A Comparative Study of Effectiveness of Antacids

A Comparative Study of Effectiveness of Antacids2

Chemistry Project

A Comparative Study of Effectiveness of Antacids

CERTIFICATE

This is to certify that the work entered in this project file is of Master Kaushal Nerkar of class XII Science Roll no.09 has satisfactorily completed the Required Project in Chemistry for the Academic year 2014-2015 in Kendriya Vidyalaya Lab as laid down by CBSE Board.

Principals External InternalSignature Examiner Examiner

Date:

ACKNOWLEDGEMENT

I would like to express my sincere gratitude toMr. , Chemistry teacher, for his expert, valuable & sincere guidance & encouragement extended to me for doing this project on antacids.Also I would like to thank Mr. , Lab Assistant, who provided us all necessary apparatus.

I certify that all sources of information used in this project have been fully acknowledged.

Thank youKaushal Nerkar

INDEX

Introduction Antacids Classifications of antacids Experiments Aim Apparatus Procedure Observations Result& Inference Precautions Difficulties Bibliography Photos

INTRODUCTIONThis project is aimed at analyzing some of the commercially available antacids to determine their ability to neutralize hydrochloric acid and hence to determine the best of brands which has the highest ability to neutralize acids.The Project can provide important information about the various antacids available commercially.

We all know that the food we eat undergoes various biochemical reactions resulting in digestion. In this process various enzymes working at different conditions are required.The enzymes of stomach require an acidic pH to function, hence dilute HCl is produced in stomach.However, sometimes the stomach starts producing excess of HCl .this condition is called Gastric Hyperacidity and is usually caused by over eating highly spiced food.In an uncontrolled condition this HCl can destroy the Mucous lining of the stomach and result in peptic ulcer.

Antacids

Antacids are commercially available products which neutralize the excess HCl secreted in the stomach.The action of antacids is based on the fact that base can neutralize an acid forming salt and water.The antacid should not contain excess alkali that may lead to an alkaline medium in the stomach and make the enzyme inactive.Thus some additional compounds are added to the antacids to keep the pH optimum. The action of an acid is for a short time, irrespective of dose; hence it is required to take an antacid at frequent intervals.

Commercially Available Antacids

Classification of Antacids Absorbable Antacids:- NaHCO3 mixture is commonly used for giving relief from indigestion.It has moderate neutralizing power.However, it releases CO2 gas in the stomach and causes swelling of deep Ulcers and hence it is not generally used.

Non Absorbable Antacids:-These are available in three broad groups 1. Aluminium salts: All these drugs have common buffering action and reduce acidity in the stomach .Eg-Al(OH)3,AlPO4.2. Magnesium salts: Their action is slow and these cause a purgative action.Eg-MgCo3, MgO, Mg(OH)2.3. Calcium salts: These are powerful antacids. They have no buffering action and can therefore neutralize the acid completely in stomach.

EXPERIMENT

Aim:- A comparative study of effectiveness of different commercially available antacids .Apparatus:- burrete, pipette, conical flask ,glass rod, mortar and pastel, weighing machine, measuring flask, beaker.Chemical required :- HCl 0.1N solution, NaOH 0.1N solution ,phenolphthalein , methyl orange, antacids.

PROCEDURE1. Prepare 0.1N NaOH solution by dissolving 0.2 Gram of NaOH in 50 ml of water.2. Take 50ml of 0.1N HCl in conical flask.3. Add 2-3 ml of phenolphthalein or methyl orange to the conical flask which serves as an indicator.4. Add 1 gram of finely powered antacid to the conical flask. Use mortar and pastel to powder it.5. Shake well and now titrate the solution by taking NaOH in the burette, and HCl in conical flask.6. Observe the end point a pink or yellow colored solution.7. Repeat this with other antacids and note the readings.

OBSERVATIONSTablet/sample antacid(1gm)Volume of NaOH used(ml) Volume of HCl neutralized (ml)Volume of HCl neutralized /gm of antacid

Digine30.619.419.4

Eno22.327.727.7

Omez21.228.828.8

Gelusil32.617.417.4

Ulgel26.823.223.2

RESULT

Among the five different antacids tested, OMEZ has highest acid neutralizing capacity per gram of the antacid.

INFERENCEOMEZ is better antacid amongst the five we tested because it could neutralize more amount of HCl (0.1 N) than any other antacid.

PRECAUTIONS

1. The weighing should be accurate.2. Powder should be fine to promote maximum dissolution.3. Should not add much of indicator.4. The amount of HCl should be sufficiently in excess so as to neutralize every bit of antacid.5. Should keep the eye in level with the Meniscus of the solution.6. Should read the lower meniscus in case of colorless solutions.

DIFFICULTIES

While carrying out above experiment some antacid salts like solution of rabicip, Eno(orange) and Zantac, the color of salt solution was red, orange and red respectively, so while titration of these antacids the indicator did not show any significant change in color, so finding end point of titration was very difficult .Due to pink colour of antacid gelusil, phenolphthalein was not used as indicator and methyl orange was used.

BIBLIOGRAPHY

Following sources of information have been referred for this project:- Together with Chemistry lab manual. Wikipedia Chem4kids.com

PHOTOS

Copyright Kaushal and Omkar (2014)