Chronic Inflammation
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Transcript of Chronic Inflammation
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Chronic Inflammation
Dr. Raid Jastania
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Chronic Inflammation:• Chronic inflammation is a prolonged inflammation
with continuous:1. Cell injury2. Active inflammation3. Ongoing healing (repair) process
• It is characterized by:1. Mononulcear cells (lymphocytes, macrophages, plasma
cells)2. Tissue destruction3. Repair process (including new vessel formation and
fibrosis)
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Cellular Events in Chronic Inflammation:
• Monocyte – histiocyte – macrophage – giant mutincleated cell
• Tissue macrophages: eg. Kupffer cell in liver, alveolar macrophage in lung…
• Macrophage is responsible for:1.Mononuclear phagocytic system, and hence2.Alert the Immune system.
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Cellular Events in Chronic Inflammation:
• Macrophages also produce:1.Acid and neutral proteases to break down
extracellular components2.Complement components and coagulation
factors.3.Oxygen-free radicals and NO4.AA metabolites5.Cytokines (eg. IL-1, TNF)
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Cellular Events in Chronic Inflammation:
• Lymphocytes and Plasma cells:• Other cells:
– Mast cells – Eosinophils
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Granulomatous Inflammation
• Collection of activated macrophages with or without giant cells
• Rimmed by lymphocytes• May be surrounded by fibrosis
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Granulomatous Inflammation
• Granuloma can be divided (morphologically) into Necrotizing granuloma and Non-necrotizing granuloma.
• Necrotizing granuloma is seen in infections.• In tuberculosis the granuloma shows central
necrosis “Caseating Necrosis”
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Granulomatous Inflammation
• Causes:– The causes of granuloma can be divided in:
a. Infectious a. mycobacterium (like tuberculosis), and syphilis. b. Fungal infections commonly result in granuloma
(candida, aspergillous, mucor, histoplasma, blastomycosis….)
c. Parasitic infections may result in granuloma (Schistosomiasis).
b. Non-infectiousa. immune mediated (like sarcoidosis) b. foreign body granuloma ( like suture material,
pigments….)
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Lymphatic and Lymph Nodes
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What are the Causes of Acute Inflammation? And,
What are the Causes of Chronic Inflammation?
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