USP/NF Monograph (Ph. Eur applied) - Specifications - Analytical methods - US DMFs (Type IV) DMF No. Chitopharm™ L Chitopharm™ M Chitopharm™ S

Individual Customer Service, we support your individual customer requirements with: - Scientific support - Consultancy - Technical support - Customer audits - Questionnaires

Proven Efficacy - Wound healing - Anti-itching - Antimicrobical - Skin moisturizing

Extensive Purity Data - Consistent quality and product characteristics - Low endotoxins - Low heavy metals - Low microbiology

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There is a broad range of natural sources of chitin. In order to guarantee a defined and reproducible chemical grade, Chitinor has decided to use only one species, Pandalus borealis, from Norwegian fishing areas for the manufacture of Chitopharm™. Itching is a phenomenon which can significantly restrict daily life. Causes include allergic reactions, neurodermatitis, psoriasis, atopic dermatitis and dry skin. Usual treatments like products containing anti-histamine or corticoid agents, often have undesired side effects. Chitopharm™ offers a naural alternative by moisturizing the skin. The combination of improved wound healing and antimicro- bial activity makes Chitopharm™ particularly useful for biomedi-cal applications, such as wound healing gels and dressings, surgi-cal sutures and aids in cataract surgery and periodontal treatment. Chitopharm™ is used in pharmaceutical formulations to improve topical and oral drug delivery. Chitosan’s film forming abilities allows its application as matrix in topical delivery as well as a coating agent for solid dosage forms. Also encapsulation of drugs is possible. As cationic polymer Chitopharm™ is bioadhesive. Bioadhesivity is often used to enhance the residence time of a drug, thereby increasing the oral bioavailability. In ophthalmic gels Chitopharm™ increases precorneal drug residence time.

Chitosan, one of the few cationic biopolymers, is a derivative of chitin traditionally used in wound treatment.

Chitopharm™ is the optimum complex for dermal applications

Acts as an anti-microbial

Moisturizes the skin

Improves wound healing

Reducesitching

Chitopharm™ - a perfect solution for affected and itching skin

Chitopharm™ accelerates wound healing

Chitopharm™ improves drug delivery

Chitopharm™ derived from natural-based chitin

Applications - Drug delivery - Medical skin care - Wound healing - Anti-itching - Dermatology - Tissue engineering - Surgical dressings

Product portfolio Guaranteed quality due to production in a monoplant in Norway. We offer three grades - Chitopharm L (Mw 500,000 - 5,000,000 Da) - Chitopharm M (Mw 300,000 - 2,000,000 Da) - Chitopharm S (Mw 50,000 - 1,000,000 Da)

Benefits - Excellent moisturizer, support for skin barrier function - Proven antimicrobial activity - Clinically proven anti-itching effect - Film forming and mucoadhesive - Clinically proven wound healing promotion - Combination with other ingredients possible

Product characteristics - Non toxic, anti irritant - Extremely low endotoxin content - Low heavy-metal values - Analytical data according Ph. Eur and USP/NF - US Drug Master Files (type IV) - Assured continuous supply with consistent quality

Chitinor AS

Postboks 193 5501 Haugesund - Norway

Phone +47 52 85 94 80 Fax +47 52 85 94 90

www.chitinor.no info@seagarden.no

A company in the Seagarden group