Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)
-
Upload
floyd-arthur -
Category
Business
-
view
71 -
download
0
Transcript of Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)
![Page 1: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/1.jpg)
Clemastine Fumarate Partially Reverses Vision Loss From MS
By Floyd Arthur
![Page 2: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/2.jpg)
A new study from the University of California San Francisco shows that the
![Page 3: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/3.jpg)
antihistamine clemastine fumarate (Tavist) partially reverses vision loss associated
![Page 4: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/4.jpg)
with relapsing–remitting MS. Led by Dr. Ari Green of the Multiple Sclerosis Center at
![Page 5: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/5.jpg)
UCSF, the study compared the effects of clemastine fumarate to placebo in 50
![Page 6: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/6.jpg)
participants with MS and persistent optic neuropathy.
![Page 7: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/7.jpg)
The researchers will present their findings at the American Academy of Neurology's
![Page 8: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/8.jpg)
68th Annual Meeting in Vancouver, British Columbia this week.
![Page 9: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/9.jpg)
Optic Neuritis and MS
![Page 10: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/10.jpg)
Vision changes and pain associated with optic neuritis are a common and early sign of
![Page 11: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/11.jpg)
multiple sclerosis, and are often the first symptom for which MS sufferers seek medical
![Page 12: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/12.jpg)
care. The most commonly experienced visual disturbances include red-green color
![Page 13: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/13.jpg)
blindness, diplopia, and partial or complete blindness in one eye. These are usually
![Page 14: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/14.jpg)
accompanied by eye pain exacerbated by eye movement, peripheral and central visual
![Page 15: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/15.jpg)
field disturbances and diminished pupillary response to light.
![Page 16: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/16.jpg)
Optic neuritis is caused by demyelinating inflammatory changes in the optic nerve. It is
![Page 17: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/17.jpg)
the presenting symptom in about 20 percent of MS diagnoses and affects about 50
![Page 18: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/18.jpg)
percent of all patients with MS.
![Page 19: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/19.jpg)
Treatment with high-dose intravenous methylprednisolone followed by an oral
![Page 20: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/20.jpg)
prednisone taper usually results in rapid resolution of symptoms, but has not proven to
![Page 21: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/21.jpg)
be of benefit in long term recovery of visual acuity.
![Page 22: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/22.jpg)
Clemastine Fumarate Shows Promise
![Page 23: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/23.jpg)
All participants in the five-month long UCSF study had chronic stable optic neuropathy
![Page 24: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/24.jpg)
with long-term loss of visual acuity. Average age of participants was 40 years, and the
![Page 25: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/25.jpg)
average duration of MS symptoms was five years.
![Page 26: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/26.jpg)
The researchers used visual evoked potential as a measure of vision loss; included study
![Page 27: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/27.jpg)
participants had a minimum transmission delay of at least 118 milliseconds -- a
![Page 28: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/28.jpg)
biomarker for myelin loss.
![Page 29: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/29.jpg)
For the first three months of the study, participants were randomized to either clemastine fumarate
![Page 30: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/30.jpg)
or placebo. For the second two months, the study groups were reversed.
![Page 31: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/31.jpg)
At the end of the study, transmission delay in patients receiving clemastine fumarate
![Page 32: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/32.jpg)
was reduced by slightly less than 2 milliseconds per patient in each eye. Although
![Page 33: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/33.jpg)
modest, the improvements are considered an indicator of myelin regrowth. Said Dr.
![Page 34: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/34.jpg)
Green, “This study is promising because it is the first time a drug has been shown to
![Page 35: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/35.jpg)
possibly reverse the damage done by MS. Findings are preliminary,” he added, “but this
![Page 36: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/36.jpg)
study provides a framework for future MS repair studies and will hopefully herald
![Page 37: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/37.jpg)
discoveries that will enhance the brain's innate capacity for repair."
![Page 38: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/38.jpg)
Clemastine fumarate is a H1 histamine agent.The major side effect experienced by study
![Page 39: Clemastine fumarate partially reverses vision loss from ms by Floyd Arthur (PPT)](https://reader035.fdocuments.in/reader035/viewer/2022070523/58ecb36f1a28abed198b45f1/html5/thumbnails/39.jpg)
participants was fatigue.