CLUB DRUGS

DANCE ‘TILL YOU DROP

MAJOR CLUB DRUGS

• MDMA/ECSTASY• GHB/GBL• KETAMINE• NITROUS OXIDE• POPPERS• LSD

MISCELLANEOUS DRUGS

• 2C-B• GBL – GAMMA BUTYL LACTONE• DEXTROMETHORPHAN• HERBAL ECSTASY• MUSHROOMS

ESCTASY

• MDMA• METHYLENEDIOXYMETHAMPHETAMINE• ADAM• X-TC• CLARITY• ESSENCE• STACY• LOVER’S SPEED• EVE

DOSAGES

• THRESHOLD – 30 MG

• AVERAGE – 75-125 MG

• LETHAL DOSE – 106 - ~ 6000MG

MDMA ACTIONS

• DURATION • PRIMARY EFFECTS 3-4 HRS• “CRASH” 2-6 HRS• HANGOVER

– (MAY LAST UP TO 5 DAYS)

• POST –MDMA DEPRESSION

MECHANISM OF ACTION

• DECREASES DOPAMINE RELEASE• INHIBITS REUPTAKE OF SEROTONIN• RELEASES SEROTONIN• RESEMBLES HYBRID AMPHETAMINE & MESCALINE

COMMONCONTAMINANTS

• CHALK• LSD• AMPHETAMINES• HEROIN• CAFEINE• KETAMINE• EPHEDRINE

ECSTASYBEHAVIORAL EFFECTS

• INCREASED ENERGY• EMPATHY TOWARD OTHERS• INCREASED AFFECTION• EMOTIONAL OPENNESS• PROFOUND POSITIVE FEELINGS• EUPHORIA• DECREASED INHIBITIONS• DECREASED ANXIETY• EXTREME RELAXATION

MDMA ACUTE EFFECTS

• TEETH CLENCHING• NAUSEA• HALLUCINATION• CHILLS• SWEATING• TREMORS• BLURRED VISION• MUSCLE CRAMPING

ACUTE SIDE EFFECTS

• HYPERTHERMIA– INCREASED BODY TEMPERATURE

• DEHYDRATION

• CARDIOVASCULAR STIMULATION

METABOLIC ACIDOSIS

• RHAMDOMYOLOSIS– MUSCLE BREAKDOWN

ACUTE TOXICITY

• HYPERTHERMIA• CONVULSIONS• DISSEMINATED INTRAVASCULAR

COAGULATION• ACUTE RENAL FAILURE• CARDIAC ARRYTHMIAS• HEPATITIS

MDMA OVERDOSE

• HIGH BLOOD PRESSURE

• FAINTNESS• PANIC ATTACKS• LOSS OF

CONSCIOUSNESS• SEIZURES• HEART FAILURE• HEAT STROKE

MDMA AFTER EFFECTS

• ANXIETY• PARANOIA• DEPRESSION

MDMA PERMANENT DAMAGE

• DEPRESSION• ANXIETY • MEMORY LOSS• CHANGES IN SLEEP PATTERNS• LEARNING IMPAIRMENTS• EMOTIONAL PROBLEMS

MDMA TOXICITY

• SIMILAR TO HEAT STROKE• URINARY pH LESS THAN 5.6 IN

METABOLIC ACIDOSIS• CAUSES MYOGLUBIN CASTS• HYPERKALEMIA RELATED TO

CARDIAC ARRYTHMIA• WATER INTOXICATION

NEUROTOXICITY

• NEURONAL DAMAGE• DECREASE IN DOPAMINE• LOSS OF SEROTONIN NERVE

TERMINALS• PARKINSONISM• APPETITE SUPPRESSION

PROTECTIVE MEASURES?

• VIAGRA FOR SEXUAL PROBLEMS• SSRIs e.g. PROZAC • DRUGS THAT BLOCK DA RELEASE• ANTIOXIDANTS

GHB

• GAMMA HYDROXYBUTYRATE• LIQUID X, GREVIOUS BODILY HARM• CNS DEPRESSANT• ALSO USED BY BODY BUILDERS• SALTY TASTING LIQUID• ONSET OF ACTION 10-20 MIN• EFFECTS LAST UP TO 4 HOURS• CLEARED QUICKLY

GHB USES

• INTOXICATING PROPERTIES• SEDATIVE ACTIONS• EUPHORIC EFFECTS• RELIEVE ANXIETY• PRODUCE RELAXATION• GH RELEASING PROPERTIES

GHB OVERDOSE

• DROWSINESS• NAUSEA/VOMITING• HEADACHE• LOSS OF CONSCIOUSNESS• LOSS OF REFLEXES• IMPAIRED BREATHING• COMA/DEATH

GHB DANGERS

• DROWSINESS• DIZZINESS• NAUSEA• UNCONSCIOUSNESS• SEIZURES• SEVERE RESPIRATORY DEPRESSION• COMA• DEATH

GHB WITHDRAWAL

• ANXIETY• RESTLESSNESS• INSOMNIA• RAPID HEART

BEAT• NAUSEA

GHB DEATH LIST

KETAMINE

• SEDATIVE-HYPNOTIC• SPECIAL k & k• GENERAL ANESTHETIC• HALLUCINOGEN• ANALGESIC• RAPID ONSET• LASTS ~ ONE HOUR

KETAMINE EFFECTS

• IMPAIRED COORDINATION• IMPAIRED JUDGEMENT• PERISTENT MEMORY PROBLEMS• PSYCHOTIC SYMPTOMS• DREAMLIKE STATES• HALLUCINATIONS• NEAR DEATH EXPERIENCE (K-HOLE)• SENSORY IMPAIRMENT

NITROUS OXIDE

• LAUGHING GAS• DISSOCIATIVE ANESTHETIC• AVAILABLE IN “WHIPPITS”• INHALED FROM TANK OR

BALLOONS• EFFECTS IMMEDIATE & SHORT-

LIVED

NITROUS EFFECTS

• EUPHORIA• ANALGESIA• LOSS OF CONSCIOUSNESS

ADVERSE EFFECTS

• TEMPORARY LOSS OF MOTOR CONTROL

• SENSATIONS & PERCEPTIONS DISCONNECTED

• DREAMY MENTAL STATE• MILD AUDIO & VISUAL

HALLUCINATIONS

DANGERS

• COLD GAS BURNS LIPS, THROAT, LUNGS

• HYPOXIA• LONG-LASTING NUMBNESS IN

EXTREMITIES

POPPERS

AMYL NITRATE/BUTYL NITRATE• RELAX SMOOTH MUSCLE• PRODUCE FEELING OF “RUSH”• FLUSHING• DIZZINESS• HEADACHE• PROGRESSIVE LOSS OF

CONSCIOUSNESS

LSD

• POTENT HALLUCINOGEN• ERGOT FUNGUS• 30 g DOSE• ONSET WITHIN 30-90 MIN• “HIGH” LASTS 6-12 HOURS

LSD EFFECTS

• DILATED PUPILS• HIGHER BODY TEMPERATURE• INCREASED HEART RATE• INCREASED BLOOD PRESSURE• SWEATING• DRY MOUTH• TREMORS• NUMBNESS/WEKNESS

LSD ACTIONS

• DILATED PUPILS• INCREASED BODY TEMPERATURE• INCREASED HEART RATE• INCREASED BLOOD PRESSURE• LOSS OF APPETITE• INCREASED SWEATING• DRY MOUTH • TREMORS

“BAD TRIP”

• TERRIFYING THOUGHTS• SEVERE AGITATION• FEAR OF LOSING CONTROL• FEAR OF INSANITY & DEATH• SEVERE ANXIETY• SUICIDAL THOUGHTS• PRECIPITATE PSYCHOSIS• ACCIDENTAL DEATH

LSD PSYCHOSIS

• AFFECT PERCEPTION OF REALITY• INABILITY TO THINK RATIONALLY• DRAMATIC MOOD SWINGS• VIVID VISUAL DISTURBANCES• HALLUCINATIONS

HALLUCINOGEN PERSISTINGPERCEPTION DISORDER (HPPD)

• EPISODIC VISUAL DISTURBANCES• “FLASHBACKS”• FALSE FLEETING PERCEPTIONS• FLASHES OF COLOR• GEOMETRIC PSEUDOHALLUCINATIONS• POSITIVE AFTERIMAGES• PERMANENT ALTERATION IN VISUAL SYSTEM

PCP

• DEVELOPED IN 1950 • WAS USED AS IV ANESTHETIC• DISSOCIATIVE “OUT OF BODY”• PRODUCES DELIRIUM• EXTREME AGITATION• RAPID ONSET• LASTS FOR SEVERAL HOURS

PCP ACTIONS

• DISRUPTS NMDA RECEPTORS• AFFECT GLUTAMATE ACTIVITY• GLUTAMATE ROLE IN PAIN,

COGNITION, LEARNING & MEMORY

• ALSO AFFECTS DA CAUSING EUPHORIA OR “RUSH”

PCP EFFECTS

• SHALLOW RAPID BREATHING• INCREASED BLOOD PRESSURE• INCREASED HEART RATE• ELEVATED TEMPERATURE• NAUSEA• BLURRED VISION• DECREASED PAIN AWARENESS

PCP EPISODE

• DETACHEMENT FROM REALITY• DISTORTION OF TIME/SPACE• ALTERED BODY IMAGE• FEELING INVULNERABLE• EXAGGERATED STRENGTH• SEVERE DISTORIENTATION• SUICIDAL BEHAVIOR

DEXTROMETHORPHAN

• OTC COUGH MEDICINE• NMDA ANTAGONIST• DISSOCIATIVE EFFECTS

ROHYPNOL

• FLUNITRAZEPAM• ROOFIES• ILLEGAL IN US• TASTELESS/ODORLESS• 1 MG DOSE LASTS 8-12 HOURS

ROHYPNOL ACTIONS

• SEDATIVE EFFECTS 10X THAN VALIUM• EFFECTS APPEAR 15-20 MIN• LAST 4-6 HOURS• RESIDUAL EFFECTS UP TO 12 HOURS

ROHYPNOL USES

• BOOST HIGH FROM ALCOHOL• BOOST HIGH FROM HEROIN• MODULATE COCAINE EFFECTS• RAVE DRUG• “DATE RAPE” DRUG

ROHYPNOL ADVERSEEFFECTS

• LOSS OF MOTOR CONTROL• LACK OF COORDINATION• SLURRED SPEECH• CONFUSION• GI DISTRESS• RESPIRATORY DEPRESSION• IMPAIRED COGNITION• AMNESIA

METHAMPHETAMINE EFFECTS

• MEMORY LOSS• VIOLENCE• PSYCHOTIC BEHAVIOR• CARDIAC ARRYTHMIAS• NEUROLOGICAL DAMAGE

METH TOXICITY

• REDUCTION IN DA TRANSPORTERS• MASSIVE RELEASE OF DA & NE

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