CleanCision™

For hospital leaders who want to gain control over the sources of surgical site infection

Nearly 50% of abdominal incisions are contaminated during surgery 11

Incomplete skin antisepsis introduces bacteria into the incision12

Prophylactic antibiotic concentrations can fall below effective levels 14

Passive wound protection can’t clear invading bacteria

Disruptive manual irrigation can spread contamination 13

Current technology does not adequately support infection control efforts to eliminate contamination, creating critical gaps that leave patients vulnerable to infection.

No bacterial contamination

Bacterial contamination

No bacterial contamination Bacterial

contamination

0% Risk of SSI11

20%+ Risk of SSI11

Wound contamination is the primary cause of SSI. Controlling it is a constant challenge.

Easily deployed to retract the incision, CleanCision's microfluidic membrane is connected to a surgeon-selected fluid source and suction that delivers an active clearance therapy which consistently and continuously cleanses and removes contamination from the incision. By removing the contamination, CleanCision helps eliminate the root cause of infection.15

Reverse

Active Cleansing TechnologyContinuous, consistent clearance therapy delivered during surgery

66% 61%Reduction in Contamination 16 Reduction in SSI 10

% C

onta

min

atio

n

p<0.001

ControlCleanCision

50%

25%

0

35%

12%

Expected CleanCision

p = 0.04

Fight Defend

*Zero deep SSI

3.7%*

9.5%

More complete skin antisepsis, reverses pre-existing skin contamination 16

Active removal of contamination 15

Reduced CFU count / inoculum of infectious contamination at the incision 16

Combines wound irrigation and wound protection, two independently proven practices for reducing SSI 17,18

Optimizes wound healing environment, suppressing bacterial proliferation after closure19

Suction ringremoves

contaminants

Retracts & protects widest range of incisionsSterile irrigant

solution inlet

Suction Outlet Fluid irrigates

incision

Intuitive ApproachDesigned by surgeons and infection control expertsCleanCision integrates proven best practices into existing surgical workflows.

Powerful Results

% S

SI

PATIENTS

HOSPITAL

$10B spent annually treating SSI 7

Average cost per SSI $19,000 5,8

~$500k annual CMS penalty per hospital 9

Negative hospital publicity

Lower SSI rates will reduce cost of care. Project the potential savings:

Current SSI rate 1,2,3 15%300

$19, o00

$521, 550

.61

Number of Procedures*

SSI Cost / Episode 5,8

SSI Reduction 10

TOTAL SAVINGS

xxx

=*estimate the number of high-risk abdominal surgeries in your facility

3 out of 20 patients undergoing high-risk abdominal surgery will develop an infection1,2,3

15 days

8 days

MEDIAN LENGTH OF STAY4

PATIENT SATISFACTION

2X RISK OF DEATH6

ICU ADMISSION6READMISSION5

REOPERATION

27.8%

6.8%

29%

18%

With SSI Without SSI

Surgical site infection, especially in high risk abdominal and colorectal surgery, is a constant threat to patients and hospitals.

CleanCision™

More Control for Better Outcomes

Ordering InformationPrescient Surgical products can be ordered from Prescient Surgical (orders@prescientsurgical.com) and specialty distributors. For the latest product information, visit www.prescientsurgical.com or email us at info@prescientsurgical.com.

PN

CC-S

CC-M

PRODUCT

CleanCision Wound Retraction and Protection System SMALL (3-9 cm incision range)

CleanCision Wound Retraction and Protection System MEDIUM (7-17 cm incision range)

QUANTITY

4 / box

4 / box

1. WatanabeA,KohnoeS,ShimabukuroR,etal.Riskfactorsassociatedwithsurgicalsiteinfec-tioninupperandlowergastrointestinalsurgery.SurgToday.2008;38(5):404-412.

2. WickEC,Vogel JD,Church JM,Remzi F, FazioVW.Surgical site infections in a "highoutlier"institution:arecolorectalsurgeonstoblame?DisColonRectum.2009;52(3):374-379.

3. SuttonE,MiyagakiH,BelliniG,etal.Riskfactorsforsuperficialsurgicalsite infectionafterelectiverectalcancerresection:amultivariateanalysisof8880patientsfromtheAmericanCollege of Surgeons National Surgical Quality Improvement Program database. J Surg Res.2017;207:205-214.

4. deLissovoyG,FraemanK,HutchinsV,MurphyD,SongD,VaughnBB.Surgicalsite infection:incidence and impact on hospital utilization and treatment costs. Am J Infect Control.2009;37(5):387-397.

5. WickEC,HiroseK,ShoreAD,etal.Surgicalsiteinfectionsandcostinobesepatientsundergo-ingcolorectalsurgery.ArchSurg.2011;146(9):1068-1072.

6. KirklandKB,BriggsJP,TrivetteSL,WilkinsonWE,SextonDJ.Theimpactofsurgical-siteinfec-tions in the 1990s: attributable mortality, excess length of hospitalization, and extra costs.InfectControlHospEpidemiol.1999;20(11):725-730.

7. ScottRD.TheDirectMedicalCostsofHealthcare-AssociatedInfectioninUSHospitalsandtheBenefitsofPrevention.CentersforDiseaseControlandPrevention;March2009.

8. TannerJ,KhanD,AplinC,BallJ,ThomasM,BankartJ.Post-dischargesurveillancetoidentifycolorectalsurgicalsiteinfectionratesandrelatedcosts.JHospInfect.2009;72(3):243-250.

9. RauJ.LatestHospitalInjuryPenaltiesIncludeCrackdownOnAntibiotic-ResistantGerms.2016;https://khn.org/news/latest-hospital-injury-penalties-include-crackdown-on-antibiotic-re-sistant-germs/.AccessedJanuary29,2018.

10.Papaconstantinou HT, Birnbaum EH, Ricciardi R, et al. Impact of a Novel Surgical WoundProtectionDeviceonObservedversusExpectedSurgicalSiteInfectionRatesafterColectomyUsing the National Surgical Quality Improvement Program Risk Calculator. Surg Infect(Larchmt).2018.

11. Fa-Si-OenPR,KroezeF,VerhoefLH,VerwaestC,RoumenRM.Bacteriologyofabdominalwounds inelectiveopencolonsurgery:aprospectivestudyof 100surgicalwounds.ClinMicrobiolInfect.2005;11(2):155-157.

12.PriviteraGP,CostaAL,BrusaferroS,etal.Skinantisepsiswithchlorhexidineversusiodineforthepreventionofsurgicalsiteinfection:Asystematicreviewandmeta-analysis.AmJInfectControl.2017;45(2):180-189.

13.Anglen JO. Wound irrigation in musculoskeletal injury. The Journal of the AmericanAcademyofOrthopaedicSurgeons.2001;9(4):219-226.

14.Markantonis SL, Kostopanagiotou G, Panidis D, Smirniotis V, Voros D. Effects of bloodlossandfluidvolumereplacementonserumandtissuegentamicinconcentrationsduringcolorectalsurgery.ClinTher.2004;26(2):271-281.

15.PreclinicaldataonfileatPrescientSurgical.

16.PapaconstantinouHT,RicciardiR,MargolinDA,etal.ANovelWoundRetractorCombiningContinuous Irrigation and Barrier Protection Reduces Incisional Contamination inColorectalSurgery.WorldJSurg.2018;42(9):3000-3007.

17.MuellerTC,LoosM,HallerB,etal.Intra-operativewoundirrigationtoreducesurgicalsiteinfections after abdominal surgery: a systematic review and meta-analysis. LangenbecksArchSurg.2015;400(2):167-181.

18.SajidMS,RathoreMA,SainsP, SinghKK.A systematic reviewofclinicaleffectivenessofwoundedgeprotectordevices inreducingsurgicalsite infections inpatientsundergoingabdominalsurgery.UpdatesSurg.2017;69(1):21-28.

19.Suh I, Long SA, Coe J, Koehler J, Fry D, Welton ML. The Efficacy of a Novel SurgicalDevice inPreventing IntraoperativeWoundContamination inan InVivoPorcineModel. JLaparoendoscAdvSurgTechA.2018;28(4):445-451.

References:

www.prescientsurgical.com

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