Christopher W Cairo Chemical Biology & Medicinal Chemistry
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Christopher W Cairo Chemical Biology & Medicinal Chemistry Web site: http://www.chem.ualberta.ca/~cairo/ Email: [email protected] Phone: 780-492-0377 Research keywords: Medicinal chemistry, computational chemistry, glycosidase inhibitors, glycolipids, glycoproteins, glycobiology, cell biophysics, inflammation, bioconjugate, human milk oligosaccharides, fluorescence spectroscopy, fluorescence microscopy R&D capabilities: Synthesis of bioorganic compounds, design of enzyme inhibitors, single cell biophysics and imaging, super-resolution fluorescence imaging, protein-carbohydrate binding studies, affinity chromatography, metabolic labeling, bioconjugate synthesis, glycoprotein analysis Techniques and instrumentation: Microscopy, cell culture, enzyme assays, high-throughput screening, SPR binding studies (Biacore), HPLC, flow cytometry, fluorescence imaging, FPLC protein purification, proteomics, glycoprotein sequencing and profiling Examples of industrial collaborations and commercialization: • Identification of the first nanomolar active inhibitors of human Neuraminidase enzymes Our group has designed the first selective and nanomolar inhibitors of these enzymes and are leading the testing of these potential therapeutics in cell and animal models. • Development of general tyrosine phosphatase inhibitor strategy Our group has developed a strategy for tailoring specific phosphatase inhibitors. Licensing opportunities: representative patents and invention reports: 1. Cairo, C. W.; Tulsi, N.S.; and Downey, A.M. “Methods and systems for preparing irreversible inhibitors of protein tyrosine phosphatases.” U.S.P.a.T. Office. PCT/CA2011/050126; published Sep 9, 2011, WO2011106898. Potential applications: Phosphatase inhibitor development in cancer and inflammation. 2. Lowary, T. L.; Cairo, C.W.; West, L.J.; Buriak, J.M.; Meloncelli, P.J.; Jeyakanthan, M.; and Slaney, A.M. “Method and system for ABO compatible blood type matching.” U.S.P.a.T. Office. PCT/CA2012/050602; published March 7, 2013, WO2013029181. Potential applications: Development of new diagnostics in transplantation.
Transcript of Christopher W Cairo Chemical Biology & Medicinal Chemistry
Christopher W Cairo Chemical Biology & Medicinal Chemistry Web site: http://www.chem.ualberta.ca/~cairo/ Email: [email protected] Phone: 780-492-0377
Research keywords: Medicinal chemistry, computational chemistry, glycosidase inhibitors, glycolipids, glycoproteins, glycobiology, cell biophysics, inflammation, bioconjugate, human milk oligosaccharides, fluorescence spectroscopy, fluorescence microscopy R&D capabilities: Synthesis of bioorganic compounds, design of enzyme inhibitors, single cell biophysics and imaging, super-resolution fluorescence imaging, protein-carbohydrate binding studies, affinity chromatography, metabolic labeling, bioconjugate synthesis, glycoprotein analysis Techniques and instrumentation: Microscopy, cell culture, enzyme assays, high-throughput screening, SPR binding studies (Biacore), HPLC, flow cytometry, fluorescence imaging, FPLC protein purification, proteomics, glycoprotein sequencing and profiling Examples of industrial collaborations and commercialization: • Identification of the first nanomolar active inhibitors of human Neuraminidase enzymes Our group has designed the first selective and nanomolar inhibitors of these enzymes and are leading the testing of these potential therapeutics in cell and animal models. • Development of general tyrosine phosphatase inhibitor strategy Our group has developed a strategy for tailoring specific phosphatase inhibitors. Licensing opportunities: representative patents and invention reports: 1. Cairo, C. W.; Tulsi, N.S.; and Downey, A.M. “Methods and systems for preparing irreversible inhibitors of protein tyrosine phosphatases.” U.S.P.a.T. Office. PCT/CA2011/050126; published Sep 9, 2011, WO2011106898. Potential applications: Phosphatase inhibitor development in cancer and inflammation. 2. Lowary, T. L.; Cairo, C.W.; West, L.J.; Buriak, J.M.; Meloncelli, P.J.; Jeyakanthan, M.; and Slaney, A.M. “Method and system for ABO compatible blood type matching.” U.S.P.a.T. Office. PCT/CA2012/050602; published March 7, 2013, WO2013029181. Potential applications: Development of new diagnostics in transplantation.
