CLINICAL TRIALS COMPARING NOREPINEPHRINE WITH VASOPRESSIN IN PATIENTS WITH SEPTIC SHOCK: A META-ANALYSIS

CLINICAL TRIALS COMPARING NOREPINEPHRINE WITH VASOPRESSIN IN PATIENTS WITH SEPTIC SHOCK: A META-ANALYSISRiko JumattullahBACKGROUNDMethodsWe performed this meta-analysis following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA statement) guidelinesStudy selection The study selection was performed by two independent investigators (F.Z. and Q.S.). Studies that compared mortality between norepinephrine and vasopressin use in patients (aged 18 years) with septic shock were evaluated and included.Data extraction Raw data were extracted using a standard form for each study, which included the study design, year of publication, total number of patients, and patient characteristics.The main endpoint was 28-day mortalityRESULTS

Study characteristicsFive multicenter studies and two single-center studies were identified. Years : 2006 - 2013mean age 54.7 and 62.8 yearsmen 53.1% to 61.1%The mean APACHE II score 23.2 and 27.8. sepsis or septic shock diagnosed the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference criteriaEffect of norepinephrine versus vasopressin on mortalityEffect of norepinephrine versus vasopressin on hemodynamic and metabolic parametersPublication bias analysesDiscussionConclusions