 -------------------------------------------------------------------------------- 436 bbr8 -------------------------------------------------------------------------------- 432 bpe1 -------------------------------------------------------------------------------- 389 bpa9 -------------------------------------------------------------------------------- 386 ssp5 -------------------------------------------------------------------------------- 432 bja6 -------------------------------------------------------------------------------- 434 rsp8 -------------------------------------------------------------------------------- 400 msp6 -------------------------------------------------------------------------------- 436 msp10 -------------------------------------------------------------------------------- 418 bbr10 -------------------------------------------------------------------------------- 427 spo22 -------------------------------------------------------------------------------- 428 bpa14 -------------------------------------------------------------------------------- 350 bbr12 -------------------------------------------------------------------------------- 430 psp16 -------------------------------------------------------------------------------- 430 bbr7 -------------------------------------------------------------------------------- 430 bpa3 -------------------------------------------------------------------------------- 700 mma5 -------------------------------------------------------------------------------- 256 dar4 -------------------------------------------------------------------------------- 450 mma4 -------------------------------------------------------------------------------- 348 sme1 RLAPEDRRCFAFFHPQLVDDPLIFVEVALTREMPPNIADLLKEDRAPIRATDATTAVFYSISNCQEGLRGISFGNFLIKQ 673 spo12 -------------------------------------------------------------------------------- 433 mde3 -------------------------------------------------------------------------------- 454 ssp12 -------------------------------------------------------------------------------- 516 bbr13 -------------------------------------------------------------------------------- 451 pma1 -------------------------------------------------------------------------------- 456 cau1 -------------------------------------------------------------------------------- 444 tde1 -------------------------------------------------------------------------------- 464 bpa19 -------------------------------------------------------------------------------- 552 mlo1 -------------------------------------------------------------------------------- 589 rsp13 -------------------------------------------------------------------------------- 681 bme1 -------------------------------------------------------------------------------- 533 reu6 -------------------------------------------------------------------------------- 568 bja13 -------------------------------------------------------------------------------- 533 atu4 -------------------------------------------------------------------------------- 489 apo1 -------------------------------------------------------------------------------- 617 wsu4 -------------------------------------------------------------------------------- 430 vvu8 -------------------------------------------------------------------------------- 459 msp11 -------------------------------------------------------------------------------- 473 rsp12 -------------------------------------------------------------------------------- 345 sme15 -------------------------------------------------------------------------------- 579 spo15 -------------------------------------------------------------------------------- 421 spo16 -------------------------------------------------------------------------------- 440 tth1 -------------------------------------------------------------------------------- 437 rge2 -------------------------------------------------------------------------------- 440 spo18 -------------------------------------------------------------------------------- 516 dha3 -------------------------------------------------------------------------------- 430 ssp7 -------------------------------------------------------------------------------- 439 bpa10 -------------------------------------------------------------------------------- 428 spo11 -------------------------------------------------------------------------------- 437 atu10 -------------------------------------------------------------------------------- 429 mma6 -------------------------------------------------------------------------------- 470 ruler ......1210......1220......1230......1240......1250......1260......1270......1280

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- 437 vvu9 -------------------------------------------------------------------------------- 432 bpa5 -------------------------------------------------------------------------------- 430 bja4 -------------------------------------------------------------------------------- 439 msp9 -------------------------------------------------------------------------------- 610 gsu1 -------------------------------------------------------------------------------- 421 dde4 -------------------------------------------------------------------------------- 433 dde3 -------------------------------------------------------------------------------- 438 pmu6 -------------------------------------------------------------------------------- 442 psp19 -------------------------------------------------------------------------------- 439 msp12 -------------------------------------------------------------------------------- 439 psp25 -------------------------------------------------------------------------------- 429 oih3 -------------------------------------------------------------------------------- 434 rpa6 -------------------------------------------------------------------------------- 429 bja7 -------------------------------------------------------------------------------- 429 spo20 -------------------------------------------------------------------------------- 469 tfu1 -------------------------------------------------------------------------------- 510 rsp10 -------------------------------------------------------------------------------- 435 msp15 -------------------------------------------------------------------------------- 420 cgl1 -------------------------------------------------------------------------------- 438 spo21 -------------------------------------------------------------------------------- 445 reu5 -------------------------------------------------------------------------------- 436 psp6 -------------------------------------------------------------------------------- 436 bbr8 -------------------------------------------------------------------------------- 432 bpe1 -------------------------------------------------------------------------------- 389 bpa9 -------------------------------------------------------------------------------- 386 ssp5 -------------------------------------------------------------------------------- 432 bja6 -------------------------------------------------------------------------------- 434 rsp8 -------------------------------------------------------------------------------- 400 msp6 -------------------------------------------------------------------------------- 436 msp10 -------------------------------------------------------------------------------- 418 bbr10 -------------------------------------------------------------------------------- 427 spo22 -------------------------------------------------------------------------------- 428 bpa14 -------------------------------------------------------------------------------- 350 bbr12 -------------------------------------------------------------------------------- 430 psp16 -------------------------------------------------------------------------------- 430 bbr7 -------------------------------------------------------------------------------- 430 bpa3 -------------------------------------------------------------------------------- 700 mma5 -------------------------------------------------------------------------------- 256 dar4 -------------------------------------------------------------------------------- 450 mma4 -------------------------------------------------------------------------------- 348 sme1 VVEDLRRDLPRLDTFVTLSPVPGFADWLSRERQAETSNALSAADRSRLAALDEPDWADQPEIAAAIQPSLTAAAAWYFLR 753 spo12 -------------------------------------------------------------------------------- 433 mde3 -------------------------------------------------------------------------------- 454 ssp12 -------------------------------------------------------------------------------- 516 bbr13 -------------------------------------------------------------------------------- 451 pma1 -------------------------------------------------------------------------------- 456 cau1 -------------------------------------------------------------------------------- 444 tde1 -------------------------------------------------------------------------------- 464 bpa19 -------------------------------------------------------------------------------- 552 mlo1 -------------------------------------------------------------------------------- 589 rsp13 -------------------------------------------------------------------------------- 681 bme1 -------------------------------------------------------------------------------- 533 reu6 -------------------------------------------------------------------------------- 568 bja13 -------------------------------------------------------------------------------- 533 atu4 -------------------------------------------------------------------------------- 489 apo1 -------------------------------------------------------------------------------- 617 wsu4 -------------------------------------------------------------------------------- 430 vvu8 -------------------------------------------------------------------------------- 459 msp11 -------------------------------------------------------------------------------- 473 rsp12 -------------------------------------------------------------------------------- 345 sme15 -------------------------------------------------------------------------------- 579 spo15 -------------------------------------------------------------------------------- 421 spo16 -------------------------------------------------------------------------------- 440 tth1 -------------------------------------------------------------------------------- 437 rge2 -------------------------------------------------------------------------------- 440 spo18 -------------------------------------------------------------------------------- 516 dha3 -------------------------------------------------------------------------------- 430 ssp7 -------------------------------------------------------------------------------- 439 bpa10 -------------------------------------------------------------------------------- 428 spo11 -------------------------------------------------------------------------------- 437 atu10 -------------------------------------------------------------------------------- 429 mma6 -------------------------------------------------------------------------------- 470 ruler ......1290......1300......1310......1320......1330......1340......1350......1360

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 -------------------------------------------------------------------------------- 437 vvu9 -------------------------------------------------------------------------------- 432 bpa5 -------------------------------------------------------------------------------- 430 bja4 -------------------------------------------------------------------------------- 439 msp9 -------------------------------------------------------------------------------- 610 gsu1 -------------------------------------------------------------------------------- 421 dde4 -------------------------------------------------------------------------------- 433 dde3 -------------------------------------------------------------------------------- 438 pmu6 -------------------------------------------------------------------------------- 442 psp19 -------------------------------------------------------------------------------- 439 msp12 -------------------------------------------------------------------------------- 439 psp25 -------------------------------------------------------------------------------- 429 oih3 -------------------------------------------------------------------------------- 434 rpa6 -------------------------------------------------------------------------------- 429 bja7 -------------------------------------------------------------------------------- 429 spo20 -------------------------------------------------------------------------------- 469 tfu1 -------------------------------------------------------------------------------- 510 rsp10 -------------------------------------------------------------------------------- 435 msp15 -------------------------------------------------------------------------------- 420 cgl1 -------------------------------------------------------------------------------- 438 spo21 -------------------------------------------------------------------------------- 445 reu5 -------------------------------------------------------------------------------- 436 psp6 -------------------------------------------------------------------------------- 436 bbr8 -------------------------------------------------------------------------------- 432 bpe1 -------------------------------------------------------------------------------- 389 bpa9 -------------------------------------------------------------------------------- 386 ssp5 -------------------------------------------------------------------------------- 432 bja6 -------------------------------------------------------------------------------- 434 rsp8 -------------------------------------------------------------------------------- 400 msp6 -------------------------------------------------------------------------------- 436 msp10 -------------------------------------------------------------------------------- 418 bbr10 -------------------------------------------------------------------------------- 427 spo22 -------------------------------------------------------------------------------- 428 bpa14 -------------------------------------------------------------------------------- 350 bbr12 -------------------------------------------------------------------------------- 430 psp16 -------------------------------------------------------------------------------- 430 bbr7 -------------------------------------------------------------------------------- 430 bpa3 -------------------------------------------------------------------------------- 700 mma5 -------------------------------------------------------------------------------- 256 dar4 -------------------------------------------------------------------------------- 450 mma4 -------------------------------------------------------------------------------- 348 sme1 ARNRNGKTVDPVARFHLGNGARLERINFLGDRSERAMRQAHGLMVNYLYKLDDIETNHEAFATRGEVVAAPAIRRLIPAD 833 spo12 -------------------------------------------------------------------------------- 433 mde3 -------------------------------------------------------------------------------- 454 ssp12 -------------------------------------------------------------------------------- 516 bbr13 -------------------------------------------------------------------------------- 451 pma1 -------------------------------------------------------------------------------- 456 cau1 -------------------------------------------------------------------------------- 444 tde1 -------------------------------------------------------------------------------- 464 bpa19 -------------------------------------------------------------------------------- 552 mlo1 -------------------------------------------------------------------------------- 589 rsp13 -------------------------------------------------------------------------------- 681 bme1 -------------------------------------------------------------------------------- 533 reu6 -------------------------------------------------------------------------------- 568 bja13 -------------------------------------------------------------------------------- 533 atu4 -------------------------------------------------------------------------------- 489 apo1 -------------------------------------------------------------------------------- 617 wsu4 -------------------------------------------------------------------------------- 430 vvu8 -------------------------------------------------------------------------------- 459 msp11 -------------------------------------------------------------------------------- 473 rsp12 -------------------------------------------------------------------------------- 345 sme15 -------------------------------------------------------------------------------- 579 spo15 -------------------------------------------------------------------------------- 421 spo16 -------------------------------------------------------------------------------- 440 tth1 -------------------------------------------------------------------------------- 437 rge2 -------------------------------------------------------------------------------- 440 spo18 -------------------------------------------------------------------------------- 516 dha3 -------------------------------------------------------------------------------- 430 ssp7 -------------------------------------------------------------------------------- 439 bpa10 -------------------------------------------------------------------------------- 428 spo11 -------------------------------------------------------------------------------- 437 atu10 -------------------------------------------------------------------------------- 429 mma6 -------------------------------------------------------------------------------- 470 ruler ......1370......1380......1390......1400......1410......1420......1430......1440

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENTFile: Macintosh HD:Users:Ravi:Desktop:Students:Domains_paper:Sara:table3homos.psDate: Wed Sep 28 13:11:32 2005� of 19 spo8 --------------------------------- 437 vvu9 --------------------------------- 432 bpa5 --------------------------------- 430 bja4 --------------------------------- 439 msp9 --------------------------------- 610 gsu1 --------------------------------- 421 dde4 --------------------------------- 433 dde3 --------------------------------- 438 pmu6 --------------------------------- 442 psp19 --------------------------------- 439 msp12 --------------------------------- 439 psp25 --------------------------------- 429 oih3 --------------------------------- 434 rpa6 --------------------------------- 429 bja7 --------------------------------- 429 spo20 --------------------------------- 469 tfu1 --------------------------------- 510 rsp10 --------------------------------- 435 msp15 --------------------------------- 420 cgl1 --------------------------------- 438 spo21 --------------------------------- 445 reu5 --------------------------------- 436 psp6 --------------------------------- 436 bbr8 --------------------------------- 432 bpe1 --------------------------------- 389 bpa9 --------------------------------- 386 ssp5 --------------------------------- 432 bja6 --------------------------------- 434 rsp8 --------------------------------- 400 msp6 --------------------------------- 436 msp10 --------------------------------- 418 bbr10 --------------------------------- 427 spo22 --------------------------------- 428 bpa14 --------------------------------- 350 bbr12 --------------------------------- 430 psp16 --------------------------------- 430 bbr7 --------------------------------- 430 bpa3 --------------------------------- 700 mma5 --------------------------------- 256 dar4 --------------------------------- 450 mma4 --------------------------------- 348 sme1 RSSRSLVPGPNVFPPGVRSADAPGRKGDKEFTS 866 spo12 --------------------------------- 433 mde3 --------------------------------- 454 ssp12 --------------------------------- 516 bbr13 --------------------------------- 451 pma1 --------------------------------- 456 cau1 --------------------------------- 444 tde1 --------------------------------- 464 bpa19 --------------------------------- 552 mlo1 --------------------------------- 589 rsp13 --------------------------------- 681 bme1 --------------------------------- 533 reu6 --------------------------------- 568 bja13 --------------------------------- 533 atu4 --------------------------------- 489 apo1 --------------------------------- 617 wsu4 --------------------------------- 430 vvu8 --------------------------------- 459 msp11 --------------------------------- 473 rsp12 --------------------------------- 345 sme15 --------------------------------- 579 spo15 --------------------------------- 421 spo16 --------------------------------- 440 tth1 --------------------------------- 437 rge2 --------------------------------- 440 spo18 --------------------------------- 516 dha3 --------------------------------- 430 ssp7 --------------------------------- 439 bpa10 --------------------------------- 428 spo11 --------------------------------- 437 atu10 --------------------------------- 429 mma6 --------------------------------- 470 ruler ......1450......1460......1470...

CLUSTAL X (1.83) MULTIPLE SEQUENCE ALIGNMENT File...

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