Clinical Research in Atrial Fibrillation GUIDE - Department of Cardiology
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Clinical Research in Atrial Fibrillation GUIDE - Department of Cardiology Prof. dr. Isabelle C. van Gelder, e mail: [email protected] UMCG Dept. of Cardiology thoraxcenter 1. Identification of mechanisms underlying atrial fibrillation (AF risk profile) 2. Identification of risk factors and modifiers underlying a. New onset AF b. Progression to permanent AF c. AF associated cardiovascular morbidity and mortality 3. Improve therapy of AF – patient tailored therapy focusing on early AF (RACE 3, pulmonary vein isolation) 4. Does AF elimination reduce cardiovascular morbidity and mortality (EAST study) RACE 3 - Multicenter Study - Aggressive rhythm control for prevention of early atrial fibrillation compared to routine therapy AF Risk Profile - Identification of a risk profile to guide therapy in atrial fibrillation. Identification is based on clinical factors (age, sex, underlying disease, body mass index, sports, e.o.), echocardiographic factors, circulating biomarkers and genetic factors Pulmonary vein isolation - CTMM project Assessment of atrial remodeling at the scene of the calamity, i.e. the atria, using echocardiography. Treatment effect of amiodaron or flecainide on atrial remodeling and the long-term outcome after treatment 0 5 10 15 20 25 UM C G roningen Adm iraalde RuyterH osp. R ijnstate H ospital Am phia H ospital Kennem erG asthuis M aastrichtUM C Ziekenhuisgr.Twente Tergooiziekenhuizen UM C St.R adboud MartiniHospital Om m elanderZiekenhuizen DeventerH ospital IJsselland Hospital MCH,loc.W esteinde S t.Elisabeth H ospital UntilJuly 2010 A ug 2010 Sept2010 O kt2010 N ov2010 D ec 2010 Jan 2011 ECV Research Atrial Fibrillation RACE 3 – AF Risk Profile - Ablation
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CTMM project. Research Atrial Fibrillation. RACE 3 – AF Risk Profile - Ablation. Clinical Research in Atrial Fibrillation GUIDE - Department of Cardiology Prof. dr. Isabelle C. van Gelder, e mail: [email protected]. UMCG Dept. of Cardiology thoraxcenter. - PowerPoint PPT Presentation
Transcript of Clinical Research in Atrial Fibrillation GUIDE - Department of Cardiology
Clinical Research in Atrial FibrillationGUIDE - Department of Cardiology
Prof. dr. Isabelle C. van Gelder, e mail: [email protected]
UMCGDept. of
Cardiologythoraxcenter
1. Identification of mechanisms underlying atrial fibrillation (AF risk profile)2. Identification of risk factors and modifiers underlying
a. New onset AFb. Progression to permanent AFc. AF associated cardiovascular morbidity and mortality
3. Improve therapy of AF – patient tailored therapy focusing on early AF (RACE 3, pulmonary vein isolation)
4. Does AF elimination reduce cardiovascular morbidity and mortality (EAST study)
RACE 3 - Multicenter Study - Aggressive rhythm control for prevention of early atrial fibrillation compared to routine therapy
AF Risk Profile - Identification of a risk profile to guide therapy in atrial fibrillation. Identification is based on clinical factors (age, sex, underlying disease, body mass index, sports, e.o.), echocardiographic factors, circulating biomarkers and genetic factors
Pulmonary vein isolation - Epicardial and endocardial pulmonary vein isolation for the cure of atrial fibrillation and reduction of cardiovascular morbidity and mortality (EAST study)
CTMM project
Assessment of atrial remodeling at the scene of the calamity, i.e. the atria, using echocardiography.Treatment effect of amiodaron or flecainide on atrial remodeling and the long-term outcome after treatment
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UMC St. Rad
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MCH, loc.
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St. Elis
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Hos
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Until July 2010 Aug 2010 Sept 2010 Okt 2010 Nov 2010 Dec 2010 Jan 2011
ECV
Research Atrial Fibrillation RACE 3 – AF Risk Profile - Ablation
