CIPHER Vision
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Transcript of CIPHER Vision
The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER)
Linda-Gail Bekker
The implementation of this project was made possible through an unrestricted grant from ViiV Healthcare.
The content and structure of the project has been guided by paediatric experts convened by the IAS.
CIPHER Vision
Goal Optimizing clinical management and delivery of services to infants, children and adolescents affected by HIV in resource-limited settings, through advocacy and research promotion.Objectives Addressing targeted research gaps to optimize service
delivery and clinical management Strengthening paediatric HIV cohort collaboration to inform
policy decisions Advocacy and outreach to support evidence-informed
clinical, policy and programmatic decision making (new 2014)
Background 2012: CIPHER founded as 2-year flagship IAS paediatric initiative
Unrestricted educational grant from ViiV Healthcare of £1.5 M Guided by paediatric HIV experts convened by the IAS
Activities developed 2012 – 2013 Needs Assessment:
– clinical and operational research gaps Research Grant Programme Global Cohort Collaboration Online Paediatric HIV Cohort Database JIAS Special Issue: Perinatally HIV-infected Adolescents
End 2013: Paediatrics an IAS priority, branded as CIPHER CIPHER re-funded for 2014-2015: £1.5 M from ViiV Healthcare
2014-2015: Continue and build on current activities, new activities
Research Grant Programme
Clinical and Operational research projects with the potential to contribute to the optimization of HIV diagnosis, prevention, treatment and care for infants, children and adolescents affected by HIV in resource-limited settings
www.ias-cipher.org
• For early stage investigators
• Research in resource-limited settings
• 75,000 USD/year - up to two years
This programme was made possible thanks to support of an unrestricted
educational grant form ViiV Healthcare.
2014 CIPHER GRANTEES
• Tavitiya Sudjaritruk, Research Institute for Health Sciences, Chang Mai University, Thailand, for research in Thailand
Liver injury and long-term metabolic complications among perinatally HIV-infected children and adolescents receiving antiretroviral therapy
• Eric McCollum, John’s Hopkins School of Medicine, USA, for research in Malawi
Bubble CPAP treatment in hospitalized African infants failing standard pneumonia care in a high HIV prevalence country
CIPHER is pleased to announce a new round of
PAEDIATRIC HIV RESEARCH GRANTSFor 2015
Applications open from 1 to 31 October 2014
www.iasociety.org/cipher.aspxThe implementation of this project is made possible through an unrestricted grant from ViiV Healthcare.
The content and structure is guided by experts in paediatric HIV convened by the IAS.
CIPHER Cohort Collaboration Paediatric HIV Cohort Investigator
Consultation, 13-15 May 2013 Participating cohorts/networks
IeDEA (Southern, Central, West and East Africa; CCASAnet; TREAT Asia)
EPPICC (including PMTCT and Eastern European cohorts)
Médecins Sans Frontières (MSF) Baylor International Pediatric AIDS Initiative
(BIPAI) International Maternal Pediatric Adolescent AIDS
Clinical Trials (IMPAACT) P1074 Pediatric HIV/AIDS Cohort Study (PHACS) Optimal Models/ICAP
CIPHER Cohort Collaboration Priority research topics
Time on first-line ART: Estimate incidence of treatment switch to second-line ART and associated factors; describe regimen use and durability
Adolescent epidemiology: Describe the global epidemiology of perinatally HIV-infected adolescents and compare outcomes across regions
To be studied through a new, global pediatric cohort collaboration, supported by CIPHER (2014-2016)
Data and analysis centres CIDER (IeDEA Southen Africa), South Africa MRC UCL (EPPICC), UK CBAR HSPH (PHACS), USA
~ 250,000 infants, children and adolescents affected by HIV
Paediatric HIV Cohort Database Online, searchable database Platform for cohort collaboration Source of information for researchers, funders, policy
makersLaunched on World AIDS Day , Dec 2013To date: 30 cohorts/networks, representing ~250,000 infants, children and
adolescents in 59 countries 389 unique visitors, 742 total visits, from 50 different countries Next steps and ideas: Analysis tools: Summary tables, epidemiology tool... Additions: Link to online paediatric HIV resource library (with
UNICEF)
Future directions and next steps
Continue and build on current programmes Grant programme Global cohort collaboration Online database JIAS Special Issue
Adolescent Working Group: Paediatric and adult cohort investigators
Viral Load Monitoring Working Group and Early Infant Diagnosis (paediatric focus)
IAS/ILF-CIPHER Roundtable Discussions IAS 2015/ work-up to AIDS 2016