CLINICAL RESULTS 2016 - IVI Fertility · PREGNANCY RATES FOR A FIRST IVF-ICSI ATTEMPT AT IVI...
Transcript of CLINICAL RESULTS 2016 - IVI Fertility · PREGNANCY RATES FOR A FIRST IVF-ICSI ATTEMPT AT IVI...
CLINICAL RESULTS 2016
In Vitro Fertilisation (IVF-ICSI) 12,876 cycles
Ovum Donation (OVODON) 6,989 cycles
Frozen Embryo Transfer 12,068 cycles
Preimplantation Genetic Diagnosis (PGD) 5,101
RESULTS OF ASSISTED REPRODUCTIVE TREATMENTS CARRIED OUT
AT THE IVI GROUP DURING 2016
Preimplantation Genetic Diagnosis (PGD) 5,101 cycles
Vitrification of ova 4,117 cycles
Artificial Insemination (AI) 3,971 cycles
________________________________________________________________
Total 45,122 cycles
NB: Number of procedures from our clinics in Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu
Dhabi.
2016 RESULTS FOR IVF-ICSI AND OVUM DONATION (OVODON)
IVF- ICSIOVUM
DONATION
Cycles performed
(embryo transfers)12,876 (5,173) 6,989 (5,692)
No. of pregnancies 2,847 3,888No. of pregnancies 2,847 3,888
% Pregnancy per Transfer 55.0 68.3
% Pregnancy per embryo
transferred38.3 52.6
% Twin pregnancy 22.4 21.6
NB: Number of procedures from our clinics in Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi
PREGNANCY AND IMPLANTATION RATES WITH IVF AND ICSI BY AGE GROUPS 2016
488
2,206
4,849
3,525
239
3.000
4.000
5.000
6.000
40.00%
50.00%
60.00%
70.00%
80.00%
Pregnancy rate
NB: These rates include fresh cycles and its deferred transfers (transfers of cryopreserved embryos from the fresh cycles).
They apply to our clinics Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi.
71.03%64.30%
56.27%
47.54%
29.41%
50.07% 48.70%
39.16%34.41%
20.00%
239
0
1.000
2.000
0.00%
10.00%
20.00%
30.00%
<= 29 30 - 34 35 - 39 40 - 44 >= 45
Implantation rate
PREGNANCY RATES FOR A FIRST IVF-ICSI ATTEMPT AT IVI CLINICS COMPARED
TO PREVIOUS ATTEMPTS IN OTHER CLINICS.
40.0%
45.0%
50.0%
55.0%
60.0%
4,168 2,807 2,211 1,498 1,448
NB: The chart shows treatment data for patients who have undergone previous cycles, including frozen cycles,
between 2007 and 2016 at our clinics in Spain+Lisbon+Rome.
52.2% 52.0% 51.2% 51.5% 50.8%
20.0%
25.0%
30.0%
35.0%
1 2 3 4 5 or more
2016 RESULTS FOR FROZEN EMBRYO TRANSFERS
TOTAL
Embryos thawed
(Frozen Embryo Transfers)12,068(11,340)
Rate of Embryo Transfer % 94.0
No. of pregnancies 6,059
% Pregnancy per Transfer 53.4
% Embryo Implantation 39.6
NB: Number of procedures from our clinics in Spain + Lisbon + Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi
CUMULATIVE CLINICAL PREGNANCY RATE AFTER THREE ATTEMPTS (including
Frozen Embryo Transfers)
N= 94,846 N= 53,103
53.48%
70.02%
75.61%
90.97%86.97%
97.23%
60.00%
70.00%
80.00%
90.00%
100.00%
NB: The chart shows data for patients who were discharged from our clinics in Spain and Lisbon
between 2005 and 2016.
53.48%
0.00%
10.00%
20.00%
30.00%
40.00%
50.00%
OWN EGGS OVUM DONATION
1st attempt 2nd attempt 3rd attempt
2016 PGD RESULTS. Study of chromosomal abnormalities: FISH and CGH Arrays
methods combined
TOTAL
Cycles performed
(Embryo Transfers)3,210 (1,901)
% Abnormal Embryos 67.6% Abnormal Embryos 67.6
No. of Pregnancies 1,232
% Pregnancy per transfer 64.8
% Implantation 53.1
NB: The chart shows data for patients who undergone cycles with biopsy of embryos in our clinics in Spain+ Lisbon in 2016. The chart also
includes the number of transfers involving frozen embryos that were previously biopsied in 2016.
2016 PGD RESULTS. Study of monogenic disorders: PCR method.
Myotonic dystrophy, Fragile X Syndrome,
Cystic Fibrosis, Spinal Muscular Atrophy...
Cycles performed
(Embryo Transfers)121(106)
No. of Pregnancies 61No. of Pregnancies 61
% Pregnancy per Transfer 57.5
% Implantation 46.4
NB: The chart shows data for patients who undergone cycles with biopsy of embryos in our clinics in Spain+ Lisbon in 2016. The chart also
includes the number of transfers involving frozen embryos that were previously biopsied in 2016.
RESULTS FOR ARTIFICIAL INSEMINATION 2016
TreatmentArtificial Insemination
(using donor sperm)
Artificial
Insemination
No. of Cycles 1,909 2,062
Pregnancies 459 363Pregnancies 459 363
% Pregnancy/Cycle 24.0 17.6
% Twin Pregnancy 10.1 12.2
NB: Number of procedures from our clinics in Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi
LIVE BIRTH RATES (LB)
OWN EGGS
AGE OWN EGGS FRESH OWN EGGS FROZEN
OWN EGGS (FRESH+
FROZEN)
LIVE BIRTH PER CYCLE <35 43.7% 65.5% 49.4%
35-37 32.6% 30.5% 32.0%
38-39 22.3% 26.2% 23.3%
40-42 11.4% 19.1% 24.0%
43-44 2.8% 16.4% 5.1%
>44 1.6% 13.5% 3.1%
LIVE BIRTH PER EMBRYO
TRANSFERRED
<35 28.3% 45.0% 32.5%
35-37 22.7% 21.8% 22.5%
38-39 17.4% 19.4% 18.0%
40-42 13.7% 15.8% 22.8%
NB: The information shows the live birth rates from treatments at our clinics in Spain+ Lisbon between 2003 and 2015.
DONOR EGGS
FRESH OVUM
DONATION FROZEN OVUM DONATION
OVUM DONATION (FRESH+
FROZEN )
LIVE BIRTH PER CYCLE 46.8% 31.0% 41.5%
LIVE BIRTH PER EMBRYO TRANSFERRED 28.4% 21.7% 26.4%
PROPORTION OF SINGLE BIRTHS 71.8% 81.6% 74.4%
40-42 13.7% 15.8% 22.8%
43-44 7.3% 16.2% 10.3%
>44 6.6% 15.2% 9.7%
PROPORTION OF SINGLE BIRTHS <35 70.6% 79.2% 72.7%
35-37 76.8% 83.7% 78.8%
38-39 84.4% 85.9% 84.9%
40-42 88.6% 89.8% 89.0%
43-44 92.9% 88.7% 90.7%
>44 87.5% 90.5% 89.2%
GLOSSARY OF TERMS
•Pregnancy rate: the percentage of positive results from biochemical pregnancy tests in relation to
the number of embryo transfers.
•Clinical pregnancy rate: the percentage of pregnancies with a gestational sac observed by
ultrasound scan in relation to the number of embryo transfers.
•Implantation rate: the percentage of gestational sacs observed by ultrasound scan in relation to
the number of embryos transferred.
•Twin pregnancy rate: the percentage of pregnancies with 2 gestational sacs in relation to the total
number of pregnancies.
•Deferred Embryo Transfer: embryo transfers that are not performed during the same stimulation •Deferred Embryo Transfer: embryo transfers that are not performed during the same stimulation
cycle, where it is necessary to defer the transfer to a subsequent cycle using cryopreserved
embryos.
•Rate of abnormal embryos: the percentage of abnormal embryos among the biopsied embryos.
•Live birth per cycle: the percentage of procedures with LB in regards to the total number of
procedures.
•Live birth per embryo transferred: the percentage of LB in regards to the total number of
transferred embryos.
•Proportion of singleton LB: the percentage of births with a singleton LB in regards to the total
number of births.
www.ivi-fertility.com