Chromosomal disorders Inborn errors of metabolism Developmental disorders affecting brain formation...
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Transcript of Chromosomal disorders Inborn errors of metabolism Developmental disorders affecting brain formation...
![Page 1: Chromosomal disorders Inborn errors of metabolism Developmental disorders affecting brain formation Environmental influences.](https://reader035.fdocuments.in/reader035/viewer/2022080916/56649eb25503460f94bb8deb/html5/thumbnails/1.jpg)
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• Chromosomal disorders
• Inborn errors of metabolism
• Developmental disorders affecting brain formation
• Environmental influences
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• Down syndrome – A condition resulting form abnormality with the 21st pair of chromosomes; characterized by mental retardation and such physical signs as slanted appearing eyes, hypotonia, shortness, and tendency toward obesity
• Trisomy 21 – type of Down syndrome in which the 21st chromosome is a triplet
• Spina Bifida – a congenital midline defect resulting from failure of the bony spinal column to close completely during fetal development
Williams Syndrome – a condition resulting from deletion of material in the 7th pair of chromosomes
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• Fragile X Syndrome – condition in which the bottom of the X chromosome in the 23rd pair of chromosomes is pinched off
• Prader-Willi syndrome – caused by inheriting from one’s father a lack of genetic material on the 15th pair of chromosomes
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• Phenylketonuria (PKU) - metabolic genetic disorder caused by the inability of the body to convert phenylalanine to tyrosine; accumulation of phenylalanine results in abnormal brain development
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• Microcephalus – condition causing development of a small, conical- shaped head; proper development of the brain is
prevented, resulting in mental retardation
• Hydrocephalus – condition characterized by enlargement of the head because of excessive pressure of the cerebrospinal fluid
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• Fetal Alcohol Syndrome (FAS) – Abnormalities associated with the mother’s drinking alcohol during pregnancy; defects range from mild to severe
• Rubella – serious viral disease, which, if it occurs during the first trimester of pregancy, is likely to cause deformity in the fetus
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• Anoxia – deprivation of oxygen; can cause brain injury
• Low birth weight – babies who are born weighing less than 5.5 pounds; usually premature; at risk for behavioral and medical conditions, such as mental retardation
• Syphilis – venereal disease that can cause mental subnormality in a child, especially if it is contracted by the mother-to-be during the latter stages of fetal development
• Herpes Simplex – viral disease that can cause cold sores or fever blisters; if it affects the genitals and is contracted by the mother-to-be in the later stages of fetal development, it can cause metnal subnormallity in the child
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• Traumatic Brain Injury – injury to the brain resulting in total or partial disability or psychosocial maladjustment that effects educational performance
• Meningitis – bacterial or viral infection of the linings of the brain or spinal cord
• Encephalitis – inflammation of the brain; can affect the child’s mental development adversely