Circ D. Case 52 Clinical : Male baby.
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Transcript of Circ D. Case 52 Clinical : Male baby.
Case 53Case 53
Clinical: Female, 19 years. Vascular polyp Clinical: Female, 19 years. Vascular polyp on left side of nose. on left side of nose.
PGP 9.5 and CD63 = Positive. PGP 9.5 and CD63 = Positive.
S100, Melan A, SMA, Desmin, EMA, S100, Melan A, SMA, Desmin, EMA, MNF116 = Negative.MNF116 = Negative.
Case 54Case 54
Clinical: Female, 28 years old. Slowly Clinical: Female, 28 years old. Slowly growing lesion on chest wall.growing lesion on chest wall.
Immunohistochemistry: Tumour cells in Immunohistochemistry: Tumour cells in both components of the tumour are both components of the tumour are positive for CD34. Negative staining for positive for CD34. Negative staining for EMA, Desmin, SMA, S100, FXIIIa, CD31.EMA, Desmin, SMA, S100, FXIIIa, CD31.
Case 55Case 55
Clinical: Female, 30 years. Lesion on Clinical: Female, 30 years. Lesion on thigh. ?Haemangioma.thigh. ?Haemangioma.
Epithelioid haemangioma Epithelioid haemangioma 4.464.46 Cutaneous epithelioid angiomatous noduleCutaneous epithelioid angiomatous nodule 1.231.23 Microvenular haemangioma Microvenular haemangioma 0.950.95
Case 56Case 56
Clinical: Male, 73 years. Multiple nodules Clinical: Male, 73 years. Multiple nodules on the buttocks. ?Squamous cell on the buttocks. ?Squamous cell carcinoma.carcinoma.
Case 58Case 58
Clinical: Male, 23 years. Lesion right ring Clinical: Male, 23 years. Lesion right ring finger. finger.
Special stains: Lesional cells - S100 and Special stains: Lesional cells - S100 and EMA positive.EMA positive.
Case 59Case 59 Clinical: Male, 87 years. Six month history of itchy dermal nodules.Clinical: Male, 87 years. Six month history of itchy dermal nodules.
Special stains: Diffuse positivity for CD79a. Special stains: Diffuse positivity for CD79a.
Patchy CD20 and Bcl2 positivity. Patchy CD20 and Bcl2 positivity.
CD5 and CD10 negative in this population. CD5 and CD10 negative in this population.
Few aggregates of Bcl6 positive cells. CD23 highlights residual Few aggregates of Bcl6 positive cells. CD23 highlights residual FDC networks only. FDC networks only.
Prominent CD3 positive population. Prominent CD3 positive population.
Monotypic expression of Lambda light chains Monotypic expression of Lambda light chains
Case 60Case 60
Clinical: Female, 75 years. Plaque left Clinical: Female, 75 years. Plaque left shin. ?Lichen simplex.shin. ?Lichen simplex.
Case 61Case 61
Clinical: Male, 69 years. Forehead lesion. Clinical: Male, 69 years. Forehead lesion. ?Lentigo maligna just above left eyebrow ?Lentigo maligna just above left eyebrow
Case 62Case 62
Female, 61 years old. Lesion excision by Female, 61 years old. Lesion excision by plastic surgeon with a diagnosis of plastic surgeon with a diagnosis of verrucous epidermal naevus. verrucous epidermal naevus.
Case 63Case 63 Female, 38 years. Nodule on the sole of the left Female, 38 years. Nodule on the sole of the left
foot. foot.
Special stains: Cytokeratin, focally EMA and Special stains: Cytokeratin, focally EMA and S100 protein positive. S100 protein positive.
Negative for SMA, HMB45, p63, CD31 and Negative for SMA, HMB45, p63, CD31 and GFAP. GFAP.
Approximately 10% of the cells show MIB-1 Approximately 10% of the cells show MIB-1 positivitypositivity
Case 64Case 64
Male, 79 years old.Male, 79 years old.
Generalised thickening of skin, papular Generalised thickening of skin, papular like. ?Scleroderma.like. ?Scleroderma.
History of monoclonal gammopathy (IgG, History of monoclonal gammopathy (IgG, Kappa)Kappa)
Case 65Case 65
female 30 yrs. 2 yr history of cyst neck female 30 yrs. 2 yr history of cyst neck midline. midline.
EMA++ CD34++EMA++ CD34++
Case 66Case 66
Clinical: Female large tumour mass at tip Clinical: Female large tumour mass at tip of nose infiltrating septum.of nose infiltrating septum.
Strongly positive TdT, bcl2, CD99, Strongly positive TdT, bcl2, CD99, MNF116, CK20. MNF116, CK20.
Negative for CD3, CD20, CD79a, CD10, Negative for CD3, CD20, CD79a, CD10, bcl6, CD34, S100 and MPObcl6, CD34, S100 and MPO