ChroMax General Presentation - HC - Hermes...

General General PresentationPresentation

A newly-approved safe ingredientfor effective weight management

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Table of contentsTable of contents

Designed for consumers

Scientific evidence

Regulatory status

Technological data

Marketing potential

Conclusion

DesignedDesigned for for consumersconsumers

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Chromax® is a patented form of the nutritional mineral chromium (Cr3+) and tri-picolinic acid, known as chromium picolinate.

Chromax® is made from pure compounds using proprietary manufacturing and quality control processes to produce a superiorhigh purity product.

Some other chromium products on the market actually contain less than 70% pure chromium picolinate.

WhatWhat isis ChromaxChromax®®??A newly-approved safe ingredient for effective

weight management promotion

Chromax® is the only chromium picolinate approved by the EU. Its high purity and safety testing makes it superior to other chromium products on the market.


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The bioavailability of Chromax® has been clinically demonstrated as significantly better compared to other sources of chromium.

Chromax® has been clinically demonstrated as a safe and effective product in over 15 published studies.

Consumers now have a higher confidence that Chromax®

matches the high quality standards used in the efficacy studies performed over the last 15 years.

ChromaxChromax®®: : A safe and effective A safe and effective solution you can rely upon solution you can rely upon

Superior chromium bioavailability and efficacy

On the weight management market, consumers are often eager to find more reliable solutions . Indeed, they often need to choose between safety or efficacy: When they choose Chromax®, consumers are ensured have both a safe and efficient weight management solution.


ScientificScientific evidenceevidence

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ChromaxChromax®®: : ClinicallyClinically provenproven efficacyefficacy

Chromax®: increased chromium absorption and bioavailability

2 scientific studies on chromium concentration in urine1 scientific study on chromium concentration in tissues

Chromax®: carbohydrate metabolism regulation

More than 15 clinical studies on insulin sensitivity and glucose regulation

Chromax®: weight management promotion

4 clinical studies on weight and fat mass loss1 clinical study on satiety1 clinical study on carbohydrate craving

Scientific evidence

More than 15 clinical studies on over 1,800 volunteers

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1. Stability and absorption of different forms of chromium

(N=6, 48hrs, 200 mcg Cr, Chromax® 1.6 mg/day)

Scientific evidence

Increased chromium absorption & bioavailability

2. Comparison of acute absorption of chromium supplements

(N=12, 24hrs, 200 mcg Cr, Chromax® 1.6 mg/day)

0

500

1000

1500

2000

2500

1

Uri

nary

chr

omiu

m (

ng/d

ay)

Basal loss Chromium nicotinate Chromium chloride Chromium picolinate

** p<0.05

0

100

200

300

400

500

600

% increase of urinary chromium after 24h

% in

crea

se o

f ur

inar

y ch

rom

ium

aft

er 2

4h

Chromium polynicotinate Chromium nicotinate-glycinate Chromium chloride Chromax®

** p<0.05

Chromax® is significantly more abundant in urine than chromium nicotinate and chromium chloride, which indirectly shows that chromium picolinate is more absorbed

Anderson et al., 2004. DiSilvestro and Dy, 2007.

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Dietary chromium effects on tissue chromium concentrations and chromium absorption in rats

Subjects: 55 male Wistar rats

Duration: 3 weeks

Dosage: 5 µg/g of diet/day of pure chromium, under the form of chromium chloride, chromium nicotinateor chromium picolinate (Chromax®, 0.04 mg/g of diet/day)

Chromax® is significantly more concentrated in liver, muscle and heart than chromium nicotinateand chromium chloride

Scientific evidence

Increased chromium bioavailability

These studies demonstrate a significant difference in chromiumbioavailability between Chromax® and other sources of chromium

05

101520253035404550

Liver Muscle HeartControl CrCl CrNic CrPic

ng/m

g dr

y w

eigh

tAnderson et al., 1996

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Glucose Metabolism, Insulin Resistance & Disease

Impaired Glucose Metabolism“Insulin Resistance”

CVD

CognitiveImpairmentObesity

DepressionDiabetes

WeightGain

DeficienciesLack of Exercise

MedicationsGenetics

BrainMuscle & Fat

Cravings

Scientific evidence

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Chromax® potentiates insulin function for a clinicalproven action on carbohydrate metabolism

Chromax® enhances the activity of insulin receptors on cells membranes and thus increases insulin sensitivity and glucose storage in muscle cells

Chromax®, by promoting healthy blood sugar metabolism, reduces the storage of fat and contributes to healthy weight management


Carbohydrate metabolism regulation

Scientific evidence

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ChromaxChromax®®: : ClinicallyClinically provenproven efficacyefficacyScientific evidence


Enhancement in Insulin Sensitivity in HealthyVolunteers following supplementation withChromium Picolinate

• Volunteers: 6 healthy subjects

• Duration: 10 weeks

• Dosage: 1.6 mg/day of Chromax®, equivalent to 200 µg/day of pure chromium

Results:• Significant increase of fasting levels of plasma

chromium during the 5 first weeks

• Fasting Blood glucose levels tends to decrease during the supplementation

Morris et al., 1998

Chromax® significantly reduces insulin resistance at the dosage of 1.6 mg/dayChromax® significantly decrease fasting Insulin at the dosage of 1.6 mg/day

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Others studies on insulin sensitivity and glycemic regulation.At the dosage of 200µg of chromium per day, 5 clinical studies showed significant results:


Scientific evidence

Study Volunteers Duration Dosage(1) Results

Lucidi, 2005 10 with PCOS(3) 4 months 1.6 mg (200 µg) glucose tolerance

Ghosh, 2002 50 type 2 diabetics withmedication

3 months 1.6 mg (200 µg) glycated hemoglobin(2) (*p<0.05) fasting glycemia (***p<0.001)

Anderson, 1997 180 type 2 diabetics withmedication

4 months 1.6 mg (200 µg)and 8.3 mg (1000 µg)

glycated hemoglobin(2) (*p<0.05) fasting glycemia (*p<0.05) insulin production (*p<0.05)

Ravina, 1995 162 type 1 and 2 diabetics withmedication

3 months 1.6 mg (200 µg) insulin sensitivity (***p<0.001)

Evans, 1989 11 type 2 diabetics on medication 1.5 month 1.6 mg (200 µg) glycated hemoglobin(2) (*p<0.05)(1) dosage of Chromax® / day (equivalent dosage of pure chromium / day)(2) glycated hemoglobin (HbA1c) is the reference biological marker for glycemia monitoring in diabetic patients(3) PCOS = polycystic ovary syndrome, which is strongly correlated with insulin resistance and diabetes

At other dosages, >15 studies were conducted on Chromax® to show this effect.

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Weight management promotion/Fat mass loss

Effects of chromium picolinate supplementation on body composition. Kaats et al., 1998.

Volunteers:• 154 mixed volunteers• Inclusion criteria: overweight or obese (mean BMI = 30)

Duration: 72 days

Dosage: 1.6 to 3.3 mg/day of Chromax®, equivalent to 200 to 400 µg/day of pure chromium

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Effects of chromium picolinate supplementation on body composition

BCI (Body Composition Index) = net difference between lean mass gain and fat mass loss

Kaats et al., 1998

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-4

-2

0

2

4

6

8Weight loss (kg) Fat mass loss (kg) Lean mass loss (kg) Fat mass loss (% body weight) BCI (kg)

Placebo 1.6 mg/day of Chromax® 3.3 mg/day of Chromax®


*

*p<0.05

**p<0.01

***p<0.005

Weight management promotion/Fat mass loss

* **** ***

*****

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Volunteers:• 42 women• Inclusion criteria: BMI 25-40,

reporting intense carb craving

Duration: 8 weeks

Dosage: 8.3 mg/day of Chromax®

equivalent to 1000 µg/day of chromium

Scientific evidence

Weight management promotion/Satiety

0

50

100

150

200

250

300

350

400After 1 week After 8 weeks

Food

inta

ke r

educ

tion

(kc

al)

Placebo Chromax®

Effects of chromium picolinate on food intake and satiety.

Anton et al., 2008.

Chromax® significantly reduces food intake at the dosage of 8.3 mg/day

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Weight management promotion/ Carbohydrate craving

Volunteers:• 75 mixed volunteers• Inclusion criteria: experiencing

atypical depression

Duration: 8 weeks

Dosage: 5 mg/day of Chromax®, equivalent to 600 µg/day of chromium

Exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving

00.20.40.60.8

11.21.41.61.8

20 2 weeks 4 weeks 6 weeks 8 weeks

Scor

e Hunger

Carb craving

Docherty et al., 2005.

Chromax® significantly decreases hunger and carb craving from the dosage of 5 mg/day

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Chromax® has greater absorption of chromium and increased bioavailability in scientifically validated studies that have been approved by regulatory authorities worldwide

Chromax® as « chromium picolinate is among the most bioavailable forms of chromium »(The EFSA Journal (2009) 1113, 1-41)

Chromax® has clinically proven efficacy on the regulation of carbohydrate metabolism at the dosage of 2 mg/day

Chromax® is a safe and effective ingredient for success in your weight management products

Scientific evidence

Conclusions

RegulatoryRegulatory statusstatus

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IsIs ChromaxChromax®® authorizedauthorized for use?for use?

A food grade ingredient

Europe*:• The only Authorized form of chromium picolinatefor use in foodstuffs for particular nutritional uses and foods intended for the general population (including food supplement)

(The EFSA Journal 2010;8(12):1882)• Recommended dosage according to the current national regulations

USA:• Authorized for use in food supplements• Chromax is the only chromium picolinate authorizedfor use in functional bars and beverages;Generally Recognized as Safe (GRAS status)

Asia:• Authorized for use in food supplements in most countries: Australia, Indonesia, Malaysia,

Singapore, Taiwan, Thailand,…• Authorized for use in functional foods in most countries:

Indonesia, Singapore, Taiwan, Thailand,…

Regulatory status

A clear and well-defined regulatory status

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A health claim authorization

FDA approval for a qualified health claim regarding thereduction of risk of insulin resistance and type II diabetes

A clear label

Suggested labeling: « Chromium picolinate » (« Picolinate de chrome »)

Regulatory status

A clear and well-defined regulatory status

IsIs ChromaxChromax®® authorizedauthorized for use?for use?

Chromax® benefits from our regulatory expertise. Please feel free to contact us for further information.

TechnologicalTechnological datadata

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HowHow cancan ChromaxChromax®® bebe usedused??

Chromax® is a fine and homogeneous powder. It is red colored, water-soluble and pH-stable.

Thanks to its high density and to its low dosage (2 mg/day), Chromax® can easily be implemented into various matrices:

• Food supplements: tablets, capsules, softgels, gums,…• Functional foods: bars, dairies, chocolate, beverages,…

Several applications have already been tested.Please feel free to contact us for further information.

Technological data

Chromax® is a ready-to-use ingredient that will make the difference in your food supplement or functional food

A flexible ingredient

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In adherence with WHO (World Health Organisation) and EFSA conclusions, Hermes Consilium recommends a dosage of 2 mg/day ofChromax®, which is equivalent to 240 µg/day of pure chromium

The WHO and EFSA concluded that pure chromium is safe up to 250 µg/day and has validated Chromax® as a safe form of chromium

HowHow cancan ChromaxChromax®® bebe usedused??Recommended dosage

For consumer, only 2 mg/day of Chromax® will provide you withall the benefits of chromium without any concern for safety

Marketing Marketing potentialpotential

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Marketing potential

ChromaxChromax®®: : SuccessfulSuccessful in applicationsin applications

ChromaxChromax®® shotshot A NewlyA Newly--Approved Safe Ingredient for Effective Weight Approved Safe Ingredient for Effective Weight Management. Management. ChromaxChromax®® is the first chromium is the first chromium picolinatepicolinate that meets the high that meets the high quality standards required in the EU. quality standards required in the EU. ChromaxChromax®® potentiates insulin function for a potentiates insulin function for a clinically proven action on carbohydrate metabolism and weight mclinically proven action on carbohydrate metabolism and weight managementanagement

GlycemiaGlycemia optimizeoptimize Helps you control blood sugar level. Helps you control blood sugar level. ChromaxChromax®® acts on the moderation of glucose metabolism by enhancing the acts on the moderation of glucose metabolism by enhancing the activity of insulin. With optimized glycemic regulation, you canactivity of insulin. With optimized glycemic regulation, you can eat the eat the food you like without concern for poor glucose control.food you like without concern for poor glucose control.

Fit&SlimFit&Slim SpeedSpeed’’upup your metabolism. your metabolism. FIT&SLIM is a drink designed for FIT&SLIM is a drink designed for people who want to get slim by adding a weight manage system to people who want to get slim by adding a weight manage system to their their regular physical activity. regular physical activity. ChromaxChromax®® stimulates carbohydrate and fat stimulates carbohydrate and fat metabolism and enables development of a firm, fit and slim bodymetabolism and enables development of a firm, fit and slim body..

One bioactive for multiple applications!

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ChromaxChromax®®: : SuccessfulSuccessful in applicationsin applicationsOne bioactive for multiple applications!

Eat LessEat Less Helps you reach a healthy diet naturally. Helps you reach a healthy diet naturally. Eat less is an original Eat less is an original formulation composed of specific highformulation composed of specific high--end chromium end chromium picolinatepicolinate: : ChromaxChromax®®. It has . It has a double action both on physical satiety and on hormonal signalsa double action both on physical satiety and on hormonal signals. This delicious . This delicious beverage allows you to experience satiety and reduce your food ibeverage allows you to experience satiety and reduce your food intake, in order to ntake, in order to reach you the silhouette of your dreams.reach you the silhouette of your dreams.

Stop snackingStop snacking Control food craving for a Control food craving for a successfullsuccessfull diet diet Snacking is the Snacking is the first cause of failure during longfirst cause of failure during long--time diet. Thanks to its exclusive ingredient time diet. Thanks to its exclusive ingredient ChromaxChromax®®, which act on the carbohydrate metabolism, Stop snacking will h, which act on the carbohydrate metabolism, Stop snacking will help you elp you get the strength to resist temptation and achieve a successful dget the strength to resist temptation and achieve a successful diet.iet.

ChromaxChromax®® BMR BMR (Body Mass Reduction)(Body Mass Reduction) YourYour partnerpartner for an for an athleticathleticbodybody With With ChromaxChromax®®, lose your fat mass while preserving your muscular one. , lose your fat mass while preserving your muscular one. Coupled with an intense physical activity, Coupled with an intense physical activity, ChromaxChromax®® BMR will help you get rid of BMR will help you get rid of excess body fat without sacrificing your muscles. excess body fat without sacrificing your muscles.

ConclusionConclusion

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WhyWhy choosechoose ChromaxChromax®®??

Chromax®

Conclusion

Clinically proven efficacy on carbohydrate metabolism regulation, increased bioavailability, and weight management

Easy implementation in dietary supplements and food matrices

The most effective at the best price

The best value for moneyof the market!

The purest and the safest chromium picolinateon the market of the chrome products

Chromax® is the quality reference and has high safety compared to other products

Chromax® established its proof of efficacy though numerous clinical studies

Hermes Consilium, a reliable partnerHermes Consilium, a reliable partner

BlaBlažž Gorjup Gorjup Managing directorManaging director

(E) info@hermes(E) [email protected]

(W) www.hermes(W) www.hermes--consilium.comconsilium.com

Hermes Consilium d.o.o.Hermes Consilium d.o.o.

VValjhunova 11, SIaljhunova 11, SI--1000 Ljubljana, Slovenia1000 Ljubljana, Slovenia

(T)(T) +386+386 11 434434 5678 5678 (F)(F) +386+386 1 430 66491 430 6649

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ReferencesReferences

Anderson, R.A. ; Bryden, N.A. ; Polansky, M.M. ; Gautschi, K. (1996). Dietary chromium effects on tissue chromium concentrations and chromium absorption in rats. The Journal of Trace Elements in Experimental Medicine ; 9 ; 11-15.

Anderson, R.A. ; Cheng, N. ; Bryden, N.A. ; Polansky, M.M. ; Chi, J. ; Feng, J. (1997). Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes ; 46 ; 1786-1791.

Anderson, R.A. ; Polansky, M.M. ; Bryden, N.A. (2004). Stability and absorption of chromium and absorption of chromium histidinate complexes by humans. Biological Trace Element Research ; 101 ; 211-218.

Anton, S.D. ; Morrison, C.D. ; Cefalu, W.T. ; Martin, C.K. ; Coulon, S. ; Geiselman, P. ; Han, H. ; White, C.L. ; Williamson, D.A. (2008). Effects of chromium picolinate on food intake and satiety. Diabetes Technology and Therapeutics ; 10(5) ; 405-412.

Bahadori, B. ; Wallner, S. ; Hacker, C. ; Boes, U. ; Komorowski, J.R. ; Wascher, T.C. (1999). Effects of chromium picolinate on insulin levels and glucose control in obese patients with type-II diabetes mellitus. Diabetes ; 48 ; A349.

Cefalu, W.T. ; Bell-Farrow, A.D. ; Stegner, J. ; Wang, Z.Q. ; King, T. ; Morgan, T. ; Terry, J.G. (1999). Effect of chromium tripicolinate on insulin sensitivity in vivo. The Journal of Trace Elements in Experimental Medicine ; 12 ; 71-83.

Conclusion

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Cheng, N. ; Zhu, X. ; Shi, H. ; Wu, W. ; Jiamin, C. ; Jianying, C. ; Anderson, R.A. (1999). Follow-up survey of people in China with type 2 diabetes mellitus consuming supplemental chromium. The Journal of Trace Elements in Experimental Medicine ; 12 ; 55-60.

DiSilvestro R.A. ; Dy, E. (2007). Comparison of acute absorption of commercially available chromium supplements. The Journal of Trace Elements in Medicine and Biology ; 21 ; 120-124.

Docherty, J.P. ; Sack, D.A. ; Roffman, M. ; Finch, M. ; Komorowski, J.R. (2005). A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. Journal of Psychiatric Pratice ; 11(5) ; 302-314.

Evans, G.W. (1989). The effect of chromium picolinate on insulin controlled parameters in humans.Int. J. Biosocial. Med. Res. ; 11 ; 163-180.

Feng, J ; Lin, D. ; Zheng, A. ; Cheng, N. (2002). Chromium picolinate reduces insulin requirement in people with type 2 diabetes mellitus. Diabetes ; 51 ; A469.

Ghosh, D. ; Bhattacharya, B. ; Mukherjee, B. ; Manna, B. ; Sinha, M. ; Chowdhury, J. ; Chowdhury, S. (2002). Role of chromium supplementation in Indians with type 2 diabetes mellitus. J. Nutr. Biochem. ; 13 ; 690-697.

Jovanovic-Peterson, L. ; Gutlerrez, M. ; Peterson, C.M. (1999). Chromium supplementation for women with gestational diabetes mellitus. The Journal of Trace Elements in Experimental Medicine ; 12 ; 91-97.

Conclusion

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Kaats, G.R. ; Blum, K. ; Fisher, J.A. ; Adelman, J.A. (1998). Effects of chromium picolinatesupplementation on body composition: a randomized, double-masked, placebo-controlled study. Current Therapeutic Research ; 57(10) ; 747-756.

Lucidi, R.S. ; Thyer, A.C. ; Easton, C.A. ; Holden, A.E.C. ; Schenken, R.S. ; Brzyski, R.G. (2005). Effect of chromium supplementation on insulin resistance and ovarian and menstrual cyclicity in women with polycystic ovary syndrome. Fertil. Steril. ; 84 ; 1755-1757.

Lydic, M.L. ; McNurlan, M. ; Bembo, S. ; Mitchell, L. ; Komaroff, E. ; Gelato, M. (2006). Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome. Fertil. Steril. ; 86 ; 243-246.

Martin, J. ; Wang, Z.Q. ; Zhang, X.H. ; Wachtel, D. ; Volaufova, J. ; Matthews, D.E. ; Cefalu, W.T. (2006). Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care ; 29(8) ; 1826-1832.

Morris, B.W. ; Kouta, S. ; Robinson, R. ; MacNeil, S. ; Heller, S. (2000). Chromium supplementation improves insulin resistance in patients with type 2 diabetes mellitus. Diabet. Med. ; 17 ; 684-685.

Rabinovitz, H. ; Leibovitz, A. ; Madar, Z. ; Gabai, G. ; Habot, B. (2000). Blood glucose and lipid levels following chromium supplementation in diabetic elderly patients on a rehabilitation program. Gerontologist ; 40.

Conclusion

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Ravina, A. ; Slezak, L. ; Rubal, A. ; Mirsky, N. (1995). Clinical use of the trace element chromium (III) in the treatment of diabetes mellitus. The Journal of Trace Elements in Experimental Medicine ; 8 ; 183-190.

Ravina, A. ; Slezak, L. ; Mirsky, N. ; Bryden, N.A. ; Anderson, R.A. (1999). Reversal of corticosteroid-induced diabetes mellitus with supplemental chromium. Diabet. Med. ; 16 ; 164-167.

Vrtovec, M. ; Vrtovec, B. ; Briski, A. ; Kocijancic, A. ; Anderson, R.A. ; Radovancevic, B. (2005). Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus. American Heart Journal ; 149(4) ; 632-636.

Wang, Z.Q. ; Qin, J. ; Martin, J. ; Zhang, X.H. ; Sereda, O. ; Anderson, R.A. ; Pinsonat, P. ; Cefalu, W.T. (2007). Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation. Metabolism ; 56 ; 1652-1655.

Conclusion

ChroMax General Presentation - HC - Hermes...

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