Christ freeze drying summary nz

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JohnMorris John Morris Scientific

Service plus Solutions

2Toll Free: 0800 651 700 www.jms.co.nz

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Freeze Dryers For Every Application

Selecting the right freeze dryer for your needs:

1. Select the application as to how it will be used: • Routine: Entry level control system (LDplus) for day-to-day freeze drying applications • Advanced: For more advanced/critical freeze drying applications (LSCplus) such as pharmaceutical, environmental & microbiology • Pilot: Offer the same benefits as Advanced yet more suited for clinical trial phase, small batch production and production R&D applications - TGA/FDA validation packages available • Production: Processing pharmaceutical and biotech products or use in industrial applications - we are able to customise solutions to meet your needs (plus install and train your staff)2. Decide the type of product to be dried - Aqueous or Solvent (Organic/Inorganic)3. Choose the Ice Condenser Capacity of product to be frozen

John Morris Scientific also provides specialised pumps designed for each type of product to be dried:

Aqueous Products Vacuubrand RZ6 Rotary Vane Pump

• Highwatervapourloadtolerance-idealfor freezedrying• Largeoilvolume(longintervalsbetween oilchanges)• Ultimatevacuumof2x10-3mbar• Pumpingspeedof5.7m3/hr

Solvent Products Vacuubrand RC6 Hybrid Pump

• Unparalleledcorrosivevapourresistance(dueto uniquechemistrydiaphragm&rotaryvane pumpcombination)• Highwatervapourloadtolerance-idealfor freezedrying• Oilchangesreducedby90%• Ultimatevacuumof2x10-3mbar• Pumpingspeedof5.9m3/hr

Aqueous

Alpha 1-2 LDplus

Alpha 1-4 LDplus

Alpha 2-4 LDplus

Alpha 1-4 LSCplus

Alpha 2-4 LSCplus

Beta 1-8 LDplus

Beta 2-8 LDplus

Beta 1-8 LSCplus

Gamma 1-16 LSCplus

Delta 1-24 LSCplus

Beta 2-8 LSCplus

Epsilon 2-6 LSCplus

Epsilon 2-10 LSCplus

Customised solutions

Gamma 2-16 LSCplus

Delta 2-24 LSCplus

Routine Advanced Pilot Production

Solvent Aqueous Solvent Solvent SolventIce Condenser Capacity

2 kg

4 kg

6 kg

8 kg

10 kg

16 kg

24 kg

20 - >1,000 kg

John Morris Scientific also has a wide selection of Vacuubrand pumps


Routine Applications (LDplus)

Entry level control system (LDplus)for day-to-day freeze drying applications.

Ice Condenser • Capacity 2.5 kg 4 kg 8 kgIce Condenser • Performance 2 kg/24 hour 4 kg/24 hour 6 kg/24 hourIce Condenser • Temp Aqueous -55ᵒC (Alpha 1-2) -55ᵒC (Alpha 1-4) -55ᵒC (Beta 1-8) Solvent - -85ᵒC (Alpha 2-4) -85ᵒC (Beta 2-8)Product Temperature (Inside Ice Condenser) Aqueous -25ᵒC (Alpha 1-2) -25ᵒC (Alpha 1-4) -25ᵒC (Beta 1-8) Solvent - -50ᵒC (Alpha 2-4) -50ᵒC (Beta 2-8)Product Shelves • Drying Outside Ice Condenser 3 Shelves 5 Shelves 5 Shelves ø 200 mm ø 360 mm ø 360 mm ≈ 920 cm2 ≈ 0.5 m2 ≈ 0.5 m2

• Drying in Injection Vials with Stoppering 2 Shelves 4 Shelves 4 Shelves ø 200 mm ø 250 mm ø 250 mm ≈ 557 cm2 ≈ 0.18 m2 ≈ 0.18 m2

Drying in Round Bottom Flasks (max) 8 Pieces 24 Pieces 24 Pieces Base Unit Dimensions W x H x D (mm) 315 x 345 x 460 390 x 415 x 555 780 x 415 x 545 Weight Aqueous 28 kg (Alpha 1-2) 42 kg (Alpha 1-4) 63 kg (Beta 1-8)(excluding chamber) Solvent - 65 kg (Alpha 2-4) 78 kg (Beta 2-8)Electrical Connection 230 V; 50 Hz 230 V; 50 Hz 230 V; 50 Hz

Specifications

Alpha 1-2 LDplus

Chamber Configuration Options

(more options & accessories are available to meet your specific product drying requirements)

Alpha 1-4 LDplusAlpha 2-4 LDplus

Beta 1-8 LDplusBeta 2-8 LDplus

Base unit + 3 shelves & 8 ports

Base unit + 3 shelves, 8 ports & drip tray

Base unit + stoppering device, 2 shelves & 8 ports

Base unit + 8 ports

Base unit + stoppering device, 2 shelves & 8 ports

Base unit + 5 shelves


Base unit +ampoule manifold





To ensure you select the right freeze dryer for your needs, simply contact John Morris Scientific for professional assistance.


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For more advanced/critical freeze drying applications (LSCplus) such as pharmaceutical, environmental & microbiology - refer page 7 for the benefits of LSCplus.

Ice Condenser • Capacity 4 kg 8 kg 16 kg 24 kg • Performance 4 kg/24 hour 6 kg/24 hour 12 kg/24 hour 18 kg/24 hour • Temp Aqueous -55ᵒC (Alpha 1-4) -55ᵒC (Beta 1-8) -55ᵒC (Gamma 1-16) -55ᵒC (Delta 1-24) Solvent -85ᵒC (Alpha 2-4) -85ᵒC (Beta 2-8) -85ᵒC (Gamma 2-16) -85ᵒC (Delta 2-24) • Chamber Volume 6.5 L 11 L 30 L 45 L Temp Inside Condenser Aqueous -25ᵒC (Alpha 1-4) -25ᵒC (Beta 1-8) -40ᵒC (Gamma 1-16) -40ᵒC (Delta 1-24) Solvent -35ᵒC (Alpha 2-4) -35ᵒC (Beta 2-8) -50ᵒC (Gamma 2-16) -50ᵒC (Delta 2-24)Product Shelves • Inside Condenser & 1 shelf 1 shelf 5 shelves 10 shelves Single Chamber (max) ø 200 mm ø 200 mm ø 200 mm ø 200 mm ≈ 0.031 m2 ≈ 0.031 m2 ≈ 0.155 m2 ≈ 0.031 m2

• Vials Inside Condenser 1 shelf 1 shelf 2 shelves 4 shelves with Stoppering & ø 200 mm ø 200 mm ø 200 mm ø 250 mm Single Chamber (max) ≈ 0.031 m2 ≈ 0.031 m2 ≈ 0.09 m2 ≈ 0.18 m2

• Outside Condenser & 10 shelves 10 shelves 10 shelves 10 shelves Double Chamber (max) ø 200 mm ø 200 mm ø 200 mm ø 200 mm ≈ 0.031 m2 ≈ 0.031 m2 ≈ 0.031 m2 ≈ 0.031 m2

• Vials Outside Condenser 4 shelves 4 shelves 4 shelves 4 shelves with Stoppering & ø 250 mm ø 250 mm ø 250 mm ø 250 mm Double Chamber (max) ≈ 0.18 m2 ≈ 0.18 m2 ≈ 0.18 m2 ≈ 0.18 m2

Drying in Round Bottom Flasks or Wide Neck 12/24 Pieces 12/24 Pieces 12/24 Pieces 12/24/36 Pieces Filter Bottles Base Unit Dimensions W x H x D (mm) 390 x 415 x 555 780 x 415 x 540 860 x 485 x 650 860 x 1050 x 650 Weight Aqueous 48 kg (Alpha 1-4) 63 kg (Beta 1-8) 135 kg (Gamma 1-16) 215 kg (Delta 1-24)(excluding chamber) Solvent 60 kg (Alpha 2-4) 78 kg (Beta 2-8) 160 kg (Gamma 2-16) 250 kg (Delta 2-24)Electrical Connection 230 V; 50 Hz 230 V; 50 Hz 230 V; 50 Hz 3 X 400 V; 50 Hz

Specifications

Alpha 1-4 LSCplusAlpha 2-4 LSCplus

Base unit + 5 heated shelves + 12 ports

Base unit + manifold for 8 ports

Base unit + 2 drying chambers

Base unit + stoppering device & 4 heated shelves

Beta 1-8 LSCplusBeta 2-8 LSCplus

Gamma 1-16 LSCplusGamma 2-16 LSCplus

Delta 1-24 LSCplusDelta 2-24 LSCplus

Advanced Applications (LSCplus)

Chamber Configuration Options

(more options & accessories are available to meet your specific product drying requirements)

Base unit + LyoCube 4-8 LSCplus (5 heated shelves)

Base unit + manifold for 20 ports

Base unit + LyoCube 4-8 LSCplus (5 heated shelves)



Base unit + 5 heated shelves

Base unit + 2 drying chambers & 24 ports

Base unit + 10 heated shelves & 12 ports



• Upto65%savingindryingtimeviaunique WirelessShelfTechnology(nocables)• ConfigurationoptioncompatiblewithallAlpha, Beta,Gamma&DeltaLSCplusunits• Temperatureofeachshelfisindividuallycontrolled (±1ᵒKelvin)

Chart illustrating the drying time of pure water saved using heated shelves v’s unheated shelves

5 heated shelves (more options available)

Alpha 1-4 LSCplus with LyoCube 4-8 LSCplus (5 heated shelves)Unique Wireless Heated Shelving

• Fastfrontloadingchamberavoidssamplemelting• Configurationoptioncompatiblewith Alpha1/2-4LSCplus&Beta1/2-8LSCplus • Massiveshelfareaupto0.61m2

• HeatedshelveswithWirelessShelfTechnology (fasterdryingtime&nocableconnections)• OnetemperatureorLyoRxsensorpershelffor optimumprocesscontrol

Chamber Volume 58 LChamber Dimensions - Inner (mm) W: 336 D: 370 H: 426 Shelf Dimensions (mm) W: 256 D: 300 H: 18 Weight 47 kg

Usable Total DistanceShelves Shelf Area Between Shelves1 Shelf 0.08 m2 348.0 mm2 Shelves 0.15 m2 165.0 mm3 Shelves 0.23 m2 104.0 mm4 Shelves 0.31 m2 73.5 mm5 Shelves 0.38 m2 55.2 mm6 Shelves 0.46 m2 43.0 mm7 Shelves 0.54 m2 34.2 mm8 Shelves 0.61 m2 27.7 mm

Specifications

LyoCube 4-8 LSCplus

Shelf Options (with MPT or Deep-Well Plates)


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• Pre-freezingonliquid-controlledshelves• Freezedryingaccordingtopre-selected desiredtime,temperature&pressurelimits• ValidationpackagesavailableforTGA/FDA guidelines• Largerangeofprocessoptimisationtools• H2O2decontamination&isolatoroptions

• Icecondensercapacitiesfrom20to>1000kg• Singleordoublechambersystems• Freezing&dryinginthedryingchamber• SIP/H2O2disinfection,CIP,IQ/OQ,etc• Processintegration(loadingsystems,peripheralequipment)• Wecandesigncustom-buildsystemstomeetyourneeds- plusinstall&providetrainingforyourstaff

John Morris Scientific also supplies an extensive range of accessories & spare parts.

In addition, our Instrument Services Division provides routine maintenance & repairs to keep your equipment operating to its optimum performance.

Ice Condenser • Capacity 6 kg 10 kg • Performance 4 kg/24 hour 8 kg/24 hour • Temperature -85ᵒC -85ᵒC • Chamber Volume 23 L 25 L Shelf Temperature -50ᵒC to + 60ᵒC -55ᵒC to + 60ᵒC Shelf Temperature Accuracy ± 1ᵒC ± 1ᵒC Outside Unit Dimensions (mm) 860 (W) 650 (D) 1267 (H) 1190 (W) 850 (D) 1295 (H) Drying Chamber Dimensions (mm) 320 (W) 335 (D) 320 (H) 470 (W) 470 (D) 460 (H) Shelf Dimensions (mm) 225 (W) 300 (D) 350 (W) 400 (D) Weight 330 kg 750 kg Shelves Up to 6+1 Up to 7+1

Specifications

Epsilon 2-6D LSCplus 2-10D LSCplus

Pilot Applications

Production Applications

Accessories

Repairs & Maintenance



Applications

Control System Display

Vacuum Control

Product Temperature Measurement

Freezing Point Determination

Pressure Increase Test

Comparative Pressure Measurement

Freezing & Drying (Single Chamber - Inside)

Drying Only (Double Chamber - Outside)

Software

LSCplus Advancedfreezedryersforresearch&developmentapplications(4-24kg)LDplus Freezedryersforroutinelaboratoryuse(2-8kg)

LSCplus • Colourtouch-screencontrol(automaticormanualsequencing) • Graphicaldiagramofthefreezedryingprocess • Selectionofdifferentproductswitchingconditions (temperature,resistance,pressureincreasetest,etc) • Storageforupto32user-definedprograms(optional)

LDplus • GraphicLCdisplayshowingthemostimportantprocessdata • Vacuumcontrolforoptimisation/reductionofprocesstimes • Conversionofproducttemperature&vacuumaccording tothevapourpressurecurveaboveice

LSCplus The vacuum pressure within a freeze dryer determines the product temperature(vacuumcontrolisessentialtokeeptheproductfrozenwhile limitingtheamountofvapourproduced)-includedLDplus As per LSCplus above (optional)

LSCplus Direct - every shelf can be equipped with a PT-100 sensor to measure the product temperature directlyLDplus Indirect - converts vacuum into product temperature

LSCplus LyoRx sensor measures temperature & electrical resistance simultaneously-resultingdatacanbeutilisedfortheautomatic determinationofproductfreezingpoint.LDplus -

LSCplus Automaticallydeterminestheendofdryingcycle-isolationoficecondenser &dryingchamber(optional)LDplus -

LSCplus UsesPirani&Capacitivevacuumsensorstodetermineendofmaindrying phase-whenthedifferenceofthepressuremeasurementfallsbelowa pre-definedlimit,thesecondarydryingphaseautomaticallystarts(optional)LDplus -

LSCplus • Inthisconfiguration,theproductisfrozen&thendried insidetheicecondenserchamber • Thismethodisparticularlysuitableforsubstanceswith alowfreezingpointorforthermolabilesubstances • Freezingassistedbyafan(optional)

LDplus -

LSCplus • Inthisconfiguration,theproductispre-frozen separately&thendriedabovetheicecondenserchamber • Thismethodenablestheuseofalargevariety ofaccessories • Anintermediatevalvecanbeusedtosealthe productchamberagainsttheicecondenserchamber forapressureincreasetest

LDplus AsperLSCplus above(exceptpressureincreasetest)

LSCplus Windowsbasedsoftwaretocontrol,storerecipes&recordprocessparameters (LPCplus)-complieswithcurrentGAMP/CFRPart11guidelines, LyoLogplusUSBdatalogging(optional)LDplus Windowsbasedsoftwaretorecordprocessparameters(LyoLogplus)(optional)

Benefits of LSCplus

For Over 50 Years

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At John Morris Scientific we offer more than just the product - we provide the full package -

sales and servicing of instrumentation plus design tailored solutions to meet your needs.

Address 78 Wellesley Street Auckland NZ 1010Toll Free 0800 651 700Enquiries +64 (0) 9 366 3999 Email [email protected] www.jms.co.nz

Christ freeze drying summary nz

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