Client: Ken Campbell, Ph.D. Advisor: Glennys Mensing Team Mouse Heart: –Michael Kosir –Ankur...
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Transcript of Client: Ken Campbell, Ph.D. Advisor: Glennys Mensing Team Mouse Heart: –Michael Kosir –Ankur...
University of Wisconsin - MadisonBiomedical Engineering Design Courses
INTELLECTUAL PROPERTY STATEMENT
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Anyone to whom this information is disclosed:
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2) Agrees not to use this information for any other purpose unless given writtenapproval in advance by the Project Group, the Client / SDC, and the Advisor.
3) Agrees to keep this information in confidence until the University and therelevant parties listed in Part (2) above have evaluated and secured anyapplicable intellectual property rights in this information.
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Client: Ken Campbell, Ph.D.Client: Ken Campbell, Ph.D.
Advisor: Glennys Mensing Advisor: Glennys Mensing
Team Mouse Heart:Team Mouse Heart:– Michael KosirMichael Kosir– Ankur SharmaAnkur Sharma– Steve TrierSteve Trier
Problem DefinitionProblem Definition
To design a device that can To design a device that can rapidlyrapidly pump pump saline into a catheter for stiffness saline into a catheter for stiffness measurements during specific intervals in measurements during specific intervals in the cardiac cycle.the cardiac cycle.
Inject 3 Inject 3 L of saline in less than 5 msL of saline in less than 5 msRemove injected portionRemove injected portionStiffness = ∆P/∆VStiffness = ∆P/∆V
-Already a device to measure ∆P-Already a device to measure ∆P-Need a device to cause a ∆V-Need a device to cause a ∆V
Background/MotivationBackground/Motivation
Diastolic Dysfunction:Diastolic Dysfunction:– Impaired ventricular fillingImpaired ventricular filling– Decreased stroke volume from LVDecreased stroke volume from LV– Greater end-diastolic pressureGreater end-diastolic pressure
Cause:Cause:– Delayed ventricular relaxation and stiffness Delayed ventricular relaxation and stiffness
of ventricular wallsof ventricular walls
Implicated in more than 70% of heart Implicated in more than 70% of heart failure patients that are 80+failure patients that are 80+
Design SpecificationsDesign Specifications
Inject a fixed quantity (3-5 µl) of saline through Inject a fixed quantity (3-5 µl) of saline through a catheter into a left ventricular balloona catheter into a left ventricular balloonOperate in less than 5 msOperate in less than 5 msAttach to a catheter with 200 µm diameter Attach to a catheter with 200 µm diameter openingopeningMust operate with an electrical logic pulse Must operate with an electrical logic pulse Length of catheter from fluid injector to end of Length of catheter from fluid injector to end of tube is at least 2-3 cmtube is at least 2-3 cm
Design OverviewDesign Overview
Source: Campbell, 2003
Size ComparisonSize Comparison
Mouse Heart
Catheter: Inserted Into Left Ventrical
Previous DesignPrevious Design
Circuit
Pressure Source
Micro Solenoid Valve
To Catheter
Previous DesignPrevious Design
Advantages:Advantages:– Rapid response timeRapid response time– Simple circuitry requiredSimple circuitry required– CompactCompact– CheapCheap
Disadvantages:Disadvantages:– Less AccurateLess Accurate– No Retraction MechanismNo Retraction Mechanism
Flow AnalysisFlow Analysis
(dV(dVss/dt)/dt)ds+P+1/2ds+P+1/2VVss22++gz=Cgz=C
AA11VV11=A=A22VV22
• Unsteady Bernoulli’s Equation and Unsteady Bernoulli’s Equation and Continuity PrincipleContinuity Principle
• Cross sectional area of the plunger Cross sectional area of the plunger based on the area of the tubing usedbased on the area of the tubing used• 6.0 mm diameter6.0 mm diameter
Piezoelectric StackPiezoelectric Stack
Source: Physik Instrumente, Part 239.90
Piezoelectric StackPiezoelectric StackSub-millisecond Response
High Force Generation – 4500 N Push, 500 N Pull
Extreme Reliability – Max displacement=180 µm
High voltage input – Maximum operating voltage = -1000 V
Cost: $2,940.00
Current DifficultiesCurrent Difficulties
LEMO to BNC connector on orderLEMO to BNC connector on order
Current amplifier incompatible Current amplifier incompatible – Does not handle capacitance of piezo stackDoes not handle capacitance of piezo stack– Impedance too largeImpedance too large– Requires a relay controlled by TTL trigger to Requires a relay controlled by TTL trigger to
fire stackfire stack– Two possible solutionsTwo possible solutions
High Voltage Piezo AmplifierHigh Voltage Piezo Amplifier
-3 to -1100 V output-3 to -1100 V output
Up to 50 W peak powerUp to 50 W peak power
0 to 0 to ±11 V control input±11 V control input
50 mA peak output current50 mA peak output current
Designed for use with Designed for use with piezo actuatorpiezo actuator
Source: Physik Instrumente, Part 507.00
Alternate CircuitryAlternate Circuitry
1000V power supply1000V power supply
Charge capacitorCharge capacitor– Acts as voltage supplyActs as voltage supply
Close transistor with Close transistor with TTL pulseTTL pulse
Capacitor drives Capacitor drives piezostackpiezostack
1000V
capacitor
stack
transistorTTL input
Source: http://www.physikinstrumente.de
Current DeviceCurrent Device
What’s NextWhat’s Next
Ordering piezo stack partsOrdering piezo stack parts
Fabricating piston and nozzleFabricating piston and nozzle– SyringeSyringe
Connecting catheter and nozzleConnecting catheter and nozzle
Operating on logic pulseOperating on logic pulse
TestingTesting
AcknowledgmentsAcknowledgments
Ken CampbellKen Campbell
Burke O’NeilBurke O’Neil
Naomi CheslerNaomi Chesler
John WebsterJohn Webster
Glennys MensingGlennys Mensing
Machine shopMachine shop
ReferencesReferencesPhysik Instrumente online tutorial of Piezoelectrics. Available at: Physik Instrumente online tutorial of Piezoelectrics. Available at: http://www.physikinstrumente.de/products/section4/content.phphttp://www.physikinstrumente.de/products/section4/content.phpKlabunde, R. (2003). Cardiovascular Physiology Concepts: Diastolic Dysfunction. Klabunde, R. (2003). Cardiovascular Physiology Concepts: Diastolic Dysfunction. Retrieved September, 2003, from www.cvphysiology.com/Heart%20Failure.HF006.htmRetrieved September, 2003, from www.cvphysiology.com/Heart%20Failure.HF006.htmCampbell, K. (2003). Campbell, K. (2003). Glassey, S., Stockner, A., (2002), HEUI—A New Direction for Diesel Engine Fuel Glassey, S., Stockner, A., (2002), HEUI—A New Direction for Diesel Engine Fuel Systems. Developed by Caterpillar Inc. SAE paper (930270).Systems. Developed by Caterpillar Inc. SAE paper (930270).Arnold, C., (2003). Hydraulically-actuated, Electronically-controlled Unit Injectors. The Arnold, C., (2003). Hydraulically-actuated, Electronically-controlled Unit Injectors. The Power Shop Inc., retrieved October, 2003, from www.thepowershop.com/HEUI.htm.Power Shop Inc., retrieved October, 2003, from www.thepowershop.com/HEUI.htm.Biomedical Technical Support Center. “MicroInjection System”, University of Calgary Biomedical Technical Support Center. “MicroInjection System”, University of Calgary [Electronic Version] Retrieved September 10, 2003 [Electronic Version] Retrieved September 10, 2003 URL:http://www.ucalgary.ca/md/BTSC/MInj_Sys.htmURL:http://www.ucalgary.ca/md/BTSC/MInj_Sys.htmParker Hannifin Corporation. “Picospritzer: Operating Manual” [Electronic Version] Parker Hannifin Corporation. “Picospritzer: Operating Manual” [Electronic Version] Retrieved September 16, 2003 Retrieved September 16, 2003 URL:http://www.lamers-gmbh.de/picospritzer3.htmURL:http://www.lamers-gmbh.de/picospritzer3.htm “ “Eppendorf FemtoJet Microinjections System” Northwestern University Cell Imaging Eppendorf FemtoJet Microinjections System” Northwestern University Cell Imaging facility. [Electronic Version] Retrieved October 6, 2003 facility. [Electronic Version] Retrieved October 6, 2003 URL:http://www.feinberg.northwestern.edu/cif/femtojet.htmURL:http://www.feinberg.northwestern.edu/cif/femtojet.htm “ “What Is a Solenoid?” Detroit Coil Company. [Electronic Version] Retrieved October 6, What Is a Solenoid?” Detroit Coil Company. [Electronic Version] Retrieved October 6, 20032003URL: http://www.detroitcoil.com/whatis.htmURL: http://www.detroitcoil.com/whatis.htmThe Lee Company. Essex, CT. http://www.theleeco.comThe Lee Company. Essex, CT. http://www.theleeco.com