#0136

Table 2 : NO desensitizing toothpaste (n = 29)

air probe scalerAt baseline 5.97 ± 2.4 3.30 ± 2.7 5.57 ± 2.9 3 weeks 3.08 ± 2.0 1.73 ± 1.8 3.53 ± 2.5

% improvement 48% 47% 36%

Clinical effectiveness of a tooth-coating cream containing Casein Phosphopeptide - Amorphous Calcium Phosphate for the treatment of dentin hypersensitivity.

1 1 1 1 1 2 1André Poitevin *, Marleen Peumans , Jan De Munck , Kirsten Van Landuyt , Eduardo Coutinho , Marc Braem , Bart Van Meerbeek 1 2Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, Catholic University of Leuven, Belgium; University of Antwerp, Department TEWO, Belgium

Dentin sensitivity is a widespread oral discomfort that remains difficult to treat. In this preliminary study, private practitioners evaluated the clinical effectiveness of a newly developed tooth-coating cream (GC Tooth Mousse), containing Casein Phosphopeptide - Amorphous Calcium Phosphate (CCP-ACP).

Introduction

On a 0-10 visual analogue scale (VAS), 61 patients (37 female, 24 male, 19-67 yr age range, mean 45 yrs) were evaluated for dentin sensitivity using a CPP-ACP-paste.

Materials & Methods

andre.poitevin@med.kuleuven.ac.be

-CPP

13mg/g

(325mM)Ca Content

5.6mg/g (181mM)

P Content

10%ACP

7.8pH

0 100 10

No pain

at baseline and after 21 days using air blast (A), probe (P) and ultrasonic scaler (US)

daily, during 21 days

Results

Reduction in sensitivity was found in 63% of the scores (A,P and US).

ConclusionOut of this clinical study, GC Tooth Mousse appeared effective in reducing dentin sensitivity. However, neglecting aetiological or predisposing factors will result in recurrence of sensitivity or failure of treatment.

Score by the dentist

Daily score by the patients

DaysDaysDays

PAIN NO PAIN

Instruction during 21 days :

• brush teeth every evening

• apply GC Tooth Mousse in tray or

with swab

• leave cream for 3 min

• do not eat or drink for 30 min

CPP-ACP readily binds to biofilm and tooth surface, thereby helping to maintain a state of supersaturation of calcium and phosphate ions with respect to tooth enamel, preventing demineralization and promoting remineralization (Reynolds et al. J Dent Res. 1995, 1997, 2003).

As sensitive dentin presents a greater number and wider tubules (Addy et al. 2002), the treatment approach of GC Tooth Mousse is, consistent with the hydrodynamic theory (Bränström, 1963), based on occluding dentinal tubules, similar to a bur smear layer or calcium phosphate deposits from saliva.

Visual analogue scale (VAS)

Unbearable pain

Score by dentist

Score by patient

After 3 weeks, the dentists recorded a significant reduction (Wilcoxon signed ranks test, p<0.0001) in dentin sensitivity. The change in sensitivity was more apparent after the air stimulus than the tactile stimuli. In particular the group that did not use desensitizing toothpaste reacted very well.

Better (63%)

No effect (29%)

Worse (8%)

Regarding the daily evaluation by the patient, the sensitivity also decreased from 5.7 ± 2.3 (at baseline) to 2.4 ± 2.2, a remarkable reduction of 58.5% in 3 weeks. Note: a placebo response results in, on average, a 30% reduction (Curro, 2000).

5.9

3.3 3.12.0

6.1

4.2

Table 1 : ALL patients (n = 61) mean ± SD

air probe scalerAt baseline 5.87 ± 2.8 3.06 ± 2.8 6.14 ± 2.9 3 weeks 3.27 ± 2.8 2.01 ± 2.4 4.15 ± 3.3

% improvement 44% 34% 32%

Table 3 : WITH desensitizing toothpaste (n = 32)

air probe scalerAt baseline 5.78 ± 3.1 2.85 ± 2.8 6.61 ± 3.0 3 weeks 3.45 ± 3.5 2.25 ± 2.8 4.68 ± 3.9

% improvement 40% 21% 29%

smear plug

smearlayer

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 210

1

2

3

4

5

6

7

8

9