Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin...

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Ciclo cellulare

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Transcript of Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin...

Page 1: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Ciclo cellulare

Page 2: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Quattro stadi

Page 3: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Regolazione del ciclo cellulareProtein factors• Cyclin• CDK-cyclin-dependent

kinase• Cyclin complex

– G1 cyclin-CDK complexes– S phase cyclin-CDK complex– Mitotic cyclin-CDK complex

• Cell cycle inhibitors• Cell cycle promoting factor -

ubiquitin ligase lead to degradation of cell cycle inhibitors– SCF and APC

Mechanisms

• Phosphorylation and dephosphorylation

• Activation of gene transcription and translation

• Proteasome-mediated degradation

Page 4: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Il ciclo cellulare è controllato dai complessi ciclina-CDK

Page 5: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Attivazione delle CDK

Page 6: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Variazione dell’attività di specifiche CDKs durante il ciclo cellulare

Page 7: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Regolazione delle CDK attraverso fosforilazione e proteolisi

Page 8: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Depolimerizzazione della lamina nucleare

Page 9: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Anaphase-promoting complex (APC)

Page 10: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Il controllo del ciclo cellulare

Page 11: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

Controllo del ciclo cellulare

Page 12: Ciclo cellulare. Quattro stadi Regolazione del ciclo cellulare Protein factors Cyclin CDK-cyclin-dependent kinase Cyclin complex – G 1 cyclin-CDK complexes.

I fattori di crescita


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