Chronic Myelogenous Leukemia Diagnosis and Treatment
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Transcript of Chronic Myelogenous Leukemia Diagnosis and Treatment
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Chronic Myelogenous LeukemiaDiagnosis and Treatment
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Survival in Early CP CML
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OS, PFS, and Probability of Remaining in CHR and EFS by ITT Analysis
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Outcomes: ENESTnd and DASISION
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DASISION: 4-Year Rates of MMR
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ENESTnd: Cumulative Incidence of MMR
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Progression to AP/BC on Study According to Sokal Risk Score
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DASISION: Transformation to AP/BP
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ENESTnd: Progression to AP/BC
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DASISION: OS and PFS
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ENESTnd: 5-Year EFS and PFS
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Compliance to Imatinib: ADAGIO Study
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Adherence and Molecular Response
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Cumulative Incidence of MMR According to BCR-ABL Level at 3
Months
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When to Consider Mutational Analysis
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Response and PFS With 2G-TKIsin Imatinib-Resistant CP-CML
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Newly Approved Agents for CML Patients Resistant or Intolerant to Prior Therapy
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Bosutinib Third Line: Best Cumulative Response
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PACE: Response to Ponatinib by Previous CP CML Therapy
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CCyR Rates After 2G-TKI Failure
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ENESTnd: Cardiovascular Events by 5 Years
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DASISION: Arterial Occlusive Events
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Take-Home Message
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IS TKI Therapy Forever?The STIM Trial
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Complete Molecular Remission After Discontinuation of Imatinib
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Abbreviations
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Abbreviations
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References
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References (cont)
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References (cont)
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References (cont)
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References (cont)