Clinical Impact of Carcinoembryonic

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    Clinical Impact ofCarcinoembryonic AntigenMessenger Ribonucleic Acid

    Expression in Tumor-DrainingVein Blood on PostoperativeLiver Metastasis in Patients WithColorectal Carcinoma

    A Prospective, Cohort Study

    Journal Diseases of the

    Colon & Rectum

    Publisher Springer New YorkISSN 0012-3706 (Print)

    1530-0358(Online)

    Subject Medicine

    Issue Volume 46,

    Number 4 / April,2003

    DOI 10.1007/s10350-004-6584-3

    Pages 467-473Online Date Thursday,

    February 19, 2004

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    Koki Sunouchi1 ,

    Rikuo Machinami1,

    Masaki Mori1,

    Kazunobu Namiki1,

    Shouichi Hattori1,

    Yujiro Murata1,

    Takeshi Tsuchiya1,Hideaki Mizuno1and

    Masao Tadokoro1

    (1) Departments ofSurgery,Pathology, andInternal Medicine,Kawakita GeneralHospital,Suginami-ku,Tokyo, Japan

    Abstract PURPOSE:This study wasdesigned to determinethe clinical impact ofcarcinoembryonicantigen messengerribonucleic acidexpression in tumor-draining vein blood onpostoperative livermetastasis in patients

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    all three patients withsynchronous livermetastasis.Immunohistochemicalstudies revealed thatall tumor specimenswith stromal type(5/5) ofcarcinoembryonicantigen staining had

    positive expression ofcarcinoembryonicantigen messengerribonucleic acid.Postoperative livermetastasis wasdetected in fourpatients, three ofwhom (75 percent)had positiveexpression ofcarcinoembryonicantigen messenger

    ribonucleic acid intumor-draining veinblood. CONCLUSIONS:Positive expression ofcarcinoembryonicantigen messengerribonucleic acid intumor-draining veinblood differed by thetype ofimmunohistochemicalstaining withcarcinoembryonic

    antigen. These datasuggest that patientswith positiveexpression ofcarcinoembryonicantigen messengerribonucleic acid intumor-draining veinblood may be at a highrisk for postoperativeliver metastasis.

    Keywords Colorectal

    carcinoma - Livermetastasis - Tumor-draining vein - CEAmRNA - Polymerasechain reaction

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